scholarly journals HUBUNGAN MEAN PLATELET VOLUME DENGAN HbA1C DAN PROFIL LIPID PADA PENDERITA DIABETES MELITUS

2020 ◽  
Vol 13 (2) ◽  
pp. 73-80
Author(s):  
Rosdiana Mus ◽  
Yeremiah Rubin Camin ◽  
Noortiningsih Noortiningsih
Keyword(s):  
Mean Platelet Volume ◽  
Platelet Volume ◽  
Cross Sectional ◽  
Diabetes Melitus

Prevalensi Diabetes Melitus (DM) dari tahun ke tahun semakin meningkat. DM adalah ditandai dengan hiperglikemia dan intoleransi glukosa yang terjadi karena kelenjar pankreas tidak dapat memproduksi insulin secara adekuat atau karena tubuh tidak dapat menggunakan insulin yang diproduksi secara efektif atau kedua-duanya. Pada penderita DM, aterosklerosis menyumbang hampir 80% dari semua kematian. Pada penderita DM terjadi disfungsi dari trombosit. Trombosit berperan dalam proses hemostasis dan memiliki peran penting dalam aterosklerosis dan trombosis arteri. Rata-rata Volume trombosit atau dikenal dengan Mean Platelet Volume (MPV) adalah penanda fungsi dan aktivasi trombosit. Penelitian ini bertujuan untuk melihat adanya hubungan antara MPV dengan HbA1C dan profil lipid pada penderita DM. Penelitian ini merupakan penelitian cross sectional terhadap data rekam medik di Rumah Sakit Umum Daerah Pasar Rebo dengan sampel sebanyak 300 pasien. Data diperoleh dari bulan Januari 2014 sampai Desember 2015. Data dianalisis dengan menggunakan bantuan SPSS 22.0 dengan metode uji regresi linear ganda. Hasil uji statistik yang diperoleh menunjukkan tidak terdapat hubungan yang signifikan antara MPV dengan profil lipid dan glukosa pp (p>0,05) tetapi terdapat hubungan yang signifikan antara MPV dengan HbA1C dan glukosa puasa (p<0.05) pada penderita DM.

scholarly journals RERATA VOLUME TROMBOSIT DI DIABETES MELITUS (Mean Platelet Volume in Diabetes Mellitus)

2018 ◽  
Vol 21 (1) ◽  
pp. 24
Author(s):  
Maria Enrica ◽  
Nina Tristina ◽  
Anna Tjandrawati
Keyword(s):  
Diabetes Mellitus ◽  
Mean Platelet Volume ◽  
Vascular Complication ◽  
Coagulation System ◽  
Inclusion Criteria ◽  
Platelet Volume ◽  
Significant Difference ◽  
Impaired Insulin ◽  
And Function ◽  
Diabetes Melitus

Diabetes Mellitus (DM) is a state of chronically hyperglycemia, which is caused by impaired insulin secretion and function. Thealteration in coagulation system in DM patients served as the basic etiology of macro and micro vascular complication. Platelets are oneof the factors that have a role in the coagulation system and undergo pathological changes in DM patients. Mean Platelet Volume (MPV)is an indicator of platelet function and activation. Larger platelets have more dense and more reactive pro coagulant granules. The aimof this study was to know whether there were differences in MPV between DM patients compared to medical check-up participants atthe Dr. Hasan Sadikin Hospital, Bandung.. The research used analytical descriptive, retrospective data. The inclusion criteria of thisresearch was DM patients and medical check up participants whose serum fasting glucose and two (2) hours post prandial serum glucosewere within the normal range. The data were taken from medical records of DM patients and medical check up participants. The datawere further analyzed with SPSS ver. 15 program using unpaired T-test. In this study, no significant difference between DM patientsand medical check up participants (p>0.05) was found. It can be concluded that Mean Platelet Volume if used as single, can not predictvascular complication in DM patients.

scholarly journals Mean Platelet Volume (MPV) as an indicator of  disease activity and severity in lupus

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 126 ◽  
Author(s):  
Abidullah Khan ◽  
Iqbal Haider ◽  
Maimoona Ayub ◽  
Salman Khan
Keyword(s):  
Disease Activity ◽  
Lupus Erythematosus ◽  
Mean Platelet Volume ◽  
Activity Index ◽  
Disease Activity Index ◽  
Sampling Technique ◽  
Cross Sectional Study ◽  
Strong Positive Correlation ◽  
Platelet Volume ◽  
Cross Sectional

