scholarly journals DISTRIBUTION OF ABO/RHESUS BLOOD GROUPS AMONG HEPATITIS B VIRUS (HBV) POSITIVE PATIENTS IN LAGOS, SOUTH-WESTERN, NIGERIA

2020 ◽  
Vol 4 (3) ◽  
pp. 197-200
Author(s):  
ESTHER OLADELE ◽  
T. O. Yahaya ◽  
O. O. Adewumi ◽  
B. David ◽  
A. J. Oladipo
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Blood Group ◽  
Public Awareness ◽  
Relevant Information ◽  
Blood Groups ◽  
Hbv Infection ◽  
B Virus ◽  
Type Ab ◽  
The City

The study aims to determine the distribution of the ABO/Rhesus Blood Groups among Hepatitis B virus (HBV) positive patients in Lagos State. Copies of structured questionnaires were distributed to 162 HBV patients that visited selected health facilities within 6 months in the city. After obtaining relevant information, whole blood samples were collected from each participant in an EDTA bottle. Thereafter, the ABO blood group types (A, B, AB, and O) as well as Rhesus blood groups were determined using standard protocols. Results showed that 48.1% of the participants had type O blood group, followed by type A (26.5%), type B (24.7%), and type AB (0.6%). Moreover, 94.4% of the participants were Rh+. The study showed that HBV was more prevalent among participants with type O blood group (48.1%) with rhesus positivity of 94.4%, compared to other blood group types. This indicates that type O individuals in the city could be more susceptible to HBV infection. There should be public awareness on the association between ABO/Rh blood groups and the prevalence of HBV infection in the state.  

scholarly journals Hepatitis B virus infection and ABO/Rh blood groups

2017 ◽  
Vol 5 (9) ◽  
pp. 3782
Author(s):  
Ozlem Genc
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Blood Group ◽  
Blood Groups ◽  
Hbv Infection ◽  
Control Group ◽  
Chronic Hbv Infection ◽  
B Virus ◽  
Chronic Hbv

Background: Chronic HBV infection is a significant public health problem all around the world. It is not clear if ABO/Rh blood groups have a role in the development of chronic forms of hepatitis B virus (HBV) infection. The aim of the study was to investigate the relationship between chronic HBV infection and ABO/Rh blood groups.Methods: The study was designed as a retrospective study that included totaled 937 individuals: 453 patients diagnosed with chronic hepatitis and 484 healthy individuals as the control group. HBsAg (hepatitis B surface antigen) and blood groups results of patients between the years 2013-2015 were collected by reviewing the laboratory results. During these three years HBsAg was performed on the architect i2000sr (Abbott diagnostic, Illinois, USA) with ELISA and ABO/Rh blood groups were analyzed with gel centrifugation method (Grifols, Barcelona, Spain).Results: Blood group A Rh positive was higher than other blood types in the chronic hepatitis B group (44.3%) and in control group (41.9%), whereas blood types O, AB, and B were similar between cases with chronic hepatitis and controls (p>0.05). HBV infection was moderately less frequent in subjects with AB positive blood group (p=0.07). The prevalence of Rh positive was 89.1% in patients and 88.2% in the control group (p>0.05).Conclusions: This study showed that there was not an association between ABO/Rh blood groups and chronic HBV infection, but there is a need for different and more numerous case-control studies about this subject.

scholarly journals ABO blood groups and hepatitis B virus infection: a systematic review and meta-analysis

BMJ Open ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. e034114 ◽  
Author(s):  
Wenzhan Jing ◽  
Siyu Zhao ◽  
Jue Liu ◽  
Min Liu
Keyword(s):  
Systematic Review ◽  
Hepatitis B Virus ◽  
Blood Group ◽  
Meta Analysis ◽  
Blood Groups ◽  
Hbv Infection ◽  
Abo Blood Group ◽  
Abo Blood Groups ◽  
B Virus ◽  
Group B

