scholarly journals Analysis and Design Consideration of a High Sensitivity Silicon Avalanche Photodiode Receiver for Low Frequency Applications

2019 ◽  
pp. 133-138
Keyword(s):  
Low Frequency ◽  
High Sensitivity ◽  
Avalanche Photodiode ◽  
Design Consideration ◽  
Analysis And Design

Analysis and design of suitable model structures for activated sludge tanks with circulating flow

1999 ◽  
Vol 39 (4) ◽  
pp. 55-60 ◽  
Author(s):  
J. Alex ◽  
R. Tschepetzki ◽  
U. Jumar ◽  
F. Obenaus ◽  
K.-H. Rosenwinkel
Keyword(s):  
Activated Sludge ◽  
Large Scale ◽  
Wastewater Treatment Plants ◽  
Treatment Plant ◽  
High Sensitivity ◽  
Suitable Model ◽  
Model Structure ◽  
Analysis And Design ◽  
Hydraulic Behaviour ◽  
Model Structures

Activated sludge models are widely used for planning and optimisation of wastewater treatment plants and on line applications are under development to support the operation of complex treatment plants. A proper model is crucial for all of these applications. The task of parameter calibration is focused in several papers and applications. An essential precondition for this task is an appropriately defined model structure, which is often given much less attention. Different model structures for a large scale treatment plant with circulation flow are discussed in this paper. A more systematic method to derive a suitable model structure is applied to this case. Results of a numerical hydraulic model are used for this purpose. The importance of these efforts are proven by a high sensitivity of the simulation results with respect to the selection of the model structure and the hydraulic conditions. Finally it is shown, that model calibration was possible only by adjusting to the hydraulic behaviour and without any changes of biological parameters.

scholarly journals Magnetoelastic Coupling and Delta-E Effect in Magnetoelectric Torsion Mode Resonators

Sensors ◽  
2021 ◽  
Vol 21 (6) ◽  
pp. 2022
Author(s):  
Benjamin Spetzler ◽  
Elizaveta V. Golubeva ◽  
Ron-Marco Friedrich ◽  
Sebastian Zabel ◽  
Christine Kirchhof ◽  
...  
Keyword(s):  
Low Frequency ◽  
High Sensitivity ◽  
Element Model ◽  
Mode Number ◽  
Frequency Change ◽  
General Description ◽  
Resonance Modes ◽  
Field Sensor ◽  
Magnetic Sensitivity ◽  
Bending Modes

Magnetoelectric resonators have been studied for the detection of small amplitude and low frequency magnetic fields via the delta-E effect, mainly in fundamental bending or bulk resonance modes. Here, we present an experimental and theoretical investigation of magnetoelectric thin-film cantilevers that can be operated in bending modes (BMs) and torsion modes (TMs) as a magnetic field sensor. A magnetoelastic macrospin model is combined with an electromechanical finite element model and a general description of the delta-E effect of all stiffness tensor components Cij is derived. Simulations confirm quantitatively that the delta-E effect of the C66 component has the promising potential of significantly increasing the magnetic sensitivity and the maximum normalized frequency change ∆fr. However, the electrical excitation of TMs remains challenging and is found to significantly diminish the gain in sensitivity. Experiments reveal the dependency of the sensitivity and ∆fr of TMs on the mode number, which differs fundamentally from BMs and is well explained by our model. Because the contribution of C11 to the TMs increases with the mode number, the first-order TM yields the highest magnetic sensitivity. Overall, general insights are gained for the design of high-sensitivity delta-E effect sensors, as well as for frequency tunable devices based on the delta-E effect.

scholarly journals Enhanced specificity of clinical high-sensitivity tumor mutation profiling in cell-free DNA via paired normal sequencing using MSK-ACCESS

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
A. Rose Brannon ◽  
Gowtham Jayakumaran ◽  
Monica Diosdado ◽  
Juber Patel ◽  
Anna Razumova ◽  
...  
Keyword(s):  
Cancer Patients ◽  
De Novo ◽  
Low Frequency ◽  
High Sensitivity ◽  
Clinical Analysis ◽  
De Novo Mutation ◽  
Cell Free Dna ◽  
Free Dna ◽  
Somatic Alterations ◽  
Mutation Profiling

AbstractCirculating cell-free DNA from blood plasma of cancer patients can be used to non-invasively interrogate somatic tumor alterations. Here we develop MSK-ACCESS (Memorial Sloan Kettering - Analysis of Circulating cfDNA to Examine Somatic Status), an NGS assay for detection of very low frequency somatic alterations in 129 genes. Analytical validation demonstrated 92% sensitivity in de-novo mutation calling down to 0.5% allele frequency and 99% for a priori mutation profiling. To evaluate the performance of MSK-ACCESS, we report results from 681 prospective blood samples that underwent clinical analysis to guide patient management. Somatic alterations are detected in 73% of the samples, 56% of which have clinically actionable alterations. The utilization of matched normal sequencing allows retention of somatic alterations while removing over 10,000 germline and clonal hematopoiesis variants. Our experience illustrates the importance of analyzing matched normal samples when interpreting cfDNA results and highlights the importance of cfDNA as a genomic profiling source for cancer patients.

