scholarly journals The Comparison of the Effects of Voluntary Running Wheel and Endurance Training on Il-6 and Testosterone Levels in the Rats With PCOS

2021 ◽  
Vol 24 (3) ◽  
pp. 412-423
Author(s):  
Faranak Moradi ◽  
◽  
Ali Akbarnejad ◽  
Keyword(s):  
Endurance Training ◽  
Wheel Running ◽  
Polycystic Ovary ◽  
Training Group ◽  
Reproductive Age ◽  
Running Wheel ◽  
Voluntary Activity ◽  
Cross Sectional ◽  
Training Groups ◽  
Significant Difference

Background and Aim: Polycystic Ovary Syndrome (PCOS) is an endocrine disorder in women of reproductive age. In cross-sectional and longitudinal studies, exercise training is an effective solution for treating and declining the symptoms. This study aims to compare the effects of the voluntary and the endurance exercise on some of the inflammatory and hormonal markers in rats with PCOS. Methods & Materials: In this study, Which was experimental and applied in terms of purpose, 40 female Wistar rats with Mean±SD weight of 220±20 g were divided randomly into four groups of ten: 1) control, 2) PCOS, 3) PCOS + Running wheel and 4) PCOS + endurance training. The rats in the voluntary group experienced voluntary activity of wheel running for 8 weeks (5 times a week). Alternatively, the endurance training group underwent aerobic exercises for 8 weeks (5 sessions in a week) on a treadmill. The blood samples were taken from the heart to measure the concentration of interleukin-6 and testosterone level and were analyzed by one-way analysis of variance and LSD post hoc test. Ethical Considerations: This study was approved by the Tehran University, Iran (Code: IR.UT.REC.1395016). Results: The results showed no significant difference in IL-6 and testosterone indices between endurance and voluntary training groups (P=0.565), (P=0.496). Both training groups (endurance and voluntary) separately resulted in a significant reduction in il6 and testosterone compared to rats with PCOS (P=0.002), (P=0.000), (P=0.038), (P=0.007). Conclusion: Altogether, the present study’s findings suggest that voluntary and endurance training in rats have similar effects on IL-6, Testosterone, and weight.

scholarly journals Spontaneous ovulation and pregnancy in women with polycystic ovarian disease; a cross sectional study

2018 ◽  
Vol 7 (2) ◽  
pp. 359
Author(s):  
Mostafa A. Sleem ◽  
Ibrahim I. Mohamed ◽  
Mahmoud S. Zakherah ◽  
Ahmed M. Abbas ◽  
Momen A. Kamel
Keyword(s):  
Polycystic Ovary ◽  
Cross Sectional Study ◽  
Reproductive Age ◽  
Sectional Study ◽  
Cross Sectional ◽  
Significant Difference ◽  
The Mean ◽  
The Right ◽  
Study Participants ◽  
Health Hospital

Background: Polycystic ovary disease (PCOD) is the most common endocrine disorder in women of reproductive age, with a prevalence of approximately 5-10%. This study aims to assess the rate of spontaneous ovulation and pregnancy in patients. The present study was a cross sectional study conducted at Woman's Health Hospital, Assiut University, Assiut, Egypt.Methods: The current study was a cross sectional study carried out in Assiut Women's Health Hospital between the 1st October 2016 and 31st July 2017. The patients were selected as infertile patients with PCOD. The patient ages range between 20 and 35 years. The BMI is between 18 and 30 Kg/m2. The main outcome measure was the rate of spontaneous ovulation and spontaneous pregnancy in the 3 cycles.Results: The mean age of the study participants was 26.64±4.59 years and the mean BMI was 24.46±2.62Kg/m2. The sonographic ovarian volume was 12.47±0.69 mm3 for the right ovary and 12.74±0.73 mm3 for the left ovary. No difference in the serum FSH, LH, FSH/LH ratio and prolactin over the 3 consecutive cycles. The rate of spontaneous ovulation in the 3 cycles was 6 women (8.6%) and 2 cases (2.8%) became pregnant spontaneously during the study period. There is no statistical significant difference between ovulating and non-ovulating women according to the BMI and ovarian volume.Conclusions: The present study concluded that the rate of spontaneous ovulation was 8.6% in women with PCOD within 3 cycles with no adverse effects of drugs or surgical interference.

scholarly journals The relationship between the expression of PLIN3 and PLIN5 protein flowing endurance training in streptozotocin rats

