scholarly journals Clinical Characteristic of Congenital Fetal Anomaly In Tertiary Referral Hospital in East Java, Indonesia

2021 ◽  
Vol 2 (2) ◽  
pp. 40-46
Author(s):  
Fariska Zata Amani ◽  
Wardhana M. P ◽  
Cininta N. I ◽  
Aryananda R. A ◽  
Gumilar K. E ◽  
...  
Keyword(s):  
Congenital Anomaly ◽  
General Hospital ◽  
Congenital Anomalies ◽  
Neonatal Morbidity ◽  
Tertiary Hospital ◽  
Fetal Anomaly ◽  
Fetal Anomalies ◽  
Tertiary Referral Hospital ◽  
Cross Sectional ◽  
Organ Systems

Background: Congenital fetal anomalies were defined as any structural defect present at birth. Congenital fetal anomalies are an important causes of neonatal morbidity and mortality in developed and developing countries that affect health care system. Reliable data on these congenital anomalies are still lacking, especially in Indonesia. Objective: This study aims to determine the characteristic profile of congenital fetal anomaly in single tertiary hospital in East Java, Indonesia. Methods: Retrospective cross-sectional by using medical record data of dr. Soetomo General Hospital on January – December 2017. Results: There were 58 cases (4,3%) with fetal congenital anomaly from 1360 deliveries in 2017. The majority of cases were referral cases (51 cases; 88%) and only seven cases were booked cases in obstetric outpatient dr. Soetomo General Hospital. Most of these congenital fetal anomaly cases ( 25 cases / 43,1%) were born from mother with ages 20 – 30 years old. Most cases (34 cases; 58,64%) were diagnosed first at third trimester (gestational age > 28 weeks). There were 36 cases (62%) had active termination of pregnancy. Thirty eight percent (22 cases) were born at 37-42 weeks and majority were born section caesaria. The three highest proportion of organ systems involved in fetal congenital anomalies were those of abdomen (22 cases; 37,9%); head (20 cases; 34,5%); thorax and muskuloskeletal (each 12 cases; 20,7%). Conclusion: The incidence of congenital fetal anomaly in dr. Soetomo Hospital at 2017 was 4,3%. Omphalocele and CTEV were two most common types of congenital fetal anomaly found. Most cases of congenital fetal anomalies have a poor prognosis, 67% cases born died. Further research about  risk factors and comprehensive database are needed on cases of congenital anomaly to establish appropriate prevention and management.

scholarly journals ALLERGIC REACTION TO ESCHERICHIA COLI-ASPARAGINASE IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA: A STUDY IN A TERTIARY HOSPITAL IN INDONESIA

2020 ◽  
pp. 142-146
Author(s):  
NUR MELANI SARI ◽  
NABILLA PUTRI OSSEVA ◽  
NUR SURYAWAN
Keyword(s):  
Escherichia Coli ◽  
Acute Lymphoblastic Leukemia ◽  
Allergic Reaction ◽  
General Hospital ◽  
Lymphoblastic Leukemia ◽  
Bone Marrow Examination ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
E Coli

Objective: The objective of the study was to determine and describe the characteristics of allergic reactions to Escherichia coli-Asparaginase (E. coli-ASP). Methods: This cross-sectional study was performed at Hasan Sadikin Bandung General Hospital on acute lymphoblastic leukemia patients diagnosed from January 1, 2018, to August 31, 2019, confirmed by bone marrow examination. Data were extracted from Bandung Online Pediatric Cancer Registry, medical records, protocol therapy documents, and interview with patient’s guardian. Results: Out of 68 patients, 26 patients (37.6%) were allergic to E. coli-ASP. Twenty-two patients with recorded manifestation’s data evoked 35 symptoms and graded according to common terminology criteria for adverse event v3.0., fever, and urticaria are the most frequent manifestation. While Grade 2 and Grade 3 are the most often developed allergic reaction, patients with age range from 1 to 14 years, male and high risk is mainly allergic. Conclusion: Allergic rate to E. coli-ASP at Hasan Sadikin General Hospital is 37.6%. The most frequent manifestation is fever and urticaria (20%, respectively), Grades 2 and 3 (32%, respectively), and emerged mostly after administration of fourth dose E. coli-ASP (26.9%). Despite the characteristic differences between allergic and non-allergic group, it is not statistically significant.

