scholarly journals Discussing The Foundations for Interpretivist Digital Government Research

2021 ◽  
Author(s):  
Keegan McBride ◽  
Yuri Misnikov ◽  
Dirk Draheim
Keyword(s):  
Research Funding ◽  
Critical Discussion ◽  
Digital Government ◽  
Comprehensive Overview ◽  
The Core ◽  
Philosophical Basis ◽  
Research Philosophy ◽  
Government Research ◽  
Research Domain

As the research domain of digital government continues to develop itself as an important body of scholarly research, and it continues to grow in terms of researchers, publications, research funding, and other related indicators, it is important to understand the core theoretical and philosophical basis of the discipline. However, there is currently a lack of critical discussion about the concrete role of research philosophy for digital government research; which is one of the biggest current criticisms against the domain. This paper makes a first step in addressing this criticism by presenting arguments and discussion in favor of the importance of an interpretivist research philosophy for the domain of digital government. The paper provides a comprehensive overview of an interpretivist ontology and epistemology for digital government, discusses relevant theories and methods, and concludes with an overview of what is essential for conducting and carrying out interpretivist digital government research. This paper’s contribution represents one of the first concentrated efforts to lay out some initial foundations for the role of interpretivism, and research philosophy more generally, for the field.

Introduction: Psychiatric Research and Extraordinary Science

2017 ◽  
Keyword(s):  
Scientific Research ◽  
Psychiatric Research ◽  
Research Practice ◽  
Research Domain Criteria ◽  
Current Crisis ◽  
The Core ◽  
Research Programs ◽  
Research Domain

This chapter introduces the core thematic ideas of the present volume: that psychiatric research is in crisis, that it has entered a period of extraordinary science, and that a fully adequate response to the crisis should be responsive to the perspectives and interests of persons. We identify various sources of the crisis, drawing special attention to controversies concerning the role of the DSM in psychiatric research. And, we identify different strategies of response to the current crisis, including approaches that emphasize the importance of personal perspectives and the needs of the clinic and those that emphasize the important role of various scientific research programs. Further, we survey various developments (e.g., debates over fundamentals and a role for philosophical analysis, probing of the problems of the DSM framework, relaxation of standard forms of research practice, the introduction of the Research Domain Criteria initiative and other novel research programs) that are jointly suggestive of Thomas Kuhn’s characterization of periods of crisis that can arise in scientific research and of the “extraordinary science” that ensues. We suggest that this Kuhnian framework is useful for understanding the state of psychiatric research and it provides a framework for thinking about responses to the current crisis. We conclude with brief overviews of the contributions to the volume, each of which provides such a response.

The dynamics of ‘Moralized Markets’: a field perspective

2019 ◽  
Author(s):  
Philip Balsiger
Keyword(s):  
Empirical Studies ◽  
Critical Discussion ◽  
Distinctive Features ◽  
Moral Principles ◽  
The Core ◽  
Role Of The State ◽  
Moral Standards ◽  
Market Practices ◽  
Field Perspective

Abstract This article describes the distinctive features and structural properties of ‘moralized markets’, that is, markets in which producers set higher moral standards than those governing conventional market practices, and consumers buy products that respect those higher moral standards. Starting from a critical discussion of existing theoretical conceptualizations in terms of conventionalization/co-optation, quality conventions and resource partitioning, this article conceptualizes moralized markets as fields where actors are in strategic interaction. Using illustrations from several empirical studies, it suggests that all moralized markets are composed of a plurality of actors whose understanding of and commitments to moral principles vary. It reveals the main dimensions of the field, characterizes typical positions, and identifies and describes the core strategies used in struggles around field boundaries and the issues of policing and regulation of field settlements. The article concludes by offering six propositions regarding different possible outcome scenarios for the dynamics of moralized market fields, highlighting the role of the state for the stabilization of field settlements.

Challenges of Fear Conditioning Research in the Age of RDoC

2017 ◽  
Vol 225 (3) ◽  
pp. 189-199 ◽  
Author(s):  
Tina B. Lonsdorf ◽  
Jan Richter
Keyword(s):  
Fear Conditioning ◽  
Clinical Diagnosis ◽  
Research Domain Criteria ◽  
Major Focus ◽  
The Future ◽  
Definition Of ◽  
Methodological Considerations ◽  
Research Domain

Abstract. As the criticism of the definition of the phenotype (i.e., clinical diagnosis) represents the major focus of the Research Domain Criteria (RDoC) initiative, it is somewhat surprising that discussions have not yet focused more on specific conceptual and procedural considerations of the suggested RDoC constructs, sub-constructs, and associated paradigms. We argue that we need more precise thinking as well as a conceptual and methodological discussion of RDoC domains and constructs, their interrelationships as well as their experimental operationalization and nomenclature. The present work is intended to start such a debate using fear conditioning as an example. Thereby, we aim to provide thought-provoking impulses on the role of fear conditioning in the age of RDoC as well as conceptual and methodological considerations and suggestions to guide RDoC-based fear conditioning research in the future.

