scholarly journals Antinociceptive activity of methanolic extract of the leaves of Feronia limonia Linn

2014 ◽  
Vol 26 (1-2) ◽  
pp. 21-24
Author(s):  
Moni Rani Saha ◽  
Sheikh Zahir Raihan ◽  
Akm Shahidur Rahman
Keyword(s):  
Body Weight ◽  
Methanolic Extract ◽  
Diclofenac Sodium ◽  
Antinociceptive Activity ◽  
Tail Flick ◽  
Immersion Method ◽  
Tail Flick Test ◽  
Standard Drug ◽  
Swiss Albino Mice ◽  
Albino Mice

The antinociceptive activity of the methanolic extract of the leaves of Feronia limonia Linn. (Family Rutaceae) was investigated using acetic acid-induced writhing model and tail flick test in swiss albino mice. The extract produced about 26.01% ( p< 0.01), 39.88% ( p< 0.01) and 57.07% (p< 0.01) writhing inhibition at the dose of 100, 200 and 400 mg/kg of body weight respectively, which was comparable to the standard drug diclofenac sodium where the inhibition was about 63.58% (p< 0.01) at the dose of 25 mg/kg of body weight. All doses of extracts significantly (p<0.05) increased latency of flick tail in tail immersion method. The methanolic extract showed dose dependent antinociceptive activity in both type of test in swiss albino mice. Phytochemical investigations of the leaves extract indicate the presence of tannins, saponins, steroids, alkaloids and flavonoids. The preliminary study of the methanolic extract showed antinociceptive activity in both writhing and tail flick test in mice. http://dx.doi.org/10.3329/bjpp.v26i1-2.19962 Bangladesh J Physiol Pharmacol 2010; 26(1&2) : 21-24

scholarly journals Antinociceptive Activity of Methanol Extract of Tamarix indica

1970 ◽  
pp. 1-3
Author(s):  
MAM Sarker ◽  
Md Abdul Matin Sarker
Keyword(s):  
Body Weight ◽  
Acetic Acid ◽  
Reducing Sugars ◽  
Diclofenac Sodium ◽  
Antinociceptive Activity ◽  
Standard Drug ◽  
Swiss Albino Mice ◽  
Phytochemical Investigation ◽  
Albino Mice ◽  
Dose Dependent

The antinociceptive activity of the methanolic extract of the barks of Tamarix indica Roxb. was investigated using acetic acid-induced writhing model in swiss albino mice. The extract produced about 26.89%( P< 0.01) and 43.55% (P< 0.001) writhing inhibition at the dose of 250 and 500 mg/ kg of body weight respectively, which was comparable to the standard drug diclofenac sodium where the inhibition was about 63.64% (P< 0.001) at the dose of 25 mg/kg of body weight. At the above doses, the extract exhibited significant and dose dependent antinociceptive activity in acetic acid-induced writhing model in swiss albino mice. Phytochemical investigation of the extract indicate the presence of reducing sugars, tannins, gums, flavonoids and saponin. Key words: Tamarix indica; antinociceptive activity; acetic acid-induced writhing; phytochemical test. DOI: 10.3329/bjpp.v25i1.5736Bangladesh J Physiol Pharmacol 2009; 25(1&2) : 1-3

scholarly journals Screening of analgesic activity of Phoenix sylvestris leaves in rodents

2018 ◽  
Vol 4 (1) ◽  
pp. 22-24
Author(s):  
Pankaj Jain ◽  
◽  
Sonika Jain ◽  
Surendra Kumar Swarnkar ◽  
Swapnil Sharma ◽  
...  
Keyword(s):  
Body Weight ◽  
Acetic Acid ◽  
Analgesic Activity ◽  
Leaf Extract ◽  
Methanolic Extract ◽  
Standard Drug ◽  
Swiss Albino Mice ◽  
Tail Immersion ◽  
Albino Mice ◽  
Withdrawal Reflexes

Aim: The present study evaluated the central and peripheral analgesic activity of methanolic leaf extract of Phoenix sylvestris (PSLME) in swiss albino mice. Method: Peripheral and central analgesic activity was evaluated by tail immersion and acetic acid writhing in swiss albino mice. Dextropropoxyphene was used as a standard drug in the dose of 65mg/kg body weight in both models. PSLME was tested at 100 and 500mg/kg dose level. Results: The result revealed that methanolic extract exhibit 48% and 40.5% writhing inhibition at 500 and 100 mg/kg doses whereas ~30% tail withdrawal reflexes inhibition at 500mg/kg which was analogous to the standard drug dextropropoxyphene. Conclusion: Methanolic extract of leaves of P. sylvestris possesses both peripheral and central analgesic activity in experimental animal.

scholarly journals Analgesic and Anti-Inflammatory Activities of the Methanolic Stem Bark Extract ofNyctanthes arbor-tristisLinn.

