Oligodendroglioma with lethal exposure. Clinical case

2021 ◽  
Vol 19 (2) ◽  
pp. 92-95
Author(s):  
S. S. YASHIN ◽  
◽  
Yu. R. YUNUSOVA ◽  
A. D. IBRAGIMOVA ◽  
A. D. DUDKO ◽  
...  
Keyword(s):  
Clinical Case ◽  
Statistical Data ◽  
Correct Diagnosis ◽  
Diagnostic Error ◽  
Vital Activity ◽  
True Nature ◽  
Primary Tumors ◽  
Practical Medicine ◽  
The Brain ◽  
Timely Treatment

Tumors of the brain constitute only 2% of all primary tumors, but it is they that lead to disastrous, sometimes even fatal consequences. Patients have progressive disorders of vital activity, which in the absence of timely treatment can lead to death. It is important to note that brain tumors are not only difficult to diagnose, but also difficult to treat. The purpose — to determine the etiological and pathomorphogenetic features of oligodendroglioma, familiarizing readers with the problem of discrepancy between clinical and pathological diagnoses in practical medicine. Material and methods. The work presents a clinical case of a patient with fatal oligodendroglioma and statistical data on the disease. Results. When comparing the final clinical diagnosis and the pathological anatomical diagnosis, a discrepancy of the II category was determined due to the difficulty of diagnosing the disease: in a medical institution, the correct diagnosis was possible, but the occurring diagnostic error did not generally affect the outcome of the disease. Despite the use of high-precision medical imaging methods, it is impossible to establish the true nature of the onset of neurological symptoms in a patient in serious condition. With a routine approach, both clinicians and pathologists were unable to suspect a tumor in a patient prior to histological examination, which once again confirms the relevance of describing complex clinical cases.

scholarly journals DIAGNOSTIC ERRORS DURING INTRAMEDULLAR PROCESSES

2019 ◽  
Vol 72 (1) ◽  
pp. 129-132
Author(s):  
Kateryna Tarianyk ◽  
Natalia Lytvynenko ◽  
Tetiana Purdenko ◽  
Viktoriia Hladka
Keyword(s):  
Spinal Cord ◽  
Malignant Tumor ◽  
Clinical Case ◽  
Correct Diagnosis ◽  
Spinal Cord Tumor ◽  
Diagnostic Errors ◽  
Diagnostic Approaches ◽  
Brain And Spinal Cord ◽  
The Brain

Introduction: The article describes a clinical case of a malignant tumor of the brain and spinal cord with metastasis, which remained undetected for many years and was treated as syringomyelia. Long-term exhausting examinations of the brain and spinal cord, dynamic follow-up of medical specialists, and repeated surgical interventions on the spine helped to differentiate this process and make the correct diagnosis. The aim: The objectives of the present paper are to analyze the existing classifications of syringomyelia; to examine its etiology, pathogenesis, diagnostic approaches and treatment tactics; to present a clinical case of a malignant tumor of the brain and spinal cord with metastasis, which was misdiagnosed as syringomyelia. Materials and methods: The authors analyzed the existing classifications of syringomyelia and studied its etiology, pathogenesis, diagnostic approaches and treatment tactics using the method of content analysis, analyticalб comparative and contrastive methods. Clinical case: The described clinical case is a variant of the course of syringomyelia, associated with the spinal cord tumor, namely, in particular, anaplastic ependymoma. For a long time, the process remained undetected, despite the long-term examination and drainage of the syringomyelic cavity. Analyzing this case, it is highly important to pay attention to careful history collection, examination of the patient, analysis of the occurrence of certain disorders in order to conduct the neuroimaging examinations in time. Conclusions: Favorable outcome of the disease is directly related to the diagnosis at early stages, especially in young people, the clinical variant of the process, progression of the course, the degree of involvement of various parts of the nervous system and extraneural formations, the severity of the lesion. The treatment tactics and the ability to restore the functions will depend on all these factors.

scholarly journals Magnetic Susceptibility MRI in Differential Diagnostics of Primary CNS Lymphoma and Anaplastic Astrocytoma Clinical Observation