Does a Ribosome Really Read? On the Cognitive Roots and Heuristic Value of Linguistic Metaphors in Molecular Genetics. Part 2

2020 ◽  
Vol 63 (2) ◽  
pp. 46-62
Author(s):  
Suren T. Zolyan
Keyword(s):  
Information Processing ◽  
Genetic Information ◽  
Formal Organization ◽  
Dual Nature ◽  
Reading Frame ◽  
The Core ◽  
Genetic Information Processing ◽  
Cognitive Frame ◽  
Effective Instrument

We discuss the role of linguistic metaphors as a cognitive frame for the understanding of genetic information processing. The essential similarity between language and genetic information processing has been recognized since the very beginning, and many prominent scholars have noted the possibility of considering genes and genomes as texts or languages. Most of the core terms in molecular biology are based on linguistic metaphors. The processing of genetic information is understood as some operations on text – writing, reading and editing and their specification (encoding/decoding, proofreading, transcription, translation, reading frame). The concept of gene reading can be traced from the archaic idea of the equation of Life and Nature with the Book. Thus, the genetics itself can be metaphorically represented as some operations on text (deciphering, understanding, code-breaking, transcribing, editing, etc.), which are performed by scientists. At the same time linguistic metaphors portrayed gene entities also as having the ability of reading. In the case of such “bio-reading” some essential features similar to the processes of human reading can be revealed: this is an ability to identify the biochemical sequences based on their function in an abstract system and distinguish between type and its contextual tokens of the same type. Metaphors seem to be an effective instrument for representation, as they make possible a two-dimensional description: biochemical by its experimental empirical results and textual based on the cognitive models of comprehension. In addition to their heuristic value, linguistic metaphors are based on the essential characteristics of genetic information derived from its dual nature: biochemical by its substance, textual (or quasi-textual) by its formal organization. It can be concluded that linguistic metaphors denoting biochemical objects and processes seem to be a method of description and explanation of these heterogeneous properties.

Exploring the Mechanism of Lingzhu San in Treating Febrile Seizures by Using Network Pharmacology

2020 ◽  
Vol 23 ◽  
Author(s):  
Xiao Zhou ◽  
Xiao-Fei Zhang ◽  
Dong-Yan Guo ◽  
Yan-Jun Yang ◽  
Lin Liu ◽  
...  
Keyword(s):  
Febrile Seizures ◽  
Network Pharmacology ◽  
Biological Processes ◽  
Active Compounds ◽  
Potential Core ◽  
R Language ◽  
The Core ◽  
Multiple Factors ◽  
Therapeutic Mechanism

Objective: Lingzhu San (LZS) is a traditional Chinese medicine (TCM) prescription which can be effective in treating febrile seizures (FS) and has few researches on the mechanisms. In order to better guide the clinical use of LZS, we used the research ideas and methods of network pharmacology to find the potential core compounds, targets and pathways of LZS in the complex TCM system for the treatment of FS, and predict the mechanism. Materials and Methods: Databases such as BATMAN, TCMSP, TCMID, and SWISS TARGET are used to mine the active compounds and targets of LZS, and the target information of FS was obtained through GENECARDS and OMIM. Using Venny2.1.0 and Cytoscape software to locked the potential core compounds and targets of FS. The R language and ClusterProfiler software package were adopt to enrich and analyze the KEGG and GO pathways of the core targets and the biological processes and potential mechanisms of the core targets were revealed. Results: 187 active compounds and 2113 target proteins of LZS were collected. And 38 potential core compounds, 35 core targets and 775 metabolic and functional pathways were screened which involved in mediating FS. Finally, the role of the core compounds, targets and pivotal pathways of LZS regulated FS in the pathogenesis and therapeutic mechanism of FS was discussed and clarified. Conclusions: In this paper, the multi-compounds, multi-targets and multi-pathways mechanism of LZS in the treatment of FS was preliminarily revealed through the analysis of network pharmacology data, which is consistent with the principle of multi-compounds compatibility of TCM prescriptions and unified treatment of diseases from multiple angles, and it provides a new way for TCM to treat complex diseases caused by multiple factors.

Acid ceramidase, a double-edged sword in cancer aggression: A minireview

2020 ◽  
Vol 20 ◽  
Author(s):  
Helen Shiphrah Vethakanraj ◽  
Niveditha Chandrasekaran ◽  
Ashok Kumar Sekar
Keyword(s):  
Cell Fate ◽  
Cancer Progression ◽  
Potential Role ◽  
Tumour Progression ◽  
Acid Ceramidase ◽  
The Core ◽  
The Past ◽  
Sphingosine 1 Phosphate ◽  
Key Enzyme

