Risk Factors of Peripartum Cardiomyopathy

Study Objective: To assess risk factors of peripartum cardiomyopathy (PCMP) based on the past medical history, genetic predisposition and peculiarities if this pregnancy. Study Design: retrospective cohort case study. Materials and Methods. We have performed a retrospective analysis of pregnancies and labours of 13 patients at V.A. Almazov National Medical Research Centre with PCMP in 2012–2019. For diagnostics and differential diagnosis, we used general, laboratory and instrumental test methods. Results. We have identified such risk factors as family history of cardiovascular pathologies (61.5%), age 35+ years (53.8%), obesity (53.8%), first labour (46.2%), preeclampsia (38.4%), caesarean delivery (23.1%), gestational diabetes mellitus (15.4%), multiple fetation (15.4%), and history of smoking (15.4%). 76.9% of patients had PCMP developed during pregnancy; 23.1% — on day 1–3 postpartum; a significant factor was operative delivery due to obstetrical symptoms; in one case, caesarean section was followed by a massive blood loss resulting from normal placenta abruption. Prevention of preeclampsia with drugs was indicated for one woman, although in 15.4% of patients it was diagnosed during the previous pregnancy, and 38.4% of women had preeclampsia during the current pregnancy. Conclusion. PCMP is a rare pathology with poorly studied ethiology and high risk of maternal mortality. When analysing clinical cases of 13 patients hospitalised with PCMP to V.A. Almazov National Medical Research Centre, we found out a significant number of PCMP risk factors; however, we have not identified any clear evidence of the impact from a certain factor. An important conclusion is the relation between PCMP and preeclampsia, which can be seen both in our study and in studies by foreign researchers; it is a potential platform for further research of this phenomenon. Keywords: peripartum cardiomyopathy, risk factors, pregnancy, labour

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Stress, Cortisol and Suicide Risk

10.31234/osf.io/92b7z ◽

2019 ◽

Author(s):

Daryl Brian O'Connor

Keyword(s):

Risk Factors ◽

Suicidal Behavior ◽

Suicide Risk ◽

Stressful Events ◽

Additional Risk ◽

Global Health Issue ◽

History Of ◽

Hpa Axis Activity ◽

The Impact

Suicide is a global health issue accounting for at least 800,000 deaths per annum. Numerous models have been proposed that differ in their emphasis on the role of psychological, social, psychiatric and neurobiological factors in explaining suicide risk. Central to many models is a stress-diathesis component which states that suicidal behavior is the result of an interaction between acutely stressful events and a susceptibility to suicidal behavior (a diathesis). This article presents an overview of studies that demonstrate that stress and dysregulated hypothalamic-pituitary-adrenal (HPA) axis activity, as measured by cortisol levels, are important additional risk factors for suicide. Evidence for other putative stress-related suicide risk factors including childhood trauma, impaired executive function, impulsivity and disrupted sleep are considered together with the impact of family history of suicide, perinatal and epigenetic influences on suicide risk.

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Infectious safety during primary specialized accreditation in the COVID-19 pandemic

Virtual Technologies in Medicine ◽

10.46594/2687-0037_2021_1_1288 ◽

2021 ◽

pp. 14-20

Author(s):

Evgeny Germanovich Ripp ◽

A. R. Fattakhov ◽

T. M. Ripp ◽

R. A. Postanogov ◽

N. M. Iminov ◽

...

Keyword(s):

Medical Education ◽

Medical Research ◽

Research Centre ◽

Face To Face ◽

Technological Processes ◽

Specialized Accreditation ◽

National Medical ◽

Technical Personnel ◽

The Face ◽

Simulation Center

This article is devoted to the organization of the work of the Accreditation and Simulation Center of the Institute of Medical Education of the Almazov National Medical Research Centre during the primary specialized accreditation in the COVID-19 pandemic. Organizational solutions, technological processes and routing of accredited (308 people), support and technical personnel (98 people) and employees of the Accreditation and Simulation Center (14 people) and members of accreditation commissions (67 people) are presented to ensure infectious safety and the effectiveness of the face-to-face practice-oriented stage of accreditation.

