scholarly journals Signs of palmar dermatoglyphics as markers of atopic diseases

2019 ◽  
Vol 25 (1) ◽  
pp. 39-44
Author(s):  
V.S. Shkolnikov ◽  
L.А. Klimas ◽  
D.G. Smolko ◽  
I.M. Makarchuk ◽  
S.V. Koliadenko
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Bronchial Asthma ◽  
Young Women ◽  
Young Men ◽  
Data Bank ◽  
Women Patients ◽  
Quantitative Indices ◽  
The Family ◽  
Medical University

The family character of atopic conditions, confirmed by many studies, has become the basis for the use of the method of dermatoglyphics to clarify the genetic nature of the “atopic march”. The purpose of the study was to identify differences in the features of palmar dermatoglyphics between patients with atopic dermatitis, allergic rhinitis and bronchial asthma. Primary indexes of palmar dermatoglyphics of young men and young women patients with atopic dermatitis, allergic rhinitis and bronchial asthma were taken from the data bank of the research center of National Pirogov Memorial Medical University, Vinnytsya. According to the method of Cummins H. and Midlo Ch. dermatoglyphic study of 320 young men and young women with allergic rhinitis (n = 69), bronchial asthma (n = 108) and atopic dermatitis (n = 143) was performed. Quantitative indices of palmar dermatoglyphics were subject to analysis. The results obtained were processed using the Statistica 6.1 license package using non-parametric methods. It is established that the differences of quantitative indices of palmar dermatoglyphics between young men / young women with atopic dermatitis and allergic rhinitis cover 50.0% / 66.67%; among patients with atopic dermatitis and bronchial asthma – 38.89% / 33.33%; among patients with allergic rhinitis and bronchial asthma – 22.22% / 55.56% respectively. Thus, in young men, the marker potential for signs of palmar dermatoglyphics in the prognosis for the development of bronchial asthma in the presence of allergic rhinitis (22.22%) or atopic dermatitis (38.89%) are insignificant compared with the prognosis for the development of allergic rhinitis in the presence of atopic dermatitis (50.0%). In young women, the marker features of palmar dermatoglyphics in the prognosis for the development of bronchial asthma in the presence of atopic dermatitis are insignificant (33.33%) compared with the prognosis for the development of bronchial asthma in the presence of allergic rhinitis (55.56%) and the prognosis for the development of allergic rhinitis (66.67%).

scholarly journals Qualitative signs of digital dermatoglyphics as markers of diseases of atopic nature

2019 ◽  
pp. 5-12
Author(s):  
V. G. Cherkasov ◽  
О. Ye. Маievskyi ◽  
I. V. Serheta ◽  
I. M. Makarchuk ◽  
N. M. Smolko
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Bronchial Asthma ◽  
Young Women ◽  
Young Men ◽  
Statistical Processing ◽  
Random Pattern ◽  
Healthy Population ◽  
Atopic Diseases ◽  
Polygenic Inheritance

The lawfulness of the application of the method of dermatoglyphics in the study of atopic diseases is ensured by the polygenic inheritance of signs of dermatoglyphics, on the one hand, and the pathogenetic heterogeneity of these diseases, on the other hand, as well as high informative ability of signs of dermatoglyphics as markers of diseases of hereditary and multifactorial nature. The purpose of the study is to detect differences in qualitative signs of digital dermatoglyphics between patients with atopic dermatitis, allergic rhinitis and bronchial asthma. Primary indicators of digital dermatoglyphics of sick young men and young women of the Podillia region are taken from the data bank of the research center of the National Pirogov Memorial Medical University, Vinnytsya and were used in previous studies when compared with the practically healthy population of this region. Imprints were obtained by the method of “printing ink” by Gladkova T. D. By the method of Cummins H. and Midlo Ch. a dermatological study was performed for 320 young men and young women with allergic rhinitis (n=69), bronchial asthma (n=108) and atopic dermatitis (n=143). The frequency and location of 8 types of finger patterns were subject to analysis. Statistical processing of the obtained results was carried out in the package “Statistica 6.1” using nonparametric methods. The reliability of the difference in values between independent qualitative values was determined by the formula of Weber E. (1961). The specificity of the digital typology of atopic diseases is established, which is based on the differences in the frequency and location of the whorl, central pocket and arches between the young men, except those indicated - a random pattern between young women, patients with atopic dermatitis, bronchial asthma, allergic rhinitis. Additionally, when comparing young men, patients with allergic rhinitis with patients with bronchial asthma and atopic dermatitis - ulnar loop; for bronchial asthma with patients with allergic rhinitis and atopic dermatitis - lateral pocket loop (in young men) and ulnar, lateral pocket and double loops (in young women); when comparing young men, patients with atopic dermatitis with patients with bronchial asthma, and allergic rhinitis - a random pattern.