2019 ◽  
Vol 21 (4) ◽  
pp. 194-199
Author(s):  
Mahdi Ghafari ◽  
Ebrahim Banitalebi ◽  
Mohamad Faramarzi
Keyword(s):  
Insulin Resistance ◽  
Endurance Training ◽  
High Intensity ◽  
Training Group ◽  
Control Group ◽  
High Intensity Training ◽  
Significant Difference ◽  
Post Hoc ◽  
The Relationship ◽  
Intensity Training

Background and aims: Intermuscular lipolysis disorder plays an important role in insulin resistance and diabetes mellitus and perilipin PLIN5 and PLIN3 are the key proteins in regulating muscle cellular lipolysis. Therefore, the purpose of this study was to examine the relationship between the expression of PLIN3 and PLIN5 protein following endurance training in streptozotocin (STZ) rats. Methods: A number of 24 male Wistar rats were randomly divided into low endurance training group (n = 8), high-intensity training group (n = 8), and control group (n = 8). Diabetes was induced in every rat by STZ injection. Three days after injection, the blood samples were taken from the cut tip of the tails of the mice and animals with blood glucose greater than 300 mg/dL were considered diabetic. The training program included eight weeks of aerobic training at different intensities. Training in high- and low-intensity groups included 22-25 and 5-8 m/min of training. Finally, one-way analysis of variance (ANOVA) and correlation was used to determine the significance of the differences between variables, followed by utilizing Tukey’s post-hoc test for significance. Results: The comparison between the groups by ANOVA showed significant differences in PLIN3 (P=0.0006) and PLIN5 (P=0.012). The results of Tukey post hoc test also demonstrated a statistical difference between the mean values of diabetic control group and high-intensity endurance group regarding PLIN3 (P=0.01) and PLIN5 (P=0.009), but no significant increase was observed in the lowintensity exercise group as compared to the control group (PLIN3, P=0.067 & PLIN5, P=0.44). As regards insulin resistance, there was a significant difference among the three groups (P=0.0001). Eventually, the result of the correlation between PLIN3 and PLIN5 showed similar enhancement by increasing the intensity (P=0.0026). Conclusion: According to research results, high-intensity endurance training increased the expression of PLIN3 and PLIN5 in diabetic specimens and PLIN3 and PLIN5 followed a similar increase pattern in high-intensity training

scholarly journals Expression Level of Cyclin-D1 between Endometriomas and Ovarian Carcinomes

2021 ◽  
Vol 21 (1) ◽  
pp. 59-65
Author(s):  
Alfun Dhiya An ◽  
Supriyatiningsih Supriyatiningsih
Keyword(s):  
Ovarian Carcinoma ◽  
Cyclin D1 ◽  
Reproductive Age ◽  
Research Subjects ◽  
Ovarian Endometriosis ◽  
Cross Sectional ◽  
Anova Test ◽  
Significant Difference ◽  
Poorly Differentiated ◽  
The Mean

Endometrioma on the ovaries is a benign gynecological disorder that is often found in women of reproductive age. The approach was made to the malignant transformation through the study of cyclin-D1 expression. This research aim to analyze differences in the level of Cyclin-D1 expression in ovarian endometriosis and ovarian carcinoma associated with the pathogenesis of endometrioma and ovarian carcinoma. Analytical observational study with cross sectional approach to cyclin-D1 expression between endometrioma and ovarian carcinoma with good and bad differentiation. The research subjects were 20 cases of endometrioma, each of the 20 cases of ovarian carcinoma were well and poorly differentiated. Statistical analysis using the ANOVA test on the level of cyclin-D1 expression between groups. The mean cyclin-D1 expression in endometrioma was 67.25. The mean of well-differentiated ovarian carcinoma was 132.41. The mean of poorly differentiated ovarian carcinoma was 128.83. Anova test resulted in a significant difference between the expression of cyclin-D1 endometrioma and ovarian carcinoma with good and bad differences (p = 0.00 0.05). There is a significant difference between endometrioma and ovarian carcinoma with good and bad differentiation. Endometrioma cyclin-D1 expression was lower than ovarian carcinoma with good and bad differentiation.

scholarly journals Triglycerides, independent of Ferriman Gallwey Score, is a main determinant of free testosterone index in PCOS

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 94
Author(s):  
Andon Hestiantoro ◽  
Putri Deva Karimah ◽  
Amalia Shadrina ◽  
Budi Wiweko ◽  
R. Muharam ◽  
...  
Keyword(s):  
Free Testosterone ◽  
Cross Sectional Study ◽  
Pcos Patient ◽  
Reproductive Age ◽  
Bivariate Analysis ◽  
Sample Collection ◽  
Cross Sectional ◽  
Significant Difference ◽  
Shbg Level ◽  
Metabolic Dysfunctions