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Prevalence and the risk factors for the carriage of beta-haemolytic streptococci among women visiting a tertiary care hospital in South India

Indian Journal of Microbiology Research ◽

10.18231/j.ijmr.2021.062 ◽

2021 ◽

Vol 8 (4) ◽

pp. 308-312

Author(s):

Pendru Raghunath ◽

LN Rao Sadanand

Keyword(s):

Risk Factors ◽

Teaching Hospital ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Latex Agglutination ◽

Research Centre ◽

Care Hospital ◽

Microbiological Techniques ◽

History Of ◽

Group B

Streptococci are gram positive cocci arranged in chains and are part of normal flora of humans and animals. The present study is carried out to determine the prevalence and risk factors for the carriage of beta-haemolytic streptococci (BHS) among women visiting Dr. VRK Women’s Teaching Hospital & Research Centre, Hyderabad. Vaginal swabs were collected from 250 patients attending outpatient department (OPD) of Dr. VRK Women’s Teaching hospital. Swabs were inoculated onto 5% sheep blood agar plates and incubated for 24 h at 37°C in a candle jar. BHS isolates were phenotypically identified by standard microbiological techniques, all the isolates presumptively identified as BHS were tested for Bacitracin susceptibility. Sensitive isolates were presumptively identified as GAS and resistant isolates were identified as non-group A BHS (NGABHS). Presumptively identified GAS & NGABHS isolates were serogrouped by Lancefield grouping using a commercially available latex agglutination test. BHS were isolated from 12.4% of samples. As many as 12 BHS isolates were identified as GAS and 19 were identified as NGABHS. Ten of nineteen were identified as group B (GBS), 4 (12.9%) were identified as group C (GCS) and 5 (16.12%) were identified as group G (GGS). Among six clinical groups, the prevalence of GAS is highest i.e. 7.5% in female patients visiting Gynaecology OPD with history of white discharge. Prevalence of NGABHS was more among post insertion (18%) IUCD group compared to pre insertion (8%) IUCD group. GBS were isolated from 7% of samples from IUCD group and 4% of samples from prostitutes.This study reports the prevalence of BHS among women visiting a tertiary care hospital in Hyderabad. This study also identified certain risk factors such as IUCD usage and working as a FSW are associated with the increased prevalence of NGABHS especially GBS.

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Risk factor for gestational diabetes mellitus and impact of gestational diabetes mellitus on maternal and fetal health during the antenatal period

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20213169 ◽

2021 ◽

Author(s):

Uma Jain ◽

Kusumlata Singhal ◽

Shikha Jain ◽

Deepali Jain

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Congenital Malformation ◽

Fetal Health ◽

Antenatal Period ◽

Study Results ◽

History Of ◽

The Impact

Background: Gestational diabetes mellitus (GDM) is defined as any degree of dysglycaemia that occurs for the first time or is first detected during pregnancy. The adverse effects of GDM on pregnant women are pre-eclampsia, PIH, PPH, polyhydramanios, PROM, meanwhile, there would be an increase in dystocia, birth injury, and cesarean sectionMethods: This retrospective study was conducted in a Gynecology clinic in District Shivpuri to find out the various risk factors for GDM and to evaluate the impact of GDM on maternal and fetal health during the antenatal period. 84 patients who were diagnosed with GDM were included in the study. Results: Among risk factors; BMI >25 kg/m2 before pregnancy was found in 15.47% of the case, family history of diabetes mellitus 8.33%, Previous history of macrosomia 17.85%, Poor reproductive history 17.85%, baby with congenital malformation 8.33%, H/o unexplained IUFD 11.90%. H/o polyhydramnios 15.47%. History of PCOS 13.09% and preeclampsia was found in 17.85% of cases. In antenatal complications; miscarriages was found in 15.47%. polyhydramnios in 17.85%. Oligohydramnios in 8.33%, preterm labor in 11.90%, PROM in 9.52%, pre-eclampsia in 17.85%, sudden IUFD in 8.33% and congenital malformation was found in 4.76% of cases. On USG; IUGR was found in 7.14% of cases. Large for date fetus in 16.66% of cases and the normal growth was found in 76.19% of cases.Conclusions- In conclusion appropriate and timely diagnosis and treatment of GDM will result in decreased maternal and neonatal adverse outcomes comparable to general population rates, therefore, early diagnosis is important.

