scholarly journals To Compare Efficacy of Nishkatakadi Kwath with Metformin in Madhumeha With Special Refrence to Diabetes Mellitus ii

2020 ◽  
Vol 3 (1) ◽  
pp. 01-16
Author(s):  
Bhairav B. Tawshikar ◽  
Shrikant G. Deshmukh ◽  
Yashashree B. Kulkarni
Keyword(s):  
Diabetes Mellitus ◽  
Clinical Symptoms ◽  
The Body ◽  
Type I ◽  
Type Ii ◽  
Diabetes Mellitus Type Ii ◽  
Ancient Times ◽  
Almost All ◽  
And Control

Madhumeha is a disease known since ancient times to the mankind, its upsurge is quiet alarming. On the basis of its symptomatology Madhumeha can be correlated to the features of Diabetes mellitus. Diabetes mellitus is a metabolic disorder of carbohydrate, fat, & protein characterized by hyperglycemia with or without glycosuria. It is associated with long-term potentially catastrophic effects on almost all systems of the body. Ayurveda can provide better management for Madhumeha without hazardous side effects. In Ayurveda, Madhumeha has been described as one among one of the 20 types of Prameha and is a sub-type of Vatika Prameha. In the former type the patients are usually asthenic can be correlated with Type I DM and in the latter type patients are obese and can be equated with Type II DM. Nishakatakadi Kwath has been mentioned in Sahasrayoga under Kashaya Prakaran for Prameha Chikitsa, Nishakatakadi Kwath is being used widely for the treatment of Madhumeha in Kerala. That is why Nishakatakadi Kwath has been selected for the present study. In this study to study various clinical symptoms of madhumeha with special reference to Diabetes Mellitus II. To compare efficacy of Nishkatakadi Kwath with Metformin inthe management of Madhumeha, To observe any possible adverse effect of Nishkatakadi kwath if reported during the study. In the present study Trial and Control groups comprising 30 patients each of Madhumeha (Diabetes Mellitus type II) were treated with Nishkatakadi kwath with tab metformin and Tab Metformin alone respectively. This study shows that both the drugs NISHKATAKADI KWATH with metformin are more effective than METFORMIN in Madhumeha to reduce symptoms and patients score.

Sitagliptin (Januvia)

Top Drugs ◽  
2015 ◽  
Author(s):  
Jie Jack Li
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Type Ii Diabetes ◽  
Kidney Diseases ◽  
Type I Diabetes ◽  
Glycosylated Hemoglobin ◽  
Insulin Injection ◽  
Type I ◽  
Type Ii ◽  
Ancient Times

Diabetes has been known since antiquity. In fact, the term “diabetes mellitus” comes from the Greek meaning “siphon and honey” due to the excess excretion (siphon or faucet) of hyperglycemic (sweetened, or honeyed) urine associated with diabetes. In ancient times, diabetes was mostly type I, which usually manifests acutely in the young, secondary to certain underlying insults (possibly infections) to the islet cells of the pancreas resulting in an absolute lack of insulin. Insulin was discovered by Banting and Best in 1921, and insulin injection has literally saved millions of lives since then. With the wondrous efficacy that insulin bestows, type I diabetes is largely controlled because type I diabetes is insulindependent. However, type II diabetes, a more prevalent form of diabetes, is not insulin-dependent. In ancient times, when nutrition was scarce and obesity was not prevalent, type II diabetes mellitus (T2DM) was extremely rare. Indeed, type II diabetes is a disease more frequently associated with maturity, obesity, and gradually increasing blood glucose concentrations, and it may be asymptomatic for some time, only discovered on routine glucose screening. In fact, with the increasing body weight of the general population of the developed world, type II diabetes is becoming an epidemic. Serious complications of diabetes include nephropathy (kidney diseases), neuropathy (nerve damage), and retinopathy (blindness). Diabetes is the most common cause of blindness and amputation in the elderly in the United States. Oral diabetes drugs are required for most type II diabetic patients. Diabetes drugs may be classified into four categories: (a) agents that augment the supply of insulin such as sulfonylureas; (b) agents that enhance the effectiveness of insulin such as biguanides and thiazolidinediones; (c) GLP agonists; and (d) DPP4 Inhibitors. The efficacy of all the antidiabetic drugs can be monitored by measuring glycosylated hemoglobin (HaA1c) as a long term marker of elevated blood glucose. The amount of HaA1c reflects the average level over the last 120 days, the life span of a red blood cell, and should remain below 7%.

scholarly journals Predictors of No-Reflow Phenomenon: Diabetes Mellitus type II and Obesity and their Associated Mortality in Stemi Patients after Primary PCI