: Acid ceramidase (AC), the key enzyme of the ceramide metabolic pathway hydrolyzes pro-apoptotic ceramide to sphingosine, which by the action of sphingosine-1-kinase is metabolized to mitogenic sphingosine-1-phosphate. The intracellular level of AC determines ceramide/sphingosine-1-phosphate rheostat which in turn decides the cell fate. The upregulated AC expression during cancerous condition acts as a “double-edged sword” by converting pro-apoptotic ceramide to anti-apoptotic sphingosine-1-phosphate, wherein on one end, the level of ceramide is decreased and on the other end, the level of sphingosine-1-phosphate is increased, thus altogether aggravating the cancer progression. In addition, cancer cells with upregulated AC expression exhibited increased cell proliferation, metastasis, chemoresistance, radioresistance and numerous strategies were developed in the past to effectively target the enzyme. Gene silencing and pharmacological inhibition of AC sensitized the resistant cells to chemo/radiotherapy thereby promoting cell death. The core objective of this review is to explore AC mediated tumour progression and the potential role of AC inhibitors in various cancer cell lines/models.

Argumentation theory: competition between modern research approaches

2018 ◽  
pp. 77-87
Author(s):  
Анатолий Мигунов ◽  
Anatoliy Migunov ◽  
Елена Лисанюк ◽  
Elena Lisanyuk
Keyword(s):  
Social Life ◽  
Critical Discussion ◽  
Procedural Semantics ◽  
Social Success ◽  
Large Structures ◽  
Criteria Importance ◽  
Practical Argumentation ◽  
Argumentative Structure ◽  
Theory Competition

To overcome the crisis in the sphere of argumentation studies, the project proposes a logical-cognitive concept of argumentation which is a compound formalized theory that includes formalisms for modeling argumentation of different types, a relevant conceptual framework and a methodology for the use of scientific research in the practice. Three types of argumentation are defined: theoretical (two types) and practical. Theoretical argumentation is a critical discussion of the agents’ knowledge and opinions about facts aimed to substantiate a certain view or to change it – i.e. persuasion. Practical argumentation is a critical discussion of opinions about actions which includes, in addition to the statements about knowledge and opinions, statements of a non-descriptive nature about the agents’ values and intentions to adhere to a certain line of behavior. The study of argumentation needs to focus on the large structures that reflect specifics of the criticism and defense of the positions of the parties. An atom unit of such study is the argument as a statement of reason, while its molecular elements are the argumentative structure of a dispute (frame), a multitude of arguments that express the parties’ positions, a multitude of the agents’ knowledge and opinions that act as the bases for the formation of positions, lines of behavior, etc. Within the framework of this trend, both indefeasible (deductive) and defeasible argumentations can be studied. The argumentation effectiveness can be assessed based on the procedural semantics and using analogues of such logical notions as consistency and completeness. Modern approaches to the argumentation, including those claiming the compound status, can be classified using two methods: based on the substantive and practical criteria. Importance of the research outcomes amounts to the theoretical and methodological role of the new conception of argumentation and the general “umbrella” term argumentation that allows systematizing the manifold research and educational approaches and concepts in this field and is associated with communicative nature of modern social life where efficiency and social success rely on argumentative and narrative competences.

Alcohol Use Disorder

2018 ◽  
Author(s):  
Igor Ponomarev
Keyword(s):  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Critical Discussion ◽  
Epigenetic Mechanisms ◽  
Future Directions ◽  
Clinically Significant ◽  
Early Life Exposures ◽  
The Brain ◽  
Epigenetic Research

Alcohol use disorder (AUD) is characterized by clinically significant impairments in health and social function. Epigenetic mechanisms of gene regulation may provide an attractive explanation for how early life exposures to alcohol contribute to the development of AUD and exert lifelong effects on the brain. This chapter provides a critical discussion of the role of epigenetic mechanisms in AUD etiology and the potential of epigenetic research to improve diagnosis, evaluate risks for alcohol-induced pathologies, and promote development of novel therapies for the prevention and treatment of AUD. Challenges of the current epigenetic approaches and future directions are also discussed.

The Fox Diet

2018 ◽  
Author(s):  
Yochai Benkler ◽  
Robert Faris ◽  
Hal Roberts
Keyword(s):  
First Year ◽  
Right Wing ◽  
Justice Department ◽  
Fox News ◽  
The Core ◽  
Deep State ◽  
Media Ecosystem ◽  
Conservative Media ◽  
The Right

This chapter focuses on the role of the dominant player in conservative media, Fox News, during the first year of Donald Trump’s presidency. It looks at three case studies to illustrate how Fox News used its position at the core of the right-wing media ecosystem repeatedly to mount propaganda attacks in support of Trump: the Michael Flynn firing in March 2017, when Fox adopted the “deep state” framing of the entire controversy; the James Comey firing and Robert Mueller appointment in May 2017; when Fox propagated the Seth Rich murder conspiracy; and in October and November, when the arrests of Paul Manafort and guilty plea of Flynn seemed to mark a new level of threat to the president, Fox reframed the Uranium One story as an attack on the integrity of the FBI and Justice Department officials in charge of the investigation.

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