scholarly journals Prevention of respiratory distress disease in pregnancy and newborn: a case review of the capacity of primary healthcare tier in Delta State Nigeria

2020 ◽  
Vol 2 (6) ◽  
pp. 01-05
Author(s):  
Omatseye Akuirene
Keyword(s):  
Respiratory Distress ◽  
Distress Syndrome ◽  
Mortality Rates ◽  
Health Inequity ◽  
Case Review ◽  
Health Seeking ◽  
New Born ◽  
Primary Health ◽  
Seeking Behavior ◽  
Pregnant Mothers

The Universal Declaration on Human Rights regarding Primary Health Care (PHC) in Nigeria is to provide adequate and equitable healthcare to pregnant mothers and new born. This includes those who are at risk of respiratory distress disease. The objective of this work is to identify the capacity of PHC in the management of respiratory distress syndrome among pregnant mothers and new born. A narrative review of literatures on respiratory distress performed. There have been shortages of staff and health inequity while improvement in maternal and child mortality rates may be attributable to improved knowledge and health seeking behavior. PHC practitioners’ need to be motivated because they are available and useful in rendering preventive services for respiratory distress disease during pregnancy and new deliveries for better results.

A THERAPEUTIC APPROACH IN 100 CASES OF THE RESPIRATORY DISTRESS SYNDROME OF THE NEWBORN INFANT

PEDIATRICS ◽  
1964 ◽  
Vol 33 (6) ◽  
pp. 956-964
Author(s):  
James H. Hutchison ◽  
Margaret M. Kerr ◽  
T. A. Douglas ◽  
J. A. Inall ◽  
J. C. Crosbie
Keyword(s):  
Sodium Bicarbonate ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Umbilical Vein ◽  
Prognostic Significance ◽  
Supportive Therapy ◽  
Respiratory Acidosis ◽  
Mortality Rates ◽  
Trial Series

A method of treatment in 100 cases of the idiopathic respiratory distress syndrome of severe degree is described. This includes the rapid correction of metabolic acidosis with 8.4% solution of sodium bicarbonate (1 ml = 1 mEq). The sodium bicarbonate is given by periodic intravenous injections by the umbilical vein, and the dosage is controlled by frequent estimations in the blood of the pH, pCO2, plasma standard bicarbonate and base excess by means of the Astrup micro-apparatus. The total daily fluid intake by the same route is brought up to 60 ml/kg with 20% fructose solution. In view of the serious prognostic significance of severe or persisting respiratory acidosis, which cannot be relieved by sodium bicarbonate, a trial of Tris-(hydroxymethyl)-aminomethane (THAM) was made in 26 cases. In each of these very severely affected infants the pCO2 was above 70 mm Hg. The results failed to show sufficient advantage to justify the increased risks with THAM. The mortality figures in the trial series have been compared with those recorded in the same hospital in cases of comparable severity which were treated by standard methods in 1960 and 1961. The over-all mortality rates in 1960, 1961, and the trial series, including patients who also had intraventricular hemorrhage or other major complications, were 66, 64, and 46% respectively. The mortality rates in cases of the uncomplicated respiratory distress syndrome in 1960, 1961, and the trial series were 49, 44.7, and 11.5% respectively. It is considered that the improvement in the mortality figures with this type of supportive therapy is sufficiently striking to encourage its trial use in other centers.

scholarly journals Does Prone Positioning Decrease Mortality Rate in ARDS? A Systematic Review

2018 ◽  
Author(s):  
Joseph Sarkis
Keyword(s):  
Systematic Review ◽  
Acute Respiratory Distress Syndrome ◽  
Mortality Rate ◽  
Respiratory Distress Syndrome ◽  
Supportive Care ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Mortality Rates ◽  
Prone Positioning ◽  
Reduce Mortality Rate