Background: Polycystic Ovarian Syndrome (PCOS) is the most common endocrinopathy in women of reproductive age, affecting 5-20% of women worldwide. Hyperandrogenism, as the primary characteristic of PCOS, is not always present in every patient. The hyperandrogenic phenotype of PCOS patients is influenced by both hormonal and metabolic dysfunctions. Therefore, this study aims to determine the correlation between hormone profile, lipid profile, and clinical profile with free testosterone index in subjects with PCOS. Methods: This prospective cross-sectional study was conducted in the Dr. Cipto Mangunkusumo General Hospital between July 2014 and December 2016. The study involved 76 women with PCOS, who were classified into 2 subgroups: 39 subjects in the hyperandrogenism group and 37 subjects in the non-hyperandrogenism group. Each subject underwent physical examination, blood sample collection, and USG examination. Bivariate analysis was done using independent t-tests and Mann Whitney U-tests, while multivariate analysis was done using logistic regression. Results: Triglyceride and testosterone level showed weak (r = 0.232, p = 0.044) and moderate (r = 0.460, p ¡ 0.001) positive correlation with FTI, while SHBG level showed moderate negative correlation (r = -0.483, p ¡ 0.001). Triglyceride was also found to be determinant of hyperandrogenism condition in PCOS patient (OR 0.02, 95% CI 0.00–0.04, p = 0.013). However, there was no significant difference observed between FGS and hyperandrogenism (p = 0.43). Conclusions: Triglycerides, testosterone, and SHBG were associated with hyperandrogenism in PCOS patients, while FGS showed no such association.

scholarly journals Phenotypic Variation of Insulin Resistance among Polycystic Ovarian Syndrome Patients in Semiurban North Indian Population

2021 ◽  
Author(s):  
Chaitali Maitra ◽  
Ramesh Chandra Gupta ◽  
Rishika Raj
Keyword(s):  
Insulin Resistance ◽  
Regression Analysis ◽  
Polycystic Ovarian Syndrome ◽  
Specific Treatment ◽  
Reproductive Age ◽  
Model Assessment ◽  
Cross Sectional ◽  
Significant Difference ◽  
Ovarian Syndrome ◽  
Rotterdam Criteria

Introduction: Polycystic Ovarian Syndrome (PCOS) is a common endocrine disorder in the women of reproductive age. Studies show that there is an intensive relationship between insulin and gonadal function. As per Rotterdam Criteria, there are four major phenotypes of PCOS with different presentation. Early detection of Insulin Resistance (IR) and consequential prevention of Metabolic Syndrome (MS) associated with PCOS may lead to better prospect for the disease. Aim: To find the pattern of IR in all the phenotypes of PCOS in relation to Waist Hip Ratio (WHR), Body Mass Index (BMI) and Testosterone and thereby, providing data for designing phenotype specific treatment of the disease. Materials and Methods: In this cross-sectional observational study, fasting insulin and fasting glucose were analysed to calculate Homeostasis Model Assessment (HOMA-IR) and Testosterone for total 144 female subjects of reproductive age group (18-40 years). Subjects were classified in to four groups as per Rotterdam Criteria. Complete PCOS (PCO-COM), PCO with Oligo/Anovulation (PCO-O), Anovulation with Hyperandrogenism (O-HA), and PCO with Hyperandrogenism (PCO-HA). Regression analysis was done to find the relation among the study variables. Analysis of Variance (ANOVA) was used to analyse the significant variance among the groups. Results: IR was found to be maximum among O-HA phenotype (2.4±0.37) and lowest among PCO-HA phenotypes (1.3±0.22). Regression analysis shows that there exist significant associations between IR and BMI (t=4.96, p=0.001) as well as between IR and WHR (t=2.97, p=0.003). No independent association between testosterone and IR was observed. Conclusion: Significant difference of IR, WHR, and BMI was observed among the four phenotypes of PCOS. Due to increased IR, O-HA and PCO-COM phenotypes are more predisposed to Cardiometabolic consequences of PCOS.

