scholarly journals Traumatic Panniculitis-the Spectrum

2021 ◽  
Vol 6 (5) ◽  
pp. 01-04
Author(s):  
Jochanan Naschitz
Keyword(s):  
Adipose Tissue ◽  
Clinical Picture ◽  
Symptomatic Treatment ◽  
The Other ◽  
Tissue Necrosis ◽  
Case Histories ◽  
Physical Trauma ◽  
Subcutaneous Nodules ◽  
Chemical Agents ◽  
Subcutaneous Mass

Panniculitis, when induced by physical trauma or by chemical agents at injection sites, presents as indurated subcutaneous nodules or plaques. The clinical picture may vary, but the context makes usually the diagnosis easy. Three case histories from our department illustrate the spectrum of traumatic panniculitis: subcutaneous nodules at injection sites, a large subcutaneous mass disproportionate to mild trauma, and, at the other end of the spectrum, severe adipose tissue necrosis with liquefied fat discharging through surface wounds. Traumatic panniculitis is self-limiting and only requires symptomatic treatment.

scholarly journals Regional muscle-adipose distribution is different in patients with heart failure with preserved or reduced ejection fraction

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
H Ishikawa ◽  
Y Izumiya ◽  
A Shibata ◽  
T Yoshida ◽  
H Hayashi ◽  
...  
Keyword(s):  
Heart Failure ◽  
Body Mass Index ◽  
Adipose Tissue ◽  
Ejection Fraction ◽  
Exercise Capacity ◽  
Exercise Tolerance ◽  
The Other ◽  
Reduced Ejection Fraction ◽  
Significant Difference ◽  
Regional Muscle

Abstract Background Epicardial adipose tissue (EAT) has been recognized to contribute inflammatory activity and atherosclerosis. On the other hand, it has been reported that the volume of EAT is lower in non-ischemic heart failure (HF) patients than healthy individuals. However, the difference in regional muscle-adipose distribution including EAT between HF with preserved ejection fraction (HFpEF) and HF reduced ejection fraction (HFrEF) has not been investigated. In addition, we investigated whether distribution of body composition contributed to exercise capacity. Methods The study included 105 non-ischemic HF patients diagnosed by cardiac catheterization between September 2017 and November 2019. Epicardial, abdominal and thigh muscle and adipose tissue volume were measured by computed tomography (CT), and exercise tolerance was evaluated by symptom-limited cardiopulmonary exercise test. Results Patients were divided into 2 groups according to the left ventricular ejection fraction, ≥40% as HFpEF (n=28) or <40% as HFrEF (n=77). There was no significant difference comorbidity, including hypertension, dyslipidemia, chronic kidney disease, and body mass index. Plasma B-type natriuretic peptide level was significantly higher in HFrEF than HFpEF group (146.2 vs 393.2 pg/ml, p<0.01), whereas, high-sensitive troponin T level was not different between two groups. Although there was no significant difference in BMI between two groups, the volume of EAT was significantly higher in HFpEF than HFrEF group (81.8 vs 136.4 ml, p=0.01). On the other hand, HFpEF had more thigh adipose tissue compared with HFrEF group (54.6 vs 42.1 ml, p=0.03). There were negative correlations between EAT volume and parameters of exercise capacity such as anaerobic threshold (r=−0.42, p<0.01) and peak VO2 (r=−0.32, p<0.01). Muscle volume itself does not corelate with these parameters. Conclusion In patient with nonischemic HF, the pattern of regional adipose distribution may have important role in pathologically. HFpEF and HFrEF has different pattern despite similar body mass index. These differences may be related to impaired exercise tolerance in these 2 different types of HF. Correlation between EAT and AT, peak VO2 Funding Acknowledgement Type of funding source: None

scholarly journals The Future of Fat Grafting

2021 ◽  
Vol 41 (Supplement_1) ◽  
pp. S69-S74
Author(s):  
Summer E Hanson
Keyword(s):  
Adipose Tissue ◽  
Breast Reconstruction ◽  
Fat Grafting ◽  
The Other ◽  
Special Topic ◽  
Autologous Fat Grafting ◽  
Upper Arm ◽  
Future Directions ◽  
Autologous Fat ◽  
The Face

