scholarly journals “Thirst for Obedience”: A Freudian Analysis of the Father-Leader in Adorno and Beauvoir

2019 ◽  
Author(s):  
Jules Ostro
Keyword(s):  
Psychoanalytic Theory ◽  
Large Majority ◽  
Symbolic Gesture ◽  
Social Actors ◽  
Authoritarian State ◽  
Second Sex ◽  
Mass Psychology ◽  
And Function ◽  
And Control

Theodor W. Adorno’s 1951 essay, “A Freudian analysis of Fascist Propaganda,” is a fertileground for comparison with the work of feminist existential philosopher Simone de Beauvoir’s The Second Sex, which was published just a couple of years earlier in 1949. The following exposition of Adorno’s essay and the “Introductory" and “Independent Woman” chapters in Beauvoir’s The Second Sex examines how Adorno’s application of Freudian psychoanalytic theory of mass psychology and the modern authoritarian state aligns with Beauvoir’s theoretical dialectic of the man as transcendent Subject versus the woman as immanent Other. The connective thread in both contexts is a hegemonic teleology of dominance. This hegemony is the apparatus and function of both predominately male fascist dictators and sexist social actors who pander to collective entities of followers captivated by the ostensible auspices of the Father-Leader. The following use of the term Father-Leader will be used as a symbolic gesture and catch-all term to simplify the analogy between Adorno’s fascist dictator and the historically paternalistic man. The symbolic authority of the Father-Leader lies in his ability to generate an affect-driven, hypnotic libidinal bond through the mechanisms of identification and idealization with a mass ancillary entity, in this case either a fascist following of a nation or a large majority of the population, thus maintaining social and political privilege, influence, and control.

scholarly journals Metagenomic Analysis of the Fecal Archaeome in Suckling Piglets Following Perinatal Tulathromycin Metaphylaxis

Animals ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1825
Author(s):  
Mohamed Zeineldin ◽  
Ameer Megahed ◽  
Benjamin Blair ◽  
Brian Aldridge ◽  
James Lowe
Keyword(s):  
Sequencing Analysis ◽  
Metagenomic Sequencing ◽  
Post Intervention ◽  
Gastrointestinal Microbiome ◽  
Health And Wellbeing ◽  
Suckling Piglets ◽  
And Function ◽  
Changes Over Time ◽  
And Control ◽  
The Impact

The gastrointestinal microbiome plays an important role in swine health and wellbeing, but the gut archaeome structure and function in swine remain largely unexplored. To date, no metagenomics-based analysis has been done to assess the impact of an early life antimicrobials intervention on the gut archaeome. The aim of this study was to investigate the effects of perinatal tulathromycin (TUL) administration on the fecal archaeome composition and diversity in suckling piglets using metagenomic sequencing analysis. Sixteen litters were administered one of two treatments (TUL; 2.5 mg/kg IM and control (CONT); saline 1cc IM) soon after birth. Deep fecal swabs were collected from all piglets on days 0 (prior to treatment), 5, and 20 post intervention. Each piglet’s fecal archaeome was composed of rich and diverse communities that showed significant changes over time during the suckling period. At the phylum level, 98.24% of the fecal archaeome across all samples belonged to Euryarchaeota. At the genus level, the predominant archaeal genera across all samples were Methanobrevibacter (43.31%), Methanosarcina (10.84%), Methanococcus (6.51%), and Methanocorpusculum (6.01%). The composition and diversity of the fecal archaeome between the TUL and CONT groups at the same time points were statistically insignificant. Our findings indicate that perinatal TUL metaphylaxis seems to have a minimal effect on the gut archaeome composition and diversity in sucking piglets. This study improves our current understanding of the fecal archaeome structure in sucking piglets and provides a rationale for future studies to decipher its role in and impact on host robustness during this critical phase of production.

TRPC1, TRPC3, and TRPC4 in Rat Orofacial Structures

2017 ◽  
Vol 204 (5-6) ◽  
pp. 293-303 ◽  
Author(s):  
Masatoshi Fujita ◽  
Tadasu Sato ◽  
Takehiro Yajima ◽  
Eiji Masaki ◽  
Hiroyuki Ichikawa
Keyword(s):  
Transient Receptor Potential ◽  
Sympathetic Neurons ◽  
Receptor Potential ◽  
Monovalent Cation ◽  
Calcitonin Gene ◽  
Cervical Ganglion ◽  
Parasympathetic Neurons ◽  
Transient Receptor ◽  
And Function ◽  
And Control

