scholarly journals A CLINICAL STUDY OF INTRATHECAL KETAMINE WITH ADRENALIN FOR LOWER ABDOMINAL SURGERIES

2019 ◽  
Vol 3 (6) ◽  
Author(s):  
Dr. Raghvendra Singh ◽  
Dr. Shiv Charan Meena
Keyword(s):  
Metabolic Disorders ◽  
Systemic Disease ◽  
Maximum Level ◽  
Physical Status ◽  
Exclusion Criteria ◽  
Sensory Blockade ◽  
Keywords Anaesthesia ◽  
Arterial Blood ◽  
Severe Systemic Disease ◽  
Diastolic Arterial Blood Pressure

Background: This study was designed to evaluate the efficacy, onset and duration of sensory and motor blockade, occurrence of delirium reaction and other complications of Ketamine with Adrenaline given intrathecally. Methods: After informed and written consent, ASA Physical status I and II aged 18-60 years, of either sex randomly selected 100 Patients for elective lower abdominal surgeries were been enrolled after inclusion and exclusion criteria. Patients with severe systemic disease metabolic disorders, neurological, congenital or cardiovascular diseases were excluded from this study. Results: In the present study the maximum level achieved ranged from T6-T10. The time taken to achieve maximum sensory blockade ranged from 2-8 minutes. There were no significant changes in mean systolic and diastolic arterial blood pressure or pulse rate. Intra-operatively, nystagmus was seen in all patients. Sedation and delirium was seen in 72 patients and 2 patients respectively. Conclusion: We conclude that intra thecal ketamine with adrenaline produces a reliable anaesthesia, better operative conditions and patients comfort with minimal side effects in elective lower abdominal surgeries. Keywords: Anaesthesia,  Ketamine,  Adrenaline, Intrathecal.

Assessment of a prototype equipment for cuffless measurement of systolic and diastolic arterial blood pressure

2011 ◽  
Vol 44 (2) ◽  
pp. e57
Author(s):  
Giandomenico Nollo ◽  
Michela Masè ◽  
Walter Mattei ◽  
Roberta Cucino ◽  
Luca Faes
Keyword(s):  
Blood Pressure ◽  
Arterial Blood Pressure ◽  
Arterial Blood ◽  
Diastolic Arterial Blood Pressure

scholarly journals Outbreaks of canid herpesvirus 1 disease in puppies in southern Brazil

2015 ◽  
Vol 35 (6) ◽  
pp. 557-561 ◽  
Author(s):  
Juliana F. Cargnelutti ◽  
Eduardo K. Masuda ◽  
Mariana G. Neuls ◽  
Rudi Weiblen ◽  
Eduardo F. Flores
Keyword(s):  
Phylogenetic Analyses ◽  
Systemic Disease ◽  
Reproductive Age ◽  
Nucleotide Sequencing ◽  
Southern Brazil ◽  
Virus Identification ◽  
Clinicopathological Findings ◽  
Antibody Titers ◽  
Herpesvirus 1 ◽  
Severe Systemic Disease

Abstract: Canid herpesvirus 1 (CHV-1) is a widespread pathogen of dogs and produces infertility, abortions and severe systemic disease in young puppies. Clinical data indicate the circulation of CHV-1 among Brazilian dogs yet definitive diagnosis has rarely been accomplished. This article describes the clinicopathological findings of four independent cases/outbreaks of neonatal disease by CHV-1 in Bulldog puppies followed by virus identification and genetic characterization. Three events occurred in a kennel holding dogs of different breeds at reproductive age (March 2013, October 2013 and April 2014). Puppies from three French or English Bulldog litters, aging 9 to 30 days were affected, presenting dyspnea, agonic breathing, pale mucous, abdominal pain and tension, evolving to death within about 24 hours. At necropsy, the puppies presented necrohemorrhagic hepatitis, multifocal and moderate necrohemorrhagic nephritis and fibrinonecrotic interstitial pneumonia. Virus isolation was positive in clinical specimens from one litter and CHV-1 DNA was detected by PCR in tissues from all four cases. Virus-neutralizing assays with samples of the affected kennel revealed 9/12 adult animals with high antibody titers to CHV-1. Nucleotide sequencing of glycoprotein B, C and D genes revealed 99-100% of identity among the viruses and with CHV-1 sequences available in GenBank. Phylogenetic analyses of gC sequences showed a segregation of the samples, even among three isolates from the same kennel. These findings support CHV-1 infection as the cause of disease and death in these dog litters, reinforcing the need for correct etiologic diagnosis, prevention and immunization against CHV-1 in dogs from Southern Brazil.

scholarly journals Intensive Observation of Toxic Side Effects After Several-Year of Cyclosporin Treatment in Kidney Transplant Patient

