scholarly journals Emerging threat in antifungal resistance on superficial dermatophyte infection

2019 ◽  
Vol 51 (1-2) ◽  
pp. 21-24
Author(s):  
Razia Sultana ◽  
Md Wahiduzzaman

Background: Dermatophytosis are most common fungul infection globally and according to WHO the prevalence is about 20-25% and does not spare people of any race or age. Over the past few years antifungal resistance has been emerged due to irrational use of antifungal drugs in cutaneous mycosis. Objective: The aim of the study is to evaluate the efficacy of different antifungul drugs (Terbinafin. Fluconazole, Itraconazole, Griseofulvin) on superficial mycosis depending on various factors. Methods: This prospective study was conducted among the Superficial fungul infected patients from April' 2017 to October 2017 in Khulna Medical College Hospital (KMCH) and dermatologist's private chamber in Khulna city. All the enrolled patients were put on oral Terbinafin, Fluconazole, Itraconazole and Griseofulvin. Each patient was given single antifungal drug orally. These cases were thus followed up after two months of treatment to look for persistent infection, cure or any relapse clinically. Result: Among 194 patient 89 were given Tab. Terbinafin (250mg) where resistance cases were 20.22%. More cases (33.96%) were resistant to Cap. Fluconazol (50mg). High percentage of cases were resistant to Cap. Itraconazole (76.47%). Griseofulvin resistant cases were observed in 25.71%. Drug response is very poor (69%) in patient who had been suffering from diabetes mellitus. Conclusion: Appropriate antifungal drugs should be chosen with strict indication, dose, duration, selection of perfect local preparation and taking laboratory facilities where necessary. Bang Med J (Khulna) 2018; 51 : 21-24

1981 ◽  
Vol 46 (04) ◽  
pp. 722-724 ◽  
Author(s):  
U Khanduri ◽  
R Pulimood ◽  
A Sudarasanam ◽  
R H Carman ◽  
M Jadhav ◽  
...  

SummaryFour cases of essential athrombia have been diagnosed in the 14 year period from June, 1966 to June, 1980 at the Coagulation Laboratory of the Christian Medical College Hospital, Vellore. All cases fit Inceman’s description of the original case and fulfill the diagnostic criteria of prolonged bleeding time, decreased platelet aggregation, normal platelet count, normal morphology and normal clot retraction. No cases have been reported from India in the past 15 years.


1970 ◽  
Vol 15 (1) ◽  
pp. 26-30 ◽  
Author(s):  
Maleka Afroz ◽  
Nasima Akhtar ◽  
Belayat Hossain Siddiquee

Metastatic neck node is not uncommon in the otolaryngology department of a tertiary level hospital. Ignorance, illiteracy, delay in seeking medical advice and poor orientation of our general practitioners regarding management causes these patients to suffer from marked morbidity and mortality. It is a prospective study with random selection of sixty (60) cases of metastatic neck node admitted in the otolaryngology department of BSMMU and Dhaka Medical College Hospital during a period extending from September, 2002 to August, 2003. Here 53(88.33%) cases of metastatic neck nodes having a known primary in the head neck region and in other seven (11.67%) cases primary site of malignancy could not be detected. The commonest site of known primary was supraglottic larynx. Highest number 19 (31.67%) of presentation was seen in 5th decade. Male incidence 47 (78.33%) was more compared to female 13 (21.67%). Keywords: Neck gland, Metastatic neck node, Unknown primary.DOI: 10.3329/bjo.v15i1.4307 Bangladesh J of Otorhinolaryngology 2009; 15(1): 26-30


2020 ◽  
Vol 52 (1-2) ◽  
pp. 25-29
Author(s):  
Shamima Akhter ◽  
SM Kamal ◽  
Md Farhadul Islam ◽  
Md Khosrul Alam Mollick ◽  
Md Nazrul Islam

Background: Community acquired pneumonia (CAP) is a leading cause of morbidity and mortality in Bangladesh. There is difficulty in identification of the causative organism due to lack of facility of sputum culture and sensitivity test in many hospitals of Bangladesh. So targeted anti microbial therapy is not possible and empirical antibiotic prescription is done. The choice of empirical selection of antibiotic should be the best effective drug for the treatment of CAP. Objective: To assess the efficacy of selected empirical antibiotic selection for the treatment of CAP. Methods: This prospective observational study involves 82 patients with CAP admitted in medicine ward of Khulna medical college hospital, Khulna, Bangladesh. Patients were selected by inclusion and exclusion criteria. Diagnosis of CAP was confirmed by chest x-ray. Empirical selection of antibiotic was based on clinical experience. Most of the patients were treated with combined antibiotic except a few with monotherapy. Evaluation of the empirical choice of ant biotic was done by the outcome. Data of different parameter were recorded during study in preformed proforma. Statistical analysis was done by using SPSS. Result: Out of 82 patients 62 (76%) were male and 20 (24%) were female. Mean age was 54.4 (± 9.6) years. Duration of antibiotic treatment was 7 days. No drug related adverse effect was observed. One patient developed paraneumonic effusion and none of the patient developed lung parenchymal damage or lung abscess. All the patient recovered completely. Conclusion: CAP is treated in many hospitals of Bangladesh by selecting the antibiotic empirically. Improvement of hospital laboratories to perform sputum for culture and sensitivity test is necessary for selecting an effective anti biotic. Bang Med J (Khulna) 2019; 52 : 25-29