Abstract One of the earliest reported cases of autologous fat grafting (AFG) was by Neuber in 1893 and consisted of the transfer of small lobules of fat from the upper arm for cicatrical depression of the face. He advocated the use of smaller grafts, noting that pieces larger than the size of a bean would form cysts. In 1895, Czerny excised a lumbar lipoma and transplanted it to the chest for breast reconstruction. Since these early reports, the knowledge base around AFG has expanded exponentially, as illustrated by the other papers within this special topic. As we embark on the next phase of AFG in the clinical setting, there are several directions which are near-clinical translation. This paper discusses future directions in fat grafting that build on optimization of our current techniques as clinical indications expand, such as supplementing purified lipoaspirate and the associated regulatory burden, or deconstructing adipose tissue to selectively use adipose graft components for a variety of regenerative indications.

Pharmacogenetics: Its Place in Medicine and Biology

1992 ◽  
Vol 5 (6) ◽  
pp. 312-316 ◽  
Author(s):  
Werner Kalow
Keyword(s):  
Infectious Disease ◽  
Drug Toxicity ◽  
Rare Variants ◽  
The Other ◽  
New Drugs ◽  
Case Histories ◽  
High Incidence ◽  
New Knowledge ◽  
Toxic Exposures ◽  
Technical Advances

A young science serves its purpose if it leads not only to new knowledge, but to new insights and concepts. This article opens with examples to illustrate some former thinking that the introduction of pharmacogenetic has overcome. Pharmacogenetic case histories from discovery to the present illustrate the interlocking of observations, technical advances, and changing concepts. There are striking biological similarities between pharmacogenetics and those inborn factors that cause resistance to infectious disease: Both represent person-to-person variations that may help the survival of populations, one when facing massive toxic exposures, the other when facing plagues and epidemics. Thus pharmacogenetics represents a biologically necessary variability of the defenses against chemical intruders, and this includes drugs. While this variability is desirable, drug toxicity occurring on the basis of this variability must be avoided. The most successful defendants against toxicity due to polymorphic (ie, high incidence) variants should be the designers of new drugs. The only defender concerned with rare variants can be the attentive clinician.

scholarly journals Comparative Reading of Motherhood Identities in East African and Indonesian Literature

2020 ◽  
Vol 32 (2) ◽  
pp. 170
Author(s):  
Stanley Elias
Keyword(s):  
Social Stigma ◽  
Male Child ◽  
The Other ◽  
Literary Texts ◽  
East African ◽  
Physical Trauma ◽  
Religious Orientations ◽  
Other Hand ◽  
Reduced Forms

The study comparatively examines the representation of motherhood identities and the trauma of being childless to women in African and Indonesian literary texts namely Ngugi wa Thiong’o’s Secret Lives and other Stories, Elieshi Lema’s Parched Earth, Ratih Kumala’s Genesis and Iwan Setyawan’s Ibuk. Central to the analysis of this study is the argument that the existing cultural and religious discourses significantly contribute to the ways motherhood identities are construed in the society. Of a particular note, motherhood is argued to be a desired position that every woman wants most and is ready to sacrifice for it. Importantly, marriage, religious orientations and orders of the patriarchy certify motherhood and its related identities in the society. On the other hand, childlessness or failure to bear a male child circumscribe women in reduced forms of their identities and so subjects them to psychological and physical trauma and of course a social stigma.

scholarly journals Adipose tissue in control of metabolism

2016 ◽  
Vol 231 (3) ◽  
pp. R77-R99 ◽  
Author(s):  
Liping Luo ◽  
Meilian Liu
Keyword(s):  
Adipose Tissue ◽  
Metabolic Pathways ◽  
The Body ◽  
The Other ◽  
Whole Body ◽  
Endocrine Organ ◽  
Lipid Mobilization ◽  
Adipose Tissue Dysfunction ◽  
Body Energy ◽  
Beige Adipose Tissue

