scholarly journals Characterization of Forcespun Polycaprolactone Fibers Infused with Bio-Based Hydroxyapatite for Biomedical Applications

2020 ◽  
Vol 2 (2) ◽  
pp. 23
Keyword(s):  
Mechanical Properties ◽  
Particle Size ◽  
Biomedical Applications ◽  
Size Reduction ◽  
Biological Assessment ◽  
Fish Scales ◽  
Particle Size Reduction ◽  
Uniform Dispersion ◽  
Bead Mill

A novel Force spinning technique was used to fabricate microfibers from polycaprolactone (PCL) infused with bio-based hydroxyapatite (HA). The aim of this study is to analyze the thermo-mechanical properties of the developed fibers in addition to cell adhesion and proliferation analysis. The HA is synthesized from sundried raw fish scales of carpa family. The fish scales are calcinated at 800°C in a box furnace and are bead milled for one hour in a nano agitator bead mill for particle size reduction. Thus obtained nanoparticles are characterized using XRD, SEM, and TEM for particle size reduction, crystallinity, and structure. The PCL solution formed by dissolving 16 wt% of PCL in chloroform is magnetically stirred for 3 hrs at 170 rpm. The HA nanoparticles were infused in this solution by 1, 2, and 3 wt% and is stirred in a think mixer under vacuum for 7 mins for uniform dispersion of nanoparticles in the solution. The solution mixture is injected into the spinneret of force spinning apparatus. The PCL/HA fibers were collected at rotational aped 7000 rpm with a spin time of 10mins. The thermo-mechanical properties of the fibers were analyzed using tensile test, DSC, and DMA analyses. The biological assessment of the fibers is done using in vitro cell studies of the scaffolds that were cut from the fibers. These scaffolds can be further used for various biomedical applications such as sutures and controlled wound healing.

Rutin nanosuspension for potential management of osteoporosis: effect of particle size reduction on oral bioavailability, in vitro and in vivo activity

2020 ◽  
Vol 25 (8) ◽  
pp. 971-988
Author(s):  
Sonia Gera ◽  
Venkatesh Pooladanda ◽  
Chandraiah Godugu ◽  
Veerabhadra Swamy Challa ◽  
Jitendra Wankar ◽  
...  
Keyword(s):  
Particle Size ◽  
Oral Bioavailability ◽  
Size Reduction ◽  
Particle Size Reduction ◽  
Effect Of Particle Size

Fatty acid bioaccessibility and structural breakdown from in vitro digestion of almond particles

2019 ◽  
Vol 10 (8) ◽  
pp. 5174-5187 ◽  
Author(s):  
Clay Swackhamer ◽  
Zhichao Zhang ◽  
Ameer Y. Taha ◽  
Gail M. Bornhorst
Keyword(s):  
Particle Size ◽  
Fatty Acid ◽  
In Vitro Digestion ◽  
Size Reduction ◽  
Gastric Digestion ◽  
Particle Size Reduction ◽  
Structural Breakdown ◽  
Peristaltic Contractions

In vitro gastric digestion of almond particles using a model with simulated peristaltic contractions resulted in particle size reduction and higher fatty acid bioaccessibility than in vitro digestion using a model that lacked peristaltic contractions.

Influence of Particle Size Reduction on Structural and Mechanical Properties of Extruded Rye Bran

2013 ◽  
Vol 7 (7) ◽  
pp. 2121-2133 ◽  
Author(s):  
Syed Ariful Alam ◽  
Jenni Järvinen ◽  
Satu Kirjoranta ◽  
Kirsi Jouppila ◽  
Kaisa Poutanen ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Particle Size ◽  
Size Reduction ◽  
Particle Size Reduction

scholarly journals Mechanical properties improvement of epoxy composites by natural hy-droxyapatite from fish scales as a fillers

2019 ◽  
Vol 10 (2) ◽  
pp. 1424-1429
Author(s):  
Majhool AA ◽  
Zainol I ◽  
Azziz SSSA ◽  
Aiza Jaafar CN
Keyword(s):  
Mechanical Properties ◽  
Particle Size ◽  
Biomedical Application ◽  
Filler Loading ◽  
Thermal Method ◽  
Fish Scales ◽  
Spray Method ◽  
Uniform Dispersion ◽  
The Impact ◽  
Natural Hydroxyapatite

This study was carried out to prepare epoxy/ natural hydroxyapatite composite for potential biomedical application. Natural hydroxyapatite (nHAp) powder was extracted from Tilapia fish scales via the thermal method. The natural hydroxyapatite was milled for 48 hours and dried by spray method. The nHAp particle size was determined using mastersizer 2000 particle size analyser and the chemical structure was confirmed using (XRD) and FTIR analysis. The particle size of nHAp was identified to be between 1 and 10 microns. Mechanical properties of epoxy/ natural hydroxyapatite were investigated by using impact and flexural test. The highest flexural strength of epoxy/nHAp composite was recorded when the nHAp filler was 10 wt% which is 77 % increment as compared to epoxy alone. The impact strength was increased up to two-fold as compared to neat epoxy. The scanning electron micrograph (SEM) and EDX analysis showed uniform dispersion of nHAp particles within the epoxy matrix for the composites with 10 wt% filler loading.