Low-frequency multiplex CARS microscopy with a high-repetition near-infrared supercontinuum laser

2021 ◽  
Author(s):  
Yusuke Arashida ◽  
Atsushi Taninaka ◽  
Takayuki Ochiai ◽  
Hiroyuki Mogi ◽  
Shoji YOSHIDA ◽  
...  
Keyword(s):  
Near Infrared ◽  
High Efficiency ◽  
Signal To Noise Ratio ◽  
Low Frequency ◽  
High Sensitivity ◽  
High Repetition ◽  
Spectrum Shaping ◽  
Crystal Phase Transition ◽  
Wavenumber Region ◽  
Anti Stokes

Abstract We have developed a multiplex Coherent anti-Stokes Raman scattering (CARS) microscope effective for low-wavenumber measurement by combining a high-repetition supercontinuum light source of 1064 nm and an infrared high-sensitivity InGaAs diode array. This system could observe the low-wavenumber region down to 55 cm-1 with high sensitivity. In addition, using spectrum shaping and spectrum modulation techniques, we simultaneously realized a wide bandwidth (<1800 cm-1), high wavenumber resolution (9 cm-1), high efficiency, and increasing signal to noise ratio by reducing the effect of the background shape in low-wavenumber region. Spatial variation of a sulfur crystal phase transition with metastable states was visualized.

scholarly journals PARAMETRIC AMPLIFICATION OF THE SIGNALS IN THE ELECTROSTATIC GRAVIINERTIAL SENSOR

2017 ◽  
Vol 8 (2) ◽  
pp. 108-121
Author(s):  
I. Z. Gilavdary ◽  
S. N. Mekid ◽  
N. N. Riznookaya
Keyword(s):  
Torsional Rigidity ◽  
Low Frequency ◽  
High Sensitivity ◽  
Elastic Stiffness ◽  
Parametric Amplification ◽  
Distinctive Features ◽  
Torsion Suspension ◽  
Wide Range ◽  
Differential Circuits ◽  
Simultaneous Reading

The challenges of designing simple, reliable, and high sensitivity graviinertial sensors are investigated. The sensor comprises a proof mass (PM) and is fixed with the housing by the elastic torsion suspension. PM makes small rotations under the action of gravitational forces or inertial forces.The distinctive features of the sensor are that the differential electrostatic system provides simultaneous reading of the desired signal and a control the torsional rigidity of suspension. In addition, the PM's rotational angular velocity transforms in the alternating current flowing through the capacitors. The presence of аlternating current (AC) voltage sources allows to get the parametric amplification of AC and significantly to improve the sensitivity of the sensor. In the simplest case, the sensor does not contain any feedback circuits.As an example, calculations of the micromechanical linear accelerations confirm that the periodic modulation of the coefficient of elastic stiffness of the suspension can significantly increase the sensitivity in the low frequency range, even in the absence of parametric resonance.Conditions for suppressions of background current participating in the output signal from a parametric pumping due to the asymmetry of the differential circuits are set. The frequency characteristics calculations of the sensor were carried out. It is expected, that the proposed sensor design ensures minimum noise level, which can be achievable in the graviinertial sensors. This design and the constructed theory can serve as a basis for creating a wide range of graviinertial devices operating on a movable base, for example, linear and angular accelerometer, gravity gradiometer, gravimeters, and inclinometers, which can be realized in the hybrid and in the micromechanical versions.

scholarly journals A broadband two axis flux-gate magnetometer

1998 ◽  
Vol 41 (3) ◽  
Author(s):  
P. Palangio
Keyword(s):  
Magnetic Field ◽  
Low Frequency ◽  
High Sensitivity ◽  
Magnetic Sensors ◽  
Frequency Range ◽  
Field Station ◽  
Low Weight ◽  
Highly Sensitive ◽  
Flux Gate ◽  
Magnetic Field Variations