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History of the Medical and Rehabilitation Clinical Center “Yudino” — Branch of the National Medical Research Center of Rehabilitation and Balneology (1988–2021)

10.38006/00187-092-0.2021.18.24 ◽

2021 ◽

pp. 18-24

Author(s):

M. A. Eremushkin

Keyword(s):

Medical Research ◽

Research Center ◽

National Medical ◽

Clinical Center ◽

History Of

В работе рассмотрены вопросы создания и деятельности лечебно-реабилитационного клинического центра «Юдино» — филиала Федерального государственного бюджетного учреждения «Национальный медицинский исследовательский центр реабилитации и курортологии» Министерства здравоохранения Российской Федерации с начала его открытия (1988 г.) по текущее время, с указанием его бывших и настоящего руководителей, отмечены основные достижения и наработки, полученные в реабилитационном комплексе в прошлом и современные направления его деятельности

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History of the Medical and Rehabilitation Clinical Center “Yudino” — Branch of the National Medical Research Center of Rehabilitation and Balneology (1988–2021)

10.38006/00187-092-0.2021.8.14 ◽

2021 ◽

pp. 8-14

Author(s):

M. A. Eremushkin

Keyword(s):

Medical Research ◽

Research Center ◽

National Medical ◽

Clinical Center ◽

History Of

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575. Evaluation of Risk Factors and Clinical Outcomes of Patients with Vancomycin-Resistant Enterococcus Infections

Open Forum Infectious Diseases ◽

10.1093/ofid/ofz360.644 ◽

2019 ◽

Vol 6 (Supplement_2) ◽

pp. S271-S271

Author(s):

Gauri Chauhan ◽

Nikunj M Vyas ◽

Todd P Levin ◽

Sungwook Kim

Keyword(s):

Risk Factors ◽

Hospital Mortality ◽

Clinical Outcomes ◽

Subgroup Analysis ◽

Term Care ◽

Treatment Groups ◽

Increased Risk ◽

History Of ◽

Vancomycin Resistant ◽

The Impact

Abstract Background Vancomycin-resistant Enterococci (VRE) occurs with enhanced frequency in hospitalized patients and are usually associated with poor clinical outcomes. The purpose of this study was to evaluate the risk factors and clinical outcomes of patients with VRE infections. Methods This study was an IRB-approved multi-center retrospective chart review conducted at a three-hospital health system between August 2016-November 2018. Inclusion criteria were patients ≥18 years and admitted for ≥24 hours with cultures positive for VRE. Patients pregnant or colonized with VRE were excluded. The primary endpoint was to analyze the association of potential risk factors with all-cause in-hospital mortality (ACM) and 30-day readmission. The subgroup analysis focused on the association of risk factors with VRE bacteremia. The secondary endpoint was to evaluate the impact of different treatment groups of high dose daptomycin (HDD) (≥10 mg/kg/day) vs. low dose daptomycin (LDD) (< 10 mg/kg/day) vs. linezolid (LZD) on ACM and 30-day readmission. Subgroup analysis focused on the difference of length of stay (LOS), length of therapy (LOT), duration of bacteremia (DOB) and clinical success (CS) between the treatment groups. Results There were 81 patients included for analysis; overall mortality was observed at 16%. Utilizing multivariate logistic regression analyses, patients presenting from long-term care facilities (LTCF) were found to have increased risk for mortality (OR 4.125, 95% CI 1.149–14.814). No specific risk factors were associated with 30-day readmission. Patients with previous exposure to fluoroquinolones (FQ) and cephalosporins (CPS), nosocomial exposure and history of heart failure (HF) showed association with VRE bacteremia. ACM was similar between HDD vs. LDD vs. LZD (16.7% vs. 15.4% vs. 0%, P = 0.52). No differences were seen between LOS, LOT, CS, and DOB between the groups. Conclusion Admission from LTCFs was a risk factor associated with in-hospital mortality in VRE patients. Individuals with history of FQ, CPS and nosocomial exposure as well as history of HF showed increased risk of acquiring VRE bacteremia. There was no difference in ACM, LOS, LOT, and DOB between HDD, LDD and LZD. Disclosures All authors: No reported disclosures.