scholarly journals Cephalometric studies of Ukrainian adolescents with orthognathic bite by the method of E.P. Harvold

2018 ◽  
Vol 24 (2) ◽  
pp. 38-43
Author(s):  
A. V. Chernysh
Keyword(s):  
Young Women ◽  
Young Men ◽  
Statistical Processing ◽  
Data Bank ◽  
Cross Sectional ◽  
Lower Jaw ◽  
Facial Height ◽  
Literary Sources ◽  
Normal Occlusion ◽  
Medical University

According to many numerical literary sources, the modern direction of provision of dental care involves an individual approach to the patient, in particular, based on his gender, age and nationality. This calls for the creation of its own regulatory bases for the population of different countries and ethnic groups, taking into account all possible criteria. The purpose of the study is to establish and analyze the cephalometric parameters by the method of E.P. Harvold in young men and women of Podillia region of Ukraine with orthognathic bite. Primary lateral teleroentgenograms of 38 young men and 55 women with normal occlusion close to orthognathic bite, obtained using the Veraviewepocs 3D device, Morita (Japan), were taken from the data bank of the research center of the National Pirogov Memorial Medical University, Vinnytsya. Cephalometric measurements were performed according to the recommendations of E.P. Harvold. Statistical processing of the obtained results was carried out in the license package "Statistica 6.0" using nonparametric methods of estimating the results. When comparing teleroentgenographic indices between boys and girls of the Podillia region of Ukraine with orthognathic occlusion, significantly higher values of the length of the upper and lower jaw, lower facial height and interjaw differences in young men were established, and Ap1uAp1l-DOP angle was significantly higher in young women. When comparing these data with the results obtained by E.P. Harvold, the boys and girls of the Podillia region of Ukraine with orthognathic bite have significantly lower values of the length of the upper and lower jaw and lower facial height. In addition, Ukrainian young women have significantly higher values of the Ap1uAp1l-DOP angle and a tendency to lower interjaw differences, while in young men, the tendency towards higher values of the cross-sectional angle than the value of these parameters obtained by E. Harvold is established. The results of the study confirm the need to create a normative basis for teleroentgenographic indices by the method of E.P. Harvold for the population of different regions of Ukraine, taking into account both sexual and age affiliation.

Atopic dermatitis: new horizons of therapy

2019 ◽  
Vol 1 (7) ◽  
pp. 29-32 ◽  
Author(s):  
L. S. Kruglova ◽  
E. M. Gensler
Keyword(s):  
Blood Pressure ◽  
Immune Response ◽  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Targeted Therapy ◽  
Inflammatory Response ◽  
Bronchial Asthma ◽  
New Horizons ◽  
The Past

Over the past decades, the first breakthrough milestone in the treatment of severe forms of atopic dermatitis (AD) has been targeted therapy aimed at inhibiting IL-4 and IL-13. This was made possible thanks to advances in the understanding of the pathogenesis of AD, the driver of which is the Th2-type immune response, which also underlies such manifestations of atopy as bronchial asthma, allergic rhinitis, and polynosis. In the case of the Th2-type immune response, cytokines IL-4 and IL-13 are secreted, which are the main promoters of the inflammatory response in AD. Inhibition of IL-4 and IL-13 leads to the prevention of inflammation and is an effective approach to therapy. The use of therapy aimed at inhibition of cytokines allows you to effectively cope with the manifestations of severe and moderately severe blood pressure.

scholarly journals APPLICATION OF VITAMIN D IN DIFFERENT DOSAGE TO TREAT CHILDREN WITH ALLERGIC DISEASES

2020 ◽  
Vol 73 (7) ◽  
pp. 1377-1383
Author(s):  
Olexandra V. Tiazhka ◽  
Zoriana V. Selska
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Blood Serum ◽  
Bronchial Asthma ◽  
Vitamin D3 ◽  
Allergic Diseases ◽  
Acute Disease ◽  
Disease Remission ◽  
Significant Difference ◽  
Different Doses