Acute Respiratory Distress Syndrome (ARDS) is a clinical condition in which the lungs suffer severe irreversible, large-scale damage causing a grievous form of hypoxemic respiratory failure. Acute respiratory distress syndrome is one of the most evasive diagnosis confronted in the Intensive care unit (ICU) as the name, definition and diagnostic standards have adapted over the past four decades. An ARDS diagnosis is established by physiological criteria and continues to be a diagnosis of exclusion, which makes it crucial that medical professionals expand their knowledge base to effectively diagnose ARDS. Patients admitted with ARDS have high mortality rates ranging from 40 to 60 percent. High-level quality supportive care continues to be the sole option for ARDS treatment. Even with improved supportive care, however, ARDS prognosis is still poor. Extended prone positioning (PP) has been shown to increase alveolar recruitment end expiratory lung volume, thereby improving oxygenation and survival. Unfortunately, few studies have examined the association of mortality and prone positioning in ARDS. A systematic review was conducted to examine the following research question: Does prone positioning compared to supine positioning in patients with ARDS decrease mortality rates? This systematic review was guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Critical Appraisal Skills Programme (CASP). A literature review was performed and data were collected from each study. A cross study analysis was performed and PP was found to reduce mortality rate in patients who were severely hypoxic. The reviewed studies demonstrated that incorporating early and longer periods of PP may improve mortality in ARDS patients, but further research is needed.

scholarly journals Intestinal Collinsella may mitigate infection and exacerbation of COVID-19 by producing ursodeoxycholate

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0260451
Author(s):  
Masaaki Hirayama ◽  
Hiroshi Nishiwaki ◽  
Tomonari Hamaguchi ◽  
Mikako Ito ◽  
Jun Ueyama ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Gut Microbiota ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Mortality Rates ◽  
Sequencing Data ◽  
Angiotensin Converting Enzyme 2 ◽  
Underlying Mechanisms ◽  
Apoptotic Effects

The mortality rates of COVID-19 vary widely across countries, but the underlying mechanisms remain unelucidated. We aimed at the elucidation of relationship between gut microbiota and the mortality rates of COVID-19 across countries. Raw sequencing data of 16S rRNA V3-V5 regions of gut microbiota in 953 healthy subjects in ten countries were obtained from the public database. We made a generalized linear model (GLM) to predict the COVID-19 mortality rates using gut microbiota. GLM revealed that low genus Collinsella predicted high COVID-19 mortality rates with a markedly low p-value. Unsupervised clustering of gut microbiota in 953 subjects yielded five enterotypes. The mortality rates were increased from enterotypes 1 to 5, whereas the abundances of Collinsella were decreased from enterotypes 1 to 5 except for enterotype 2. Collinsella produces ursodeoxycholate. Ursodeoxycholate was previously reported to inhibit binding of SARS-CoV-2 to angiotensin-converting enzyme 2; suppress pro-inflammatory cytokines like TNF-α, IL-1β, IL-2, IL-4, and IL-6; have antioxidant and anti-apoptotic effects; and increase alveolar fluid clearance in acute respiratory distress syndrome. Ursodeoxycholate produced by Collinsella may prevent COVID-19 infection and ameliorate acute respiratory distress syndrome in COVID-19 by suppressing cytokine storm syndrome.

Comparing Indonesian men's health-seeking behavior and likelihood to suffer from illness across sociodemographic factors

2021 ◽  
Keyword(s):  
Mental Illness ◽  
Health Insurance ◽  
High Risk ◽  
Age Groups ◽  
Risk Category ◽  
Health Seeking ◽  
Primary Health ◽  
High Risk Category ◽  
Seeking Behavior ◽  
Primary Health Facilities

Background and objective: This study aims to examine men's health-seeking behavior and likelihood to suffer from acute diseases compared to women. Material and methods: We used the Indonesian National Health Insurance Agency for the period of 2015 and 2016 to obtain information about transactions in primary health facilities. We analyzed the data using negative binomial regression and logistic regression. The incidence rate ratio of health-seeking frequency and the odds ratio of men (compared to women) suffering from infectious diseases (i.e., acute upper respiratory infection; the number one acute disease in Indonesia), top three diagnoses, and non-communicable disease (i.e., mental illness) were assessed. Other sociodemographic variables i.e., age, marital status, and the source of National Health Insurance funding were also analyzed. Results: This study found that adolescent males visited primary health facilities the least often compared to all age groups and were among the top three age groups of men who were most likely to suffer from acute and mental illnesses. Low-income and divorced, self-employed and married, and employed and divorced adolescent men were in the high-risk category of suffering from acute illness; on the other hand, adolescent men who were married and poor were in the high-risk category of suffering from mental illness. This study also found that young men were suffering from acute disease and mental illness, which is worrying for a developing country such as Indonesia. Conclusion: Urgent interventions should be considered moving forward. The findings of this study suggest that men who marry at a young age may experience negative health outcomes.