2012 ◽  
Vol 18 (Number 1) ◽  
pp. 38-47
Author(s):  
K S Anwar ◽  
AKM S Uddin

A retrospective study was done to evaluate the availability of medical investigation facilities in Holy Family Red Crescent Medical College Hospital (HFRCMCH) for a period of 6 months. The study was designed to find out the gaps in the study Institute which is a tertiary level hospital in Dhaka city. Data was collected from medical records by check list and interview schedule. Out of 49687 patients. 85.28% received services from out patient department and 14.72% from in patient department. Among them. 26151 cases were referred for investigation from out patient and inpatient departments. Out of those 24.36% were blood for routine examination. 17.72% urine for routine examination and 10.77% blood urea and 24.46% blood sugar. 3.82% stool for routine examination and 18.87% for radiological investigation of chest. hi the inpatient department, routine examination of blood was highest (25.38%). next was blood sugar (23.01%). Some specific investigation namely S. Creatinin, S. Electrolytes, Liver function tests, VDRL, widal test, Blood grouping. Culture & sensitivity test were done. Out of specific tests. Blood grouping was highest followed by serum electrolytes. Majority of doctors (86.67) expressed satisfaction in regard to availability of Reagent and Films. Most doctors (93.33) expressed satisfactions in regard to result of laboratory tests and imaging. Regarding the skill of laboratory technician, 43.33% doctors opined good and 56.67% opined as moderate. The results of the study might help the administrator and planner to take steps for further improvement and appropriate utilization of laboratory facilities. However, there is an urgent need for improvement and horizon of investigation facilities should be expanded.


2019 ◽  
Vol 6 (8) ◽  
pp. 2802
Author(s):  
Robinson George ◽  
Veerabhadra Radhakrishna ◽  
Mebin Mathew ◽  
Aswini Thenamangalath ◽  
Ashna Rahman

Background: Laparoscopy is the standard technique for abdominal surgeries. There has been a debate over the safest laparoscopic entry technique over the past two decades. But, no technique has been regarded as the best, leading to numerable techniques. We use a modified Hasson technique to enter the peritoneal cavity. Hence, we conducted a study to evaluate the efficacy of our modified Hasson technique.Methods: A retrospective study was conducted in the Department of General Surgery, Al Azhar Medical College Hospital from January 2013 to December 2018.Results: A total of 156 patients were studied. Inguinal hernia repair was the most common indication. The mean entry time was 2±0.7 minutes. The postoperative complications included port site seroma [1 (0.6%)] and port site infection [1 (0.6%)]. Both the complications were found at the umbilical port and all following surgery for appendicular perforation. There was no incidence of preperitoneal placement of port, intraabdominal injury, port site hematoma or port site hernia. There was no mortality in the study group.Conclusions: Modified Hasson technique is a safe and quick technique to enter the abdomen.


2020 ◽  
pp. 133-139
Author(s):  
Sanatan Ratna ◽  
B Kumar

In the past few decades, there has been lot of focus on the issue of sustainability. This has occurred due to the growing concerns related to climate change and the growing awareness about environmental concerns. Also, the competition at global level has led to the search for the most sustainable route in the industries. The current research work deals with the selection of green supplier in a Nickle coating industry based on certain weighted green attributes. For this purpose, a hybrid tool comprising of Fuzzy AHP (Fuzzy Analytical Hierarchy) and VIKOR (VlseKriterijumska Optimizacija I Kompromisno Resenje) is used. The Fuzzy AHP is used for assigning proper weights to the selected criteria for supplier evaluation, while VIKOR is used for final supplier selection based on the weighted criteria. The three criterions for green supplier selection are, Ecological packaging, Corporate socio-environmental responsibility and Staff Training. The outcome of the integrated model may serve as a steppingstone to other SMEs in different sectors for selecting the most suitable supplier for addressing the sustainability issue.


