scholarly journals ANALGESIC AND ANTI-CONVULSANT ACTIVITIES OF CYPERUS ROTUNDUS (LINN.)

2019 ◽  
Vol 1 (1) ◽  
pp. 10-13
Author(s):  
Suneet Kumar Rawal
Keyword(s):  
Body Weight ◽  
Anticonvulsant Activity ◽  
Methanolic Extract ◽  
Diclofenac Sodium ◽  
Cyperus Rotundus ◽  
Tail Flick ◽  
Maximal Electroshock ◽  
Tropical Regions ◽  
Methanolic Extracts ◽  
Soxhlet Apparatus

Introduction: Cyperus rotundus Linn. (Family- Cyperaceae) is an important medicinal plant found in upland and paddy fields in temperate to tropical regions throughout India, China, Pakistan, Europe, France, Sri Lanka, Switzerland and Austria. The scented rhizomes of Cyperus rotundus posses tremendous pharmacological potentials. Objective: To determine analgesic and anticonvulsant activities of the methanolic extracts of rhizomes of Cyperus rotendus. Materials and Methods: Rhizomes were extracted in methanol using Soxhlet apparatus and concentrated under vaccume. The Analgesic activity was performed on rats by Tail flick method using Analgesiometer. Anticonvulsant activity was carried out using Maximal Electroshock (MES) method in mice. Results: The methanolic extract (500 and 1000mg/kg body weight.) showed significant analgesic effect (p<0.01) when compared with control and standard Diclofenac Sodium. Cyperus rotundus at 100mg/kg and 150 mg/kg body weight, i.p. produced a significant (p<0.01) effects in the extensor phase, 5.6530.187** sec, 3.18 sec respectively and recovery 20.1330.620** and 9.890.135** (P<0.001) sec, compared to control 8.2710.142 and 198.463.465 sec, respectively. The Metanolic extract of Cyperus rotundus at doses 100mg/kg and 150mg/kg didn’t abolish the hind limb extension, but decreased it by nearly half the extension time in control. Conclusion: The present study revealed that methanolic extract of rhizomes of Cyperus rotundus possess significant analgesic and anticonvulsant activity and can be employed to develop future medicines for treatment of diseases like Epilepsy.

Analgesic Activity of Tragia involucrata

1970 ◽  
Vol 4 (1) ◽  
Author(s):  
M Alimuzzaman ◽  
Muniruddin Ahmed
Keyword(s):  
Body Weight ◽  
Acetic Acid ◽  
Oral Dose ◽  
Ethyl Acetate ◽  
Analgesic Activity ◽  
Methanolic Extract ◽  
Radiant Heat ◽  
Tail Flick ◽  
Methanolic Extracts ◽  
Whole Plant

The work was carried out to investigate the analgesic activity of the whole plant of Tragia involucrata Linn. The dried whole plant was successively extracted with petroleum ether, ethyl acetate and methanol. Experiments were carried out with these extracts for their peripheral and central antinociceptive potentials on acetic acid induced writhing and radiant heat tail-flick models in mice, respectively. Both the ethyl acetate and methanolic extracts showed significant writhing inhibition while the elongation of tail-flick time was most prominent with methanolic extract at an oral dose of 500 mg/kg body weight. Key words: Tragia involucrata, Analgesic activity, Acetic acid induced writhing, Radiant heat tail-flick. Dhaka Univ. J. Pharm. Sci. Vol.4(1) 2005 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

scholarly journals Antinociceptive activity of methanolic extract of the leaves of Feronia limonia Linn

2014 ◽  
Vol 26 (1-2) ◽  
pp. 21-24
Author(s):  
Moni Rani Saha ◽  
Sheikh Zahir Raihan ◽  
Akm Shahidur Rahman
Keyword(s):  
Body Weight ◽  
Methanolic Extract ◽  
Diclofenac Sodium ◽  
Antinociceptive Activity ◽  
Tail Flick ◽  
Immersion Method ◽  
Tail Flick Test ◽  
Standard Drug ◽  
Swiss Albino Mice ◽  
Albino Mice

