Hematological and Biochemical Parameter Changes Related to Methotrexate Therapy

2014 ◽  
Vol 40 (3) ◽  
pp. 40-43
Author(s):  
Samaresh Chandra Hazra ◽  
Agha Masood Choudhury ◽  
Lubana Khondker ◽  
Md Shirajul Islam Khan ◽  
Nafiza Ahmed
Keyword(s):  
Lichen Planus ◽  
Biochemical Parameter ◽  
Pulse Therapy ◽  
Control Group ◽  
Case Group ◽  
Increasing Trend ◽  
Function Test ◽  
Group A ◽  
Group B ◽  
Medical University

A clinical trial was conducted to evaluate the hematological and biochemical changes related to methotrexate in the treatment of lichen planus. A total of forty four patients with lichen planus, attendign at the department of Dermatology and Venereology, Bangabandhu Seikha Mujib Medical University (BSMMU), Dhaka, Bangladesh durign the period of january 2009 to December 2010 were enrolled in this study purposively. Of them, 23 patients in group-A (case group) and 21 patients in group-B (control group) were selected randomly. The case group was treated with oral methotrexate and the control group was trated with betamethasone oral mini- pulse therapy. A decreasing trend of hemoglobin level and platet count was observed between two groups. An increasing trend of SGPT was observed among the case adn control up to 6th week of observation and then it decreased. This study also revealed abnormlity in platelet count and liver function test in both the groups. But the overall effects were less in cases than control. So it cand be concluded from this study that methtrexate can be used as an alternative saf drug therapy for the treatmetn of lichen planus. DOI: http://dx.doi.org/10.3329/bmj.v40i3.18674 Bangladesh Medical Journal 2011 Vol.40(3):40-43

scholarly journals Low Iron Level is related to Telogen Effluvium in Women

2013 ◽  
Vol 21 (2) ◽  
pp. 84-89 ◽  
Author(s):  
Md Manjurul Karim ◽  
Md Abdul Wahab ◽  
Lubna Khondoker ◽  
Md Shirajul Islam Khan
Keyword(s):  
Hair Loss ◽  
Control Group ◽  
Case Group ◽  
Iron Level ◽  
History Of ◽  
Group A ◽  
The Mean ◽  
Group B ◽  
Medical University ◽  
Control Study

A case-control study conducted in the Department of Dermatology and Venereology of Bangabandhu Sheikh Mujib Medical University, Dhaka from July 2008- December 2010. A total 60 female patients of telogen effluvium attending in outpatient department (OPD) were enrolled in the study with 30 having hair loss considered as case (Group-A) and another 30 females had no history of hair loss were considered as control (Group-B). The study included 60 patients and the mean age were 25.4±7 years ranging from 18 to 42 years in group A and 24.8±5.6 years ranging from 17 to 36 years in group B. Maximum number was found in the age group of 21- 30 years in both groups and nearly three fourth (73.4%) patients were unmarried in group A and 18(60.0%) in group B. Most of the patients were student in both groups, which were 21(70.0%) and 17(56.7%) in group A and group B respectively and majority of the the patients were HSC level in both groups, 15(50.0%) and 14(46.7%) in Group A and Group B respectively. Most of the patients came from middle class, which were 20(66.7%) and 16(53.3%) in group A and group B respectively. The mean serum ferritin were 18.8±8.1 g/L ranging from 4.5 to 36.54 g/L and 36.6±9.9 mg/L ranging from 18.46 to 56.3 mg/ L in group A and group B respectively. The mean Hb level was 11.5±1.4 gm/dl ranging from 8.5 to 14.0 gm/dl in group A and 12.8±1.1 gm/dl ranging from 10.5 to 14.5 gm/dl in group B. The mean difference of Hb level was statistically significant (p<0.05) between two groups in unpaired t-test. It can be concluded that low iron level is associated with telogen effluvium in women. DOI: http://dx.doi.org/10.3329/bjmed.v21i2.13617 Bangladesh J Medicine 2010; 21: 84-89

scholarly journals Adverse outcome of methotrexate and mini pulse betamethasone in the treatment of lichen planus

2013 ◽  
Vol 39 (1) ◽  
pp. 22-27 ◽  
Author(s):  
SC Hazra ◽  
AM Choudhury ◽  
ATM Asaduzzaman ◽  
HK Paul
Keyword(s):  
Adverse Effects ◽  
Lichen Planus ◽  
Adverse Outcome ◽  
Adverse Outcomes ◽  
Haematological Parameter ◽  
Morning Dose ◽  
Group A ◽  
Laboratory Investigations ◽  
Group B ◽  
Medical University

