scholarly journals Identification of types and frequency of pre-analytical errors in hematology laboratory at a tertiary hospital of Nepal

2021 ◽  
Vol 11 (1) ◽  
pp. 1842-1846
Author(s):  
Kricha Pande ◽  
Prabesh Dahal ◽  
Laxman Pokharel
Keyword(s):  
Blood Count ◽  
Complete Blood Count ◽  
College Teaching ◽  
Common Source ◽  
Cross Sectional ◽  
Common Error ◽  
Blood Samples ◽  
Laboratory Errors ◽  
Analytical Errors ◽  
Inpatient Department

Background: In the laboratory, errors can occur at any stage of sample processing; pre-analytical, analytical, and post-analytical. Since the pre-analytical phase is the most common source of laboratory errors, the goal of this study is to identify the types and frequency of pre-analytical errors in the hematology laboratory.Materials and Methods: This is a cross-sectional descriptive study done at Nepal Medical College Teaching hospital for a duration of nine months (January 2020 to September 2020). All blood samples received at the hematology laboratory were included whereas biochemistry and special tests blood samples were excluded. Samples were checked for misidentification (incorrectly labeled vials/vials without labels/incorrectly filled forms), incorrect samples (wrong choice of vials), clotted samples, inadequate samples, diluted samples, hemolyzed samples. The errors that occurred in these samples (both inpatient and outpatient) were noted down and measures were taken accordingly before analyzing the sample.Results: The total number of samples received was 15,337. Pre-analytical errors were seen in 857 samples (5.5%). Inadequate samples (25%) were the most common error followed by incorrect samples (20%), hemolyzed samples (20%), misidentification (14%), clotted samples (12%), and diluted samples (9%). Complete blood count test was most affected. Samples from the inpatient department were most affected.Conclusions: The preanalytical error rate in the hematology unit was 5.5% with an inadequate sample being the commonest error. Most of the errors were seen in the test requested for a complete blood count. Samples from the inpatient department showed the most errors.

scholarly journals CORRELATION BETWEEN WDF, WNR, AND RET ABNORMAL SCATTERGRAM DETECTED BY SYSMEX XN-1000 AND PARASITEMIA OF MALARIA PATIENTS IN MERAUKE HOSPITAL

2019 ◽  
Vol 26 (1) ◽  
pp. 91
Author(s):  
Merylin Ranoko ◽  
Aryati Aryati ◽  
Arifoel Hajat
Keyword(s):  
General Hospital ◽  
Health Problem ◽  
Gold Standard ◽  
Blood Count ◽  
Complete Blood Count ◽  
Cross Sectional Study ◽  
Response To Therapy ◽  
Sectional Study ◽  
Cross Sectional ◽  
Degree Of Severity

Malaria remains a health problem in Indonesia. Microscopic examination with Giemsa staining is the gold standard for diagnosing malaria. The density of parasites correlates with the degree of severity and response to therapy of malaria. Malaria-causing plasmodium can be detected by Sysmex XN-1000 which is marked by abnormalities in the WDF, WNR and RET scattergram. This research aimed to determine the correlation of WDF, WNR and RET abnormal scattergram detected by Sysmex XN-1000 and the parasitemia index of malaria at the Merauke General Hospital. This was a cross-sectional study with observational approach conducted between November 2017 – February 2018 at the Merauke General Hospital. Positive malaria samples were stained with Giemsa, their parasitemia index was calculated, routine complete blood count using Sysmex XN-1000 was performed, and the scattergram abnormalities were then analyzed. There were 65 positive malaria samples as follows: P.falciparum (35%), P.vivax (60%), P.ovale (3.1%), and P.malariae (1.5%), but the species did not correlate with parasitemic index (p=0.691). Abnormalities of WDF and WNR scattergram were predominantly found than RET scattergram (80% vs. 27.7%). P.vivax predominantly caused abnormalities of the WDF and WNR scattergram in 36 of 39 samples (92.3%), whereas P.falciparum predominantly caused abnomalities of the RET scattergram in 14 of 23 samples (60.9%). There was 95% positivity of an abnormality in WDF/WNR/RET scattergram with a cut-off of > 5,0165.5/µL. There was correlation between WDF, WNR, RET scattergram detected by Sysmex XN-1000 and the parasitemia index.