The antinociceptive activity of the methanolic extract of the leaves of Feronia limonia Linn. (Family Rutaceae) was investigated using acetic acid-induced writhing model and tail flick test in swiss albino mice. The extract produced about 26.01% ( p< 0.01), 39.88% ( p< 0.01) and 57.07% (p< 0.01) writhing inhibition at the dose of 100, 200 and 400 mg/kg of body weight respectively, which was comparable to the standard drug diclofenac sodium where the inhibition was about 63.58% (p< 0.01) at the dose of 25 mg/kg of body weight. All doses of extracts significantly (p<0.05) increased latency of flick tail in tail immersion method. The methanolic extract showed dose dependent antinociceptive activity in both type of test in swiss albino mice. Phytochemical investigations of the leaves extract indicate the presence of tannins, saponins, steroids, alkaloids and flavonoids. The preliminary study of the methanolic extract showed antinociceptive activity in both writhing and tail flick test in mice. http://dx.doi.org/10.3329/bjpp.v26i1-2.19962 Bangladesh J Physiol Pharmacol 2010; 26(1&2) : 21-24

scholarly journals Anti-arthritic Evaluation of Different Extracts of Boerhaavia diffusa Linn. in FCA Induced Arthritis In Rats

2018 ◽  
Vol 8 (5-s) ◽  
pp. 388-393 ◽  
Author(s):  
Deepika Parmar ◽  
Neetesh Kumar Jain ◽  
Vivek Tomar
Keyword(s):  
Body Weight ◽  
Phenolic Compounds ◽  
Methanolic Extract ◽  
Hematological Parameters ◽  
Extraction Methods ◽  
The Body ◽  
Haematological Parameters ◽  
Phytochemical Study ◽  
Methanolic Extracts ◽  
Boerhaavia Diffusa

The main aim of study is to evaluate the anti-arthritic effect of different extracts of Boerhaavia diffusa in arthritic rats. Different extracts were prepared by successive solvent extraction methods by using the various polar and non polar solvents and their % yields were calculated. Arthritis was induced by FCA induced arthritis model in rats and paw volume was measured on different days. Body weights of all animals were also measured simultaneously and at the end of experiment some haematological parameters were measured. On preliminary phytochemical studies extracts showed the presence of alkaloids, fatty acids, terpenoids, flavonoids and phenolic compounds. Among all extracts, methanolic extract significantly decreased the paw volume in all treated groups. Methanolic extracts also restored the body weight significantly. The results of our study revealed that all the extracts treated group’s causes significant alterations in the hematological parameters and maximal effects were observed at 400 mg/kg. Since methanolic extract showed best activity in arthritic model and its phytochemical study showed presence of flavonoids and phenolic compounds, so it may be possible that anti-arthritic activity of root extracts may be due to presence flavonoids.  Keywords: Arthritis, FCA induced arthritis, Boerhaavia diffusa, haematological parameters, and Body weight

Phytochemical and pharmacological evaluation of Tragia cannabina for anti-inflammatory activity

2012 ◽  
Vol 1 (8) ◽  
pp. 213 ◽  
Author(s):  
Raju Venkategowda Hosahally ◽  
Ganapaty Seru ◽  
Prasanna Shankarrao Sutar ◽  
Vijaya Gopalachar Joshi ◽  
Kishori Prasanna Sutar ◽  
...  
Keyword(s):  
Body Weight ◽  
Methanolic Extract ◽  
Pharmaceutical Journal ◽  
Inflammatory Activity ◽  
Reference Standard ◽  
Paw Edema ◽  
Pharmacological Evaluation ◽  
Whole Plant ◽  
Soxhlet Apparatus ◽  
Anti Inflammatory