Socio-Demographic Characteristics and Hysteroscopic Findings among Women with Unsafe Abortion in South-South Nigeria

2021 ◽  
Vol 6 (03) ◽  
pp. 174-177
Author(s):  
Ekpo Effiong Edet ◽  
Efiok Eyo Efiok ◽  
Amarachukwu Nnaemezie Njoku ◽  
Sylvester Etenikang Abeshi ◽  
Ezukwa Omoronyia Ezukwa ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
Demographic Characteristics ◽  
Reproductive Age ◽  
Unsafe Abortion ◽  
Cervical Stenosis ◽  
Intrauterine Adhesions ◽  
Cross Sectional ◽  
Sociodemographic Data ◽  
Significant Difference ◽  
Structured Questionnaire

Background: Abortion is unsafe when it is carried out either by a person lacking the necessary skills or in an environment that does not conform to minimal standard, or both. It is complicated by intrauterine adhesions and secondary infertility. Objectives: To determine the socio-demographic features and hysteroscopic findings of women that had unsafe abortion in Calabar, Nigeria. Methodology: It was a cross-sectional study of 66 women in reproductive age, presenting in gynaecological clinic who consented to hysteroscopy between August 2019 to September 2020. A structured questionnaire was used to obtain sociodemographic data and hysteroscopy was done. Results: There was no significant difference in socio-demographic characteristics between women that have undergone unsafe abortion and those that have not. Cervical stenosis (76.9%) (p = 0.005) and intrauterine adhesions (68.3%) (p = 0.005) were significantly higher in women who had unsafe abortion. The odd ratios of cervical stenosis and intrauterine adhesions for 1 and ≥2 unsafe abortions were not significant. Conclusion: Cervical stenosis and intrauterine adhesions were significant complications of unsafe abortion in our environment. Multiple unsafe abortions do not confer significant higher risk of cervical stenosis or intrauterine adhesions.

scholarly journals The relationship between premenstrual syndrome and anger

2019 ◽  
Vol 35 (2) ◽  
Author(s):  
Havva Yeşildere Sağlam ◽  
Fatma Basar
Keyword(s):  
Premenstrual Syndrome ◽  
Personal Information ◽  
Cross Sectional Study ◽  
Reproductive Age ◽  
Anger Control ◽  
Cross Sectional ◽  
Creative Commons ◽  
Syndrome Scale ◽  
Significant Difference ◽  
The Relationship

Objective: Premenstrual Syndrome (PMS) is a significant disorder affecting the daily life of women of reproductive age. The aims of this study was to determine the PMS prevalence and the examination of the relationship between PMS and anger. Methods: This was a cross sectional study. The study was carried out with 720 women between the ages of 15-49 living in the province of Kutahya, Turkey. A Personal Information Form, the Premenstrual Syndrome Scale (PMSS) and the State-Trait Anger Scale (STAS) were used to collect data. Results: The PMS prevalence was 48.75%. There was a statistically significant difference between the groups in terms of constant anger, anger-in, anger-out and anger control subscales (p <0.001). The average scores of women with PMS for constant anger anger-in and anger-out was significantly higher. The anger control scores were at a significantly lower level. Conclusion: Women with PMS had higher anger and lower anger control levels. It should be advisable to recommend anger control management and provide social support so these women can cope with the symptoms. The result of our study emphasizes the importance of careful assessment of anger in women with premenstrual symptoms. How to cite this:Saglam HY, Basar F. The relationship between premenstrual syndrome and anger. Pak J Med Sci. 2019;35(2):---------.  doi: https://doi.org/10.12669/pjms.35.2.232 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals The Effects of Rhythm Training on Tennis Performance

2012 ◽  
Vol 33 (1) ◽  
pp. 123-132 ◽  
Author(s):  
Mustafa Söğüt ◽  
Sadettin Kirazci ◽  
Feza Korkusuz
Keyword(s):  
University Students ◽  
Training Group ◽  
The Other ◽  
Measurement Instruments ◽  
Experimental Procedure ◽  
Tennis Players ◽  
Training Groups ◽  
Significant Difference ◽  
Fast Tempo ◽  
Slow Tempo

The Effects of Rhythm Training on Tennis PerformanceRhythm training is an integral part of sports. The purposes of the study were to analyze the effects of rhythm training on tennis performance and rhytmic competence of tennis players, to compare the improvement levels of tennis specific and general rhythm training and to examine the effects of shorter and longer tempos on rhythmic competence. Thirty university students whose mean score of International Tennis Number (ITN) was 7.3 (±0.9) were divided randomly into three sub-groups: Tennis Group, General Rhythm Training Group and Tennis-Specific Rhythm Training Group. The experimental procedure lasted 8 weeks. During this period, all groups had the same tennis training twice a week. The Tennis Group had regular tennis training sessions. In addition to regular tennis training sessions, the General Rhythm Training Group followed the general rhythm training sessions and the Tennis-Specific Rhythm Training Group had tennis-specific rhythm training. The measurement instruments were ITN, Rhythmic Competence Analysis Test and Untimed Consecutive Rally Test. The results indicated that participation in tennis-specific or general rhythm training resulted in progress in tennis playing levels, forehand consistency performance and rhythmic competence of the participants. On the other hand, attendance to the regular 8-week tennis training was enough to solely increase the tennis playing level but not sufficient to develop forehand consistency performance and rhythmic competence. Although the participants in the TRTG had better improvement scores than the ones in the GRTG, no significant difference was found between the rhythm training groups. The results also revealed that participants exhibited higher rhythmic competence scores on fast tempo compared to slow tempo.