2020 ◽  
Vol 3 (4) ◽  
pp. 94-100
Author(s):  
D. V. Sashin ◽  
M. B. Dolgushin ◽  
E. A. Kobyakova ◽  
E. A. Nechipay ◽  
T. G. Gasparyan
Keyword(s):  
Clinical Case ◽  
Clinical Observation ◽  
Correct Diagnosis ◽  
Malignant Gliomas ◽  
Primary Cns Lymphoma ◽  
Differential Diagnostics ◽  
Cns Lymphoma ◽  
Rapid Progression ◽  
The Central Nervous System ◽  
The Brain

Primary lymphomas of the central nervous system (PCLCS) are relatively rare tumors, usually having a multifocal manifestation in the brain and rapid progression. It is not always possible to make a correct diagnosis for MRI, since similar radiological manifestations (markers) of this disease, when using routine protocols, MRI can occur, for example, in malignant gliomas. This article presents a clinical case of a refinement diagnosis — PLCNS when using MRI in sequence (SWI), which was confirmed by the data of histological examination of surgical material.

Middle ear tuberculosis - clinical case

ORL ro ◽  
2016 ◽  
Vol 2 (1) ◽  
pp. 12-14
Author(s):  
A. Sandul ◽  
M. Buracovschi ◽  
N. Buracovschi
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Human Population ◽  
Clinical Case ◽  
Correct Diagnosis ◽  
Tuberculous Otitis Media ◽  
Type V

Tuberculosis is one of the oldest pathologies that affect human population, being a significant cause of morbidity/mortality in several countries. Middleear tuberculosis is a rare pathology, often misdiagnosed because of an atipic evolution, as a result leading to severe complications. This paper presents a case of tuberculous otitis media complicated with facial nerveparalysis House Brackmann type V in a patient who underwent multiple middleear surgeries before correct diagnosis was established.  

Rab11 family-interacting protein 4, RAB11FIP4, is a differentially expressed gene in brain metastatic human breast cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Differentially Expressed Gene ◽  
Metastatic Breast ◽  
Metastatic Tumor ◽  
Clinical Problem ◽  
Interacting Protein ◽  
Primary Tumors ◽  
Free Survival ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that Rab11 family-interacting protein 4, encoded by RAB11FIP4, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. RAB11FIP4 mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Importantly, expression of RAB11FIP4 in primary tumors was significantly correlated with patient recurrence-free survival and distant metastasis-free survival. Modulation of RAB11FIP4 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.

scholarly journals Therapeutic Management of Rare Primary Ovarian Neoplasms: Carcinosarcoma, Leiomyosarcoma, Melanoma and Carcinoid

2021 ◽  
Vol 18 (15) ◽  
pp. 7819
Author(s):  
Mateusz Kozłowski ◽  
Katarzyna Nowak ◽  
Agnieszka Kordek ◽  
Aneta Cymbaluk-Płoska
Keyword(s):  
Clinical Case ◽  
Ovarian Neoplasms ◽  
Treatment Guidelines ◽  
Case Reports ◽  
Review Of The Literature ◽  
Pharmacological Treatments ◽  
International Database ◽  
Primary Tumors ◽  
Fertility Sparing ◽  
Oncological Centers

Carcinosarcoma, leiomyosarcoma, melanoma and carcinoid as primary tumors in the ovary are extremely rare. In this paper, the authors reviewed the literature from 2010 to 2021, based on specific criteria, to analyze the treatment of these rare ovarian neoplasms. We also aimed to verify whether modern therapies have been found in recent years. For this article, 80 papers were finally selected. The vast majority of the articles were clinical case reports. Despite single mentions of new potential pharmacological treatments, surgery (radical or fertility-sparing) is definitely the mainstay of treatment. There are currently no treatment guidelines for these tumors. A review of the literature has revealed the use of various adjuvant treatments. We, therefore, believe that a more detailed understanding of the biology of these tumors is necessary in order to find new target points for treatment. We would like to emphasize the importance of creating an international database of rare ovarian tumors which would make it possible to gather data from various oncological centers and enable further research into these neoplasms.