Background: Amongst the different clinical and laboratory parameters used to monitor disease activity in systemic lupus erythematosus (SLE), mean platelet volume (MPV) is a novel biomarker. Although MPV has been studied in other rheumatological conditions like rheumatoid arthritis, its role in adult SLE needs to be defined, especially in Pakistan. Methods: The aim of this study was to evaluate the role of MPV as a biomarker of disease activity in SLE. Fifty patients were recruited through a consecutive non-probability sampling technique for this cross-sectional study.  On the basis of their SLE disease activity index (SLEDAI) score of greater or lesser than 5, these 50 participants were divided into two equal groups respectively;25 patients with active SLE, and another 25 participants with stable, inactive lupus. MPV was measured in each group and compared using SPSS version 16. MPV was also correlated with SLEDAI and erythrocyte sedimentation rate (ESR). Independent sample t-test and Spearman’s rho and Pearson’s correlation tests were applied. Sensitivity and specificity of MPV were checked through ROC analysis.    Results: The MPV of patients with active SLE (n=25, mean [M]=7.12, SD=1.01) was numerically lower than those in the inactive-SLE group (n=25, M= 10.12, SD=0.97), and this was statistically significant ( P<0.001). MPV had an inverse relationship with both ESR (r=-0.93, P<0.001) and SLEDAI (rs= -0.89, P<0.001). However, there was a strong positive correlation between ESR and SLEDAI (rs=0.90, P<0.001). For MPV, a cutoff value of less than 8.5fl had a sensitivity of 92% and a specificity of 100% ( P< 0.001).  Conclusions: Higher disease activity in SLE is associated with a correspondingly low MPV.

scholarly journals THE CORRELATION BETWEEN THE MEAN PLATELET VOLUME VALUES WITH THROMBOCYTE AGGREGATION IN NEPHROPATHY DIABETIC PATIENTS

2019 ◽  
Vol 25 (1) ◽  
pp. 79
Author(s):  
Agus Sunardi ◽  
Nadjwa Zamalek Dalimoenthe ◽  
Coriejati Rita ◽  
Adhi Kristianto Sugianli
Keyword(s):  
Diabetic Nephropathy ◽  
Platelet Aggregation ◽  
Mean Platelet Volume ◽  
Cross Sectional Study ◽  
Endothelial Damage ◽  
Diabetic Patients ◽  
Platelet Volume ◽  
Cross Sectional ◽  
Positive Correlation ◽  
Chronic Hyperglycemia

     Diabetic nephropathy is the most important cause of end-stage renal failure. Chronic hyperglycemia will cause glomerular endothelial damage, and this damage will stimulate hemostasis activation including platelets so that platelet aggregation will increase. The increase of platelet aggregation will increase platelet consumption, which further stimulates thrombopoiesis which will lead to immature platelets of large size to be released into the circulation. This research aimed to determine the positive correlation between MPV with platelet aggregation in patients with diabetic nephropathy. This study was an analytic observational study with a cross-sectional study design. The research was conducted in the Dr. Hasan Sadikin Hospital Bandung from July 2016 to October 2017. A total of 52 subjects who met the inclusion criteria were included in the study. Mean platelet volume and platelet aggregation were performed with venous examination with EDTA and sodium citrate 3.2% anticoagulants. The result of platelet aggregation examination showing platelet hyper-aggregation was found in 44.2% of subjects, 50% normal-aggregation, 5.8% hypo-aggregation. While the median value of MPV in this study was 9.2 fL with the range of 8.00 – 11.80 fL. A positive correlation was found  between MPV value with platelet aggregation with r= 0.067, p= 0.634. The conclusion was that there was no correlation between MPV values with platelet aggregation in diabetic nephropathy patients. This small and insignificant r-value might be due to several factors that also affect platelet aggregation in diabetic nephropathy patients, requiring further investigation.

scholarly journals AGREGASI TROMBOSIT DAN MEAN PLATELET VOLUME DENGAN SINDROM METABOLIK TERKAIT KEGEMUKAN

2018 ◽  
Vol 21 (2) ◽  
pp. 130
Author(s):  
Nindia Sugih Arto ◽  
Adi Koesoema Aman ◽  
Dharma Lindarto
Keyword(s):  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Platelet Aggregation ◽  
Mean Platelet Volume ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Platelet Volume ◽  
Cross Sectional ◽  
The Metabolic Syndrome ◽  
The Mean