TRPC (transient receptor potential cation channel subfamily C) members are nonselective monovalent cation channels and control Ca2+ inflow. In this study, immunohistochemistry for TRPC1, TRPC3, and TRPC4 was performed on rat oral and craniofacial structures to elucidate their distribution and function in the peripheries. In the trigeminal ganglion (TG), 56.1, 84.1, and 68.3% of sensory neurons were immunoreactive (IR) for TRPC1, TRPC3, and TRPC4, respectively. A double immunofluorescence method revealed that small to medium-sized TG neurons co-expressed TRPCs and calcitonin gene-related peptide. In the superior cervical ganglion, all sympathetic neurons showed TRPC1 and TRPC3 immunoreactivity. Parasympathetic neurons in the submandibular ganglion, tongue, and parotid gland were TRPC1, TRPC3, and TRPC4 IR. Gustatory and olfactory cells were also IR for TRPC1, TRPC3, and/or TRPC4. In the musculature, motor endplates expressed TRPC1 and TRPC4 immunoreactivity. It is likely that TRPCs are associated with sensory, autonomic, and motor functions in oral and craniofacial structures.

Exploring ‘digital placemaking’

2021 ◽  
Vol 27 (3) ◽  
pp. 573-578
Author(s):  
Germaine Halegoua ◽  
Erika Polson
Keyword(s):  
Digital Media ◽  
Sense Of Place ◽  
Media Use ◽  
Special Issue ◽  
Social Actors ◽  
Broad Framework ◽  
The Many ◽  
And Control ◽  
Connected Spaces

This brief essay introduces the special issue on the topic of ‘digital placemaking’ – a concept describing the use of digital media to create a sense of place for oneself and/or others. As a broad framework that encompasses a variety of practices used to create emotional attachments to place through digital media use, digital placemaking can be examined across a variety of domains. The concept acknowledges that, at its core, a drive to create and control a sense of place is understood as primary to how social actors identify with each other and express their identities and how communities organize to build more meaningful and connected spaces. This idea runs through the articles in the issue, exploring the many ways people use digital media, under varied conditions, to negotiate differential mobilities and become placemakers – practices that may expose or amplify preexisting inequities, exclusions, or erasures in the ways that certain populations experience digital media in place and placemaking.

scholarly journals Modelling the Human Placental Interface In Vitro—A Review

Micromachines ◽  
2021 ◽  
Vol 12 (8) ◽  
pp. 884
Author(s):  
Marta Cherubini ◽  
Scott Erickson ◽  
Kristina Haase
Keyword(s):  
Drug Testing ◽  
Cell Types ◽  
In Vitro Models ◽  
Placental Development ◽  
Scientific Challenge ◽  
Induced Pluripotent ◽  
And Function ◽  
And Control

Acting as the primary link between mother and fetus, the placenta is involved in regulating nutrient, oxygen, and waste exchange; thus, healthy placental development is crucial for a successful pregnancy. In line with the increasing demands of the fetus, the placenta evolves throughout pregnancy, making it a particularly difficult organ to study. Research into placental development and dysfunction poses a unique scientific challenge due to ethical constraints and the differences in morphology and function that exist between species. Recently, there have been increased efforts towards generating in vitro models of the human placenta. Advancements in the differentiation of human induced pluripotent stem cells (hiPSCs), microfluidics, and bioprinting have each contributed to the development of new models, which can be designed to closely match physiological in vivo conditions. By including relevant placental cell types and control over the microenvironment, these new in vitro models promise to reveal clues to the pathogenesis of placental dysfunction and facilitate drug testing across the maternal–fetal interface. In this minireview, we aim to highlight current in vitro placental models and their applications in the study of disease and discuss future avenues for these in vitro models.

scholarly journals Endothelium as a Source and Target of H2S to Improve Its Trophism and Function

Antioxidants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 486
Author(s):  
Valerio Ciccone ◽  
Shirley Genah ◽  
Lucia Morbidelli
Keyword(s):  
Endothelial Dysfunction ◽  
Vessel Wall ◽  
Redox Reactions ◽  
Single Layer ◽  
Fine Tuning ◽  
Therapeutic Approaches ◽  
Impaired Wound Healing ◽  
Blood Fluidity ◽  
And Function ◽  
And Control