Adipose tissue plays a central role in regulating whole-body energy and glucose homeostasis through its subtle functions at both organ and systemic levels. On one hand, adipose tissue stores energy in the form of lipid and controls the lipid mobilization and distribution in the body. On the other hand, adipose tissue acts as an endocrine organ and produces numerous bioactive factors such as adipokines that communicate with other organs and modulate a range of metabolic pathways. Moreover, brown and beige adipose tissue burn lipid by dissipating energy in the form of heat to maintain euthermia, and have been considered as a new way to counteract obesity. Therefore, adipose tissue dysfunction plays a prominent role in the development of obesity and its related disorders such as insulin resistance, cardiovascular disease, diabetes, depression and cancer. In this review, we will summarize the recent findings of adipose tissue in the control of metabolism, focusing on its endocrine and thermogenic function.

To assess the importance of Nidana Parivarjan in the treatment of Urdhvag Amlapitta with Guduchi Satva

2020 ◽  
Vol 5 (04) ◽  
pp. 16-20
Author(s):  
Parag Vishwas Kulkarni ◽  
Mangesh Jagannath Thamake
Keyword(s):  
Treatment Group ◽  
Symptomatic Treatment ◽  
The Other ◽  
Main Principle ◽  
Complete Eradication ◽  
Clinical Conditions ◽  
Better Than

Amlapitta is one of the leading clinical conditions in today’s speedy lifestyle. Present study focuses on this burning issue and its causes mentioned in Ayurved texts and actual causes observed in day to day life. Importance and benefits of Nidanparivarjan over only symptomatic treatment was assessed during this study. Amlapitta cases were diagnosed according to Ayurvedic texts and classified into two groups. One group was administered with only treatment and the other group was advised Nidanparivarjan along with the treatment. At the end of the study, it was found that the group with Nidanparivarjan was more benefited as compared to only treatment group. This clearly states that Ayurvedic method of finding the particular Hetu of the disease and practice of avoiding those Hetu; i.e. Nidanparivarjan leads to better results and complete eradication and prevention of the disease; thus serving the main principle of Ayurved science - Prevention is better than Cure.

Dissociation Revealed in a Therapeutic Consultation

2016 ◽  
pp. 245-272
Author(s):  
Donald W. Winnicott
Keyword(s):  
Clinical Picture ◽  
Antisocial Behaviour ◽  
Case Histories

Winnicott discusses one detail of the antisocial clinical picture to illustrate the feature of dissociation, which recurs regularly in case histories. He illustrates this using a psychotherapeutic interview with a girl of eight years, which led to a cessation of stealing and which Winnicott believes was therefore significant. He writes that the child who does not acknowledge the antisocial act is the child who is in distress and who wants help and who can be helped. Another example concerns a deprived child who craved friendship but could not achieve it and did not make friends easily. The child was aware that he was suffering from a compulsion, but could not believe in what he had done under this compulsion, showing the dissociation in his psyche. Winnicott maintains that antisocial behaviour in a child is linked to a loss of hope—disillusionment—which needs to be returned to in order to recover the capacity for hope.

scholarly journals Effects of Chronic Intracerebroventricular Infusion of RFamide-Related Peptide-3 on Energy Metabolism in Male Mice

2020 ◽  
Vol 21 (22) ◽  
pp. 8606
Author(s):  
Shogo Moriwaki ◽  
Yuki Narimatsu ◽  
Keisuke Fukumura ◽  
Eiko Iwakoshi-Ukena ◽  
Megumi Furumitsu ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Energy Metabolism ◽  
Food Intake ◽  
Energy Expenditure ◽  
Body Mass ◽  
The Other ◽  
Related Peptide ◽  
Intracerebroventricular Infusion ◽  
Brown Adipose ◽  
The Masses