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Bibhuti Bhusan Kakoti ◽  
Paresh Pradhan ◽  
Sudarshana Borah ◽  
Kabita Mahato ◽  
Mritunjay Kumar
Keyword(s):  
Body Weight ◽  
Diclofenac Sodium ◽  
Stem Bark ◽  
Bark Extract ◽  
Albino Rats ◽  
Tail Flick ◽  
Immersion Method ◽  
Standard Drug ◽  
Stem Bark Extract ◽  
Anti Inflammatory

Stem bark ofNyctanthes arbor-tristisLinn. was extracted in methanol to evaluate their analgesic and anti-inflammatory activities. The analgesic activity was determined on Wistar albino rats by hot plate method, tail flick assay, and tail immersion method using Morphine sulphate as standard drug at a dose of 5 mg/kg of body weight and the results were expressed as mean increase in latency after drug administration ± SEM. The anti-inflammatory activity was assessed by Carrageenan-induced rat paw oedema using diclofenac sodium as standard drug at a dose of 100 mg/kg of body weight and expressed in terms of mean increase in paw volume ± SEM. Stem bark extract was given at a dose of 250 mg/kg and 500 mg/kg of body weight. Both standard drugs and extract were administered orally to the animals. Control received distilled water orally. Results showed thatNyctanthes arbor-tristisLinn. had potent analgesic and anti-inflammatory activities.

scholarly journals Antinociceptive effect of methanolic extract of Murraya koenigii leaves in swiss albino mice

2020 ◽  
Vol 9 (3) ◽  
pp. 426
Author(s):  
Arunkumar J. ◽  
Vijayalakshmi M. ◽  
Yesodha S. ◽  
YousufAli A. S. ◽  
Parthiban R.
Keyword(s):  
Reaction Time ◽  
Analgesic Activity ◽  
Methanolic Extract ◽  
Control Group ◽  
Murraya Koenigii ◽  
Hot Plate ◽  
Standard Drug ◽  
Swiss Albino Mice ◽  
Albino Mice ◽  
Tail Clip

Background: The objective of the study was to evaluate anti-nociceptive effect of methanolic extract of Murraya koenigii leaves on thermal and mechanical pain in swiss albino mice.Methods: Thirty adult male swiss albino mice weighing 25-30 grams were selected and allocated in to five groups. Each group consists of six animals. The control group received vehicle (10 ml/kg), standard group received morphine (10 mg/kg) and test groups received dried methanolic extract of Murraya koenigii leaves (100 mg/kg, 200 mg/kg, 400 mg/kg per oral respectively) 1 hour before placing the animal over the hot plate at temperature of 55⁰C . A cut off period of 10 sec was observed to avoid damage of the paw. The response in the form of withdrawal of paws or licking of the paws. The delay in the reaction time denotes analgesic activity. The latency was recorded before and after 15, 30, 60, 120 minutes administration of drug. After washout period of 1 month the same group of animals were utilized to evaluate the analgesic effect by tail clip method for better comparison.Results: All the doses of Murraya koenigii leaves significantly delayed reaction time in hot plate method and tail clip method. The results were comparable to that produced by standard drug morphine.Conclusions: Murraya koenigii leaves has analgesic activity which was comparable to morphine.

scholarly journals ACUTE TOXICITY STUDIES AND EVALUATION OF ANALGESIC PROPERTY OF TECTONA GRANDIS METHANOLIC SEED EXTRACT IN SWISS ALBINO MICE

2019 ◽  
pp. 106-108
Author(s):  
JHANSI RANI G ◽  
LAKSHMI BHAVANI N
Keyword(s):  
Tectona Grandis ◽  
Immersion Test ◽  
Seed Extract ◽  
Tail Flick ◽  
Tail Flick Test ◽  
Swiss Albino Mice ◽  
Analgesic Property ◽  
Plant Parts ◽  
Wide Range ◽  
Albino Mice