scholarly journals Seven Computations of the Social Brain

2021 ◽  
Author(s):  
Tanaz Molapour ◽  
Cindy C Hagan ◽  
Brian Silston ◽  
Haiyan Wu ◽  
Maxwell Ramstead ◽  
...  
Keyword(s):  
Social Interactions ◽  
Social World ◽  
Social Brain ◽  
Verbal Cues ◽  
True Nature ◽  
Multiple Modalities ◽  
The Social ◽  
Processing Demands ◽  
Social Signaling ◽  
The Brain

ABSTRACT The social environment presents the human brain with the most complex of information processing demands. The computations that the brain must perform occur in parallel, combine social and nonsocial cues, produce verbal and non-verbal signals, and involve multiple cognitive systems; including memory, attention, emotion, learning. This occurs dynamically and at timescales ranging from milliseconds to years. Here, we propose that during social interactions, seven core operations interact to underwrite coherent social functioning; these operations accumulate evidence efficiently – from multiple modalities – when inferring what to do next. We deconstruct the social brain and outline the key components entailed for successful human social interaction. These include (1) social perception; (2) social inferences, such as mentalizing; (3) social learning; (4) social signaling through verbal and non-verbal cues; (5) social drives (e.g., how to increase one’s status); (6) determining the social identity of agents, including oneself; and (7) minimizing uncertainty within the current social context by integrating sensory signals and inferences. We argue that while it is important to examine these distinct aspects of social inference, to understand the true nature of the human social brain, we must also explain how the brain integrates information from the social world.

COVID-19-associated orthostatic hypotension syndrome: direct and indirect mechanisms of development

2021 ◽  
Vol LIII (3) ◽  
pp. 64-70
Author(s):  
Elena G. Mendelevich ◽  
Alsu A. Saifeeva ◽  
Artur I. Kurbanov
Keyword(s):  
Nervous System ◽  
Orthostatic Hypotension ◽  
Clinical Case ◽  
Clinical Observation ◽  
Thrombus Formation ◽  
Correct Diagnosis ◽  
Aim Analysis ◽  
Angiotensin Converting Enzyme 2 ◽  
Mechanisms Of Development ◽  
Near Future

Background. The article presents an observation of the clinical case of orthostatic hypotension that developed after an infection caused by the SARS-CoV-2 virus. The issues of etiology, pathogenesis, diagnosis are outlined. The complexity of diagnosis at the stage of clinical observation is due to the comorbidity of possible mechanisms and the difficulty of determining the primary factor. Taking into account the study of variants of direct and indirect action of this 2019-nCoV, the description of the clinical observation of orthostatic hypotension supplements the data on the spectrum of manifestations of this disease. Aim. Analysis of the clinical case of the development of orthostatic hypotension in the post-acute period of COVID-19. Material. When conducting a literature review on the selected topic, various sources were considered. The search depth was over 7 years. For the recruitment of literature, Internet platforms UpToDate, PubMed, Medscape were used. Russian and foreign sources were studied. Methods. Anamnesis collection, objective research, specialized tests, laboratory and instrumental research methods, study of disease history, literature sources on orthostatic hypotension and the effect of COVID-19 on the autonomic nervous system. Results. The analysis of this case with the determination of the leading mechanism of orthostatic hypotension is extremely difficult. Probably, there is a combination of factors: direct and indirect effects on the nervous system at COVID-19. The direct effect is associated with the interaction of the virus with the angiotensin converting enzyme 2 receptors in the nervous system, which causes a significant increase in the concentration of bradykinin and the development of hypotension. An indirect effect is due to both increased thrombus formation with the development of PE, and autonomic dysfunction, within the framework of secondary polyneuropathy of fine fibers. Conclusion. It is likely that in the near future the number of such patients in the practice of doctors will increase, therefore, timely and correct diagnosis of these conditions, with their careful management, will be the fundamental postulates in the recovery of patients. Drawing attention to this topic will possibly expand our understanding of the spectrum of complications of COVID-19 and will greatly complement the information available today.