A broadband two axis flux-gate magnetometer was developed to obtain high sensitivity in magnetotelluric measurements. In magnetotelluric sounding, natural low frequency electromagnetic fields are used to estimate the conductivity of the Earth's interior. Because variations in the natural magnetic field have small amplitude(10-100 pT) in the frequency range 1 Hz to 100 Hz, highly sensitive magnetic sensors are required. In magnetotelluric measurements two long and heavy solenoids, which must be installed, in the field station, perpendicular to each other (north-south and east-west) and levelled in the horizontal plane are used. The coil is a critical component in magnetotelluric measurements because very slight motions create noise voltages, particularly troublesome in wooded areas; generally the installation takes place in a shallow trench. Moreover the coil records the derivative of the variations rather than the magnetic field variations, consequently the transfer function (amplitude and phase) of this sensor is not constant throughout the frequency range 0.001-100 Hz. The instrument, developed at L'Aquila Geomagnetic Observatory, has a flat response in both amplitude and phase in the frequency band DC-100 Hz, in addition it has low weight, low power, small volume and it is easier to install in the field than induction magnetometers. The sensivity of this magnetometer is 10 pT rms.

scholarly journals Effects of temperature variations in high-sensitivity Sagnac gyroscope

2021 ◽  
Vol 136 (5) ◽  
Author(s):  
Andrea Basti ◽  
Nicolò Beverini ◽  
Filippo Bosi ◽  
Giorgio Carelli ◽  
Donatella Ciampini ◽  
...  
Keyword(s):  
Earth Rotation ◽  
Mechanical Design ◽  
Low Frequency ◽  
Environmental Parameters ◽  
High Sensitivity ◽  
Rotation Axes ◽  
The Earth ◽  
Sagnac Gyroscope ◽  
Laser Gyroscopes

AbstractGINGERINO is one of the most sensitive Sagnac laser-gyroscopes based on an heterolithic mechanical structure. It is a prototype for GINGER, the laser gyroscopes array proposed to reconstruct the Earth rotation vector and in this way to measure General Relativity effects. Many factors affect the final sensitivity of laser gyroscopes, in particular, when they are used in long-term measurements, slow varying environmental parameters come into play. To understand the role of different terms allows to design more effective mechanical as well as optical layouts, while a proper model of the dynamics affecting long-term (low frequency) signals would increase the effectiveness of the data analysis for improving the overall sensitivity. In this contribution, we focus our concerns on the effects of room temperature and pressure aiming at further improving mechanical design and long-term stability of the apparatus. Our data are compatible with a local orientation changes of the Gran Sasso site below $$\mu $$ μ rad as predicted by geodetic models. This value is consistent with the requirements for GINGER and the installation of an high-sensitivity Sagnac gyroscope oriented at the maximum signal, i.e. along the Earth rotation axes.

scholarly journals Low Frequency - High Sensitivity Horizontal Inertial Sensor based on Folded Pendulum

2012 ◽  
Vol 363 ◽  
pp. 012001 ◽  
Author(s):  
Fausto Acernese ◽  
Rosario De Rosa ◽  
Gerardo Giordano ◽  
Rocco Romano ◽  
Silvia Vilasi ◽  
...  
Keyword(s):  
Inertial Sensor ◽  
Low Frequency ◽  
High Sensitivity

Topographic Correction for the Data of SQUID-based TEM Using a Ground Loop

2019 ◽  
Vol 24 (1) ◽  
pp. 111-117
Author(s):  
Yanju Ji ◽  
Yi Zhao ◽  
Shangyu Du ◽  
Dongsheng Li ◽  
Yi Zhang ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Quantum Interference ◽  
Low Frequency ◽  
High Sensitivity ◽  
Absolute Error ◽  
Correction Method ◽  
Topographic Effects ◽  
Topographic Correction ◽  
Transient Electromagnetic ◽  
Ground Loop

Superconducting quantum interference device (SQUID) can be used to detect the signal of transient electromagnetic method (TEM) due to its superiority of high sensitivity in the low frequency range. However, the measuring direction of SQUID is hardly consistent with the normal direction of the transmitting coil of a TEM system because of the undulating topography in the field. In this case, the central magnetic field measured by SQUID is only a component of the theoretical central magnetic field. There will be larger errors if we directly use the measured central magnetic field for geological interpretation. To solve this problem, we propose a topographic correction method for the data of SQUID-based TEM using ground loop. The theoretical central magnetic field of the ground loop is calculated after the trapezoidal transmitting current wave is turned off. Then, we use the theoretical central magnetic field of the ground loop as the reference to correct the measured central magnetic field of SQUID-based on the trigonometric function relation between the measuring direction of SQUID and the topographic inclination. The experiment of SQUID-based TEM using a ground loop was carried out in the field. The result shows that at the measurement point with larger topographic inclination, the average absolute error of the measured central magnetic field reduces significantly with the proposed correction method. This method can also be applied to the correction of complex topographic effects when using SQUID to measure three components of magnetic field.

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