scholarly journals Effects of COVID-19 on Testicular Function

2021 ◽  
Vol 5 (1) ◽  
pp. 01-05
Author(s):  
Nasser Mikhail ◽  
Vahid Mahabadi
Keyword(s):  
Case Reports ◽  
Semen Parameters ◽  
Testicular Function ◽  
Gonadal Function ◽  
Scrotal Pain ◽  
Testicular Dysfunction ◽  
Scrotal Ultrasound ◽  
Pubmed Search ◽  
Almost All ◽  
The Impact

Background: The impact of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome-coronavirus 2 (SARS-Cov-2) on testicular function is unclear. Objective: To clarify the effects of COVID-19 on male gonadal function. Methods: Pubmed search up to February 24, 2021. Search terms included COVID-19, testicles, testosterone, spermatogenesis, hypogonadism. Case reports, retrospective, prospective and autopsy studies are included. Results: Prevalence of patients hospitalized with COVID-19 having scrotal pain varies from 0-19%. Orchitis and/or epididymitis were demonstrated by scrotal ultrasound (US) in approximately 22-42% of men with COVID-19 admitted to the hospital and can be frequently asymptomatic. Circulating testosterone levels are reduced in men admitted with COVID-19 with concomitant elevation of luteinizing hormone (LH) suggesting testicular dysfunction. Men affected with COVID-19 exhibit abnormal semen parameters. Most, but not all, studies failed to detect SARS-CoV-2 in semen. Autopsy studies showed extensive damage of testicular tissues of men who died from severe COVID-19. Conclusion: COVID-19 negatively affects almost all aspects of male gonadal function. Physicians should evaluate testicular function during and after recovery from COVID-19 to preserve normal fertility.

scholarly journals Effects of COVID-19 on testicular function

2021 ◽  
Vol 5 (1) ◽  
pp. 01-05
Author(s):  
Nasser Mikhail
Keyword(s):  
Case Reports ◽  
Semen Parameters ◽  
Testicular Function ◽  
Gonadal Function ◽  
Scrotal Pain ◽  
Testicular Dysfunction ◽  
Scrotal Ultrasound ◽  
Pubmed Search ◽  
Almost All ◽  
The Impact

Background: The impact of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome-coronavirus 2 (SARS-Cov-2) on testicular function is unclear. Objective: To clarify the effects of COVID-19 on male gonadal function. Methods: Pubmed search up to February 24, 2021. Search terms included COVID-19, testicles, testosterone, spermatogenesis, hypogonadism. Case reports, retrospective, prospective and autopsy studies are included. Results: Prevalence of patients hospitalized with COVID-19 having scrotal pain varies from 0-19%. Orchitis and/or epididymitis were demonstrated by scrotal ultrasound (US) in approximately 22-42% of men with COVID-19 admitted to the hospital and can be frequently asymptomatic. Circulating testosterone levels are reduced in men admitted with COVID-19 with concomitant elevation of luteinizing hormone (LH) suggesting testicular dysfunction. Men affected with COVID-19 exhibit abnormal semen parameters. Most, but not all, studies failed to detect SARS-CoV-2 in semen. Autopsy studies showed extensive damage of testicular tissues of men who died from severe COVID-19. Conclusion: COVID-19 negatively affects almost all aspects of male gonadal function. Physicians should evaluate testicular function during and after recovery from COVID-19 to preserve normal fertility.

Testicular Involvement is a Hallmark of Apo A-I Leu75Pro Mutation Amyloidosis

2020 ◽  
Vol 105 (12) ◽  
pp. e4758-e4766
Author(s):  
Andrea Delbarba ◽  
Paolo Facondo ◽  
Simona Fisogni ◽  
Claudia Izzi ◽  
Filippo Maffezzoni ◽  
...  
Keyword(s):  
Follicle Stimulating Hormone ◽  
Organ Damage ◽  
University Hospital ◽  
Reproductive Hormone ◽  
Testicular Dysfunction ◽  
Amyloid Deposits ◽  
Scrotal Ultrasound ◽  
Almost All ◽  
The University ◽  
Male Subjects