The objectives of this study were to compare the adverse outcome of methotrexate and mini pulse betamethasone therapy in the treatment of lichen planus. It was a clinical trial conducted in the department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University, Dhaka, from January 2009 to December 2010. Forty four patients of lichen planus were included in the study. Patients in Group-A, (n=23) were treated with methotrexate (10 mg) single morning dose and group-B (n=21) were treated with mini pulse betamethasone (5mg) single morning dose on 2 consecutive days during the period of 12 weeks. Adverse outcomes were measured by clinical examination and laboratory investigations during follow up visits. Anemia 3(14.2%) and edema 12(57.1%) developed in group-B but none in group-A. In group-B, dyspepsia 15(71.4%), acne 10(47.6%), mooning face 8(38.1%), striae 8(38.1%) and hypertrichosis 4(19.0%) developed but none in group-A. Intermittent diarrhoea, headache, nausea and fatigue complained in both groups of patients but the percentage of complaints was higher amog group-B compared to group-A. Menstrual abnormality developed in group-B 5(71.4%) but none in group-A. Laboratory investigations showed abnormality in platelet count and SGPT in group-A but none in group-B. The adverse effects of methotrexate on haematological parameter and liver functions were mild and could be prevented by reducing the dose but the adverse effects of betamethasone were unavoidable. The overall adverse effects were less in group-A than group-B. Therefore, methotrexate can be used as an alternative safer option for the treatment of lichen planus. DOI: http://dx.doi.org/10.3329/bmrcb.v39i1.15806 Bangladesh Med Res Counc Bull 2013; 39: 22-27

scholarly journals Correlation between expression levels of IL-37, GM-CSF, and CRP in peripheral blood and atherosclerosis and plaque stability

2019 ◽  
Vol 17 ◽  
pp. 205873921984406
Author(s):  
Tao Zheng ◽  
Qingyun Zhou ◽  
Zhe Chen ◽  
Qinning Wang
Keyword(s):  
Peripheral Blood ◽  
Density Lipoprotein ◽  
Inflammatory Factors ◽  
Control Group ◽  
Case Group ◽  
Expression Levels ◽  
Gm Csf ◽  
Significant Difference ◽  
Group A ◽  
Group B

The study aimed to study the correlation between expression levels of interleukin-37 (IL-37), granulocyte macrophage colony-stimulating factor (GM-CSF), and C-reactive protein (CRP) in peripheral blood and the status of atherosclerosis (AS) and plaque stability and to confirm the clinical significance of these inflammatory factors in the pathogenesis of AS. A total of 64 AS patients (case group) were selected and divided into unstable plaque group (group A, 28 cases) and stable plaque group (group B, 36 cases) according to the color ultrasonography results of arterial vessels. At the same time, 30 healthy subjects were classified into the control group. General information of the enrolled subjects was collected, including levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), CRP, and homocysteine (Hcy). The expression levels of IL-37 and GM-CSF in the serum of peripheral blood samples collected from these subjects were measured by enzyme-linked immunosorbent assay (ELISA). There was no significant difference between the case group and the control group in the levels of TC, TG, HDL, and LDL ( P > 0.05). However, the expression level of Hcy in the case group was significantly higher than that in the control group ( P < 0.05). Compared with the control group, the expression levels of IL-37, GM-CSF, and CRP in the case group were significantly increased ( P < 0.05). In addition, compared with group B, the expression level of GM-CSF in group A was significantly increased ( P < 0.05), while no significant difference was detected between group A and group B in the expression levels of IL-37 and CRP ( P > 0.05). In conclusion, inflammatory factors IL-37, GM-CSF, CRP, and Hcy were all involved in the pathogenesis of AS, and the increased levels of GM-CSF were closely related to the progress of unstable plaques. These results may aid the early diagnosis/treatment of AS.

scholarly journals Effect of Single Dose of Pregabalin on Post Tracheal Intubation Sore Throat after General Anesthesia

2019 ◽  
Author(s):  
Hassan Mohammadipour Anvari ◽  
Maarouf Ansari Kazaj ◽  
Khosro Kolahdouzan ◽  
Nasser Ghobanian ◽  
Afsaneh Khobeydeh
Keyword(s):  
Single Dose ◽  
Tracheal Intubation ◽  
General Anesthesia ◽  
Sore Throat ◽  
Control Group ◽  
Case Group ◽  
Double Blind ◽  
Analgesic Effects ◽  
Group A ◽  
Group B