The aim: To study the dynamics of the level of 25(ОН)D, ІL-4, ІL-10, and IgG in the blood serum of children with allergic diseases and to study the clinical effect of vitamin D3 administration n different dosage in this category of patients. Materials and methods: 153 children aged 3-16 with such allergic diseases as bronchial asthma, atopic dermatitis and allergic rhinitis have been examined. The level of 25(ОН) D was determined using the electrochemiluminescence method, while the levels of ІL-4, ІL-10 and IgG were assessed using enzyme-linked immunoassay. Results: In the contrasting of the initial level of 25(ОН)D in the blood serum of patients after administration of 2,000 IU of vitamin D3 over 2 months, after summer and after treatment with cholecalciferol in higher doses (4,000–5,000 IU) over 2 months, significant difference was established between the indicators by the Friedman criterion (λ2 = 41.211; P < 0.05). In the similar contrasting of ІL-4 indicators, a significant difference between them was traced (P < 0.05) in the period of acute disease as well as the downward tendency in the period of remission. In the similar contrasting of ІL-10 indicators, a significant difference between them was traced (P < 0.05) in the acute period and in the period of disease remission. In the similar contrasting of IgG indicators, a downward tendency was traced in the period of acute disease and significant decrease (P < 0.05) – in the period of disease remission. In the contrasting of 25(ОН)D and ІL-4, ІL-10 figures a strong reverse correlation relationship was traced. The therapeutic effect of the administration of vitamin D3 medication in different doses in children with allergic diseases was traced. Conclusions: The data obtained shows that in the treatment of children with bronchial asthma, allergic rhinitis and atopic dermatitis the complex therapy should include vitamin D3 medications in different doses within a long-term course of treatment.

Prevalence and severity of allergic rhinitis in house dust mite-allergic patients with bronchial asthma or atopic dermatitis

2002 ◽  
Vol 32 (8) ◽  
pp. 1160-1165 ◽  
Author(s):  
I. Terreehorst ◽  
A. J. Oosting ◽  
Z. Tempels-Pavlica ◽  
J. G. R. De Monchy ◽  
C. A. F. M. Bruijnzeel-Koomen ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Bronchial Asthma ◽  
House Dust ◽  
House Dust Mite ◽  
Dust Mite

scholarly journals The Role of Interleukin-37 in the Pathogenesis of Allergic Diseases

Acta Naturae ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 54-64
Author(s):  
I. P. Shilovskiy ◽  
M. E. Dyneva ◽  
O. M. Kurbacheva ◽  
D. A. Kudlay ◽  
M. R. Khaitov
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Bronchial Asthma ◽  
Interleukin 1 ◽  
Allergic Diseases ◽  
Biological Properties ◽  
Negative Regulator ◽  
Cellular Mechanisms ◽  
Wide Range

Cytokines of the interleukin-1 (IL-1) family play an important role in the realization of the protective functions of innate immunity and are the key mediators involved in the pathogenesis of a wide range of diseases, including various manifestations of allergy. The IL-1 family includes more than 11 members. However, the functions of many of them remain to be elucidated. Recently, new members of the IL-1 family have been discovered. In 2000, several independent research groups reported the discovery of a new interleukin of this family, which was named IL-37, or IL-1F7 (according to the new nomenclature). IL-37 was assigned to the IL-1 family based on its structural similarity with other members of this family. The study of its biological properties showed that its activity changes in inflammatory diseases, such as rheumatoid arthritis, psoriasis, as well as allergic diseases (allergic rhinitis, bronchial asthma, and atopic dermatitis). However, unlike most members of the IL-1 family, IL-37 acts as a negative regulator of inflammation. Activation of IL-37 suppresses inflammation, resulting in the suppression of inflammatory cytokines and chemokines, which in turn prevents infiltration of pro-inflammatory cells, mainly eosinophils and neutrophils. The exact molecular and cellular mechanisms of the anti-inflammatory effect of IL-37 in the development of allergic diseases (AD) have not been fully studied. This review summarizes and analyzes the accumulated experimental data on the role of IL-37 in the pathogenesis of AD, such as allergic rhinitis, bronchial asthma, and atopic dermatitis.

scholarly journals Effectiveness of leukotriene receptor antagonists in the treatment for atopic pathology in children

2020 ◽  
pp. 38-42
Author(s):  
A. I. Zariankina ◽  
M. Kh. Mirrakhimova ◽  
E. R. Shamsieva
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Bronchial Asthma ◽  
Eosinophil Count ◽  
Allergic Diseases ◽  
Receptor Antagonists ◽  
Leukotriene Receptor Antagonists ◽  
Leukotriene Receptor