Abstract Context Apo A-I Leu75Pro is a rare hereditary form of amyloidosis that mainly involves the kidney, the liver, and the testis. Objective To define the characteristics of organ damage and testis impairment in the largest cohort collected to date of men with Apo A-I Leu75Pro amyloidosis. Design, Setting, and Patients Retrospective study from a prospectively collected database of 129 male subjects >18 years with Apo A-I Leu75Pro amyloidosis from a reference center at the University Hospital of Brescia, Italy. Main outcome measures We evaluated liver and renal function, scrotal ultrasound, reproductive hormone levels, testis biopsy, hypogonadal symptoms, and fertility. Results Progressive involvement of testis, kidney, and liver was observed in 96/129 (74.4%) cases. Testis impairment was found in 88/129 patients (68.2%), liver in 59 (45.7%) and renal in 50 (38.8%). Testis damage was often the first manifestation of the disease and the only dysfunction in 30% of younger patients (<38 years). Testicular involvement was characterized mainly by primary (73/88 patients, 83.0%) and subclinical (8/88, 9.1%) hypogonadism. Almost all (85/88, 96.6%) also had high follicle-stimulating hormone, suggesting a primary global damage of endocrine and spermatogenic functions, and 30% of them did not conceive. Macroorchidism was found in 53/88 (60.2%) patients, especially in men <54 years (30/33, 90.9%). Apo A-I amyloid deposits were found in Sertoli cells, germinal epithelium, and vessel walls. Conclusion In men with Apo A-I Leu75Pro amyloidosis, testicular involvement is the hallmark of the disease, characterized by global primary testicular dysfunction and macroorchidism due to amyloid deposits.

scholarly journals The impact of the National Heart, Lung, and Blood Institute data: analyzing published articles that used BioLINCC open access data

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 30
Author(s):  
Saif Aldeen AlRyalat ◽  
Osama El Khatib ◽  
Ola Al-qawasmi ◽  
Hadeel Alkasrawi ◽  
Raneem al Zu’bi ◽  
...  
Keyword(s):  
Open Access ◽  
Open Data ◽  
Blood Institute ◽  
Open Access Data ◽  
Pubmed Search ◽  
Number Of Publications ◽  
Almost All ◽  
Number Of Citations ◽  
The Impact ◽  
Access Data

Background: Data sharing is now a mandatory prerequisite for several major funders and journals, where researchers are obligated to deposit the data resulting from their studies in an openly accessible repository. Biomedical open data are now widely available in almost all disciplines, where researchers can freely access and reuse these data in new studies. We aim to study the BioLINCC datasets, number of publications that used BioLINCC open access data, and the impact of these publications through the citations they received. Methods: As of July 2019, there was a total of 194 datasets stored in BioLINCC repository and accessible through their portal. We requested the full list of publications that used these datasets from BioLINCC, and we also performed a supplementary PubMed search for other publications. We used Web of Science (WoS) to analyze the characteristics of publications and the citations they received. Results: 1,086 published articles used data from BioLINCC repository for 79 (40.72%) datasets, where 115 (59.28%) datasets didn’t have any publications associated with it. Of the total publications, 987 (90.88%) articles were WoS indexed. The number of publications has steadily increased since 2002 and peaked in 2018 with a total number of 138 publications on that year. The 987 open data publications received a total of 34,181 citations up to 1st October 2019. The average citation per item for the open data publications was 34.63. The total number of citations received by open data publications per year has increased from only 2 citations in 2002, peaking in 2018 with 2361 citations. Conclusion: Majority of BioLINCC datasets were not used in secondary publications. Despite that, the datasets used for secondary publications yielded publications in WoS indexed journals and are receiving an increasing number of citations.

scholarly journals Relevance of the Isoflavone Absorption and Testicular Function: A Systematic Review of Preclinical Evidence

2021 ◽  
Vol 2021 ◽  
pp. 1-14
Author(s):  
Amanda Alves Lozi ◽  
Sérgio Luis Pinto da Matta ◽  
Mariáurea Matias Sarandy ◽  
Fabiana Cristina Silveira Alves de Melo ◽  
Diane Costa Araujo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Leydig Cells ◽  
Testicular Function ◽  
Bias Analysis ◽  
Testicular Dysfunction ◽  
High Doses ◽  
Cellular Components ◽  
Fragmented Data ◽  
The Impact