RFamide-related peptide-3 (RFRP-3), the mammalian ortholog of avian gonadotropin-inhibitory hormone (GnIH), plays a crucial role in reproduction. In the present study, we explored the other functions of RFRP-3 by investigating the effects of chronic intracerebroventricular infusion of RFRP-3 (6 nmol/day) for 13 days on energy homeostasis in lean male C57BL/6J mice. The infusion of RFRP-3 increased cumulative food intake and body mass. In addition, the masses of brown adipose tissue (BAT) and the liver were increased by the administration of RFRP-3, although the mass of white adipose tissue was unchanged. On the other hand, RFRP-3 decreased O2 consumption, CO2 production, energy expenditure, and core body temperature during a short time period in the dark phase. These results suggest that the increase in food intake and the decrease in energy expenditure contributed to the gain of body mass, including the masses of BAT and the liver. The present study shows that RFRP-3 regulates not only reproductive function, but also energy metabolism, in mice.

Vision, subalternity, and religious imaginary in southern Italy

2020 ◽  
pp. 003776862096065
Author(s):  
Roberto Beneduce
Keyword(s):  
Religious Experience ◽  
Southern Italy ◽  
The Other ◽  
Comparative Perspective ◽  
Traumatic Experience ◽  
Case Histories ◽  
New Horizons ◽  
The World ◽  
Ways Of Life ◽  
Religious Imaginary

Vision and divine voice, however defined, are at the heart of religious experience. The meeting with the Other sustains new ways of life and grants deep transformations in subjectivity. After chronicling the difficulty, indeed outright impossibility, of circumscribing and defining these complex experiences, as well as the opacity of the dominant categories that have been adopted by sociology, anthropology, phenomenology, and psychiatry, this article explores three case histories from southern Italy. Each one reveals a particular knot where private (and traumatic) experience has incorporated historical horizons and collective anxieties. By adopting a historical and comparative perspective, the author investigates how visions, voices – and more generally the encounter with transcendence – enable subalterns to deal with suffering and marginality and, more importantly, to build a view of how the world is and works. Finally, the article suggests that these experiences allow a transformation of the nostalgia for agency into new ‘horizons of expectation’.

scholarly journals Changes in the sensitivity to glucagon of lipolysis in adipocytes from pregnant and lactating rats

1988 ◽  
Vol 254 (3) ◽  
pp. 661-665 ◽  
Author(s):  
V A Zammit
Keyword(s):  
Adipose Tissue ◽  
The Other ◽  
High Concentration ◽  
Response Curves ◽  
Pregnant Rats ◽  
Adipose Tissue Lipolysis ◽  
The Right ◽  
Peak Lactation ◽  
Stimulation Of

1. Rates of lipolysis were measured at different concentrations of glucagon in adipocytes prepared from parametrial adipose tissue of fed or starved rats in different reproductive states. All experiments were performed in the presence of a high concentration of adenosine deaminase (1 unit/ml). 2. Maximal rates of lipolysis (elicited by 25 nM-glucagon in each instance) were higher in adipocytes from peak-lactating rats than those from pregnant animals in both the fed and starved states. 3. Of adipocytes from fed animals, those from peak-lactating rats were the most sensitive to glucagon, whereas those from late-pregnant and early-lactating rats were 1-2 orders of magnitude less sensitive. 4. Adipocytes from 24 h-starved rats showed a much smaller stimulation of lipolysis by glucagon, making the assessment of sensitivity difficult. Therefore, rates of lipolysis were also measured in the presence of a maximally anti-lipolytic dose of insulin. The presence of insulin did not alter the relative sensitivities to glucagon of adipocytes from fed animals in different reproductive states, although all dose-response curves were shifted to the right. When lipolysis in adipocytes from starved animals was measured in the presence of insulin, it became evident that starvation for 24 h markedly increased the sensitivity of adipocytes from late-pregnant rats to glucagon, but did not affect that of cells from animals in the other reproductive states. 5. It is concluded that the large changes in sensitivity to glucagon that occurred during the reproductive cycle may enable the modulation of adipose-tissue lipolysis in vivo to satisfy the different metabolic requirements of the animal in the transition from pregnancy to peak lactation.

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