scholarly journals Low Birth Weight Infants Outcome In Single Tertiary Referral Hospital

2019 ◽  
Vol 1 (1) ◽  
pp. 32-37
Author(s):  
Dimas Abdi Putra ◽  
Cininta N.I ◽  
Wardhana M.P ◽  
Aryananda R.A ◽  
Gumilar K.E. ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
General Hospital ◽  
Pregnancy Termination ◽  
Behavior Disorder ◽  
Positive Trend ◽  
Tertiary Referral Hospital ◽  
Low Birth Weight Infants ◽  
Cross Sectional ◽  
Tertiary Teaching

ABSTRACT Background: Low birth weight (LBW) is defined by infants with birth weight less than 2500 gram, commonly caused by prematurity. Preterm infants are prone to problems such as organ immaturity, neurodevelopmental impairment until behavior disorder. Hypertension on pregnancy and preeclampsia is the most case referred and treated in dr. Soetomo General Hospital as a single tertiary teaching hospital in Surabaya, Indonesia which require early delivery and possess consequences to maternal and perinatal side. Objective: This study aims to determine the incidence and outcome of LBW infants born in dr. Soetomo General Hospital. Methods: Retrospective cross-sectional by using medical record data of dr. Soetomo General Hospital on January 2014 – December 2017. Results: There were 2350 infants with birth weight of 500-2499 gram, in which majority was on the range of 2001-2499 gram (38%.) Hypertension on pregnancy and the complications were the most indication for pregnancy termination that resulted in LBW infants. This study also found that the LBW outcome was linear with birth weight. In addition, the gestational age and five minutes APGAR score also had important role to the LBW outcome. Conclusion: The major cause of LBW infants in dr. Soetomo General Hospital was hypertension on pregnancy. There was a positive trend of survival in infants with birth weight range of 1501-2000 gram.

scholarly journals Satisfaction and intention to return for donation among non-remunerated blood donors in a tertiary hospital in Malaysia

2021 ◽  
Author(s):  
Pei Pei Tan ◽  
Chee Tao Chang ◽  
Jernih Abdul Rahman ◽  
Sabariah Mohd Noor
Keyword(s):  
Blood Donors ◽  
Blood Donation ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Tertiary Referral Hospital ◽  
Cross Sectional ◽  
High Satisfaction ◽  
Donation Process ◽  
Intention To Return ◽  
Self Administered Questionnaire

Abstract BackgroundIn Malaysia, blood supply relies mainly on non-remunerated blood donors. This study aimed to assess the satisfaction and experience of blood donors during the blood donation process and their intention to return for donation in future.Materials and MethodsThis was a cross-sectional study conducting using a self-administered questionnaire among blood donors. Study was conducted in a tertiary referral hospital and two mobile sites in the Perak state of Malaysia. The questionnaire was initially developed in the Malay language with 5-point Likert scale. The questionnaire comprised of three domains: i) sociodemographic characteristics ii) donor’s satisfaction towards staff iii) donors’ experience and satisfaction towards the donation process. ResultOf the 400 questionnaires distributed, 369 (92.3%) were analysed. The mean age of the donors was 35.98±10.67 years. Most of the donors were male (75.1%), of Malay ethnicity (60.2%) and regular donors (65.6%). Majority of the blood donors reported high satisfaction towards the interviewer (99.0%), blood taking skill of the staff (97.5%), politeness and friendliness of the staff (99.5%) and communication with the staff (98.9%). Minority of the blood donors expressed dissatisfaction towards the parking spaces (13.4%), refreshment (0.8%), and the blood donation operation hours (0.8%). Generally, the respondents had high overall satisfaction level (99.2%) and high intention to donate blood again in the future (98.9%). Conclusion Blood donors in the current study were highly satisfied towards the staff and blood donation process. Translation of high intention to return for donation to actual donation behaviour require further exploration in future studies.