Isoflavone is a phytoestrogen found in different types of food that can act as endocrine disrupters leading to testicular dysfunction. Currently, fragmented data on the action of this compound in the testicles make it difficult to assess its effects to define a safe dose. Thus, we systematically reviewed the preclinical evidence of the impact of isoflavone on testicular function. We also determined which form (aglycones or glycosylated) was the most used, which allowed us to understand the main biological processes involved in testicular function after isoflavone exposure. This systematic review was carried out according to the PRISMA guidelines using a structured search on the biomedical databases MEDLINE (PubMed), Scopus, and Web of Science, recovering and analyzing 22 original studies. The bias analysis and the quality of the studies were assessed by the criteria described in the risk of bias tool developed by SYRCLE (Systematic Review Centre for Laboratory Animal Experimentation). The aglycones and glycosylated isoflavones proved to be harmful to the reproductive health, and the glycosylates at doses of 50, 100, 146, 200, 300, 500, and 600 mg/kg, in addition to 190 and 1000 mg/L, appear to be even more harmful. The main testicular pathologies resulting from the use of isoflavones are associated with Leydig cells resulting from changes in molecular functions and cellular components. The most used isoflavone to evaluate testicular changes was the genistein/daidzein conjugate. The consumption of high doses of isoflavones promotes changes in the functioning of Leydig cells, inducing testicular changes and leading to infertility in murine models.

scholarly journals The impact of the National Heart, Lung, and Blood Institute data: analyzing published articles that used BioLINCC open access data

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 30
Author(s):  
Saif Aldeen AlRyalat ◽  
Osama El Khatib ◽  
Ola Al-qawasmi ◽  
Hadeel Alkasrawi ◽  
Raneem al Zu’bi ◽  
...  
Keyword(s):  
Open Data ◽  
Data Repository ◽  
Blood Institute ◽  
National Heart Lung ◽  
Pubmed Search ◽  
Number Of Publications ◽  
Almost All ◽  
Number Of Citations ◽  
The Impact ◽  
Access Data

Background: Data sharing is now a mandatory prerequisite for several major funders and journals, where researchers are obligated to deposit the data resulting from their studies in an openly accessible repository. Biomedical open data are now widely available in almost all disciplines, where researchers can freely access and reuse these data in new studies. We aim to assess the impact of open data in terms of publications generated using open data and citations received by these publications, where we will analyze publications that used the Biologic Specimen and Data Repository Information Coordinating Center (BioLINCC) as an example. Methods: As of July 2019, there was a total of 194 datasets stored in BioLINCC repository and accessable through their portal. We requested the full list of publications that used these datasets from BioLINCC, and we also performed a supplementary PubMed search for other publications. We used Web of Science (WoS) to analyze the characteristics of publications and the citations they received. Results: 1,086 published articles used data from BioLINCC repository, but only 987 (90.88%) articles were WoS indexed. The number of publications has steadily increased since 2002 and peaked in 2018 with a total number of 138 publications on that year. The 987 open data publications received a total of 34,181 citations up to 1st October 2019. The average citation per item for the open data publications was 34.63. The total number of citations received by open data publications per year has increased from only 2 citations in 2002, peaking in 2018 with 2361 citations. Conclusion: The vast majority of studies that used BioLINCC open data were published in WoS indexed journals and are receiving an increasing number of citations.

scholarly journals The use of scrotal ultrasound in the evaluation of varicoceles: A survey study of reproductive specialists

2019 ◽  
Vol 14 (8) ◽  
Author(s):  
Jabez Gondokusumo ◽  
Mohit Butaney ◽  
Adithya Balasubramanian ◽  
Joanathan Beilan ◽  
Alexander Tatem ◽  
...  
Keyword(s):  
Online Survey ◽  
Male Reproduction ◽  
Survey Study ◽  
Semen Parameters ◽  
Categorical Variables ◽  
Retrograde Flow ◽  
Scrotal Ultrasound ◽  
Chi Squared ◽  
Venous Diameter ◽  
Almost All

