scholarly journals Serum Total Protein and Albumin Levels in Different Grades of Protein Energy Malnutrition

1970 ◽  
Vol 3 ◽  
pp. 58-60 ◽  
Author(s):  
Md Serajul Islam Chowdhury ◽  
Nayeema Akhter ◽  
Mahmudul Haque ◽  
Rehana Aziz ◽  
Nazibun Nahar
Keyword(s):  
Early Diagnosis ◽  
Total Protein ◽  
Protein Energy Malnutrition ◽  
Healthy Children ◽  
Serum Total Protein ◽  
Protein Energy ◽  
Severity Of The Disease ◽  
Grade Iii

The present study has been designed to estimate serum total protein and albumin levels in different grades of protein energy malnutrition and this will be helpful in early diagnosis, management and rehabilitation of PEM. The serum total protein and albumin levels were studied on 20 healthy children and 30 children suffering from protein energy malnutrition of different grades. Serum total protein and albumin levels of different grades of protein energy malnutrition were significantly lowered than that of control. Lowering being maximum in grade III PEM. This lowering of total protein and albumin occur in any form of PEM and related to severity of the disease. doi: 10.3329/jbsp.v3i0.1799 J Bangladesh Soc Physiol.2008 Dec;(3):58-60.

scholarly journals Effect of PEM on thyroid status, serum total protein and A/G ratio in pre-school going children

2017 ◽  
Vol 5 (10) ◽  
pp. 4486
Author(s):  
Sumesh Prasad Sah ◽  
Manisha Aroral ◽  
Sudeep Kumar ◽  
Jyoti Batra ◽  
Imran Mustafa ◽  
...  
Keyword(s):  
Total Protein ◽  
Protein Energy Malnutrition ◽  
Thyroid Stimulating Hormone ◽  
Healthy Children ◽  
Serum Total Protein ◽  
Cross Sectional ◽  
Malnourished Children ◽  
Protein Energy ◽  
Serum T3 ◽  
G Ratio

Objective: The objective of the study was to evaluate and compare serum total protein, serum albumin and thyroid hormones in children with Protein Energy Malnutrition (PEM) and in healthy controls.Methods: Present study was a cross sectional hospital based case control study, total 75 children of age group 1-5 years were included in this study. Triiodothyronine (T3), thyroxine (T4) and thyroid stimulating hormone (TSH) was estimated by electro-chemiluminescence immunoassay method, serum total protein by biuret method, albumin by BCG method and plasma hemoglobin by CMG method. Result: In malnourished children, there is significant decrease in serum total protein (4.76 gm %), albumin (2.24 gm %) and Hb (10.57 gm %) as compared to normal healthy children. Serum T3 (0.51 ng/ml), and T4 (3.93 µg/ml) levels were significantly decreased and non-significant changes in TSH (4.26 µUI/ml) levels in children with PEM was observed as compared to healthy controls. Conclusion: The reduction in protein is due to decreased intake of proteins and reduced biosynthesis. The decreased in T3 and T4 levels in malnourished children is probably due to a decrease in circulating plasma proteins.

scholarly journals Serum Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) Levels in Different Grades of Protein Energy Malnutrition

1970 ◽  
Vol 2 ◽  
pp. 17-19 ◽  
Author(s):  
Md Serajul Islam Chowdhury ◽  
ABM Ziaur Rahman ◽  
Mahmudul Haque ◽  
Nazibun Nahar ◽  
Abu Taher
Keyword(s):  
Clinical Chemistry ◽  
Protein Energy Malnutrition ◽  
Control Group ◽  
Healthy Children ◽  
Protein Energy ◽  
Paired Student ◽  
Serum Aspartate Aminotransferase ◽  
Systemic Disorder ◽  
Grade Ii ◽  
Grade Iii

The present study was designed to analyze serum AST, ALT levels in different grades of protein energy malnutrition to facilitate early diagnosis, management and rehabilitation of PEM. The serum AST and ALT levels of 50 children of aged 5months to 5 years of both sexes were studied. Among them, 30 children suffering from protein energy malnutrition of 3 different grades were selected for experimental group. Age and sex matched 20 apparently healthy children with no systemic disorder and with weight/height ratio greater than 80% were included in control group. Serum AST and ALT levels were measured by kinetic ultraviolet method according to International Federation of Clinical Chemistry. Data were analyzed statistically by un-paired student 't' test. Mean Serum AST and ALT levels of different grades of protein energy malnutrition were significantly higher (p<0.001) than that of control. Values of mean serum AST and ALT levels were highest in grade-I PEM and it were significantly higher (p<0.001) than both grade-II and grade-III. Again mean serum AST and ALT levels were significantly higher (p<0.001) in grade-II PEM than that of grade-III PEM. The elevated levels of serum AST and ALT is due to tissue break down and hepatobiliary disorder. The results of this study indicate that serum ALT and AST levels are increased in PEM which varies according to its severity. Key Words: Aminotranserase; Malnutrition; Protein  DOI:10.3329/jbsp.v2i0.978 J Bangladesh Soc Physiol. 2007 Dec;(2): 17-19.