Agenesis of the epiglottis and false vocal folds with maxillary hypoplasia in an adult

2003 ◽  
Vol 117 (11) ◽  
pp. 895-898 ◽  
Author(s):  
Ki Hwan Hong ◽  
Yoon Soo Yang
Keyword(s):  
Congenital Anomaly ◽  
Early Childhood ◽  
Congenital Anomalies ◽  
Vocal Folds ◽  
Feeding Problems ◽  
Multiple Congenital Anomalies ◽  
Maxillary Hypoplasia ◽  
Organ Systems ◽  
Infancy And Early Childhood ◽  
False Vocal

Hypoplasia or absence of the epiglottis in an adult is a rarely reported congenital anomaly that usually occurs in association with congenital anomalies of other organ systems. Most epiglottic anomalies usually present in infancy and early childhood with respiratory and feeding problems and the affected individual dies shortly after birth due to multiple congenital anomalies. We present a case of congenital absence of the epiglottis and false vocal folds with hypoplastic maxillae in an adult.

scholarly journals Impact of expanding the clinical pharmacy service in the emergency department at Hamad General Hospital, a tertiary hospital in Qatar: A cross-sectional audit

2021 ◽  
Vol 2021 (2) ◽  
Author(s):  
Rawan Salameh ◽  
Asma Ezzeldin ◽  
Ashraf El-Malik ◽  
Ibtisam Musameh ◽  
Sara Nazzal ◽  
...  
Keyword(s):  
Emergency Department ◽  
High Risk ◽  
General Hospital ◽  
Medical Records ◽  
Tertiary Hospital ◽  
Clinical Pharmacy Service ◽  
Cross Sectional ◽  
Retrospective Audit ◽  
High Risk Populations ◽  
The Impact

Background: The emergency department (ED) is a complex environment presenting unique challenges for high-risk populations such as critically ill patients who often require the use of high-risk medications. One study suggests that clinical pharmacists (CPs) may improve the fulfillment of safety goals for the ED patient as per the Joint International Commission. Some published reports have asserted that ED-based CPs would have the potential to increase patient safety. In our hospital, the number of CPs covering the ED increased from 2 to 9 starting from November 2019. Methods: This is a retrospective audit covering the period from January 1st 2019 till October 25th 2020 at Hamad General Hospital (HGH) in Doha, Qatar, to determine the impact of increasing the number of CPs covering the ED on the number of identified, solved, and documented drug related problems (DRPs) on the electronic medical records of ED patients. The interventions retrieved from pharmacy reports were analyzed and evaluated in terms of numbers by classification and percentages by the investigators. Results: A total number of 8,946 interventions covering 6,284 patients were carried out in 2020 compared with 1,515 interventions covering 1,001 patients in 2019 which represents a 6-fold increment by increasing the CPs from 2 to 9. Even the detection of adverse drug reactions increased by 1.5 times with only 38 documented in 2019 compared to 64 in 2020. Classifications and quantities of interventions were also analyzed in detail. Conclusion: This audit demonstrates that pharmaceutical intervention can positively contribute to the identification and resolution of DRPs. The benefit of CP involvement in patient care was observed based on the number of interventions that occurred. Studies are needed to assess the impact of those interventions on patients’ outcomes and cost effectiveness.

scholarly journals Congenital anomalies in antenatal ultrasound scan at a tertiary care teaching hospital

2018 ◽  
Vol 5 (1) ◽  
pp. 26-30
Author(s):  
Shreejana Shrestha ◽  
Yogita Dwa ◽  
Pooja Jaiswal ◽  
Binod Parmar
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Congenital Anomalies ◽  
Descriptive Analysis ◽  
Tertiary Care ◽  
Fetal Anomalies ◽  
Cross Sectional ◽  
Antenatal Ultrasound ◽  
Previous Child ◽  
The Central Nervous System

Introductions: Early detection of congenital fetal anomalies by ultrasonography (USG) helps to identify the severity and termination of pregnancy in severe cases. Anomalies cause significant perinatal morbidity and mortality. Aim of this study was to analyse real-time USG detection of prenatal anomalies. Methods: This was a cross-sectional descriptive study of fetal anomalies detected during 2nd and 3rd trimester antenatal USG scan done from 2011 to 2015, in Patan Hospital. Age of mother, parity, gestational age when anomalies detected and, anomalies of previous child, use of folic acid were analysed. Descriptive analysis was done. Results: There were 35,571 deliveries in four years period with 134 (0.37%) congenital anomalies, 99 (79.2%) detected during antenatal USG during 2nd and 3rd trimester. Among 99 anomalies, 29 (29.29%) were detected before 22 weeks. Central nervous system (CNS) anomalies were 47, gastrointestinal 23, renal 12, skin and fetal compartment 8 and rest were less common. Young mothers of less than 30 years were 109 (81.34%) and primi were 85 (63.4%). Conclusions: Antenatal ultrasound can detect fetal anomalies in 2nd and 3rd trimester with higher frequencies belonging to the central nervous system followed by gastrointestinal tract anomalies and renal.