<p>The present study investigates the anti-inflammatory activity of methanolic and chloroform extracts of<strong><em> </em></strong><em>Tragia cannabina</em>. The whole plant of <em>Tragia cannabina</em> was extracted with methanol and chloroform by using soxhlet apparatus. The effect of both extracts of <em>Tragia cannabina</em> was studied on carrageenan induced paw edema. The methanolic extract decreased the edema induced in hind paw. The percentage inhibition of paw edema was maximum with methanolic and chloroform extracts of <em>Tragia cannabina</em> at 300mg/kg body weight and has showed significant anti-inflammatory activity. It has been concluded that both the methanolic and chloroform extracts of <em>Tragia cannabina</em> showed significant anti-inflammatory activity comparable to that of reference standard Ibuprofen.</p><p>DOI: <a href="http://dx.doi.org/10.3329/icpj.v1i8.10857">http://dx.doi.org/10.3329/icpj.v1i8.10857</a></p> <p>International Current Pharmaceutical Journal 2012, 1(8): 213-216</p><p> </p>

scholarly journals Evaluation of Aphrodisiac Activity of Buchanania axillaris (Linn.) Leaves

2017 ◽  
Vol 9 (2) ◽  
Author(s):  
Neeruganti Dora Babu ◽  
Battu Ganga Rao ◽  
Devarakonda Ramadevi
Keyword(s):  
Body Weight ◽  
Adverse Effects ◽  
Methanolic Extract ◽  
Mating Behaviour ◽  
Male Rats ◽  
Albino Rats ◽  
Normal Male ◽  
Methanolic Extracts ◽  
Intromission Frequency ◽  
Mating Performance

The study was aimed at investigate the effect of methanolic extract of Buchanania axillaris linn. (Anacardiaceae) on general mating behaviour, libido, and adverse effects on sexually normal male albino rats. Methanolic extract was administered orally at the dose of 100, 200, and 400 mg / kg, to different groups of male rats (n = 8) once a day for 14 days. All the doses resulted in significant increase in mount frequency, intromission frequency and anogenital sniffing when compared to normal. The methanolic extract of Buchanania axillaris leaves at higher concentration (400 mg/kg body weight) showed significant aphrodisiac activity on male Wister albino rats as evidenced by an increase in number of mounts and mating performance. Thus, in experimental rats, the results of the present study suggest that the methanolic extracts of Buchanania axillaris exert significant aphrodisiac activity

scholarly journals Histological and body weight effects of Datura innoxia seeds and leaves extracts in rats

2021 ◽  
Vol 1 (1) ◽  
pp. 018-027
Author(s):  
Ali A. Eltayeib ◽  
Siddige A. N. T. Matter
Keyword(s):  
Body Weight ◽  
Oral Administration ◽  
Toxic Effects ◽  
Gas Chromatography Mass Spectrometry ◽  
Control Group ◽  
Datura Innoxia ◽  
Weight Changes ◽  
Methanolic Extracts ◽  
Soxhlet Apparatus ◽  
Histological Results

The study aim to determine the chemical compounds in aqueous and methanolic extracts of Datura innoxia seeds and leaves and to evaluate their toxic effects on experimental rats. Seeds and leaves were collected from El-Obied, North Kordofan State, Sudan, in October, 2016. The aqueous and methanol extracts were carried out by using maceration method and soxhlet apparatus respectively. Sixty five male Albino Wistar rats, three months old and with an average body weight ranged 110-120 g, were randomly divided into thirteen Groups, consisting of five rats in each Group. Group 1 served as control and fed with normal rats’ food and water for thirty days. Groups 2, 6 and 10 administered aqueous seeds extract, Groups 4, 8 and 12 received methanol seeds extract, Groups 3, 7 and 11 received aqueous leaves extracts, Groups 5, 9 and 13 received methanol leaves extract, all the Groups received the same type of extract were administered 40, 60 and 80 mg/kg body weight respectively. The extracts administered to the rats intra gastrically using cathodal tube daily for thirty days. The effects of oral administration of leaves and seeds extracts to 60 healthy rats over 30 days were evaluated by histological studies and body weight changes. The analysis by gas chromatography-mass spectrometry (GC-MS) of aqueous and methanolic extracts revealed the presence of alkaloids (Scopolamine, atropine and Hyoscyamine), fatty acids, esters, amides, amino acids, ketones, coummarins, terpinoids, phenols, alcohols and hydrocarbons compounds. The histological results showed that administration of extracts caused pathologic changes in the organs studied. The treated Groups had lower (p ≤ 0.05) body weight gains than control Group. The study concluded that the toxicity of seeds and leaves (methanolic and aqueous) extracts are nearly have the same toxic effects on rats due to their same active ingredients (alkaloids) and the oral administration of the extracts was found to be safe up to 40 mg/kg.