The hyperactivity of platelet had been seen in patients with metabolic syndrome which can be caused by several factors, such as:insulin resistance, obesity, dyslipidemia and hypertension. The hyperactivity of platelet leads to its aggregation that can be increased therisk of cardiovascular disease. This study is aimed to know the platelet aggregation and mean platelet volume in patients with metabolicsyndrome and obesity by determination 30 patients were choosen for this cross sectional study, those whom attended to the laboratoryand policlinic at H. Adam Malik Medan Hospital, between May 2013 until August 2013. The diagnosis used of metabolic syndromecriteria established by the International Diabetic Federation 2005. From the 30 patients with 15 metabolic syndrome and 15 obesity,four patients were excluded because of their tryglyceride were more than 200 mg/dL. There is no significant differences between theplatelet aggregation with the agonist adenosin difosfat (ADP) in patient with metabolic syndrome and obesity. And there is no significantdifferences of the mean platelet volume values between the metabolic syndrome (9.6±0.93) and the obesity group (9.73±0.74), with pvalue 0.846. Based on this study there is no significant differences between the platelet aggregation and the Mean Platelet Volume values(MPV) in the metabolic syndrome and the obese group

scholarly journals Mean Platelet Volume (MPV) as an indicator of  disease activity and severity in lupus

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 126 ◽  
Author(s):  
Abidullah Khan ◽  
Iqbal Haider ◽  
Maimoona Ayub ◽  
Salman Khan
Keyword(s):  
Disease Activity ◽  
Lupus Erythematosus ◽  
Mean Platelet Volume ◽  
Activity Index ◽  
Disease Activity Index ◽  
Sampling Technique ◽  
Cross Sectional Study ◽  
Strong Positive Correlation ◽  
Platelet Volume ◽  
Cross Sectional

Background: Amongst the different clinical and laboratory parameters used to monitor disease activity in systemic lupus erythematosus (SLE), mean platelet volume (MPV) is a novel biomarker. Although MPV has been studied in other rheumatological conditions like rheumatoid arthritis, its role in adult SLE needs to be defined, especially in Pakistan. Methods: The aim of this study was to evaluate the role of MPV as a biomarker of disease activity in SLE. Fifty patients were recruited through a consecutive non-probability sampling technique for this cross-sectional study.  On the basis of their SLE disease activity index (SLEDAI) score of greater or lesser than 5, these 50 participants were divided into two equal groups respectively;25 patients with active SLE, and another 25 participants with stable, inactive lupus. MPV was measured in each group and compared using SPSS version 16. MPV was also correlated with SLEDAI and erythrocyte sedimentation rate (ESR). Independent sample t-test and Pearson’s correlation tests were applied. Sensitivity and specificity of MPV were checked through ROC analysis.   Results: The MPV of patients with active SLE (n=25, mean [M]=7.12, SD=1.01) was numerically lower than those in the inactive-SLE group (n=25, M= 10.12, SD=0.97), and this was statistically significant (P<0.001). MPV had an inverse relationship with both ESR (r=-0.93, P<0.001) and SLEDAI (r= -0.94, P<0.001). However, there was a strong positive correlation between ESR and SLEDAI (r=0.95, P<0.001). For MPV, a cutoff value of less than 8.5fl had a sensitivity of 92% and a specificity of 100% (P< 0.001). Conclusions: Higher disease activity in SLE is associated with a correspondingly low MPV.

scholarly journals Assessment of Mean Platelet Volume in Patients with Systemic Lupus Erythematosus

2018 ◽  
Vol 12 (1) ◽  
pp. 129-138 ◽  
Author(s):  
Lisandra Torres Hartmann ◽  
Ana Paula Alegretti ◽  
Alice Beatriz Mombach Pinheiro Machado ◽  
Eduardo Ferreira Martins ◽  
Rafael Mendonça da Silva Chakr ◽  
...  
Keyword(s):  
Disease Activity ◽  
Lupus Erythematosus ◽  
Mean Platelet Volume ◽  
Activity Index ◽  
Disease Activity Index ◽  
Inactive Disease ◽  
Control Group ◽  
Platelet Volume ◽  
Complement Components ◽  
Cross Sectional

Introduction: The Mean Platelet Volume (MPV) is a platelet activation biomarker that has been recently correlated with disease activity in SLE. We aimed to evaluate the MPV in patients with SLE comparing it with healthy individuals, to study the correlation between MPV and SLE Disease Activity Index (SLEDAI) in SLE patients and to analyze possible correlation between MPV and Erythrocyte Sedimentation Rate (ESR), C-Reactive Protein (CRP), and complement components C3 and C4. Methods: This is a cross-sectional study in which 81 patients with SLE according to the American College of Rheumatology (ACR) diagnostic classification criteria and 58 healthy controls were included. Active disease was defined as SLEDAI>0. Results: Patients with active SLE had decreased MPV when compared to inactive disease group (10.0±0.7fL vs. 10.7±1.0fL, p=0.005, respectively) and when compared to control group (10.9±1.0fL, p<0.001). Our study found a weak negative correlation between the SLEDAI and the MPV (r=-0.29, p=0.009). There was no correlation between MPV and CRP, ESR, C3 and C4. Also, no correlation between SLEDAI and CRP, ESR, C3 and C4 was found. Conclusion: MPV decreases in patients with active SLE and is inversely correlated with SLEDAI.