Introduction: Urologists use ultrasound in the male infertility workup to evaluate scrotal contents and objectively identify varicoceles if their presence is questionable on physical examination. We assessed practice patterns and diagnostic criteria of male reproductive urologists using ultrasound to evaluate varicoceles. Methods: An anonymous online survey was sent to the Society for Male Reproduction and Urology (SMRU) members. We queried respondents about ultrasonographic criteria and ultrasound techniques employed in varicocele evaluation. Chi-squared was used to determine association between categorical variables. Results: In total, 110/320 (34.4%) SMRU members responded. Sixty percent of respondents (66/110) reported performing scrotal ultrasound; 92.4 % (61/66) were attending urologists and 87.9% (58/66) completed an andrology fellowship. A total of 37.9% (25/66) performed their own ultrasound, while the remainder had ultrasound performed by an alternate practitioner. Among those performing their own ultrasound, 95.5% (21/22) measured varicocele venous diameter compared to 76% (29/38) when another practitioner performed the ultrasound. Venous diameter used to define a varicocele ranged from 2–4 mm. Although 80% (49/61) of respondents assessed retrograde flow during ultrasound, only 52.5% reported that retrograde flow was required for varicocele diagnosis. Almost all (60/61) indicated that they would fix palpable varicoceles in patients with abnormal semen parameters. Fewer (42.6%, 26/61) respondents stated they would repair varicoceles found exclusively on ultrasound. Conclusions: Ultrasound is commonly employed by male reproductive urologists to diagnose varicoceles. We identified that practitioners use various ultrasonographic criteria and techniques for varicocele diagnosis. Study limitations include recall bias and high degree of specialization among respondents.

Dietary Vitamin and Stability of Oral Anticoagulation: Proposal of a Diet with Constant Vitamin K1 Content

1997 ◽  
Vol 77 (03) ◽  
pp. 504-509 ◽  
Author(s):  
Sarah L Booth ◽  
Jacqueline M Charnley ◽  
James A Sadowski ◽  
Edward Saltzman ◽  
Edwin G Bovill ◽  
...  
Keyword(s):  
Dietary Intake ◽  
Vitamin K ◽  
High Performance ◽  
Case Reports ◽  
Food Composition ◽  
Dietary Guidelines ◽  
Dietary Vitamin ◽  
Vitamin K1 ◽  
The Stability ◽  
The Impact

SummaryCase reports cited in Medline or Biological Abstracts (1966-1996) were reviewed to evaluate the impact of vitamin K1 dietary intake on the stability of anticoagulant control in patients using coumarin derivatives. Reported nutrient-drug interactions cannot always be explained by the vitamin K1 content of the food items. However, metabolic data indicate that a consistent dietary intake of vitamin K is important to attain a daily equilibrium in vitamin K status. We report a diet that provides a stable intake of vitamin K1, equivalent to the current U.S. Recommended Dietary Allowance, using food composition data derived from high-performance liquid chromatography. Inconsistencies in the published literature indicate that prospective clinical studies should be undertaken to clarify the putative dietary vitamin K1-coumarin interaction. The dietary guidelines reported here may be used in such studies.

Contemporary Qur'anic Studies in Iran and its Relationship with Qur'anic Studies in the West

2012 ◽  
Vol 14 (1) ◽  
pp. 45-72
Author(s):  
Morteza Karimi-Nia
Keyword(s):  
Islamic Law ◽  
Human Sciences ◽  
The West ◽  
Communications Technologies ◽  
Religious Learning ◽  
The Status ◽  
Islamic Republic Of Iran ◽  
Almost All ◽  
The Impact ◽  
The Relationship

The status of tafsīr and Qur'anic studies in the Islamic Republic of Iran has changed significantly during recent decades. The essay provides an overview of the state of Qur'anic studies in Iran today, aiming to examine the extent of the impact of studies by Western scholars on Iranian academic circles during the last three decades and the relationship between them. As in most Islamic countries, the major bulk of academic activity in Iran in this field used to be undertaken by the traditional ʿulamāʾ; however, since the beginning of the twentieth century and the establishment of universities and other academic institutions in the Islamic world, there has been increasing diversity and development. After the Islamic Revolution, many gradual changes in the structure and approach of centres of religious learning and universities have occurred. Contemporary advancements in modern sciences and communications technologies have gradually brought the institutions engaged in the study of human sciences to confront the new context. As a result, the traditional Shīʿī centres of learning, which until 50 years ago devoted themselves exclusively to the study of Islamic law and jurisprudence, today pay attention to the teaching of foreign languages, Qur'anic sciences and exegesis, including Western studies about the Qur'an, to a certain extent, and recognise the importance of almost all of the human sciences of the West.