The vascular endothelium consists of a single layer of squamous endothelial cells (ECs) lining the inner surface of blood vessels. Nowadays, it is no longer considered as a simple barrier between the blood and vessel wall, but a central hub to control blood flow homeostasis and fulfill tissue metabolic demands by furnishing oxygen and nutrients. The endothelium regulates the proper functioning of vessels and microcirculation, in terms of tone control, blood fluidity, and fine tuning of inflammatory and redox reactions within the vessel wall and in surrounding tissues. This multiplicity of effects is due to the ability of ECs to produce, process, and release key modulators. Among these, gasotransmitters such as nitric oxide (NO) and hydrogen sulfide (H2S) are very active molecules constitutively produced by endotheliocytes for the maintenance and control of vascular physiological functions, while their impairment is responsible for endothelial dysfunction and cardiovascular disorders such as hypertension, atherosclerosis, and impaired wound healing and vascularization due to diabetes, infections, and ischemia. Upregulation of H2S producing enzymes and administration of H2S donors can be considered as innovative therapeutic approaches to improve EC biology and function, to revert endothelial dysfunction or to prevent cardiovascular disease progression. This review will focus on the beneficial autocrine/paracrine properties of H2S on ECs and the state of the art on H2S potentiating drugs and tools.

scholarly journals Critical requirement of SOS1 RAS-GEF function for mitochondrial dynamics, metabolism, and redox homeostasis

Oncogene ◽  
2021 ◽  
Author(s):  
Rósula García-Navas ◽  
Pilar Liceras-Boillos ◽  
Carmela Gómez ◽  
Fernando C. Baltanás ◽  
Nuria Calzada ◽  
...  
Keyword(s):  
Mitochondrial Dynamics ◽  
Redox Homeostasis ◽  
Atp Production ◽  
Oxidative Energy Metabolism ◽  
Ras Activation ◽  
Mitochondrial Defects ◽  
Critical Requirement ◽  
Dynamics And Function ◽  
And Function ◽  
And Control

AbstractSOS1 ablation causes specific defective phenotypes in MEFs including increased levels of intracellular ROS. We showed that the mitochondria-targeted antioxidant MitoTEMPO restores normal endogenous ROS levels, suggesting predominant involvement of mitochondria in generation of this defective SOS1-dependent phenotype. The absence of SOS1 caused specific alterations of mitochondrial shape, mass, and dynamics accompanied by higher percentage of dysfunctional mitochondria and lower rates of electron transport in comparison to WT or SOS2-KO counterparts. SOS1-deficient MEFs also exhibited specific alterations of respiratory complexes and their assembly into mitochondrial supercomplexes and consistently reduced rates of respiration, glycolysis, and ATP production, together with distinctive patterns of substrate preference for oxidative energy metabolism and dependence on glucose for survival. RASless cells showed defective respiratory/metabolic phenotypes reminiscent of those of SOS1-deficient MEFs, suggesting that the mitochondrial defects of these cells are mechanistically linked to the absence of SOS1-GEF activity on cellular RAS targets. Our observations provide a direct mechanistic link between SOS1 and control of cellular oxidative stress and suggest that SOS1-mediated RAS activation is required for correct mitochondrial dynamics and function.

scholarly journals Netrin-1 in Atherosclerosis: Relationship between Human Macrophage Intracellular Levels and In Vivo Plaque Morphology

Biomedicines ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 168
Author(s):  
Susanna Fiorelli ◽  
Nicola Cosentino ◽  
Benedetta Porro ◽  
Franco Fabbiocchi ◽  
Giampaolo Niccoli ◽  
...  
Keyword(s):  
Progressive Increase ◽  
Human Macrophage ◽  
Plaque Morphology ◽  
Artery Disease ◽  
Atherosclerotic Process ◽  
And Function ◽  
And Control ◽  
Macrophage Accumulation

Netrin-1 is a laminin-like protein that plays a pivotal role in cell migration and, according to the site of its release, exerts both pro and anti-atherosclerotic functions. Macrophages, key cells in atherosclerosis, are heterogeneous in morphology and function and different subpopulations may support plaque progression, stabilization, and/or regression. Netrin-1 was evaluated in plasma and, together with its receptor UNC5b, in both spindle and round monocyte-derived macrophages (MDMs) morphotypes from coronary artery disease (CAD) patients and control subjects. In CAD patients, plaque features were detected in vivo by optical coherence tomography. CAD patients had lower plasma Netrin-1 levels and a higher MDMs expression of both protein and its receptor compared to controls. Specifically, a progressive increase in Netrin-1 and UNC5b was evidenced going from controls to stable angina (SA) and acute myocardial infarction (AMI) patients. Of note, spindle MDMs of AMI showed a marked increase of both Netrin-1 and its receptor compared to spindle MDMs of controls. UNC5b expression is always higher in spindle compared to round MDMs, regardless of the subgroup. Finally, CAD patients with higher intracellular Netrin-1 levels showed greater intraplaque macrophage accumulation in vivo. Our findings support the role of Netrin-1 and UNC5b in the atherosclerotic process.