ObjectiveHepatitis B virus (HBV) infection is a major public health problem worldwide. Several studies have reported that ABO blood groups may be associated with HBV infection. However, its association is still controversial. We performed a meta-analysis to investigate whether ABO blood groups were associated with HBV infection.DesignSystematic review and meta-analysis.Data sourcesRelevant studies available before 1 December 2019 were identified by searching PubMed, EMBASE, Web of Science, ScienceDirect and the Cochrane Library.Eligibility criteriaAll cross-sectional or cohort studies from which the data of ABO blood group distribution and HBV infection could be extracted.Data extraction and synthesisStudies were identified and extracted by two reviewers independently. Risk ratios (RRs) and 95% CIs were pooled by random-effect models to quantify this association.ResultsThirty-eight eligible articles including 241 868 HBV-infected subjects and 6 487 481 uninfected subjects were included. Overall, the risk of HBV infection had decreased by 8% in subjects with blood group B when compared with non-B blood group (RR=0.92, 95% CI 0.86 to 0.98). In the subgroup analyses, the inverse relationship between blood group B and HBV infection remained stable in higher endemic areas (HBV prevalence ≥5%), Asian people, larger sample size studies (≥2000), general population and blood donors, lower middle income group and studies published before the year 2010. Additionally, subjects with blood group O had a 12% increased risk of HBV infection (RR=1.12, 95% CI 1.01 to 1.24) in higher endemic areas. In the sensitivity analysis, the pooled risk estimates of blood group B and HBV infection were still stable.ConclusionsOur data suggested that the blood group B was associated with a lower risk of HBV infection. More research is needed to clarify the precise role of the ABO blood group in HBV infection to address the global question of HBV infection.

scholarly journals Susceptibility of Human Blood Groups to Human Immunodeficiency Virus (HIV) and Hepatitis B Virus (HBV) Infections

2015 ◽  
Vol 6 ◽  
pp. 35-40
Author(s):  
M U Eteng ◽  
D O Otu ◽  
D O Ochalefu ◽  
O E Amali ◽  
G O Obochi ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
General Hospital ◽  
Blood Group ◽  
Liver Damage ◽  
Blood Groups ◽  
Serum Samples ◽  
B Virus ◽  
Group B ◽  
Hiv Aids

Susceptibility of blood groups to HIV/AIDS and Hepatitis B virus infections in human subjects was studied. One hundred and fifty adult male and female patients who came for routine check up at the Heart to Heart Centre, General Hospital Calabar and the General Hospital Ogoja in Cross River State were used for this investigation.The patients were classified into three groups with group I consisting of sixty (60) normal subjects ( i.e. non HIV/AIDS and non HBV patients) serving as control. Group II was made up of sixty (60) HIV/AIDS infected patients only and group III had thirty (30) patients co-infected with HIV/AIDS and HBV. Blood and serum samples were collected and screened for both HIV/AIDS and HBV. The blood and serum samples were assayed for totalprotein and bilirubin levels, aspartate aminotransferase(AST), alanine aminotransferase(ALT) activities, antioxidants vitamins levels and determination of blood groups. The results showed that group O+ had increased levels relative to control and others,suggesting that patients with blood group O+ are more susceptible to HIV/AIDS and HBV infections. The results showed that blood group B+ had decreased level relative to the control and other blood groups, suggesting that patients with blood group B+ may resist HIV/AIDS and HBV infections. The results also revealed that AST and ALT activities were significantly increased, suggesting hepatic peroxidation and liver damage. The results also showed that the antioxidant vitamins(vitamin A and vitamin C) were significantly decreased, suggesting high level of free radicals leading to hepatic peroxidation and liver damage.

scholarly journals HEPATITIS B VIRUS INFECTION AND ITS ASSOCIATED RISK FACTORS;

2012 ◽  
Vol 19 (05) ◽  
pp. 668-671
Author(s):  
GHULAM MUJTABA SIDDIQI ◽  
MANZOOR A NAEEM ◽  
M ADIL KHURSHID ◽  
Zafar Altaf Jafary ◽  
Khursheed Anwer
Keyword(s):  
Risk Factors ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Public Awareness ◽  
Tertiary Care ◽  
Hbv Infection ◽  
Enzyme Linked Immunosorbent Assay ◽  
Care Hospital ◽  
B Virus ◽  
Associated Risk Factors

Objective: The present study was carried out to screen for prevalence of Hepatitis B Virus (HBV) infection and its associatedrisk factors in patients presenting for various complaints at a tertiary care hospital. Study design: Cross-sectional descriptive study. Place &Duration: Nawaz Sharif social security Hospital, Multan Road Lahore from January 2008 through December, 2009. Materials & Methods: Atotal of 15403 patients, aged 14 to 60 years, belonging to low socio-economic group were screened for Hepatitis B surface antigen (HbsAg)during the study period. Relevant information was obtained through a pre-designed questionnaire prepared in accordance with the objectivesof the study. Patient’s serum was tested qualitatively for HbsAg by rapid immunochromatographic technique (ICT devices, Accurate, USA)according to the manufacturer’s instructions.All sera showing reactivity were then confirmed with Enzyme Linked Immunosorbent Assay(ELISA). Results: HbsAg positivity was found in 488 (3.16%) patients of the screened population. Associated risk factors were: therapeuticinjections (25.0%), shaving from community barbers (15.98%), blood or blood product transfusions (10.04%), HbsAg positive sexual partners(7.99%), dental treatment (6.96%), past surgical history (4.91%), occupational exposure (3.07%), pricking nose/ears (3.07%), H/ohemodialysis (2.04%) and medical endoscopy (1.02%). 5.94% cases revealed no risk factor whereas 13.93% cases had multiple risk factors.Conclusions: A high prevalence of known etiological risk factors for HBV infection in the HBV positive patients documented in our studyshould not go without serious concern. Public awareness programs should be launched through mass media to discourage the malpracticesrelated to risk factors.