Thyroid hormone status in children with protein energy malnutrition a hospital based case control study

2017 ◽  
Vol 4 (2) ◽  
pp. 351 ◽  
Author(s):  
Gurdeep S. Dhanjal ◽  
Mrigind Singh
Keyword(s):  
Thyroid Hormone ◽  
Total Protein ◽  
Case Control Study ◽  
Protein Energy Malnutrition ◽  
Case Control ◽  
Severe Malnutrition ◽  
Serum Total Protein ◽  
Protein Levels ◽  
Protein Energy ◽  
Control Study

Background: WHO estimates that about half of all deaths, occurring among children aged less than five years in the developing countries, can be attributed to malnutrition. In malnourished children various endocrinal changes are noted. There is reduced synthesis of plasma proteins that affects secretion and metabolism of thyroid hormone. The present study has been conducted to study the effect of protein energy malnutrition (PEM) on thyroid hormone and plasma protein levels; and to find correlation between thyroid hormones and plasma protein levels in PEM children.Methods: A cross sectional hospital based case-control study was carried out in tertiary care hospital of Northern India. 50 children with PEM, and equal number of age and sex matched healthy controls (1-5 years) were included in the study. Detailed clinical assessment of nutritional status followed by anthropometric measurement was recorded in a predesigned performa. The cases were categorized into moderate and severe malnutrition as per WHO classification (weight for height). Free Triiodothyronine (fT3), free Thyroxine (fT4), thyroid stimulating hormone (TSH), serum total protein and serum albumin were estimated. The parameters were compared among cases and controls using appropriate statistical tool. Results: Mean hemoglobin, serum protein, serum albumin, fT3, fT4 and TSH levels were significantly low in case group, when compared to the control group (p <0.001).The levels of biochemical variables, decreases as the severity of malnutrition increases. The difference within the cases (moderate and severe malnutrition) was also found to be statistically significant (p <0.001).Conclusions: PEM is associated with decrease level of thyroid hormone levels and were positively correlated with serum total protein and albumin levels. The decrease level of thyroid hormone may have a contributory role in retarded growth and development.

scholarly journals Serum albumin and total protein level as plausible marker for diagnosis of protein energy malnutrition in children under age 5 years

2020 ◽  
Vol 7 (8) ◽  
pp. 1758
Author(s):  
Saroj Sanjeev Gupta ◽  
Pranav Sanjeev Gupta
Keyword(s):  
Serum Albumin ◽  
Total Protein ◽  
Protein Energy Malnutrition ◽  
Venous Blood ◽  
Bromocresol Green ◽  
Control Group ◽  
Case Group ◽  
Healthy Controls ◽  
Serum Total Protein ◽  
Protein Energy

Background: The circulating concentration of transport protein, traditionally albumin, has been used to define protein deficiency. However, few studies have been conducted to see if there is any correlation between serum total protein and albumin levels in children with PEM. Hence the study was planned to estimate serum total protein, serum albumin levels in children with PEM and healthy controls.Methods: All the children were divided in two groups. Case Group A consist of 250 children with protein energy malnutrition and control Group B consist of healthy 250 children. Venous blood of amount 3 ml was collected with full aseptic precautions. The blood was collected in the EDTA vacutainer and test tube. Serum total protein was estimated by Biuret method, serum albumin was estimated by Bromocresol green dye method (BCG dye).Results: When the mean serum levels of albumin levels and the total protein levels were measured in the controls as well as case groups, there was decrease in levels in case group as compared to control group. This difference of decrease when evaluated statistically it was found to be statistically significant. When the albumin/globulin ratio was calculated in both the groups, it was found to be statistically lower in case group as compared to control group. PEM children have low serum total protein and albumin levels as compared to healthy controls (p<0.001), this is probably due to decreased intake of proteins and reduced biosynthesis. PEM children have lower hemoglobin levels as compared to healthy controls; this is probably due to deficiency of iron and other micronutrients, which is often found in a child with malnutrition.Conclusions: Early diagnosis and prompt management of PEM and its complications can prevent development of permanent physical and mental retardation.

scholarly journals PENGARUH PEMBERIAN TEPUNG BEKICOT TERHADAP KADAR TOTAL PROTEIN DARAH PADA RATTUS NOVE RGICUS STRAIN WISTAR DENGAN DIET NON PROTEIN