2007 ◽  
Vol 7 (2) ◽  
pp. 134-137 ◽  
Author(s):  
Mensura Ašćerić ◽  
Sevleta Avdić ◽  
Sabrija Nukić ◽  
Muamera Vrabac-Mujčinagić
Keyword(s):  
Side Effects ◽  
Kidney Transplant ◽  
Transplant Patient ◽  
Daily Basis ◽  
Kidney Transplant Patient ◽  
Arterial Blood ◽  
Cyclosporine Therapy ◽  
Intensive Observation ◽  
Medium Time ◽  
Diastolic Arterial Blood Pressure

In this work we are going to show results of intensive observation of adverse reactions of cyclosporine therapy during 18 months. The research was applied on 30 patients with kidney transplant. The medium time of kidney transplant survival was 9,7+/-2,3 years, with time span of 6 to 15 years. All the patients were subjects to several years' cyclosporine treatment, which was applied on a daily basis with a dosage of 2 to 5 mg/kg of body weight. The concentration of cyclosporine in blood was measured once a month. The concentration of cyclosporine in blood in 19 patients was in referent values of 122,50 nag/ml up to 280,50 nag/ml of blood. In 4 of the patients the concentration was heightened up to 370 to 538 nag/ml (X=766,37 nag/ml), and in 7 patients cyclosporine was below normal dosage down to 30,78 to 96,30 nag/ml in blood (x=77,12 nag/ml). We noticed these toxic side effects: increased values of systolic and diastolic arterial blood pressure in 5 patients, neurotoxic tremor effects in 4 patients, hyperplasia gingival and hirsute in 1 patient each.

scholarly journals Plasmapheresis and hyperbaric oxygenation in the treatment of psoriasis complicated by polyarthritis

2001 ◽  
Vol 82 (4) ◽  
pp. 301-302
Author(s):  
V. N. Korobkov ◽  
G. G. Slepukha ◽  
I. G. Yapparov ◽  
A. K. Saetgaraev
Keyword(s):  
Metabolic Disorders ◽  
Hyperbaric Oxygenation ◽  
Immune Status ◽  
Systemic Disease ◽  
Free Radical Oxidation ◽  
Skin Inflammation ◽  
Practical Medicine ◽  
Radical Oxidation ◽  
Skin Cells ◽  
Oxidative Processes

Treatment of psoriasis (Ps) is still one of the most difficult tasks of practical medicine. The disease often affects young and able-bodied people, and the process itself has a persistent and progressive nature, not amenable to treatment by traditional methods. PS as a systemic disease is based on the phenomena of chronic nonspecific skin inflammation with intracellular edema, infiltration, microcirculatory and metabolic disorders. PS is also characterized by disorders of oxidative processes in skin cells and in the system of free-radical oxidation of lipids. The study of immune status in PS patients revealed disorders of circulating immune complexes (CIC), in particular immunoglobulins A, M, G, against the background of suppressed cellular immunity and phagocytic activity of neutrophils.

scholarly journals Neurologic and Neuroscientific Evidence in Aged COVID-19 Patients

2021 ◽  
Vol 13 ◽  
Author(s):  
Shraddha Mainali ◽  
Marin E. Darsie
Keyword(s):  
Elderly Patients ◽  
Systemic Disease ◽  
Respiratory Illness ◽  
The Elderly ◽  
Cerebrovascular Diseases ◽  
Medical Comorbidities ◽  
Viral Illness ◽  
Atypical Presentations ◽  
Severe Systemic Disease

The COVID-19 pandemic continues to prevail as a catastrophic wave infecting over 111 million people globally, claiming 2. 4 million lives to date. Aged individuals are particularly vulnerable to this disease due to their fraility, immune dysfunction, and higher rates of medical comorbidities, among other causes. Apart from the primary respiratory illness, this virus is known to cause multi-organ dysfunction including renal, cardiac, and neurologic injuries, particularly in the critically-ill cohorts. Elderly patients 65 years of age or older are known to have more severe systemic disease and higher rates of neurologic complications. Morbidity and mortality is very high in the elderly population with 6–930 times higher likelihood of death compared to younger cohorts, with the highest risk in elderly patients ≥85 years and especially those with medical comorbidities such as hypertension, diabetes, heart disease, and underlying respiratory illness. Commonly reported neurologic dysfunctions of COVID-19 include headache, fatigue, dizziness, and confusion. Elderly patients may manifest atypical presentations like fall or postural instability. Other important neurologic dysfunctions in the elderly include cerebrovascular diseases, cognitive impairment, and neuropsychiatric illnesses. Elderly patients with preexisting neurologic diseases are susceptibility to severe COVID-19 infection and higher rates of mortality. Treatment of neurologic dysfunction of COVID-19 is based on existing practice standards of specific neurologic condition in conjunction with systemic treatment of the viral illness. The physical, emotional, psychologic, and financial implications of COVID-19 pandemic have been severe. Long-term data are still needed to understand the lasting effects of this devastating pandemic.

scholarly journals Serum Analysis in Patients with Temporomandibular Disorders: A Controlled Cross-Sectional Study in Norway