2019 ◽  
Vol 16 (4) ◽  
pp. 7-12
Author(s):  
Larisa Renata Pantea-Roșan ◽  
Otilia Anca Ţica ◽  
Mădălina Moisi ◽  
Vlad Alin Pantea ◽  
Ovidiu Ţica ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Diabetes Mellitus Type ◽  
Type Ii ◽  
Primary Pci ◽  
Diabetes Mellitus Type Ii ◽  
No Reflow ◽  
No Reflow Phenomenon ◽  
Short And Long Term

AbstractThe prognosis of STEMI patients experiencing the no-reflow phenomenon is unfavorable both in the short- and long-term compared to patients who do not develop this pathology, and it is even worse as other cardiovascular risk factors There is a correlation between the no-reflow phenomenon and diabetes mellitus type II and obesity and this conditions represent stong predictors of mortality.

scholarly journals Management of Patients with Hereditary Angioedema During the COVID-19 Pandemic

2021 ◽  
Vol 19 (3) ◽  
pp. 166-173
Author(s):  
Eray YILDIZ ◽  
Şevket ARSLAN ◽  
Fatih ÇÖLKESEN ◽  
Filiz Sadi AYKAN ◽  
Recep EVCEN ◽  
...  
Keyword(s):  
Hereditary Angioedema ◽  
Clinical Symptoms ◽  
Type I ◽  
Type Ii ◽  
Kinin System ◽  
Beneficial Effects ◽  
Phone Calls ◽  
History Of ◽  
Kallikrein Kinin System

Objective: The aim of this study was to determine the clinical course and treatment outcomes of patients with hereditary angioedema (HAE) after infection with coronavirus disease 2019 (COVID-19). Materials and Methods: Thirty-nine patients with HAE were included in this study. These patients were regularly followed up over phone calls since the first COVID-19 case was seen in our country. Patients were asked to visit the hospital if there was a history of contact with a confirmed COVID-19 patient or if the patient developed clinical symptoms of COVID-19.Results: There were 21 (54%) patients with type I HAE, and 18 (46%) with type II HAE. All patients received treatment for angioedema attacks (C1-inhibitor [C1-INH], icatibant), and seven (20%) received long-term prophylaxis (danazol). Treatment for attacks was continued for all patients during the pandemic. Patients taking danazol were switched to long-term prophylaxis using the C1-INH concentrate. Eleven (28%) patients with HAE developed COVID-19 during this study. Only one patient had severe COVID-19. Six patients (54.5%) were diagnosed with type II HAE, and five (45.5%) were diagnosed with type I HAE. The most common COVID-19 symptoms were fever (7/11; 64%) and myalgia (6/11; 55%). Mild angioedema attacks were experienced by 36% (4/11) of the HAE patients diagnosed with COVID-19. Icatibant was used in all patients.Conclusion: Agents used for HAE block the kallikrein-kinin system and may be useful in the treatment of COVID-19. Considering their beneficial effects on COVID-19, it is recommended that HAE patients should continue the use of agents blocking the kallikrein-kinin system. Keywords: COVID-19, hereditary angioedema, kallikrein-kinin system, bradykinin, C1-INH

scholarly journals Some parameters of the oxidative stress in lens, humour aqueous and serum of patients with diabetes and age-related cataract

2003 ◽  
Vol 131 (3-4) ◽  
pp. 137-142 ◽  
Author(s):  
Lepsa Zoric
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Lipid Peroxidation ◽  
The Body ◽  
Diabetes Mellitus Type ◽  
Type Ii ◽  
Diabetes Mellitus Type Ii ◽  
Age Related ◽  
Lipid Oxidation Products ◽  
Patients With Diabetes

Contemporary hypothesis considers the oxidative stress as a crucial event in age-related processes in the body, as well as in the age-related cataract formation. The secondary aging factors accelerate ageing processes. One of them is diabetes. With the aim of investigation of the noninsulin-dependent diabetes (Type II) influence on cataract genesis here were analyzed contents of the lipid oxidation products (lipid peroxides - LP) and total sulfhydryle groups (TSH) in the lens? corticonuclear blocks and antioxidative capacity in their humour aqueous expressed as percent of induced malondyaldehyde (% iMDA) in 14 samples obtained from patients with cataract and diabetes mellitus type II (without diabetic complications) and compared to 66 samples of patients with cataract without diabetes, as well as some parameters of the oxidative stress in serums (content of vitamin C, acrobat - A dehydroascorbate - DA and their relation, vitamin E, glutathione - GSH peroxidase - P and catalase - Cat activity, content of malondyaldehyde - MDA and % iMDA) of 27 patients with age-related cataract and diabetes mellitus type II (without complications), and compared to the other 135 age-related cataract patients. Also were analyzed frequencies of the secondary senium diseases in a clinical group of 162 patients with cataract and sex and age matched 55 examined people without cataract, as a control group. Patients with diabetes and cataract have lower values of almost all investigated parameters of antioxidative defense in their serum and higher level of the lipid peroxidation products. Level of glutathione in their serums is significantly lower (p<0.05). Intensity of lipid peroxidation in corticonuclear lens blocks is higher in patients with diabetes, whereas their total sulfhydryle groups and % iMDA in humour aqueous shows lower antioxidant capacity in the same group, probably because of higher intensity of oxidative stress. Also, by investigation of frequencies of the secondary ageing diseases in patients with age-related cataract and age and sex matched control subjects, by a logistic regression was found high odds ratio (2.506) for diabetes. Results confirm hypothesis of the oxidative stress role in the age-related cataract genesis, and especially of patients with diabetes mellitus.