Report on Antidiabetic, Diuretic and Analgesic Activities of Methanolic Extract of Leaves of Strychnos colubrina L.an Endangered Medicinal Plant

2019 ◽  
Vol 10 (01) ◽  
Author(s):  
Indira Priyadarsini A. ◽  
S K M Basha2 ◽  
Chakrapani I S ◽  
Nagalakshmi Devamma M
Keyword(s):  
Blood Glucose ◽  
Medicinal Plant ◽  
Analgesic Activity ◽  
Methanolic Extract ◽  
Tail Flick ◽  
Methanolic Extracts ◽  
Endangered Medicinal Plant ◽  
Sugar Levels ◽  
Analgesic Activities ◽  
Dose Dependent

Strychnos colubrina L. belongs to family Loganiaceae was known as snake wood tree.The methanolic extracts from Strychnos colubrina L. leave collected from different provinces in Penchalakona of Nellore district were prepared by decoction and maceration with methanol and evaluated for their antidiabetic, diuretic and analgesic activities. Methanolic extracts from Strychnos colubrina L. leaves (SCM) were evaluated for anti diabetic effect in Streptozocin (STZ) induced diabetes in rats. The blood sugar levels were analysed as indices of diabetes. 200 mg/kg b.w. of the extract showed a greater reduction in blood glucose level which was comparable to glibenclamide. To find out diuretic efficacy, SCM of leaves were administered to experimental rats orally at doses of 100 and 200 mg/kg and compared with Furosemide (20 mg/kg,o.p) as the standard. The rats treated with SCM of leaves in a dose of 200 mg/kg shown near similar urine output and electrolytes excretion when compared to the respective control. The analgesic activity of SCM of leaves is estimated using tail flick in mice. Results demonstrated that SCM of leaves exhibited a potent dose-dependent analgesic activity in all tested models for analgesia. This report could be used for medicinal and pharmaceutical exploration in the future.

scholarly journals Analgesic and Anti-Inflammatory Activities of the Methanolic Stem Bark Extract ofNyctanthes arbor-tristisLinn.

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Bibhuti Bhusan Kakoti ◽  
Paresh Pradhan ◽  
Sudarshana Borah ◽  
Kabita Mahato ◽  
Mritunjay Kumar
Keyword(s):  
Body Weight ◽  
Diclofenac Sodium ◽  
Stem Bark ◽  
Bark Extract ◽  
Albino Rats ◽  
Tail Flick ◽  
Immersion Method ◽  
Standard Drug ◽  
Stem Bark Extract ◽  
Anti Inflammatory

Stem bark ofNyctanthes arbor-tristisLinn. was extracted in methanol to evaluate their analgesic and anti-inflammatory activities. The analgesic activity was determined on Wistar albino rats by hot plate method, tail flick assay, and tail immersion method using Morphine sulphate as standard drug at a dose of 5 mg/kg of body weight and the results were expressed as mean increase in latency after drug administration ± SEM. The anti-inflammatory activity was assessed by Carrageenan-induced rat paw oedema using diclofenac sodium as standard drug at a dose of 100 mg/kg of body weight and expressed in terms of mean increase in paw volume ± SEM. Stem bark extract was given at a dose of 250 mg/kg and 500 mg/kg of body weight. Both standard drugs and extract were administered orally to the animals. Control received distilled water orally. Results showed thatNyctanthes arbor-tristisLinn. had potent analgesic and anti-inflammatory activities.

scholarly journals Effect of Methanolic Extract of Vernonia amygdalina Leaves on Glycemic and Lipidaemic Indexes of Wistar Rats

2019 ◽  
pp. 1-14
Author(s):  
Emmanuel O. Ogbuagu ◽  
Augustine I. Airaodion ◽  
Uloaku Ogbuagu ◽  
Edith O. Airaodion
Keyword(s):  
Body Weight ◽  
Total Cholesterol ◽  
Blood Sugar ◽  
Wistar Rats ◽  
Ldl Cholesterol ◽  
Methanolic Extract ◽  
Fasting Blood Sugar ◽  
Control Group ◽  
Vernonia Amygdalina ◽  
Soxhlet Apparatus