Adult Respiratory Distress Syndrome in Full-Term Newborns

PEDIATRICS ◽  
1990 ◽  
Vol 85 (6) ◽  
pp. 1132-1132
Author(s):  
ROGER G. FAIX ◽  
MICHAEL A. DIPIETRO
Keyword(s):  
Pulmonary Hypertension ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Adult Respiratory Distress Syndrome ◽  
Distress Syndrome ◽  
Mortality Rates ◽  
Full Term ◽  
Persistent Pulmonary Hypertension ◽  
Term Newborns ◽  
The Difference

In Reply.— We appreciate the interest and continuing contributions of Drs Pfenninger and Tschaeppeler. We agree with their assessment that the difference in mortality rates is probably attributable to selection differences. All five of their infants would have been excluded from our series, since proven sepsis and documented persistent pulmonary hypertension were both among the criteria for exclusion. As we noted in our article, the low mortality in our series was not surprising because of such exclusions.

Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome in Adults

2013 ◽  
Vol 24 (2) ◽  
pp. 149-158 ◽  
Author(s):  
Kelly E. Williams
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Extracorporeal Membrane Oxygenation ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Ventilatory Support ◽  
Mortality Rates ◽  
Morbidity And Mortality ◽  
Traditional Management ◽  
Membrane Oxygenation

Despite advances in treatment, acute respiratory distress syndrome (ARDS) remains a common cause of respiratory failure requiring ventilatory support and is associated with significantly high rates of morbidity and mortality. To date, the only treatment shown to increase survival rate in patients with ARDS is the use of supportive mechanical ventilation using low tidal volumes. Extracorporeal membrane oxygenation (ECMO) is a therapy that has been used in severe cases of ARDS when patients fail to improve with traditional management. Recent literature shows varying mortality rates for the use of ECMO for ARDS; however, the literature suggests that transfer of patients to an ECMO center for treatment using specific criteria and indications may improve outcomes. Further research is needed regarding the timing of the initiation of ECMO, standardization of therapy, and which type of ECMO reduces morbidity and mortality rates in patients with ARDS.

scholarly journals Neonatal Mortality and Morbidity in a Tertiary Care Hospital of Coastal South India

2018 ◽  
Vol 37 (3) ◽  
pp. 232-237
Author(s):  
Raja Kannan ◽  
Suchetha Rao ◽  
Prasanna Mithra ◽  
SM Rajesh ◽  
Bhaskaran Unnikrishnan ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Neonatal Mortality ◽  
Congenital Malformations ◽  
Distress Syndrome ◽  
Care Hospital ◽  
Mortality And Morbidity ◽  
New Born

Correction: On 13th June, Prasanna Mithra was added as an author of this paper.Introduction: Progress in new-born survival has been slow. There is a variation in neonatal death rates across states and geographical region of a country. Understanding the pattern of mortality is essential in improving new-born survival. This study was conducted to study the mortality and morbidity profile in Neonatal Intensive Care Unit (NICU) of a university teaching hospital.Material and Methods: This was a retrospective descriptive study including records of all neonates admitted in NICU from January 2015 to December 2016.Results 3623 neonates were admitted during the study period. Majority were preterm and low birth weight babies. Neonatal jaundice (41.4%) was the leading cause of admission. Major cause of morbidity was sepsis (26.2%). Average duration of stay were higher in out borns (8.4 days) compared to inborn (6.5 days) neonates. Among mortality a higher male predominance was seen. Neonatal sepsis (36.3%) was the single most common cause of mortality followed by respiratory distress syndrome (27.4%) and congenital malformations (18.6%). Out born neonates which were self-transported had higher mortality rate than transported by ambulance.Conclusion This study identifies sepsis, prematurity and low birth weight as the major causes of morbidity. Sepsis, respiratory distress syndrome and congenital malformations were the leading causes of mortality Understanding causes of neonatal mortality may help to implement interventions to promote new-born survival.  

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