Objective: to study the effectiveness of leukotriene receptor antagonists in the treatment foratopic pathology in children.Material and methods. 224 children with allergic diseases were prescribed to take montelucast for 3– 6 months.Results. Taking montelucast has lead to positive clinical dynamics in 75 % of the cases.A significant reduction of the eosinophil count was achieved on days 10–15 of the therapy. The Cys-LTC4/D4/E4 indices came to normal after a one-month course of montelucast therapy in 40.3 % of cases in children with bronchial asthma, in 63.3 % of cases in children with allergic rhinitis and in 60.5 % of cases in children with atopic dermatitis.Conclusions. The use of montelucast has significantly enhanced the control incidencerate ofallergic diseases in children.

scholarly journals Regression models of individual cephalometric indicators used in the method of R. M. Ricketts

2018 ◽  
pp. 56-62
Author(s):  
A. V. Chernysh
Keyword(s):  
Young Women ◽  
Regression Models ◽  
Young Men ◽  
The Third ◽  
Normal Occlusion ◽  
Gender And Age ◽  
Definition Of ◽  
Base Of The Skull ◽  
Medical University ◽  
Cephalometric Measurements

It is proved that in the analysis of lateral teleroentgenograms according to different methods distances and angles have their normative indices which differ for persons of different ethnic, gender and age belongings. Therefore, for a full use in the orthodontics R.M. Ricketts method, similar studies are needed in Ukraine. The purpose of the work – in young men and women  with normal occlusion close to the orthognathic bite and harmonious face construct and analyze the regression models of teleroentgenographic indicators used in the method of R. M. Ricketts. Primary lateral teleroentgenograms of 38 young men (aged 17-21 years) and 55 young women (aged from 16 to 20 years) with normal occlusion close to orthognathic bite and harmonic face, obtained from the Veraviewepocs 3D device, Morita (Japan), taken from the bank data of research center of National Pirogov Memorial Medical University, Vinnytsya. Cephalometric measurements were performed according to the recommendations of R. M. Ricketts. All indicators were divided into three groups: 1 - metric characteristics of the skull, which usually do not change during surgical and orthodontic treatment; 2 – tooth-jaw indicators, the definition of which most often guided by performing orthodontic manipulations of patients in children and adolescents, as well as those with already formed bone skeleton when orthodontic surgery can change the width, length, angles and position of the bones of the upper and lower jaws; 3 - indicators that characterize the position of each individual tooth relative to each other, to the bony cranial structures and face profile. The regression models of individual teleroentgenographic indicators used in the R.M. Ricketts methodology are constructed using the “Statistica 6.0” licensing package. Constructed all 2 reliable models of the indicators included in the second group (distance Go-CF and Xi-Pm), depending on the indicators of the first group (in young men R2 = 0.884 and 0.928, and in young women - 0.735 and 0.719); as well as in young men, 7 out of 8 possible reliable models (R2 = from 0.568 to 0.887) of the indicators included in the third group (the magnitude of the distances 6u-6l, Overjet, Overbite, 6u-PTV, 1l-APog, 1u-APog and Xi-OcP ) depending on the indicators of the first and second groups; and only 5 models for young women (6u-PTV, 1l-APog, 1u-APog and Xi-OcP distances, and the magnitude of the Max1-APog angle). In the analysis of entering into the regression models of the relevant predictors, it was found that in young men, among the teleroentgenographic indicators of the first group included in the two models of the second group, is the distance P-PTV, and in young women the front length of the base of the skull N-CC and the back of the skull base Ar- Pt It was also found that among young men among the teleroentgenographic indicators of the first and second groups, which were included in the models of the third group, the most frequent is the value of the distance B-Pog (11.1%); while in young women - distance B-Pog (15.6%) and an angle DC-Xi-PM (9.4%).

QUANTITATIVE FEATURES OF FINGER DERMATOGLYPHICS AS MARKERS OF ATOPIC DERMATITIS, BRONCHIAL ASTHMA AND ALLERGIC RHINITIS

2019 ◽  
Vol 15 (69) ◽  
pp. 059
Author(s):  
S. V. Dmytrenko ◽  
I. K. Shcherba ◽  
N. P. Ocheretna ◽  
L. V. Kulchevich ◽  
L. O. Fik
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Bronchial Asthma
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