Primary leptomeningeal lymphoma masquerading as infectious tubercular meningitis

2021 ◽  
Vol 14 (9) ◽  
pp. e243574
Author(s):  
Salini Sumangala ◽  
Thidar Htwe ◽  
Yousuf Ansari ◽  
Lidia Martinez- Alvarez
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Correct Diagnosis ◽  
Central Nervous System Lymphoma ◽  
Final Diagnosis ◽  
Csf Analysis ◽  
Antitubercular Treatment ◽  
Lymphoma Treatment ◽  
Work Up ◽  
Timely Treatment

Primary central nervous system lymphoma (PCNSL) is infrequent and often poses diagnostic conundrums due to its protean manifestations. We present the case of a South Asian young man presenting with raised intracranial pressure and a lymphocytic cerebrospinal fluid (CSF) with pronounced hypoglycorrhachia. Progression of the neuro-ophthalmic signs while on early stages of antitubercular treatment led to additional investigations that produced a final diagnosis of primary leptomeningeal lymphoma. Treatment with chemoimmunotherapy (methotrexate, cytarabine, thiotepa and rituximab (MATRix)) achieved full radiological remission followed by successful autologous transplant. This case highlights the difficulties and diagnostic dilemmas when PCNSL presents as a chronic meningeal infiltrative process. While contextually this CSF is most often indicative of central nervous system tuberculosis and justifies empirical treatment initiation alone, it is essential to include differential diagnoses in the investigation work-up, which also carry poor prognosis without timely treatment. High suspicion, multidisciplinary collaboration and appropriate CSF analysis were the key for a correct diagnosis.

Clinical significance of acetylcholinesterase activity in brain tumors

2021 ◽  
Vol 66 (12) ◽  
pp. 718-721
Author(s):  
Larisa Mikhailovna Obukhova ◽  
I. A. Medyanik ◽  
K. N. Kontorshchikova ◽  
S. A. Simagina ◽  
L. T. Musaelyan ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Clinical Significance ◽  
Whole Blood ◽  
Tumor Tissue ◽  
Acetylcholinesterase Activity ◽  
Bioinformatic Analysis ◽  
Acetyl Cholinesterase ◽  
Primary Tumors ◽  
Grade Ii ◽  
The Brain

It has been established that the non-neuronal cholinergic system is related to the oncogenesis which increases the attractiveness of its components as the promising markers of oncologic diseases. The purpose of this work is to evaluate the clinical significance of the analysis of the activity of acetyl cholinesterase as a new marker of gliomas. The activity of acetyl cholinesterase was assessed by photo colorimetric analysis according to the Hestrin method recalculating the activity of the enzyme in the tumor tissue per 1 g of protein, and in the blood - by 0.1 g of hemoglobin. The data obtained in the primary tumors of the brain (28) in the tissue of the brain of persons who died as a result of injury (6) and in whole blood of patients with gliomas (28) and practically healthy people (10) were compared with the use of a number of statistical programs. A significant decrease in the activity of acetyl cholinesterase in tumor tissue and in whole blood is revealed as the degree of anaplasia of tumors increases, starting with Grade II. It is for the first time that a significant direct correlation was noted showing the consistency between the decrease in the activity of acetyl cholinesterase in the tumor tissue of the brain and blood. Bioinformatic analysis showed the connection of the enzyme of acetyl cholinesterase with proteins of the PI3K-AKT and Notch signaling pathways providing antiapoptotic and proliferative effects. The found dependences provide new insights into understanding of the mechanisms of gliomas genesis and can be used for selection of new diagnostic markers of brain tumors.

scholarly journals COL16A1 is differentially expressed in lymph node metastasis in human breast cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Lymph Node Metastases ◽  
Metastatic Breast ◽  
Lymphoid Organ ◽  
Primary Tumors ◽  
Node Metastases ◽  
The Brain

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). Between the breast and the brain reside the secondary lymphoid organ, the lymph nodes. We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with metastasis to the lymph nodes in humans with metastatic breast cancer. We found that collagen type XVI alpha 1 chain, COL16A1, was among the genes whose expression was most different in the lymph node metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. COL16A1 mRNA was present at decreased quantities in lymph node metastases as compared to primary tumors of the breast. Importantly, expression of COL16A1 in primary tumors of the breast was correlated with patient overall survival, in lymph node negative patients but not in lymph node positive patients. Modulation of COL16A1 expression may be relevant to the biology by which tumor cells metastasize from the breast to the lymph nodes and the brain in humans with metastatic breast cancer.

Sign in / Sign up

Export Citation Format

Share Document