Objective: Tectona grandis which is well known as teak possesses a wide range of applications in Indian and African folklore medicine. All the plant parts are having diverse bioactivities, especially the seeds, having hair growth-promoting activity, anti-inflammatory, and antimicrobial activity. Xanthones, proteins, amino acids, and fatty acids have been isolated from the oil and seeds of T. grandis. Methods: The present study was to explore the antinociceptive properties of methanolic seed extract of T. grandis. Dried seeds of the plant were defatted with non-polar solvents such as petroleum ether and extracted with methanol. Acetic acid-induced writhing test, tail flick test, and tail immersion test were employed for the extract using Swiss albino mice. Results: From the results, it is clear that the methanolic teak seed extract is safe at 1000 mg/kg and having a potent analgesic property (at a dose of 200–250 mg/kg body weight) by inhibiting pain response time. Conclusion: It can be concluded that the methanolic seed extract of T. grandis is analgesic in nature. It is considered as safe and the activity may be due to the presence of various bioactive chemicals such as flavonoids, xanthones, and glycosides.

scholarly journals ANALGESIC AND ANTI-CONVULSANT ACTIVITIES OF CYPERUS ROTUNDUS (LINN.)

2019 ◽  
Vol 1 (1) ◽  
pp. 10-13
Author(s):  
Suneet Kumar Rawal
Keyword(s):  
Body Weight ◽  
Anticonvulsant Activity ◽  
Methanolic Extract ◽  
Diclofenac Sodium ◽  
Cyperus Rotundus ◽  
Tail Flick ◽  
Maximal Electroshock ◽  
Tropical Regions ◽  
Methanolic Extracts ◽  
Soxhlet Apparatus

Introduction: Cyperus rotundus Linn. (Family- Cyperaceae) is an important medicinal plant found in upland and paddy fields in temperate to tropical regions throughout India, China, Pakistan, Europe, France, Sri Lanka, Switzerland and Austria. The scented rhizomes of Cyperus rotundus posses tremendous pharmacological potentials. Objective: To determine analgesic and anticonvulsant activities of the methanolic extracts of rhizomes of Cyperus rotendus. Materials and Methods: Rhizomes were extracted in methanol using Soxhlet apparatus and concentrated under vaccume. The Analgesic activity was performed on rats by Tail flick method using Analgesiometer. Anticonvulsant activity was carried out using Maximal Electroshock (MES) method in mice. Results: The methanolic extract (500 and 1000mg/kg body weight.) showed significant analgesic effect (p<0.01) when compared with control and standard Diclofenac Sodium. Cyperus rotundus at 100mg/kg and 150 mg/kg body weight, i.p. produced a significant (p<0.01) effects in the extensor phase, 5.6530.187** sec, 3.18 sec respectively and recovery 20.1330.620** and 9.890.135** (P<0.001) sec, compared to control 8.2710.142 and 198.463.465 sec, respectively. The Metanolic extract of Cyperus rotundus at doses 100mg/kg and 150mg/kg didn’t abolish the hind limb extension, but decreased it by nearly half the extension time in control. Conclusion: The present study revealed that methanolic extract of rhizomes of Cyperus rotundus possess significant analgesic and anticonvulsant activity and can be employed to develop future medicines for treatment of diseases like Epilepsy.

scholarly journals TO STUDY THE ANTINOCICEPTIVE EFFECT OF CINNARIZINE ALONE AND IN COMBINATION WITH TRAMADOL IN ALBINO RATS BY TAIL FLICK METHOD

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Rajiv Kumar ◽  
Aasim Shakeel ◽  
Manju Gari ◽  
Uma Shankar Prasad Keshri
Keyword(s):  
Reaction Time ◽  
Opioid Analgesic ◽  
Antinociceptive Effect ◽  
Radiant Heat ◽  
Antinociceptive Activity ◽  
Albino Rats ◽  
Tail Flick ◽  
Withdrawal Time ◽  
Tail Flick Test ◽  
Standard Drug