The Association between Bone Mineral Density and Complete Blood Count in Postmenopausal Women: A Cross-Sectional Study

2021 ◽  
Vol 104 (3) ◽  
pp. 432-437
Keyword(s):  
Bone Mineral Density ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Blood Count ◽  
Complete Blood Count ◽  
Cross Sectional Study ◽  
Mineral Density ◽  
Cross Sectional ◽  
Study Results ◽  
The Relationship

Objective: To demonstrate the relationship between anemia and complete blood count (CBC) parameters with bone mineral density (BMD) in postmenopausal women. Materials and Methods: A cross-sectional chart-review study was conducted between November 2017 and June 2019. Three hundred twenty-four postmenopausal women aged 50 years or older who had BMD and CBC results were included in the present study. Results: The prevalence of osteopenia and osteoporosis diagnosed by T-score were 53.1% and 32.7%, respectively. Simple and multiple linear regression analyses showed that no association between CBC parameter with BMD except basophil count, which was negatively associated with BMD (p=0.011). There was no correlation between anemia and BMD status (p=0.168). Conclusion: CBC parameters such as hemoglobin or white blood cell count were not statistically correlated with BMD. This is the first study demonstrating that basophil count may be an associated factor for deceased BMD. Keywords: Postmenopausal women, Bone mineral density, Complete blood count, Basophil

scholarly journals Lymphocyte-monocyte ratio as predictive factors for huvos scores in osteosarcoma extremities treated by neoadjuvan chemotherapy (cisplatin and doxorubicin)

2020 ◽  
Vol 8 (11) ◽  
pp. 3816
Author(s):  
I. Made Tusan Sidharta ◽  
I. Ketut Siki Kawiyana ◽  
I. Ketut Suyasa
Keyword(s):  
Immune Cells ◽  
Medical Records ◽  
Blood Count ◽  
Complete Blood Count ◽  
Research Subject ◽  
Exclusion Criteria ◽  
Cross Sectional ◽  
Positive Correlation ◽  
Conventional Osteosarcoma ◽  
Independent Variable

Background: Chemotherapy is a vital treatment in osteosarcoma but it’s responses are difficult to predict, and there are still no biomarkers that can estimate the prognosis of chemotherapy. Lymphocytes and monocytes are key immune cells which are examined on complete blood count test before chemotherapy and often associated with prognosis of various malignancies. Low lymphocyte-monocyte ratio (LMR) are associated with poor prognostics in some cancers.Methods: This study is cross-sectional retrospective analytics that was conducted at Sanglah Hospital from June to August 2018. The research subject was medical records of intramedullary conventional osteosarcoma patients which fulfil inclusion and exclusion criteria. In this study, LMR as independent variable and Huvos score as dependent variable.Results: The result in this study showed positive correlation between LMR before neoadjuvan Chemotherapy and Huvos score (r=0.500) with p<0.05.Conclusions: A positive correlation was found between LMR and Huvos scores. Low LMR before neoadjuvan chemotheraphy (<2.81) were correlated with low huvos scores (grade I and II).

scholarly journals SPECTRUM OF PANCYTOPENIA

2016 ◽  
Vol 23 (05) ◽  
pp. 620-626
Author(s):  
Tariq Hameed Rehmani Rehmani ◽  
Mizna Arif ◽  
Sajjad Heraid ◽  
Sarah Arif ◽  
Rabia Ahmad ◽  
...  
Keyword(s):  
Blood Count ◽  
Complete Blood Count ◽  
Megaloblastic Anemia ◽  
Clinical History ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Male Predominance ◽  
Medical College ◽  
Study Setting

Pancytopenia refers to a reduction in all the three cellular elements of blood.Pancytopenia is a common but important hematological problem encountered in routineclinical Practice. It may be a presenting feature of many underlying serious and life threateningillnesses. Objective: Present study was planned to appraise various clinico- etiologicalfactors underlining Pancytopenia. Study Design: Cross-sectional study. Setting: HematologyDepartment of Allama Iqbal Medical College/ Jinnah Hospital Lahore (AIMC&JHL). Period:July 2011 to Jun 2015. Materials and Methods: Two hundred and forty four patients withPancytopenia were included in the study. Complete blood count, bone marrow aspirations andtrephine biopsies were performed after clinical history and physical exam. Data were analyzedby using SPSS 20.0 version. Results: Out of total 244 Pancytopenia cases, hypoplastic bonemarrow 66 (27.04%) and Megaloblastic anemia 49 (20.08%) were the most common etiologicalfactors with male predominance. Fever and pallor were striking presenting clinical features.Conclusion: We conclude that Pancytopenia is a common problem with an exhaustive listof differential diagnosis, some of which are easily treatable and reversible. Therefore earlydetection with optimal diagnostic approach to Pancytopenia is required for better managementof patients.