Background: Sore throat is one of the major complications of tracheal intubation after general anesthesia. Pregabalin is an analgesic, the anti neuropathic pain and analgesic effects of which have been demonstrated in various studies. This study examined the effects of single dose pregabalin one hour before tracheal intubation, to prevent sore throat after extubation. Methods: In a double-blind, randomized clinical trial, 60 patients who had undergone general and urologic surgeries at Imam Reza hospital in Tabriz, Iran, since March to July 2015 that required tracheal intubation, were included in the study. The patients were randomly divided into two groups (group A, 30 patients and group B, 30 patients). In the group A, an hour before anesthesia, one pregabalin tablet (300mg) was given to the patients. For the patients of the group B, the placebo was given. After awareness of patients, the severity of sore throat was measured and recorded by VAS scale after 2, 6 and 24 hours of the surgery. Results: Severity and incidence of sore throat after tracheal intubation were not significantly different between two groups. Meanwhile, no side effects of pregabalin were observed in the group A. Conclusion: Administration of pregabalin as a single dose of 300 mg one hour prior to anesthesia and intubation decreased the incidence and severity of sore throat in the case group than the control group, although the amount of this reduction was not statistically significant between the two groups.

scholarly journals Application Value of Coagulation Function Test in Prognosis of Patients with Cardiovascular and Cerebrovascular Diseases

2021 ◽  
Vol 9 (4) ◽  
pp. 89
Author(s):  
Jing Luo
Keyword(s):  
Cerebrovascular Diseases ◽  
Good Prognosis ◽  
Control Group ◽  
Study Group ◽  
Test Results ◽  
Coagulation Function ◽  
Significant Difference ◽  
Function Test ◽  
Group A ◽  
Group B

<p><span lang="EN-US">Objective: to explore the application value of coagulation function test in the prognosis of patients with cardiovascular and cerebrovascular diseases. Methods: from December 2018 to December 2019, 100 patients with cardiovascular and cerebrovascular diseases were randomly selected as the study group. According to the follow-up results of patients, they were divided into study group A (good prognosis, n = 64) and study group B (disability or death, n = 36) 100 subjects served as the control group. The test results of coagulation function of the two groups were analyzed retrospectively. The test results of the study group before and after treatment were compared with those of the control group, and the test results of the study group A and study group B after treatment were compared. Results: the coagulation function of the study group after treatment was significantly improved compared with that before treatment (P &lt; 0.05), and there was a significant difference between the two groups before treatment (P &lt; 0.05), and there was no difference after treatment (P &gt; 0.05); after treatment, the coagulation function of study group A and study B was significantly different (P &lt; 0.05). Conclusion: coagulation function test has a certain application value for the prognosis of patients with cardiovascular and cerebrovascular diseases, and can be used as an index to judge the patient’s condition and treatment effect, which has good application value in clinical practice.</span></p>

scholarly journals To Compare the Effect on IOP Following Primary Trabeculectomy with MMC 0.2% versus Trabeculectomy without MMC in Primary Open Angle Glaucoma

2021 ◽  
pp. 475-480
Author(s):  
Zakaullah Gopang ◽  
Shabeer Ahmed Bhutto ◽  
Naeem Akhtar Katpar ◽  
Arslan hassan Rajper ◽  
Vijay Nagdev
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Test Group ◽  
Control Group ◽  
Open Angle ◽  
Primary Procedure ◽  
Group A ◽  
Group B ◽  
Medical University

Objective: To determine the effect on intraocular pressure following primary Trabeculectomy with MMC 0.2% versus Trabeculectomy without MMC in Primary Open Angle Glaucoma. Study Design: This is a prospective and experimental Study. Setting: Study carried out at Ophthalmology Department, Shaheed Mohtarma Benazir Bhutto Medical University Larkana, from 01-03-2020 to 31-08-2020 (06 Months). Materials and Methods: The patients with primary open angle glaucoma were selected from glaucoma clinic after taking careful history and clinical examination. Patients selected for trabeculectomy into two groups. Group A includes 43 patients while Group B also includes 43 patients. Among Group A patients adjunctive MMC 0.2mg/ml for a period of 3 minutes was used during trabeculectomy as a primary procedure (Test Group) while Group B patients were operated without MMC 0.2% (Control Group). Follow-up period of 06 months was observed in both groups. The span of study was from 01-03-2020 to 31-08-2020. Results: The total of 86 Eyes of 86 patients of POAG were included in this study. Group A patients were operated for trabeculectomy with MMC while group B patients were operated for trabeculectomy without MMC. The mean IOP before surgery of Group-A was 25.39±2.42 mmHg while in Group-B it was 26.23±4.23mmHg. At day 1 of surgery in Group-A patients IOP was 13.20±3.05 mmHg while in Group-B patients IOP, was 14.09±4.04 mmHg. After 3 months in Group-A, IOP was 13.04±3.81 mmHg in Group-B IOP was 14.01±4.18 mmHg. Out of 43 patients in Group-A, 41(95.3%) were succeeded while in Group-B, 39(90.7%)were succeeded. Significant result was found for IOP reduction after 6 months of surgeryin group-A IOP was 13.48 + 2.86 mmHg while in group-B, IOP was 15.09 ±2.64 (P=0.754). Conclusion: Trabeculectomy with MMC as a primary procedure seems to be more effective than trabeculectomy without MMC.