scholarly journals Extended High Frequency Audiometry in Polycystic Ovary Syndrome

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Cuneyt Kucur ◽  
Suna Kabil Kucur ◽  
Ilay Gozukara ◽  
Ali Seven ◽  
Kadriye Beril Yuksel ◽  
...  
Keyword(s):  
Hearing Impairment ◽  
High Frequency ◽  
Polycystic Ovary ◽  
Endothelial Damage ◽  
Reproductive Age ◽  
Control Group ◽  
Fasting Insulin ◽  
High Frequencies ◽  
High Frequency Audiometry ◽  
Significant Difference

Objective. Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder affecting 5–10% of women in reproductive age. Insulin resistance, dyslipidemia, glucose intolerance, hypertension, and obesity are metabolic disorders accompanying the syndrome. PCOS is a chronic proinflammatory state and the disease is associated with endothelial dysfunction. In diseases with endothelial damage, hearing in high frequencies are mostly effected in early stages. We evaluated extended high frequency hearing loss in PCOS patients.Material Methods. Forty women diagnosed as PCOS and 25 healthy controls were included in this study. Age and BMI of PCOS and control groups were comparable. Each subject was tested with low (250–2000 Hz), high (4000–8000 Hz), and extended high frequency audiometry (8000–20000). Hormonal and biochemical values including LH, LH/FSH, testosterone, fasting glucose, fasting insulin, HOMA-I, and CRP were calculated.Results. PCOS patients showed high levels of LH, LH/FSH, testosterone, fasting insulin, glucose, HOMA-I, and CRP levels. The hearing thresholds of the groups were similar at frequencies of 250, 500, 1000, 2000, and 4000 Hz; statistically significant difference was observed in 8000–14000 Hz in PCOS group compared to control group.Conclusion. PCOS patients have hearing impairment especially in extended high frequencies. Further studies are needed to help elucidate the mechanism behind hearing impairment in association with PCOS.

scholarly journals Locomotor activity and gait in aged mice deficient for type IX collagen

2010 ◽  
Vol 109 (1) ◽  
pp. 211-218 ◽  
Author(s):  
Kerry E. Costello ◽  
Farshid Guilak ◽  
Lori A. Setton ◽  
Timothy M. Griffin
Keyword(s):  
Locomotor Activity ◽  
Wheel Running ◽  
Age Of Onset ◽  
Disease Onset ◽  
Stride Frequency ◽  
Dark Phase ◽  
Running Wheel ◽  
Voluntary Activity ◽  
Knee Oa ◽  
Locomotor Behaviors

Osteoarthritis (OA) is a risk factor for physical inactivity and impaired mobility, but it is not well understood how these locomotor behaviors are affected by the age of onset of OA and disease severity. Male mice homozygous for a Col9a1 gene inactivation ( Col9a1−/−) develop early onset knee OA, increased tactile pain sensitivity, and gait alterations by 9 mo of age. We hypothesized that aged Col9a1−/− mice would reduce joint pain by adopting locomotor behaviors that reduce both the magnitude and daily frequency of joint loading. We tested this hypothesis by evaluating gait and spontaneous locomotor activity in 15- to 17-mo-old male Col9a1−/− ( n = 5) and Col9a1+/+(WT) ( n = 5) mice using well-controlled measures of voluntary activity in overground and running wheel conditions, as well as studies of gait in a velocity-controlled treadmill. We found no difference due to genotype in freely chosen locomotor velocity, stride frequency, hindfoot duty factor, dark phase activity time, or dark-phase travel distance during overground, running wheel, or speed-matched treadmill locomotion. Interpretation of these findings is potentially confounded by the observation that WT mice have greater knee OA than Col9a1−/− mice in the lateral tibial plateau by 17 mo of age. When accounting for individual differences in knee OA, functional locomotor impairments in aged Col9a1−/− and WT mice are manifested as reductions in total locomotor activity levels (e.g., both distance traveled and time active), particularly for wheel running. These results support the concept that current disease status, rather than age of disease onset, is the primary determinant of impaired locomotor activity with aging.

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