IFRS IMPLEMENTATION AS ONE OF THE FACTORS FOR IMPROVING THE INVESTMENT CLIMATE IN UKRAINE

2017 ◽  
Author(s):  
Kateryna Sova ◽  
◽  
Natalia Yatsenko ◽  
Denys Zagirniak ◽  
◽  
...  
Keyword(s):  
Financial Reporting ◽  
Direct Investment ◽  
Financial Statements ◽  
International Standards ◽  
Investment Climate ◽  
The European Union ◽  
Economic Activities ◽  
Financial Reporting Standards ◽  
Almost All ◽  
The Impact

The article is devoted to the study of the impact of the introduction of International Financial Reporting Standards (IFRS) on changes in the investment climate in Ukraine. The relevance of the topic is that improving the practice of applying IFRS as a tool for exchanging financial information is one of the key conditions for improving the investment climate in Ukraine. The authors have created the generalized scheme that illustrates the chronological list of enterprises that are required by law to prepare financial statements in accordance with IFRS. It was noted that in 2018, in accordance with Part 2 of Article 12 of the law on accounting and financial reporting in Ukraine and resolution of the Cabinet of Ministers of Ukraine No. 547 from 11.07.2018, the criteria of enterprises that are required to prepare financial statements in accordance with IFRS were updated. This step significantly increased the level of application of international standards due to the adoption of such a decision at the legislative level. The dynamics of the number of IFRS enterprises in Ukraine was analyzed. The analysis showed that over the past three years, the number of almost all enterprises that must apply international standards has been growing. The advantages of using IFRS for different users of financial statements were determined. It was determined that the priority users of IFRS financial statements are investors. At the same time, it was noted that the main advantage for other users of financial statements prepared in accordance with international standards is the improvement of the investment climate. The dynamics of the Investment Attractiveness Index of Ukraine based on the Likert scale in the period from 2016 to 2020 was analyzed. The direct investment receipts to Ukraine from the European Union countries were studied. The dynamics of direct investment in the Ukrainian economy was analyzed for two types of economic activities that should form financial statements in accordance with IFRS, namely, the extractive industry and quarrying, as well as financial and insurance activities.

The Impact of Entrepreneurial Behavior on Sales Volume

2017 ◽  
Vol 1 (1) ◽  
pp. 1-6
Author(s):  
Adjeng Tiara Eltari ◽  
Hendrati Dwi Mulyaningsih
Keyword(s):  
Quantitative Research ◽  
Coefficient Of Determination ◽  
Sales Volume ◽  
Entrepreneurial Behavior ◽  
Street Vendors ◽  
Quantitative Research Methods ◽  
Entrepreneurial Behaviour ◽  
Full Calculation ◽  
Almost All ◽  
The Impact

This research was conducted at the Culinary Hawkers that located on Highway Sukapura, Dayeuhkolot, Bandung. This study examines the Entrepreneurial behaviour which resulted in increased sales volumes. Almost all Culinary Hawkers on Highway Sukapura doesn’t yet have the entrepreneurial behavior in accordance with the characteristics - traits mentioned by Suryana, Confident, Own initiative, Have achievement motive, Having leadership, and Dare to take risks with the full calculation. The purpose of this study was to investigate the influence of entrepreneurial behavior to the merchant's sales volume culinary pavement on Highway Sukapura, Dayeuhkolot, Bandung.Researchers used quantitative research methods. The population in this study was 63 Merchants Culinary Street on Highway Sukapura. Samples are 63 street vendors in JalanSukapura. Data were analyzed using simple regression analysis.The results showed that entrepreneurial behavior affect the sales volume of culinary street traders in Highway Sukapura. Based on the calculation coefficient of determination (R2) can be seen the effect of entrepreneurial behavior variables (X) on sales volume (Y) is approximately 94%. While the remaining 6% are influenced by other factors such as competence, performance, and motivation.

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