scholarly journals Isolated Neutropenia/Benign Ethnic Neutropenia: A Common Clinical and Laboratory Finding in Southern and Southwestern Saudi Arabia

2020 ◽  
Author(s):  
Zuhier A. Awan ◽  
Saeed M. Al Amoudi ◽  
Muhammad Saboor ◽  
Husain Y. Alkhaldy
Keyword(s):  
Saudi Arabia ◽  
Blood Count ◽  
Complete Blood Count ◽  
Laboratory Finding ◽  
Fasting Blood Glucose ◽  
Final Analysis ◽  
Thyroid Function Test ◽  
Cross Sectional ◽  
High Prevalence ◽  
Study Laboratory

Objectives: Isolated mild neutropenia is a common clinical problem. The current study aims to validate our previous findings regarding the high prevalence of isolated neutropenia in Southern and Southwestern Saudi Arabia and explore the effect of altitude or regional differences. Methods: In this retrospective cross-sectional study, laboratory results of a commercial laboratory were screened over a period of 5 years (2016&ndash;2020) in seven different cities in South and southwestern Saudi Arabia. Participants&rsquo; laboratory investigations were reviewed and excluded for any ab-normal complete blood count, renal profile, liver profile, lipid profile, thyroid function test, fasting blood glucose, or HbA1c findings. Descriptive analysis and 95th percentile range were calculated using standard statistical methods. Results: A total of 91,880 complete blood count results were included in the final analysis. isolated neutropenia is common laboratory finding, with a prevalence ranging from 11-23%. The 2.5th percentile of the neutrophil count was lower than 1.5&times;109/L in all seven cities. Conclusions: Mild to moderate neutropenia is common in Southern and Southwestern Saudi Arabia. Benign ethnic neutropenia (BEN) may explain this high prevalence. Since BEN has no clinical significance, the reference range for normal neutrophil counts needs to be adjusted to reflect the effect of BEN.

Effects of Clinical Symptoms and Laboratory Values of COVID- 19 Patients' Tests at the Time of Hospitalization on Their Clinical Outcomes

2021 ◽  
Vol 15 (5) ◽  
pp. 1635-1640
Author(s):  
Toomaj Shahverdi ◽  
Mahdi Nikoo Hemmat ◽  
Mohammad Islamy
Keyword(s):  
Mortality Rate ◽  
Clinical Outcomes ◽  
Blood Count ◽  
Complete Blood Count ◽  
Clinical Symptoms ◽  
Cross Sectional Study ◽  
General Information ◽  
Cross Sectional ◽  
Laboratory Values ◽  
And Gender

Introduction: At the end of 2019, a new coronavirus caused pneumonia in Wuhan, China. Several studies have described the clinical features and immune manifestations in COVID-19 patients with moderate to severe symptoms, while their clinical relevance is less clear. This study investigates the effects of clinical symptoms and laboratory values of COVID-19 patients' tests at the time of hospitalization on their clinical outcomes. Methodology: This descriptive cross-sectional study was performed on COVID-19 patients hospitalized in Arak hospitals from April 2020 to March 2020. Medical records of all the hospitalized patients were retrieved. Trained personnel extracted general information (age and gender) and clinical profiles (the complete blood count and other required tests). Findings: Analyzing the laboratory indices of the blood count and LDH and CPK levels revealed a positive relationship between the patients' serum CPK levels, and the mortality rate (P = 0.001) and length of hospitalization (P = 0.015). Conclusion: The patients' serum LDH levels and fever were also associated with the mortality rate, and the need for mechanical ventilation, respectively. We hope this information helps physicians treat COVID-19 patients. Keywords: COVID-19, clinical symptoms, laboratory tests

scholarly journals Impact of Fasting on Complete Blood Count Assayed in Capillary Blood Samples

2017 ◽  
Vol 48 (4) ◽  
pp. 357-361 ◽  
Author(s):  
Barbara K Kościelniak ◽  
Aleksandra Charchut ◽  
Magdalena Wójcik ◽  
Krystyna Sztefko ◽  
Przemysław J Tomasik
Keyword(s):  
Blood Count ◽  
Complete Blood Count ◽  
Capillary Blood ◽  
Blood Samples
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