scholarly journals Síntese e caracterização do compósito zircônia/alumina para aplicação em próteses

2020 ◽  
pp. 27-37
Author(s):  
Viviane S Gomide
Keyword(s):  
Mechanical Properties ◽  
Fracture Toughness ◽  
Particle Size ◽  
Biomedical Applications ◽  
Human Fibroblasts ◽  
Life Quality ◽  
Mechanical Resistance ◽  
Alumina Composite ◽  
Selection Of

The need to repair or reconstruct bone tissues drives the development to biomedical applications by providing better life quality for people who need to resort to the replacement of tissues. For the selection of the material to be used, it is necessary to evaluate some fundamental factors such as: mechanical resistance and biocompatibility. Often, only one material does not have all the desired properties, requiring the formation of composites in order to guarantee the appropriate characteristics. The present work presents the mechanical properties of a ceramic zirconia/alumina composite developed for application as prostheses; cytotoxicity in human fibroblasts was tested in vitro. Compressive strength, microhardness, fracture toughness and particle size measurements were also performed.

Methods for particle size reduction of liposomal amphotericin B

2018 ◽  
Vol 60 (1) ◽  
pp. 42-45
Author(s):  
Tuan Quang Nguyen ◽  
Van Lam Nguyen ◽  
Thai Son Nguyen ◽  
Thi Minh Hue Pham ◽  
◽  
...  
Keyword(s):  
Particle Size ◽  
Amphotericin B ◽  
Liposomal Amphotericin ◽  
Size Reduction ◽  
Liposomal Amphotericin B ◽  
Particle Size Reduction

scholarly journals Laser Superficial Fusion of Gold Nanoparticles with PEEK Polymer for Cardiovascular Application

Materials ◽  
2021 ◽  
Vol 14 (4) ◽  
pp. 971
Author(s):  
Oktawian Bialas ◽  
Mateusz Lis ◽  
Anna Woźniak ◽  
Marcin Adamiak
Keyword(s):  
Particle Size ◽  
Laser Beam ◽  
Gold Particle ◽  
Laser Power ◽  
Biomedical Application ◽  
Parameters Optimization ◽  
Size Reduction ◽  
Particle Size Reduction ◽  
Nano Gold ◽  
Gold Particle Size

This paper analyses the possibility of obtaining surface-infused nano gold particles with the polyether ether ketone (PEEK) using picosecond laser treatment. To fuse particles into polymer, the raw surface of PEEK was sputtered with 99.99% Au and micromachined by an A-355 laser device for gold particle size reduction. Biomimetic pattern and parameters optimization were key properties of the design for biomedical application. The structures were investigated by employing surface topography in the presence of micron and sub-micron features. The energy of the laser beam stating the presence of polymer bond thermalisation with remelting due to high temperature was also taken into the account. The process was suited to avoid intensive surface modification that could compromise the mechanical properties of fragile cardiovascular devices. The initial material analysis was conducted by power–depth dependence using confocal microscopy. The evaluation of gold particle size reduction was performed with scanning electron microscopy (SEM), secondary electron (SE) and quadrant backscatter electron detector (QBSD) and energy dispersive spectroscopy (EDS) analysis. The visibility of the constituted coating was checked by a commercial grade X-ray that is commonly used in hospitals. Attempts to reduce deposited gold coating to the size of Au nanoparticles (Au NPs) and to fuse them into the groove using a laser beam have been successfully completed. The relationship between the laser power and the characteristics of the particles remaining in the laser irradiation area has been established. A significant increase in quantity was achieved using laser power with a minimum power of 15 mW. The obtained results allowed for the continuation of the pilot study for augmented research and material properties analysis.

scholarly journals Injectable non-leaching tissue-mimetic bottlebrush elastomers as an advanced platform for reconstructive surgery

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Erfan Dashtimoghadam ◽  
Farahnaz Fahimipour ◽  
Andrew N. Keith ◽  
Foad Vashahi ◽  
Pavel Popryadukhin ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Reconstructive Surgery ◽  
Biomedical Applications ◽  
The Body ◽  
Surrounding Tissue ◽  
Curing Time ◽  
Materials Used ◽  
Significant Health

AbstractCurrent materials used in biomedical devices do not match tissue’s mechanical properties and leach various chemicals into the body. These deficiencies pose significant health risks that are further exacerbated by invasive implantation procedures. Herein, we leverage the brush-like polymer architecture to design and administer minimally invasive injectable elastomers that cure in vivo into leachable-free implants with mechanical properties matching the surrounding tissue. This strategy allows tuning curing time from minutes to hours, which empowers a broad range of biomedical applications from rapid wound sealing to time-intensive reconstructive surgery. These injectable elastomers support in vitro cell proliferation, while also demonstrating in vivo implant integrity with a mild inflammatory response and minimal fibrotic encapsulation.

Sign in / Sign up

Export Citation Format

Share Document