scholarly journals Creatine Kinase Activity in Patients with Diabetes Mellitus Type I and Type II

2006 ◽  
Vol 6 (3) ◽  
pp. 5-9 ◽  
Author(s):  
Adlija Jevrić-Čaušević ◽  
Maja Malenica ◽  
Tanja Dujić
Keyword(s):  
Diabetes Mellitus ◽  
Creatine Kinase ◽  
Enzyme Activity ◽  
Diabetes Type ◽  
Diabetes Mellitus Type ◽  
Type I ◽  
Type Ii ◽  
Diabetes Mellitus Type Ii ◽  
Diabetes Type Ii ◽  
Patients With Diabetes

Diabetes mellitus can be looked upon as an array of diseases, all of which exhibit common symptoms. While pathogenesis of IDDM (insulin dependant diabetes mellitus) is well understood, the same is not true for diabetes mellitus type II. In the latter case, relative contribution of the two factors (insulin resistance or decreased insulin secretion) varies individually, being highly increased in peripheral tissues and strictly dependant on insulin for glucose uptake. Moreover, in patients with diabetes mellitus type II, disbalance at the level of regulation of glucose metabolism as well as lipid metabolism has been noted in skeletal muscles. It is normal to assume that in this type of diabetes, these changes are reflected at the level of total activity of enzyme creatine kinase. This experimental work was performed on a group of 80 regular patients of Sarajevo General Hospital. Forty of those patients were classified as patients with diabetes type I and forty as patients with diabetes type II. Each group of patients was carefully chosen and constituted of equal number of males and females. The same was applied for adequate controls. Concentration of glucose was determined for each patient with GOD method, while activity of creatine kinase was determined with CK-NAC activated kit. Statistical analysis of the results was performed with SPSS software for Windows. Obtained results point out highly expressed differences in enzyme activity between two populations examined. Changes in enzyme activity are more expressed in patients with diabetes type II. Positive correlation between concentration of glucose and serum activity of the enzyme is seen in both categories of diabetic patients which is not the case for the patients in control group. At the same time, correlation between age and type of diabetes does exist . This is not followed at the level of enzyme activity or concentration of glucose.

scholarly journals THE RELATIONSHIP BETWEEN WORKING BEHAVIOR AND THE INCIDENCE OF TYPE II DIABETES MELLITUS OF WORKERS WITH THE SNEHANDU THEORY

2021 ◽  
Vol 16 (2) ◽  
pp. 208
Author(s):  
Ninin Nuryantini Farid ◽  
Bagus Pratama Suwardono
Keyword(s):  
Diabetes Mellitus ◽  
Social Support ◽  
Personal Autonomy ◽  
Type Ii Diabetes Mellitus ◽  
The Body ◽  
Exercise Behavior ◽  
Observational Research ◽  
Type I ◽  
Type Ii ◽  
Cross Sectional

ABSTRACTThere are two types of Diabetes Mellitus (DM), namely Type I DM and Type II DM. Type II DM is caused by the inability of the body to respond to insulin that is produced by the pancreas, thus resulting in an increase in blood glucose levels. Eleven out of twenty workers at the Faculty of Public Health, Universitas Airlangga suffered from Type II DM. Observational research with a quantitative approach was conducted through a cross-sectional approach. The population selected was 89 workers at the faculty. The samples were randomly selected with the characteristics of having more than 45 years of age. There were significant variables between working behavior and the incidence of Type II DM including work, last education, and social support. Furthermore, there were insignificant variables between working behavior and the incidence of Type II DM including gender, age, family members, frequency of exercise, behavior intention, personal autonomy, accessibility to information, and action situation. In conclusion, individual’s latest education, employment, and social support had a significant relationship with exercise behavior and the incidence of Type II DM. Keywords: physical exercise, diabetes mellitus, wokers at FKM Universitas Airlangga

scholarly journals Systematic Review of effects of Shodhana & Shmana Chikitsa in Ayurveda in the Management of Diabetes Mellitus Type-II (Prameha)