Background: Pain is the most common reason for physician consultation in most countries. It is a major symptom in many medical conditions, and can interfere with a person's quality of life and general functioning. Acute pain is usually managed with medications such as analgesics and anesthetics. Cinnarizine is a piperazine derivative and Tramadol is an opioid analgesic. Cinnarizine is also a calcium channel blocker. So, in the present study an attempt has been made to access the antinociceptive activity of Cinnarizine alone & in combination with standard drug Tramadol with the hope of pharmacological synergism and better relief from pain. Material & Methods: 4 rats in 6 groups were weighed & colour coded. Basal reaction time to radiant heat was taken. Tail withdrawal time was recorded as the end point. Reaction time was taken at 0, 30 & 60 minutes on day 0, 7, 14, 21 & 28. Result: All observation were done by the ANOVA followed by post hoc Tukey’s. It is seen that Cinnarizine alone (in both doses) has antinociceptive activity but that is not statistically significant. But when it is given along with Tramadol it potentiates antinociceptive activity of Tramadol which is statistically significant. Conclusion: The result of this study conclude that Cinnarizine alone has antinociceptive activity in both doses (i.e 2.5mg/kg & 5mg/kg) but it is statistically not significant. Tramadol shows higher antinociception with Cinnarizine in dose of 5mg/kg than with 2.5mg/kg. Keywords: Antinociception, Cinnarizine, Tramadol, Tail flick test, Albino rats

scholarly journals A study of antinociceptive effect of venlafaxine in albino mice

2016 ◽  
Vol 6 (1) ◽  
pp. 184
Author(s):  
Santhosh Ramakrishna ◽  
Shivashankaramurthy K. Gurusiddappa ◽  
Kiran L. Jambulingappa
Keyword(s):  
Normal Saline ◽  
Antinociceptive Effect ◽  
Antinociceptive Activity ◽  
Tail Flick ◽  
Hot Plate Test ◽  
Tail Flick Test ◽  
Group 4 ◽  
Group 3 ◽  
Albino Mice ◽  
Group 2

Background: Serotonin and norepinephrine are important neurotransmitters involved in pain inhibition in descending pain inhibitory tracts. Venlafaxine being an antidepressant exerts its mechanism mainly by inhibiting reuptake of serotonin and norepinephrine like Tramadol. The objectives were to study the antinociceptive activity of Venlafaxine and its comparison with Pethidine.Methods: A total of 32 Swiss albino mice were divided into 4 groups with 8 animals in each group. Group 1 received normal saline as control in dose of 5ml/kg i.p, Group 2 received Pethidine as standard in dose of 30mg/kg s.c, Group 3 received Venlafaxine as in dose of 10mg/kg i.p and Group 4 received Venlafaxine in dose of 22.5mg/kg. Tail flick test and hot plate test were used for evaluating antinociceptive activity. All animals were subjected to the above mentioned tests before and 30 minutes after the administration of the drugs. Results were subjected to suitable statistical analysis.Results: The results from the above mentioned tests showed that Venlafaxine in dose of 10mg/kg showed significant antinociceptive activity as compared to normal saline (p <0.05) but was not comparable to Pethidine (p >0.05). Venlafaxine in dose of 22.5mg/kg showed significant antinociceptive activity as compared to normal saline (p <0.05) and activity was comparable to Pethidine.Conclusions: Venlafaxine in both the doses showed significant antinociceptive activity in acute models of pain in animals.

scholarly journals Analgesic and Antipyretic Activities of Methanol Extract and Its Fraction from the Root ofSchoenoplectus grossus

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Nirmal Kumar Subedi ◽  
S. M. Abdur Rahman ◽  
Mohammad Ahsanul Akbar
Keyword(s):  
Acetic Acid ◽  
Petroleum Ether ◽  
Methanol Extract ◽  
Diclofenac Sodium ◽  
Radiant Heat ◽  
Tail Flick ◽  
Dependent Manner ◽  
Tail Flick Test ◽  
Standard Drug ◽  
Pain Models

The study aims to evaluate analgesic and antipyretic activities of the methanol extract and its different fractions from root ofSchoenoplectus grossususing acetic acid induced writhing and radiant heat tail flick method of pain models in mice and yeast induced pyrexia in rats at the doses of 400 and 200 mg/kg. In acetic acid writhing test, the methanol extract, petroleum ether, and carbon tetrachloride fractions produced significant (P<0.001andP<0.05) inhibition of writhing responses in dose dependent manner. The methanol extract at 400 and 200 mg/kg being more protective with 54% and 45.45% of inhibition compared to diclofenac sodium of 56% followed by petroleum ether fractions of 49.69% and 39.39% at the same doses. The extracts did not produce any significant antinociceptive activity in tail flick test except standard morphine. When studied on yeast induced pyrexia, methanol and petroleum ether fractions significantly lowered the rectal temperature time dependently in a manner similar to standard drug paracetamol and distinctly more significant (P<0.001) after second hour. These findings suggest that the root extracts ofS. grossuspossess significant peripherally acting analgesic potential and antipyretic property. The phytochemical screening showed the presence of flavonoids, alkaloids, and tannins.

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