scholarly journals Seroprevalence and risk factors for hepatitis B virus infection among general population in Northern India

2008 ◽  
Vol 45 (2) ◽  
pp. 137-140 ◽  
Author(s):  
Rachna Behal ◽  
Renu Jain ◽  
Krishan K. Behal ◽  
Ajay Bhagoliwal ◽  
Nakshatra Aggarwal ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
General Population ◽  
Hepatitis B ◽  
Confidence Interval ◽  
Blood Group ◽  
Hepatitis B Surface Antigen ◽  
Blood Groups ◽  
Seroprevalence Rate ◽  
Hbsag Positivity ◽  
B Virus

BACKGROUND: Infection with hepatitis-B virus has been a significant cause of morbidity claiming more than a million lives every year. Epidemiological data reveals that there are 360 million carriers of hepatitis-B virus throughout the globe and 78% of the world populations’ hail from Asia. Though several studies from Indian sub-continent have provided an estimate of the prevalence of this viral infection, there exist only few studies, which reflect the status in the general population. AIM: The present study was designed to investigate the prevalence of hepatitis-B infection in North Indian general population. METHODS: The study population comprised of 20,000 healthy blood donors who were screened for hepatitis-B surface antigen (HBsAg) status using third generation ELISA kit. Seroprevalence rate of seropositive donors was calculated and stratified by age, sex and blood groups. Statistical analysis was performed using tests of proportions, chi-square and confidence interval. RESULTS: The study showed that out of 20,000 donors, 450 (2.25%) were HBsAg positive (95% confidence interval (CI), 2.0445-2.4554). Higher prevalence of HbsAg was found among males (440/19235) than females (10/765). The age specific prevalence rose from 1.78% (108/6058) in donors aged 19-25 years to a maximum of 3.03% (96/3161) in donors aged 35-45 years and decreased in older age groups. The peaks were detected in male donors aged 35-45 years and in females aged 25-35 years. Rh-negative blood group donors (21/873) and Rh-positive group donors (429/19127) had almost equivalent prevalence rates of HBsAg. HBsAg was more prevalent in blood group B donors (174/7426) and less prevalent in AB blood group donors (38/2032). CONCLUSION: It was found that variables including gender and age were significantly associated with HBsAg positivity. HBsAg positivity in our population was statistically not associated with ABO blood groups.

How Far we are towards Eradication of HBV Infection

2015 ◽  
Vol 24 (4) ◽  
pp. 473-479 ◽  
Author(s):  
Mihai Voiculescu
Keyword(s):  
Immune Response ◽  
Hepatitis B Virus ◽  
T Cell ◽  
Hepatitis B ◽  
T Cell Receptors ◽  
Hepatitis B Surface Antigen ◽  
Hbv Infection ◽  
Major Health Problem ◽  
Cell Receptors ◽  
B Virus

Hepatitis B virus (HBV) infection is a major health problem with an important biological and a significant socio-economic impact all over the world. There is a high pressure to come up with a new and more efficient strategy against HBV infection, especially after the recent success of HCV treatment. Preventing HBV infection through vaccine is currently the most efficient way to decrease HBV-related cirrhosis and liver cancer incidence, as well as the best way to suppress the HBV reservoir. The vaccine is safe and efficient in 80-95% of cases. One of its most important roles is to reduce materno-fetal transmission, by giving the first dose of vaccine in the first 24 hours after birth. Transmission of HBV infection early in life is still frequent, especially in countries with high endemicity.Successful HBV clearance by the host is immune-mediated, with a complex combined innate and adaptive cellular and humoral immune response. Different factors, such as the quantity and the sequence of HBV epitope during processing by dendritic cells and presenting by different HLA molecules or the polymorphism of T cell receptors (TOL) are part of a complex network which influences the final response. A new potential therapeutic strategy is to restore T-cell antiviral function and to improve innate and adaptive immune response by immunotherapeutic manipulation.It appears that HBV eradication is far from being completed in the next decades, and a new strategy against HBV infection must be considered. Abbreviations: ALT: alanine aminotransferase; APC: antigen presenting cells; cccDNA: covalently closed circular DNA; HBIG: hepatitis B immunoglobulin; HbsAg: hepatitis B surface antigen; HBV: hepatitis B virus; HCC: hepatocellular carcinoma; CTL: cytotoxic T lymphocyte; IFN: interferon; NUC: nucleos(t)ide analogues; pg RNA: pre genomic RNA; TLR: toll-like receptors; TOL: T cell receptors.