scholarly journals Serum adiponectin and resistin in relation to insulin resistance and markers of hyperandrogenism in lean and obese women with polycystic ovary syndrome

2011 ◽  
Vol 2 (6) ◽  
pp. 235-245 ◽  
Author(s):  
Bertha Pangaribuan ◽  
Irawan Yusuf ◽  
Muchtaruddin Mansyur ◽  
Andi Wijaya
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary ◽  
Serum Levels ◽  
Serum Adiponectin ◽  
Control Group ◽  
Case Group ◽  
Obese Women ◽  
Significant Difference ◽  
Group A ◽  
Group B

Objective: The role of insulin resistance in polycystic ovary syndrome (PCOS) has been established. However the role of adiponectin and resistin in the relationship between insulin resistance as markers of obesity and PCOS has not been conclusive. This study aims to determine the influence of the serum levels of adiponectin and resistin on PCOS, and assess possible correlations with the hormonal and metabolic parameters of the syndrome and obesity. Methods: This study continued a case control study that had finished recruiting 24 subjects of reproductive women with PCOS as a case group, and 24 subjects of normal ovulatory reproductive women without hyperandrogenism as a control group. Further, only 18 subjects of the control group had a body mass index (BMI) <25 kg/m2 and were included the data analysis, whereas others were excluded. Therefore, these study data were divided into three groups. Twenty-four PCOS patients from the case group were allocated to two groups, A ( n = 14) patients had PCOS + BMI ≥25 kg/m2; B ( n = 10) patients had PCOS + BMI <25 kg/m2. Group C was the control group of 18 reproductive women without PCOS + BMI <25 kg/m2. Blood samples were collected between day 3 and 5 of a spontaneous menstrual cycle, at 07:00 to 09:00, after overnight fasting. Serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), total testosterone, prolactin, sex hormone-binding globulin (SHBG), glucose, insulin, adiponectin and resistin were measured. Results: Serum adiponectin levels were significantly decreased in group A compared with group B and group C. No significant difference existed in adiponectin between group B and group C. Homeostasis Model of Assessment—Insulin Resistance (HOMA-IR) value in group A was found to be significantly higher than group C, but no significant differences were found between group B and group C or between group A and group B. There was no significant difference in serum resistin between all groups, nevertheless the resistin-to-adiponectin (R:A) ratio was significantly decreased in group A compared with groups B and C. In a multiple regression model, BMI, testosterone and insulin resistance were the major determinants of hypoadiponectinemia. However, only BMI was the major determinant of the resistin represented by the R:A ratio. Conclusions: Serum adiponectin levels and the ratio of resistin to adiponectin levels are reduced in obese women with PCOS. These results suggest that, by reducing adiponectin serum level, hyperandrogenemia, together with nutritional status of obesity, might contribute to insulin resistance in the pathogenesis of PCOS.

scholarly journals Association of Nasal Polyposis with Bronchial Asthma

2020 ◽  
Vol 23 (1) ◽  
pp. 11-18
Author(s):  
Md Anamul Haque ◽  
Md Kamrul Hasan Tarafder ◽  
ABM Luthful Kabir ◽  
Mohammad Harun Or Rashid ◽  
Dhiman Pramanik ◽  
...  
Keyword(s):  
Bronchial Asthma ◽  
Eosinophil Count ◽  
Nasal Polyposis ◽  
The Other ◽  
Control Group ◽  
Case Group ◽  
College Hospital ◽  
Other Hand ◽  
Group A ◽  
Group B