ADMINISTRATIVE REGULATIONS OF STATE FUNCTIONS AT THE PRESENT STAGE: DYNAMICS OF CHANGES IN THE APPROACH TO THE CONCEPT AND VARIETIES AT THE LEGAL REGULATORY

2021 ◽  
Vol 14 (6) ◽  
pp. 137-141
Author(s):  
ROMAN ZELEPUKIN ◽  
Keyword(s):  
Public Administration ◽  
Administrative Reform ◽  
The State ◽  
Present Stage ◽  
Logical Connection ◽  
Administrative Procedures ◽  
Continuous Activities ◽  
And Function ◽  
And Control ◽  
State Functions

In this article the author analyses the development of administrative regulations in the system of modern public administration. The state of administrative regulations and their institutionalisation as a result of the administrative reform is noted. It has been identified and found that there has now been a change in the approach to the delineation of the administrative regulations of the executive authorities - before 2018, administrative regulations were divided into service regulations and function regulations, where service regulations are related to requests by private persons to the state represented by its bodies and officials - and function regulations are related to the implementation of continuous activities to perform assigned powers and exercise the established competence, after 2018, administrative regulations are divided into service regulations and control (supervision) regulations. According to the author, the established approach has allowed the above varieties of regulations to be merged into such a group of types of administrative regulations as administrative regulations for the implementation of state functions. Also the author concludes that it is necessary to adopt a special legislative act systemising the functions of the executive authorities and the administrative procedures they carry out in a single logical connection.

scholarly journals Pragmatic essence of linguistic modality in media discourse

2019 ◽  
Vol 1 (16) ◽  
pp. 54-59
Author(s):  
Victoria Haenko
Keyword(s):  
Discourse Analysis ◽  
Theoretical Aspect ◽  
Media Discourse ◽  
Functional Aspect ◽  
Language Play ◽  
Social Actors ◽  
The People ◽  
Evaluative Meaning ◽  
Language Modality ◽  
And Control

The article deals with the problem of correlation between target socio groups in media discourse. It investigates the role modality plays as pragmatic-functional aspect of discourse analysis and studies modality as means of expressing evaluative meaning. The functional aspect of this view reflects the broad objectives of functional linguistics: i.e. relating linguistic structures to social structures. The pragmatic aspect reflects an emphasis that the reader is dependent on a corresponding view of the relationship between the reader, the writer and the text. The studies of modern linguists are broadly concerned with the analysis of ideology in discourse.  The article observes the effects language can have on people, whether through journalistic writing, advertising literature, politics, science.  The study became an attempt to investigate how and which aspects of language play more significant roles in ideology manipulating hearers / readers. It was seen that modality has not only received little consideration at the practical level, but that it had also been handled through the process of modal categorization; i.e. at the theoretical descriptive level. The theoretical aspect of the article is based on the belief that the speech is aimed at attaining certain goals or targets. The article deals with a problem of correlation and interaction between writer and reader, speaker and hearer, text producers and social actors in the process of interpretation. The article investigates the ways the problem can be settled in view of modality as a parameter of discourse analysis to define goals for the target groups outlined above. The study in the article refers to Halliday’s overarching functions: ideational, interpersonal and textual. The article concludes that the realiser of the interpersonal function of language, modality may be used as a linguistic tool to direct and control the behavior of the people.

Datahand: Design, Potential Performance, and Improvements in the Computer Keyboard and Mouse

1989 ◽  
Vol 33 (6) ◽  
pp. 450-454 ◽  
Author(s):  
Leland W. Knight ◽  
Dale Retter
Keyword(s):  
Data Entry ◽  
Hand Position ◽  
Preliminary Evaluation ◽  
Computer Data ◽  
Spatial Control ◽  
Empirical Results ◽  
Physical Form ◽  
Computer Keyboard ◽  
And Function ◽  
And Control

This paper presents the design and preliminary evaluation of a new computer key and spatial entry system called Datahand. It is intended to improve human-to-computer data entry and control, as well as providing possible reduction of five major identifiable problems with conventional keyboards which subject operator to injury. The overall physical form of this product, its keys, and their organization, are unique in shape and function. Such a departure from traditional keyboards has presented an opportunity to consider new approaches to hand position, key design, spatial control and function. Preliminary empirical results from first users are covered in this paper.

Sign in / Sign up

Export Citation Format

Share Document