Gianotti-Crosti syndrome associated with hepatitis B virus (HBV) infection in an adult: a case report

Kanzo ◽  
2010 ◽  
Vol 51 (11) ◽  
pp. 615-619
Author(s):  
Yuichi Honma ◽  
Masaru Harada ◽  
Masaaki Hiura ◽  
Ryoichi Narita ◽  
Shintaro Abe ◽  
...  
Keyword(s):  
Case Report ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Hbv Infection ◽  
B Virus

scholarly journals Possible role of tocopherols in the modulation of host microRNA with potential antiviral activity in patients with hepatitis B virus-related persistent infection: a systematic review

2014 ◽  
Vol 112 (11) ◽  
pp. 1751-1768 ◽  
Author(s):  
S. Fiorino ◽  
L. Bacchi-Reggiani ◽  
S. Sabbatani ◽  
F. Grizzi ◽  
L. di Tommaso ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Antiviral Activity ◽  
Hbv Infection ◽  
Cochrane Library ◽  
Viral Pathogen ◽  
Increased Risk ◽  
B Virus ◽  
Chronic Hbv

Hepatitis B virus (HBV) infection represents a serious global health problem and persistent HBV infection is associated with an increased risk of cirrhosis, hepatocellular carcinoma and liver failure. Recently, the study of the role of microRNA (miRNA) in the pathogenesis of HBV has gained considerable interest as well as new treatments against this pathogen have been approved. A few studies have investigated the antiviral activity of vitamin E (VE) in chronic HBV carriers. Herein, we review the possible role of tocopherols in the modulation of host miRNA with potential anti-HBV activity. A systematic research of the scientific literature was performed by searching the MEDLINE, Cochrane Library and EMBASE databases. The keywords used were ‘HBV therapy’, ‘HBV treatment’, ‘VE antiviral effects’, ‘tocopherol antiviral activity’, ‘miRNA antiviral activity’ and ‘VE microRNA’. Reports describing the role of miRNA in the regulation of HBV life cycle,in vitroandin vivoavailable studies reporting the effects of VE on miRNA expression profiles and epigenetic networks, and clinical trials reporting the use of VE in patients with HBV-related chronic hepatitis were identified and examined. Based on the clinical results obtained in VE-treated chronic HBV carriers, we provide a reliable hypothesis for the possible role of this vitamin in the modulation of host miRNA profiles perturbed by this viral pathogen and in the regulation of some cellular miRNA with a suggested potential anti-HBV activity. This approach may contribute to the improvement of our understanding of pathogenetic mechanisms involved in HBV infection and increase the possibility of its management and treatment.

scholarly journals Hepatitis B Virus Infection in Pregnancy: Immunological Response, Natural Course and Pregnancy Outcomes

2021 ◽  
Vol 10 (13) ◽  
pp. 2926
Author(s):  
Sirinart Sirilert ◽  
Theera Tongsong
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Pregnancy Outcomes ◽  
Natural Course ◽  
Hbv Infection ◽  
Chronic Hbv Infection ◽  
B Virus ◽  
Chronic Hbv ◽  
Adverse Pregnancy ◽  
The Impact

This review aimed to provide an update on the impact of pregnancy on the natural course of hepatitis B virus (HBV) infection and also on the impact of HBV infection on adverse pregnancy outcomes, including mother-to-child transmission (MTCT). For the literature review, original research articles, review articles, and guidelines were narratively reviewed and comprehensively validated. The databases of PubMed, EMBASE, and CINAHL were carefully searched for articles in English on topics related to HBV infection, pregnancy, and vertical transmission from 1960 to May 2021. Immunological changes during pregnancy such as suppression of Th1 response and induction of Th2 immunity lead to an impaired immune reaction to HBV and stimulate viral activity along with the reduction of CD8 T cells to escape immune detection. The impact of pregnancy on the natural course of chronic HBV infection seems to be minimal, while pregnancy can increase morbidity and mortality in the case of advanced HBV hepatitis or cirrhosis. Importantly, hepatitis flare or alanine aminotransferase (ALT) flare can occur during pregnancy and is more common during the postpartum period due to the interaction between HBV and the immune response. Interestingly, the impact of HBV infection on adverse pregnancy outcomes is more serious than ever thought. Updated evidence indicates that pregnancies with chronic HBV infection increase the risk of preterm birth and gestational diabetes, especially in cases of positive hepatitis e antigen (HBeAg).

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