Author(s):  
Monika Kushwaha ◽  
Sanjeev Narang

Background: This study is cross-sectional, observational and comparative study, at Index Medical College, Hospital & Research Centre, Indore, Madhya Pradesh from July 2017 to July 2019 with sample size 100 placentae. Method: The placenta received was evaluated blinded of maternal pregnancy outcome. The pattern of morphology was evaluated both qualitatively (type of lesion) and quantitatively (number of lesions). Result: In Present study 79% of the deliveries were term deliveries and 21% were preterm deliveries. On placental macroscopy, placenta weight was significantly low among the neonates of preterm deliveries (370.00±60.49) as compared to term deliveries (440.89±55.22). Preterm placenta had higher number of abnormal placental lesion compared to term pregnancies. Conclusion: The uteroplacental insufficiency defined as placental infarct, fibrosis of chorionic villi, thickening of blood vessels, and poor vascularity of chorionic villi. Placental histopathological lesions are strongly associated with maternal under perfusion and uteroplacental insufficiency. These are the reasons for preterm birth. Thus, knowledge of the etiological factor can be use to reduce maternal and neonatal morbidity and mortility. Keywords: Placenta, Term & Preterm.


2012 ◽  
Vol 6 (2) ◽  
pp. 7-10
Author(s):  
Mohammad Murshed ◽  
Sabeena Shahnaz ◽  
Md. Abdul Malek

Isolation and identification of post operative hospital acquired infection was carried out from July 2008 to December 2008 in Holy Family Red Crescent Medical College Hospital (private hospital). The major pathogen of wound infection was E. coli. A total; of 120 samples were collected from the surrounding environment of post operative room like floor, bed sheets, instruments, dressing materials, catheter, nasogastric and endotracheal tube. E. coli (40%) was the predominant organism followed by S. aureus (24%). DNA fingerprinting analysis using pulsed field gel electreopheresis of XbaI restriction digested genomic DNA showed that clonal relatedness between the two clinical nd environmental isolates were 100%.DOI: http://dx.doi.org/10.3329/bjmm.v6i2.19369 Bangladesh J Med Microbiol 2012; 06(02): 7-10


2012 ◽  
Vol 6 (1) ◽  
pp. 11-13
Author(s):  
Sushmita Roy ◽  
S.M. Shamsuzzaman ◽  
K.Z. Mamun

Rotavirus is one of the leading causes of pediatric diarrhea globally. Accurate and rapid diagnosis of Rotavirus diarrhea should reduce unnecessary use of antibiotics and ultimately reduce drug resistance. Study was designed for rapid diagnosis of Rotavirus antigen in stool sample by ICT (Immunochromatographic test) as well as to observe the seasonal variation of rotavirus infection. This cross sectional study was carried out in the department of Microbiology, Dhaka Medical College from January 2011 to December 2011. Eighty stool samples were collected from Dhaka Shishu Hospital and Dhaka Medical College Hospital. All samples were tested for rotavirus antigen by ICT. Among 80 patients, 42 (52.5%) samples were positive for rotavirus antigen. Among these 42 positive samples, 30 (71.43%) were from 0-12 months of age group, 10 (23.81%) from 13 to 24 months of age group and rest 2 (4.76%) from 25 to 36 months of age group. Rotavirus Ag was detected in stool samples from January to April and another peak episode from October to December. Considering the importance of Rotavirus associated diarrhea, rapid detection of Rotavirus infection in human is substantially needed and should be routinely practiced.DOI: http://dx.doi.org/10.3329/bjmm.v6i1.19354 Bangladesh J Med Microbiol 2012; 06(01): 11-13


2020 ◽  
Vol 26 (1) ◽  
pp. 11-17
Author(s):  
Md Kamruzzaman ◽  
Kazi Nurjahan ◽  
AS Gazi Sharifuddin ◽  
SK Ballav

Background: Oral cancer burden in developing countries is huge. In Bangladesh and India incidence were 10.6% and 10.4% respectively on 2018. At the same time worldwide incident was only 2%. Majority patients present at advanced stage and their survival rate is poor. Diagnostic delay from patient side and health delivery system side is significantly longer and it is more in developing countries. Like other malignancy early diagnosis can save a lot of these patient. Methods: This prospective study was carried out in Khulna Medical College Hospital from July 2017 to July 2019. Patients who will meet the criteria for this prospective study and capable and willing to give informed consent were enrolled. 20 second rinse/gargle with 10ml of 1% Tolonium chloride solution was done. Biopsy were taken from stained lesion, biopsy report were compared with TC stained lesions. Results: Out of 1650 patients in our outdoor department for various problem and only 30 cases were selected for this study according to selection criteria. Of 30 patients, 18 (60%) were male and 12 (40%) were female. The male-to-female ratio was 3:2. It was found that the sensitivity of 1% Tolonium Chloride rinse for oral precancer and cancer detection was 83.33%, whereas the specificity was 84.21%. Conclusion: Tolonium chloride rinse is a good screening test for oral cancer diagnosis with sensitivity 83.33% and specificity 84.21%. Bangladesh J Otorhinolaryngol; April 2020; 26(1): 11-17


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