Prevalence and Pattern of Congenital Anomalies in a Tertiary Hospital in Central Vietnam

2019 ◽  
Vol 66 (2) ◽  
pp. 187-193
Author(s):  
Hoang Thi Nam Giang ◽  
Susanne Bechtold-Dalla Pozza ◽  
Sarah Ulrich ◽  
Le Khac Linh ◽  
Hoang Thi Tran
Keyword(s):  
Congenital Heart Defects ◽  
Congenital Anomalies ◽  
Congenital Heart ◽  
Heart Defects ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Common Type ◽  
Cross Sectional ◽  
Live Births ◽  
Central Vietnam

Abstract Background Burden and pattern of congenital anomalies are insufficiently reported in Vietnam. This study aims to determine the prevalence and pattern of congenital anomalies in neonates in a tertiary hospital in central Vietnam. Methods A prospective cross-sectional study recruited all newborns with congenital anomalies in Da Nang Hospital for Women and Children—where nearly 60% neonates in the city are delivered. Results Over a 1-year period, 551 out of 14 335 registered live births were found to have congenital anomalies, equivalent to an overall prevalence of 384.4 per 10 000 live births. Congenital heart defects were the most common type (52.3%) with the prevalence of 200.9 per 10 000 live births, followed by anomalies of musculoskeletal system, digestive system. Conclusions This study revealed a high prevalence of congenital anomalies with the most common type being congenital heart defects in central Vietnam compared to both higher income countries and resource-limited settings.

High-Risk Histopathologic Features of Retinoblastoma Treated at a Tertiary Hospital in West Java, Indonesia

2021 ◽  
pp. 1-8
Author(s):  
Nur Melani Sari ◽  
Regina Hadiputri ◽  
Maya Sari Kuntorini ◽  
Hasrayati Agustina ◽  
Friska Mardianty
Keyword(s):  
High Risk ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Tumor Differentiation ◽  
Tertiary Referral Hospital ◽  
Cross Sectional ◽  
Undifferentiated Cells ◽  
Poorly Differentiated ◽  
Well Differentiated ◽  
Histopathological Results

<b><i>Purpose:</i></b> To evaluate the histopathological characteristics of clinically advanced retinoblastoma (RB) and its relationship with tumor differentiation. <b><i>Methods:</i></b> This was a cross-sectional study of primary enucleated group D/E intraocular RB using medical records from 2017 to 2020 in a tertiary referral hospital. Cases with incomplete histopathological results were excluded. Tumors were classified into well, moderately, and poorly differentiated and undifferentiated. High-risk histopathological features were classified as per Thaung and Karaa [<i>Community Eye Health</i>. 2018;31(101):17–3]. <b><i>Results:</i></b> This study included 121 patients (129 eyes), of which 32.2% were diagnosed at 25–36 months. High-risk features (HRFs) were found in 100/129 eyes, and of 73 complete histopathological results, the 2 most common HRFs were postlaminar optic nerve invasion and massive choroidal invasion. RB was poorly differentiated in 69.9% and well differentiated in 12.3% of eyes. There was no statistically significant association between any HRFs and tumor differentiation, with age &#x3e;2 years associated with tumor differentiation (<i>p</i> &#x3c; 0.05). <b><i>Conclusion:</i></b> The frequency of HRFs is 77.5% of primary enucleated eyes, mainly poorly and undifferentiated cells, particularly in children aged &#x3e;2 years old.

scholarly journals Congenital anomalies: Occurrence and potential risk factors

2020 ◽  
Vol 77 (3) ◽  
pp. 317-323
Author(s):  
Ivan Pavlovic ◽  
Darko Plecas ◽  
Snezana Plesinac ◽  
Jelena Dotlic ◽  
Nemanja Stojanovic
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Pregnant Women ◽  
Congenital Anomalies ◽  
Diagnostic Methods ◽  
Fetal Anomalies ◽  
Tertiary Referral Center ◽  
Organ Systems ◽  
Increased Risk ◽  
Fetal Malformations