2012 ◽  
Vol 6 (1) ◽  
Author(s):  
Prasetyo Adi ◽  
Inggit Kusumastuti ◽  
. Anida
Keyword(s):  
Total Protein ◽  
Random Sampling ◽  
Protein Energy Malnutrition ◽  
Simple Random Sampling ◽  
T Test ◽  
Group Design ◽  
Protein Energy ◽  
Post Test ◽  
Paired T Test

Protein Energy Malnutrition (PEM) adalah keadaan kurang gizi  yang disebabkan rendahnya konsumsi energi dan protein dalam makanan sehari-hari sehingga tida k memenuhi Angka Kecukupan Gizi (AKG). Karena kurangnya asupan protein yang terus berlanjut, penderita PEM dapat mengalami penurunan kadar total protein darah.  Tepung bekicot merupakan salah satu sumber protein hewani yang mengandung protein tinggi. Penelitian ini  bertujuan untuk membuktikan ba hwa tepung bekicot mampu memberikan pengaruh pada kadar total protein darah tikus dengan diet non pr otein. Studi eksperimental menggunakan the  pre-post test contro l group design dilakukan terhadap hewan coba tikus wistar jantan. Sampel dipilih dengan ca ra simple random sampling untuk  dibagi dalam empat kelompok, y aitu “P1” adalah kelompok tikus yang diberikan diet normal, “P2” kelompok tikus yang diberikan diet tepung bekicot 4%, “P3” kelompok tikus yang diberikan diet tepung bekicot 19%, “P4” kelompok tiku s yang diberikan diet tepung bekicot 50%. Variabel yang diukur  dalam penelitian ini adalah kadar total protein dar ah tikus setelah pemberian diet pada masi ng-masing perlakuan selama satu bulan. Ha sil penelitian menunjukkan bahwa pemberian tepung  bekicot memberikan pengaruh yang nyata  terhadap perubahan ka dar total protein dar ah tikus (paired t-test, p < 0,05). Namun demikian ada perbedaan bermakna pada perlakuan (anova, p < 0,05) yang terjadi pada ”P2”.  Kesimpulan dari penelitian ini adalah pemberian tepung bekicot  memberikan pengaruh terhadap kadar total protein darah, dan dosi s yang paling efektif adalah menggunakan tepung bekicot 19%. Berdasarkan hasil penelitian ini, disarankan agar dilakukan penelitian le bih lanjut tentang aplikasi tepung bekicot pada manusia dengan kondisi PEM.  Kata kunci:  total protein darah, PEM, diet non protein

Erythrocyte membrane (Ca2++Mg2+)-ATPase in human protein-energy malnutrition

1989 ◽  
Vol 9 (3) ◽  
pp. 359-368 ◽  
Author(s):  
Olufunso O. Olorunsogo
Keyword(s):  
Erythrocyte Membrane ◽  
Specific Activity ◽  
Protein Energy Malnutrition ◽  
Maximum Velocity ◽  
Red Cells ◽  
Human Protein ◽  
Healthy Children ◽  
Basal Activity ◽  
Protein Energy

Calmodulin-free ghost membranes were prepared from erythrocytes of kwashiorkor children and from healthy children in the same age bracket. In the absence of calmodulin, the specific activity of Mg2+-dependent Ca2+-pumping ATPase (Ca2++Mg2+-ATPase) of kwashiorkor membranes was more than 40 percent lower than the specific activity of the normal enzymes, whose maximum velocity was increased by at least four-fold by the modulator protein. In constrast, the maximum velocity of the enzymes of kwashiorkor membranes was enhanced by calmodulin by about 11/2 times the basal activity of the normal enzymes and by 2 times the basal activity of the kwashiorkor enzymes. The affinity of the pump for ATP was lower in the membranes of kwashiorkor children (Km for ATP=30.6±2.8 μM ATP) in comparison to normal membranes (Km for ATP=21.7±2.0 μM ATP). Similarly, calmodulin-affinity of the enzymes, was lower in kwashiorkor membranes than in the normal membranes irrespective of source of calmodulin. Calmodulin from haemolysates of kwashiorkor red cells activated the enzymes of normal and kwashiorkor membranes to the same degree as calmodulin partially purified from the haemolysate of healthy children. A determination of the dependence of the activity of the pump on calcium in the absence and presence of calmodulin reveals that the affinity of the kwashiorkor enzymes for Ca2+ is at least 70 percent lower than that of enzymes of normal membranes. Altogether, these findings suggest that the Ca2+-pumping ATPase of kwashiorkor membranes is less functional than the enzymes of healthy erythrocytes.

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