scholarly journals CORRELATIONS BETWEEN MEAN PLATELET VOLUME AND IMMATURE PLATELET FRACTION TO HEMOGLOBIN A1C IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

2018 ◽  
Vol 24 (1) ◽  
pp. 6
Author(s):  
Dian W Astuti ◽  
Sony Wibisono ◽  
Arifoel Hajat ◽  
Sidarti Soehita
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Mean Platelet Volume ◽  
Hemoglobin A1c ◽  
Platelet Volume ◽  
Immature Platelet Fraction ◽  
Diabetes Melitus

Pasien diabetes melitus tipe 2 berkebahayaan mengalami komplikasi makro dan mikrovaskuler, yang dipengaruhi oleh kendaliglikemik. Reaktivitas trombosit berperan pada timbulnya komplikasi ini, terutama komplikasi kardiovaskuler. Tujuan penelitian iniadalah membandingkan MPV dan IPF di kendali glikemik baik dan buruk dan menentukan adanya kenasaban MPV dan IPF terhadapHbA1c. Penelitian bersifat analitik observasional dengan rancang bangun potong lintang. Sampel darah EDTA dari 43 orang pasienDM tipe 2, dikumpulkan selama Januari-Februari 2016. HbA1c diperiksa dengan Dimension RxL, sedangkan MPV dan IPF diperiksadengan Sysmex XN-1000. Rerata nilai MPV 10,36±0,84 fL, rerata nilai IPF 4,22±2,29%. Uji perbedaan nilai MPV menurut kendaliglikemik didapatkan p=0,494, uji perbedaan IPF didapatkan p=0,462. Uji kenasaban Pearson antara IPF dan MPV didapatkanr=0,877 (p<0,0001), MPV dan HbA1c didapatkan r=0,018 (p=0,907), IPF dan HbA1c didapatkan r=0,128 (p=0,414). Penelitian inimenunjukkan rerata MPV berada dalam rentang normal, sedangkan rerata IPF meningkat, namun tak terdapat perbedaan bermaknanilai MPV dan IPF di kendali glikemik baik dan buruk. MPV dan IPF pada penelitian ini tak bernasab dengan HbA1c.

scholarly journals A study of mean platelet volume in acute ischemic stroke

2021 ◽  
Vol 8 (2) ◽  
pp. 214
Author(s):  
Vivekanand Kamat ◽  
Satish Kinagi ◽  
Anilkumar Patil
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Mean Platelet Volume ◽  
Platelet Reactivity ◽  
Statistical Significance ◽  
Clinical Severity ◽  
Stroke Severity ◽  
Ageing Population ◽  
Platelet Volume ◽  
Cross Sectional

Background: A stroke is defined by the abrupt onset of neurological deficit that is attributable to a focal vascular cause. Because of the growth in the number of ageing population, the burden of stroke is likely to increase automatically in the coming future. Mean platelet volume (MPV), a marker of platelet function is a physiological variable of hemostatic importance. Changes in MPV play a more important role in hemostasis than platelet count. Very few studies has looked at the association between mean platelet volume and ischemic stroke. So, the objectives were to study mean platelet volume in acute ischemic stroke, the role of mean platelet volume as an independent risk factor in acute ischemic stroke and to study the association between MPV and outcome in patients with acute ischemic stroke.Methods: A cross sectional analytical study was conducted on 60 patients with ischemic stroke identified based on clinical features and MRI of Brain admitted in Mahadevappa Rampure Medical College, Kalaburgi. Mean platelet volume (MPV) on admission was documented and severity of stroke at the presentation and at discharge was assessed using Modified Rankins scale (MRS).Results: Among 60 patients, 40% of the study patients were aged between 60-80 years and 60% of study population were male and 40% female. The co-morbid conditions present were hypertension in 50%, diabetes mellitus in 41% .The MPV was raised (>12.5fl) in 64 %of the patients. The clinical severity of stroke at presentation as determined by the Modified Rankin‘s scale (MRS) were moderate (20%), moderately severe (35%) and severe disability in 36.7% of cases. In our study MPV showed statistically significant correlation with Ischemic stroke severity. Clinical outcome as assessed by comparing MRS at admission and discharge with presentation MPV showed 25% moderately, 30% moderately severe and 23% were severely disabled. However, no statistical significance was seen.Conclusions: We conclude that MPV is raised in acute ischemic stroke and is an independent predictor of the risk of stroke. Higher MPV are associated with more severe stroke and tend to have poorer outcome. Mean platelet volume an indicator of platelet reactivity is a simple and easy test available in panel of hemogram and can serve as a valuable predictor of severity and outcome in acute ischemic stroke patients.