Objective: To find out association between Nasal polyposis and bronchial asthma. Methods: This was a cross sectional study which was carried out in the departments of Otolaryngology and Head-Neck surgery of Bangabondhu Sheikh Mujib Medical University and Dhaka Medical College Hospital during the period of February 2014 to July 2014. A Total 230 patients were selected according to selection criteria among which 30 subjects had nasal polyposis (designated as group A or cases) and 200 subjects had no nasal polyposis (designated as group B or control group). Results: In group (A), asthma was found in 30.0% cases. On the other hand, asthma was found in 2.5% of control group (B). The association of nasal polyposis with bronchial asthma was highly significant (p<.05). In both group 40.0% patients were within the 38-47 year’s age group. In case group, 80.0% patients had any sorts of allergic history on the other hand, only 15.0% patients had allergic history in control group. High eosinophil count was found 66.7% patients suffering from nasal polyposis with bronchial asthma and in comparison to patients suffering from nasal polyposis without bronchial asthma had high eosinophil count 42.85%. In group A High IgE level was found 66.7% patients suffering from nasal polyposis with bronchial asthma, on the other hand, 42.85% had IgE level among patients suffering from nasal polyposis without bronchial asthma. Conclusion: Patients with nasal polyposis and asthma are significantly associated. Both serum IgE and total circulating eosinophil count are significant associated with nasal polyposis and bronchial asthma. Bangladesh J Otorhinolaryngol; April 2017; 23(1): 11-18

scholarly journals Study of Plasma Metanephrine Level As Biochemical Parameter in Pregnant Women with Preeclampsia

2014 ◽  
Vol 11 (2) ◽  
pp. 371-377
Author(s):  
Baghdad Science Journal
Keyword(s):  
Pregnant Women ◽  
Fetal Death ◽  
Protein S ◽  
Biochemical Parameter ◽  
Mean Value ◽  
Control Group ◽  
Protein Ratio ◽  
Gestation Age ◽  
Group A ◽  
Group B

Pregnancy- including hypertension(PIH), also known as preeclampsia, is one of the major causes of maternal and fetal death. This study was carried out on 30 pregnant women with preeclampsia and 30 healthy pregnant women as control ranging in age mean ±SD (28.84±3.55) years , BMI (76.80±9.78) Kg/m2 and gestation age(30.82±0.75)week. The aim of this research was studied the plasma Metanephrine level and other biochemical parameters such as Hemoglobin(Hb), serum Protein, S. Albumin, Globulin, Albumin/Globulin ratio (Alb/Glu. ratio), S.Glutamate Pyruvate aminotransferase (GPT), S.Glutamate Oxaloacetate aminotransferase(GOT). The obtained results have been compared with 30 healthy pregnant women as control group. The result showed that there was significant increase in mean value of Hb in group A(pregnant women with preeclampsia) when compared to group B(healthy pregnant women). The present study showed no significant changes was observed in the level of S. Protein, globulin, Alb./Glu. ratio, GPT and GOT as compared to control group. While Albumin showed a significant decrease in group A(pregnant women with preeclampsia) when compared with group B(healthy pregnant women) and significant increase in the levels of metanephrine, metanephrine/protein ratio, metanephrine/Alb ratio in group A (pregnant women with preeclampsia) to group B(healthy pregnant women).The present study conclude that the increase in the levels of metanephrine, metanephrine/protein ratio, metanephrine/Alb ratio in pregnant women with preeclampsia may be used as a marker to evaluate the development of disease. The current study recommend to take more case and measurement metanephrine in plasma and urine.

scholarly journals Results of the application of the herbal complex Renotinex® in patients with urolithiasis in the early postoperative period

2020 ◽  
Vol 13 (4) ◽  
pp. 35-40
Author(s):  
S.V. Kotov ◽  
◽  
A.A. Nemenov ◽  
I.D. Boeva ◽  
◽  
...  
Keyword(s):  
Stone Formation ◽  
Randomized Study ◽  
Early Postoperative Period ◽  
Control Group ◽  
Group A ◽  
Recurrent Stone ◽  
Group B ◽  
The University ◽  
Medical University ◽  
Continuous Use

Introduction. The article analyzes the results of the clinical application of the herbal complex Renotinex®, which helps to normalize the function of the urinary tract, reduce pain, remove small stones from the kidneys and reduce the risk of recurrent stone formation. Materials and methods. At the University Clinic of Urology, Russian National Research Medical University named after N.I. Pirogov, a prospective, single-center, randomized study was carried out from November 2019 to March 2020. All patients underwent contact ureterolithotripsy. The patients were divided evenly into 2 groups: group A (n = 30) – patients receiving Renotinex® from the first day after surgery (within 1 month), and group B (n = 30) – a control group of patients not receiving specific therapy. Results. After 1 month of continuous use of the drug, there was an increase in the percentage of calculi discharge after contact ureterolithotripsy, a decrease in the severity of pain, normalization of the temperature curve and the absence of subfebrile condition in all patients. Conclusion. Renotinex® has a lithokinetic effect, its active ingredients contribute to the prevention of infectious and inflammatory complications of urolithiasis.

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