Aim: This study sought to investigate the effect of methanolic extract of Vernonia amygdalina leaves on glycemic and lipidaemic indexes of Wistar rats. Methods: Fresh plants of V. amygdalina were harvested from the Institute of Agricultural Research and Training, Ibadan. The leaves were dried and extracted using soxhlet apparatus and methanol was used as the solvent. The solvent was recovered in a rotary evaporator at 35°C with a yield of 2.24 g which represents a percentage yield of 8.96%. Ten adult male Wistar rats with body weight between 100 and 120 g were used for this study. They were randomly divided into two groups of five rats each. Animals in group 1 were administered normal saline while those in group 2 were administered V. amygdalina extract. The animals were exposed to the extract and saline solution at a dose of 3 mL per 100 g body weight 12 hourly via oral route of administration. After fourteen days of administration, the animals were fasted overnight and anaesthetized using diethyl ether. Blood samples were collected by cardiac puncture. Fasting blood sugar and lipid profile were determined using standard methods. Results: V. amygdalina  leaves was observed to significantly lower fasting blood sugar, total cholesterol, triglyceride and VLDL-cholesterol but had no significant effect on the concentrations of HDL-cholesterol, LDL-cholesterol and HDL/LDL-cholesterol ratio when compared to those of the control group at p<0.05. Conclusion: The lowering effect of V. amygdalina leaves on fasting blood sugar indicated that it has the propensity to be antidiabetic. Its effect on total cholesterol and triglyceride showed that V. amygdalina leaves could be useful in the control of obesity and hypertension.

scholarly journals ANTI-DIABETIC ACTIVITY

2018 ◽  
Vol 25 (04) ◽  
pp. 502-508
Author(s):  
Muhammad Saleh Faisal ◽  
Usman Nawaz ◽  
Abdul Matin Khan
Keyword(s):  
Body Weight ◽  
Blood Level ◽  
Aqueous Extract ◽  
Study Design ◽  
Methanolic Extract ◽  
P Value ◽  
Aqueous Extracts ◽  
Methanolic Extracts ◽  
Diabetic Rabbits

Objectives: The study was designed to evaluate the hypoglycaemic effects ofCassia sophera’s powdered seeds and its different fractions. Study Design: An experimentalstudy. Setting: Faculty of Veterinary, University of Agriculture, Faisalabad, Pakistan. Period:November 2014 to February 2017. Methodology: Initial experiments were designed to find outthe hypoglycaemic effects of Cassia sophera powdered seeds in increasing doses i.e. 2, 3, 4g/kg body weight at 0, 2, 4, 8, 12 and 24 hours intervals. The effects of methanolic and aqueousextracts equivalent to 4g/kg body weight of Cassia sophera seeds were also studied in bothnormal and diabetic rabbits. Results: At 4 hours interval, 2grams/kg body weight of grindedseeds results no significant decrease in mean blood level of glucose. At 8 and 12 hours intervals,a significant decrease while at 4, 8 and 12 hours a highly significant reduction were observedwith both 3g/kg and 4g/kg body weight. With methanolic and aqueous extracts equivalent to4g/kg body weight, normal rabbits showed significant decrease i.e. with P value less than 0.05at 8 and 12 hours. In addition, the methanolic extract of Cassia sophera seeds produced betterhypoglycaemia as compared to aqueous extract. The effects of these extracts were comparableto Acetohexamide. The same study was also done in alloxan-induced diabetic rabbits and it wasnoticed that Cassia sophera powdered seeds caused significant decrease in blood glucoselevel at increasing doses 2, 3 and 4gram/kg of body weight and highly significant reduction(with P value less than 0.001) in blood level of glucose was noticed with methanolic extracts at4 hours interval which continued upto 8 hours while treatment with aqueous extract with Cassiasophera seeds showed highly significant decrease at 12 hours. Conclusion: It is concludedthat powdered seeds of Cassia sophera constitutes more than one type of hypoglycaemicelements, which have exerted a significant and consistent hypoglycaemic effects in normal andalloxan treated diabetic rabbits.

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