2019 ◽  
Vol 2019 ◽  
pp. 1-9
Author(s):  
Kordian Staniszewski ◽  
Henning Lygre ◽  
Trond Berge ◽  
Annika Rosén
Keyword(s):  
Temporomandibular Disorder ◽  
Systemic Disease ◽  
Cross Sectional Study ◽  
Control Group ◽  
Individual Subject ◽  
Cross Sectional ◽  
Inflammatory Conditions ◽  
And Gender ◽  
Severe Systemic Disease ◽  
Masticatory Apparatus

Temporomandibular disorder (TMD) is characterized by pain and dysfunction in the temporomandibular join (TMJ) and the masticatory apparatus. Associations with autoimmune diseases, inflammatory conditions, and nutrition deficiencies have been reported in previous studies of TMD patients. To evaluate essential proteins, hormones, electrolytes, and vitamins in serum from TMD patients, a standard blood sample analysis was performed in 60 TMD patients and 60 healthy controls matched for age and gender, retrieving 19 different analyses. We found that TMD patients had significantly higher values of hemoglobin (p=0.036), cobalamin (p=0.023), albumin (p=0.005), parathyroid hormone (PTH) (p=0.038), and vitamin D (p=0.005), and significantly lower values of creatinine (p=0.006) and potassium (p=0.011), compared to controls. In the TMD group, most of the determinants had a wider range, and several subjects, compared to the control group, had values outside the normal reference area. However, most of the TMD patients and controls had values within normal biological range. Our findings could not associate any severe systemic disease, malnutrition, or systemic inflammation with the TMD. Results from our study suggest that serum analyses should neither be used as a biomarker of TMD nor a diagnostic tool for an individual subject with TMD.

Contemporary biochemical analysis of normal pericardial fluid

Heart ◽  
2019 ◽  
Vol 106 (7) ◽  
pp. 541-544 ◽  
Author(s):  
Massimo Imazio ◽  
Andrea Biondo ◽  
Davide Ricci ◽  
Massimo Boffini ◽  
Emanuele Pivetta ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Biochemical Analysis ◽  
Mononuclear Cells ◽  
Inflammatory Diseases ◽  
Systemic Disease ◽  
Pericardial Fluid ◽  
Initial Assessment ◽  
Exclusion Criteria ◽  
Pericardial Disease ◽  
Normal Composition

ObjectiveBiochemical analysis of pericardial fluid (PF) is commonly performed for the initial assessment of PF, and the results are usually interpreted according to Light’s traditional criteria for the differential diagnosis of transudates versus exudates. However, Light’s criteria have been formulated for the biochemical analysis of pleural fluid. The aim of the present paper is to evaluate the normal composition of PF in candidates for cardiac surgery.MethodsCohort study with analysis of PF from candidates for cardiac surgery. Exclusion criteria were previous pericardial disease or cardiac surgery, prior myocardial infarction within 3 months, systemic disease (eg, systemic inflammatory diseases, uremia) or drug with potentiality to affect the pericardium.ResultsFifty patients (mean age was 67 years; 95% CI 64 to 71, 29 males, 58.0%) were included in the present analysis. Levels of small molecules were similar in blood and PF. Total proteins in PF was, on average, 0.5 times lower than corresponding plasma levels (p=0.041), while the level of pericardial lactate dehydrogenase was, on average, 1.06 times higher than plasma (p=0.55). Moreover, mononuclear cells were more concentrated in PF than plasma (p=0.17). Traditional Light’s criteria misclassified all PFs as exudates.ConclusionsTraditional Light’s criteria misclassified normal PFs in candidates for cardiac surgery as exudates. This study suggests their futility for the biochemical analysis of PF in clinical practice.

scholarly journals Surgical site infection in patients submitted to heart transplantation

2016 ◽  
Vol 24 (0) ◽  
Author(s):  
Jussara Aparecida Souza do Nascimento Rodrigues ◽  
Renata Eloah de Lucena Ferretti-Rebustini ◽  
Vanessa de Brito Poveda
Keyword(s):  
Heart Transplantation ◽  
Surgical Site Infection ◽  
Systemic Disease ◽  
Wilcoxon Test ◽  
Site Infection ◽  
Test Results ◽  
Exact Test ◽  
Organ Space Infection ◽  
The Relationship ◽  
Severe Systemic Disease

Abstract Objectives: to analyze the occurrence and predisposing factors for surgical site infection in patients submitted to heart transplantation, evaluating the relationship between cases of infections and the variables related to the patient and the surgical procedure. Method: retrospective cohort study, with review of the medical records of patients older than 18 years submitted to heart transplantation. The correlation between variables was evaluated by using Fisher's exact test and Mann-Whitney-Wilcoxon test. Results: the sample consisted of 86 patients, predominantly men, with severe systemic disease, submitted to extensive preoperative hospitalizations. Signs of surgical site infection were observed in 9.3% of transplanted patients, with five (62.5%) superficial incisional, two (25%) deep and one (12.5%) case of organ/space infection. There was no statistically significant association between the variables related to the patient and the surgery. Conclusion: there was no association between the studied variables and the cases of surgical site infection, possibly due to the small number of cases of infection observed in the sample investigated.

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