2021 ◽  
pp. 36-53
Author(s):  
Punam Sawarkar ◽  
Gaurav Sawarkar ◽  
Jayashri Hadke
Keyword(s):  
Diabetes Mellitus ◽  
Clinical Features ◽  
Clinical Judgment ◽  
Meta Analysis ◽  
The Body ◽  
Diabetes Mellitus Type ◽  
Type Ii ◽  
Diabetes Mellitus Type Ii ◽  
Contemporary Science ◽  
The Individual

Introduction: Diabetes mellitus is a complex metabolic clinical condition. It induces some irreversible pathological changes in the body, which rise to multiple complications. Moreover, the side effects of the established anti-hyperglycemic agents in contemporary science on their long-term use make it more worst. Considering the higher incidence rate of Diabetes mellitus due to faulty lifestyle, it is essential to think over various safe but effective measures in alternative science. i.e., Ayurveda. In Ayurveda, diabetes mellitus can be correlated with Prameha or Madhumeha due to similarity in signs & clinical features. Aim & Objective: The prime aim of this study is to study the efficacy and safety of different Shodhana & Shamana Chikitsa in Ayurveda for glucose control & improvement in clinical features during the management of Diabetes Mellitus Type II(Prameha W.S.R). Materials & Methods: This is a meta-analysis of Ayurvedic interventions in Shodhana, or Shamana Chikitsa used to manage Prameha (Diabetes mellitus type II). On extensive Review of the literature, 42 clinical studies (R.C.T. & N.R.C.T.) fulfilling inclusion criteria & conducted with 1743 participants at different places were critically analyzed. Adequate details of the individual studies were tabulated and discussed. Observations & Results: It is reflected that the combinations of both these interventions are more effective than only Shaman Chikitsa in the management of Diabetes mellitus. Conclusion: All of these interventions in Ayurveda reviewed through this study are appeared to be generally safe and effective, having a prime or adjuvant role. However, Ayurvedic physicians should prescribe them based on their clinical judgment, patient’s references, type of pathology, chronicity of the disease & strength of the patient.

Effects of long-term optimization and short-term deterioration of glycemic control on glucose counterregulation in type I diabetes mellitus

Diabetes ◽  
1984 ◽  
Vol 33 (4) ◽  
pp. 394-400 ◽  
Author(s):  
G. Bolli ◽  
P. De Feo ◽  
S. De Cosmo ◽  
G. Perriello ◽  
G. Angeletti ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Glycemic Control ◽  
Type I Diabetes ◽  
Type I Diabetes Mellitus ◽  
Type I ◽  
Short Term

Pengaruh Senam Diabetes Mellitus terhadap Persentase Lemak Tubuh Penderita DM Tipe II di Puskesmas Godean I

2017 ◽  
Vol 19 (1) ◽  
pp. 51-55
Author(s):  
Dyda Fahmi Fadhilah ◽  
Nurul Huda Syamsiatun ◽  
Idi Setiyobroto
Keyword(s):  
Diabetes Mellitus ◽  
Local Government ◽  
Body Fat ◽  
Fat Body ◽  
Disease Risk ◽  
Psychological Intervention ◽  
The Body ◽  
Type Ii ◽  
Paired Sample ◽  
Government Clinic

Background : The number of DM victims in the world increased year by year. According to Health Elementary Research in 2013  the highest number was in DIY, it was 2,6%. Then, according to Godean I Local Government Clinic data, DM was the second rank of Non-Communicable Disease (NCD) after hypertension. The increasing of DM victims number was connected by the overweight case that was influenced by unhealthy diet and lack ofphysic activities so it caused accumulation of fat tissues. In the next time it can cause complication for the victims. There are three pillars of DM management namely, diet, psychological intervention, and exercises. The first that should be done is exercises. One of them is physic exercises namely DM gymnastic. Its functions are to control blood sugar, lose weight and body fat so cardiovascular disease risk factor can be prevented and fixed. In this research the DM gymnastic was done three times in a week for six weeks in duration time of 30-60 minutes. Objective : Purpose of the research to know the influence of DM gymnastic to the change of fat body percentage of DM type II victims in Godean I Local Government Clinic. Method : Research method this research used quasi-experiment method, the research plan used pre-post design. The population was all of DM type II victims in Godean I Local Government Clinic with the subject number were 24 people. The data analysis used statistic test Paired Sample t Test with the credibility 95%. Result : Result of the research the statistic test Paired Sample t Ttest showed that there were not differences before and after DM gymnastic treatment for six weeks. According to the average of fat body percentage after DM gymnastic treatment was higher than before (32,52% > 32,86%). Conclusion : There was no influence of DM gymnastic to the body fat percentage of DM type II victims in GodeanI Local Government Clinic p = 0,59 or p = >0,05.   Keywords: Gymnastic, Diabetes Mellitus, Fat Body Percentage

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