scholarly journals Pseudobasophilia as a Screening Tool in Dengue: A Single Center Study

2021 ◽  
Author(s):  
Kevin Manuel ◽  
Marie Moses Ambroise ◽  
Anita Ramdas ◽  
Renu G'Boy Varghese
Keyword(s):  
Platelet Count ◽  
Statistical Analysis ◽  
Early Identification ◽  
Mean Platelet Volume ◽  
Complete Blood Count ◽  
Hematological Parameters ◽  
Febrile Illness ◽  
P Value ◽  
Platelet Volume ◽  
Cross Sectional

Abstract Objectives Proper serological testing for the definite diagnosis of dengue is costly and may not be easily available in a resource-limited setting. Hematological parameters can help in the early identification of dengue cases. This study aims to evaluate the occurrence and utility of pseudobasophilia in identifying dengue-affected patients. Materials and Methods This retrospective cross-sectional study included 1,304 dengue cases confirmed by serology and 1,044 dengue serology negative acute febrile illness cases as controls. Complete blood count (CBC) values of the first EDTA (ethylenediamine tetraacetic acid) blood sample from automated hematology analyzers were reviewed. The hematological parameters in the dengue and control groups were compared and the variation of these parameters with the day of fever was also analyzed. Statistical Analysis Mann-Whitney’s test, Kruskal-Wallis test, and Fisher’s exact test were used for statistical analysis. A p-value < 0.05 was considered statistically significant for all tests. Results There was a statistically significant variation between dengue cases and controls for hematocrit, platelet count, mean platelet volume, total white blood cell count, and absolute basophil count. The dengue group had a higher hematocrit from day 2 to day 10, platelet count ≤ 100,000/µL from day 4 to day 9, higher mean platelet volume from day 2 to day 7, leucopenia from day 3 to day 5, and higher absolute basophil count from day 2 to day 10. Interestingly, pseudobasophilia was seen in 533 (40.87%) of dengue cases and only 3 (0.28%) of the controls. Pseudobasophilia was also observed to have an increasing trend to the day of fever. Conclusion Pseudobasophilia along with other CBC parameters is useful and cost effective for the early identification of dengue. This can prompt early investigations and supportive treatment leading to improved clinical outcomes.

No obvious association exists between mean platelet volume and hypertension subtypes

2021 ◽  
Author(s):  
Tingwei Li ◽  
Zhaowei Meng ◽  
Wenjuan Zhang ◽  
Yongle Li ◽  
Xuefang Yu ◽  
...  
Keyword(s):  
Mean Platelet Volume ◽  
Protective Factor ◽  
Blood Parameters ◽  
Cross Sectional Study ◽  
Continuous Variable ◽  
Platelet Volume ◽  
Cross Sectional ◽  
Diastolic Hypertension ◽  
Obvious Association ◽  
The Mean

Aims: To determine the association between mean platelet volume (MPV) and hypertension subtypes. Participants & results: 44,281 Chinese individuals were enrolled in this cross-sectional study. The mean blood pressure decreased with increasing MPV in females (p = 0.001) and increased MPV seemed to be a potential protective factor for isolated diastolic hypertension in models 1 and 2. The OR (CI) was 0.878 (0.789–0.976) for model 1 and 0.880 (0.789–0.981) for model 2 in males and 0.646 (0.495–0.841) for model 1 and 0.657 (0.503–0.858) for model 2 in females, when MPV was analyzed as a categorical variable. The OR (CI) was 0.947 (0.911–0.985) for Model 1 and 0.947 (0.910–0.985) for Model 2 in males, and 0.886 (0.807–0.973) for Model 1 and 0.892 (0.813–0.978) for Model 2 in females when MPV was analyzed as a continuous variable. However, the statistical difference of OR disappeared when we added blood-related covariates in Model 3. Conclusion: No obvious association exists between MPV and hypertension subtypes. Other blood parameters might have a greater impact on hypertension subtypes.

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