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Pregnancy failure in patients with obstetric antiphospholipid syndrome with conventional treatment: the influence of a triple positive antibody profile

Lupus ◽

10.1177/0961203317692432 ◽

2017 ◽

Vol 26 (9) ◽

pp. 983-988 ◽

Cited By ~ 25

Author(s):

J O Latino ◽

S Udry ◽

F M Aranda ◽

S D A Perés Wingeyer ◽

D S Fernández Romero ◽

...

Keyword(s):

Risk Factors ◽

Risk Factor ◽

Antiphospholipid Syndrome ◽

Pregnancy Outcomes ◽

Conventional Treatment ◽

Poor Response ◽

Anticardiolipin Antibodies ◽

History Of ◽

Obstetric Antiphospholipid Syndrome ◽

The Impact

Conventional treatment of obstetric antiphospholipid syndrome fails in approximately 20–30% of pregnant women without any clearly identified risk factor. It is important to identify risk factors that are associated with these treatment failures. This study aimed to assess the impact of risk factors on pregnancy outcomes in women with obstetric antiphospholipid syndrome treated with conventional treatment. We carefully retrospectively selected 106 pregnancies in women with obstetric antiphospholipid syndrome treated with heparin + aspirin. Pregnancy outcomes were evaluated according to the following associated risk factors: triple positivity profile, double positivity profile, single positivity profile, history of thrombosis, autoimmune disease, more than four pregnancy losses, and high titers of anticardiolipin antibodies and/or anti-βeta-2-glycoprotein-I (aβ2GPI) antibodies. To establish the association between pregnancy outcomes and risk factors, a single binary logistic regressions analysis was performed. Risk factors associated with pregnancy loss with conventional treatment were: the presence of triple positivity (OR = 5.0, CI = 1.4–16.9, p = 0.01), high titers of aβ2GPI (OR = 4.4, CI = 1.2–16.1, p = 0.023) and a history of more than four pregnancy losses (OR = 3.5, CI = 1.2–10.0, p = 0.018). The presence of triple positivity was an independent risk factor associated with gestational complications (OR = 4.1, CI = 1.2–13.9, p = 0.02). Our findings reinforce the idea that triple positivity is a categorical risk factor for poor response to conventional treatment.

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Risk factors of bronchial asthma, chronic obstructive lung disease and «OVERLAP» syndrome asthma-COPD among adults in Ekaterinburg

Rossiiskii Allergologicheskii ZHurnal ◽

10.36691/rja133 ◽

2018 ◽

Vol 15 (4) ◽

pp. 26-29

Author(s):

V C Abdullaev ◽

E K Beltyukov ◽

V V Naumova

Keyword(s):

Risk Factors ◽

Bronchial Asthma ◽

Chronic Obstructive Lung Disease ◽

Overlap Syndrome ◽

Chronic Obstructive ◽

Actual Risk ◽

History Of ◽

Definition Of ◽

The Impact ◽

Over 40 Years

Topicality. Prevalence of bronchial asthma (BA) and COPD achieves in different countries 18 and 20% respectively. The prevalence of «OVERLAP» syndrome - ASTHMA/COPD in Russia is unknown. Objective. To determine the prevalence ofBA, COPD and «OVERLAP» syndrome - ASTHMA/COPD. Materials and methods. The study included a survey using a specially developed questionnaire to identify asthma-like symptoms (ALS), risk factors for BA, COPD, and the definition of FEV^ FEV^FVC in adults in Ekaterinburg. Results. The study has revealed that the risk factors for developing ALS are exposure to tobacco smoke and age over 40 years. The impact of allergens and family history of allergy are less significant. Decrease of spirometry indices is associated with smoking, age over 40 years and the presence of ALS. The diagnostic criteria for the «OVERLAP» syndrome - ASTHMA/COPD were developed based on the answers to the questionnaire on ALS, risk factors and the results of the screening spirometry. Conclusions. Preliminary prevalence ofBA, COPD, «OVERLAP» syndrome - ASTHMA/COPD and actual risk factors have been established in Ekaterinburg in 2018. Unfavorable situation with prevalence of smoking in Ekaterinburg has been showing.

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