Background/Aim: Congenital malformations still represent one of the most important causes of prenatal and infant death. The study goal was to analyze occurrence and outcomes of different types of congenital anomalies from the tertiary referral center during a ten-year period. Moreover, study aimed at examining potential predictors of congenital anomalies based on patients? characteristics and medical history data. Methods: Study included all pregnant women directed to Clinic of Obstetrics and Gynecology Clinical Center of Serbia due to prenatally diagnosed congenital fetal anomalies during past ten years. Upon admission to our clinic a detailed general medical and obstetrical history were taken from every patient. All women underwent genetic testing. Ultrasonography and magnetic resonance were diagnostic methods for fetal malformations confirmation. Results: Study included 773 pregnant women aged from 18 to 46 years. Out of registered nine different groups of fetal anomalies/malformations, the most common were malformations of the central nervous system, while majority of fetuses had combined multiple anomalies. Genetic cause for congenital anomalies was present in 25.2% of pregnancies. Medical pregnancy abortion was performed in 71.8% of cases. Only 10.2% of pregnancies ended in term. The best outcome for children was obtained in case of gastrointestinal anomalies (52% live-born). Contrary only one child with neck and thorax malformations could be saved. According to logistic regression the most important predictor of having a child with combined multiple anomalies was mother?s age, while predictor of central nervous system anomalies was gestational diabetes. The significant predictor of genetic anomalies was mother?s age. Conclusion: In our sample neurological congenital anomalies were the most common, although abnormalities of all organ systems were registered. Majority of pregnancies had to be discontinued due to combined multiple anomalies caused by genetic disorders. Older mother?s age and diabetes can imply on the increased risk for fetal malformations.

scholarly journals Epidemiology of Congenital Anomalies among the Children born in Different Hospitals under Sylhet Division in Bangladesh- a Retrospective Study

2016 ◽  
Vol 14 (2) ◽  
pp. 225-230 ◽  
Author(s):  
Madhabi Lata Shuma ◽  
Shimul Halder ◽  
Bidyut Kanti Datta
Keyword(s):  
Congenital Anomaly ◽  
Congenital Anomalies ◽  
Body Part ◽  
Ambiguous Genitalia ◽  
Cross Sectional Study ◽  
Vitamin Supplementation ◽  
Cross Sectional ◽  
Life Threatening ◽  
The Central Nervous System ◽  
Level Of Significance

Congenital anomalies play a significant role in perinatal and neonatal mortality. Frequency of these congenital anomalies varies in different populations. Epidemiology is the study of frequency, distribution and determinants of disease in populations. The mission of epidemiology is to contribute to the understanding of etiology and prevention of disease and to improve the health of public through excellence in research. So, this study was conducted to find out proportion, types and immediate outcome of congenital anomalies. In this retrospective and cross-sectional study all patients admitted with congenital anomalies in different hospitals of Sylhet division in Bangladesh from October 2012 to January 2013 (04 months) were included. At first, the patients were examined for major and minor congenital anomalies and recorded properly. Diagnosis of congenital anomalies was based on ultrasonography and clinical evaluation of the fetus/newborn by experienced neonatologist. Major and minor congenital anomalies were categorized depending on their life threatening effects. Various data which were obtained was analyzed by using SPSS 13. Rates and proportions were calculated with 95% confidence interval. The proportions were compared using students T-test. Level of significance was set at P<0.05.The most frequently occurring anomalies involved the central nervous system (28.33%) of which myelomeningocele was the commonest CNS defect (9.09%). According to data, females were more susceptible to myelomeningocele than the male patients. The second frequently occurring congenital anomaly was associated with cardiovascular system (15%). Patients with urogenital anomalies (6.67%) were male, except for one who had ambiguous genitalia. Congenital anomaly associated with gastrointestinal -, respiratory -, musculoskeletal -, chromosomal - and dysmorphism– were noted as 11.67%, 5%, 6.67%, 5% and 3.33%, respectively. About 11% congenital anomalies were found to be linked to other body part system. After analysis of mothers’ lifestyle, it was likely to conclude that more stress and efforts should be given on the role of peri-conceptional vitamin supplementation to the pregnant mother. Folic acid was found to be the primary agent for prevention of congenital defects.Dhaka Univ. J. Pharm. Sci. 14(2): 225-230, 2015 (December)

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