scholarly journals Status of Gastric Mucosa and Liver in Mice upon Treatment with Diclofenac Sodium

1970 ◽  
Vol 5 (2) ◽  
pp. 89-93
Author(s):  
Nazmul Hoque ◽  
Md Kamrul Islam ◽  
Md Monirul Islam ◽  
Md Mustafizur Rahman Chowdhury ◽  
Md Mizanur Rahman
Keyword(s):  
Body Weight ◽  
Gastric Mucosa ◽  
Vitamin B12 ◽  
Diclofenac Sodium ◽  
Experimental Period ◽  
Laboratory Method ◽  
Erythrocyte Count ◽  
Empty Stomach ◽  
Full Stomach ◽  
Key Words Stomach

Background: Diclofenac sodium is a non-steroidal anti-inflammatory drug with reportedly undesirable harmful side effects including blood disorders, abdominal pain, ulceration and bleeding of the stomach or intestine. Objective:The present study was conducted to investigate the effect of diclofenac sodium on erythropoiesis, on stomach and liver under different conditions. Method: This experimental study on animal model was conducted in the Department of Physiology, Bangladesh Agricultural University, Mymensingh, between July and August 2007. A total of 45 Swiss Albino mice were randomly assigned into five equal groups (n=9) and they all were fed with standard broiler pellet (25 gm/mice/day) throughout the experimental period of 40 days. Keeping 1 group as control(groupA), 4 groups were treated with diclofenac sodium @ 3 mg/kg body weight (bwt) orally in empty (group B)or full stomach with (group c) or without vitamin B12 (group D) @ 10 μg/Kg body weight through intramuscular route. Total erythrocyte count (TEC) and Hb% was determined to assess erythropoiesis. Macroscopic and microscopic changes of liver and stomach were studied by standard laboratory method. Data were analyzed statistically by ANOVA and un paired t test. Result: Oral administration of this drug significantly (p<0.01) decreased Total Erythrocyte Count(TEC) and Hb in the animals treated with diclofenac sodium in empty stomach and in the animals treated with diclofenac sodium plus vitamin B12 in empty stomach. All the treated mice showed slight to moderate congestion of the gastric mucosa and liver. Conclusion: Intake of diclofenac sodium in empty stomach may produce harmful side effect on stomach and liver. Key words: Stomach; Mice; Diclofenac sodium. DOI: 10.3329/jbsp.v5i2.6783J Bangladesh Soc Physiol. 2010 December; 5(2): 89-93

scholarly journals The Effects of Feed Color on Broiler Performance between Day 1 and 21

Animals ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1511
Author(s):  
Joseph P. Gulizia ◽  
Kevin M. Downs
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Treatment Effects ◽  
Body Weight Gain ◽  
Experimental Period ◽  
Feed Consumption ◽  
Feed Conversion ◽  
Broiler Performance ◽  
Average Body ◽  
Average Body Weight

Two trials were conducted to determine feed color effects on broiler performance. A completely randomized design was used. Trial 1 included four treatments: control (complete broiler starter diet), red, green, and blue; and Trial 2 included four treatments: control, orange, yellow, and purple. Each trial had 4 treatments with 4 replicates (60 birds/treatment) fed to 240 male Cobb 500 broilers during a 21 d grow out. Data were analyzed using the GLM procedure. In Trial 1, there were no treatment effects on average body weight, body weight gain, and feed consumption (p > 0.05). Adjusted feed conversion for control (1.23) was less than red (1.27; p = 0.001) and green (1.26; p = 0.009), with blue (1.25; p = 0.056) tending to be different during the experimental period. In Trial 2, there were no treatment effects on average body weight, feed consumption, and adjusted feed conversion during this study (p > 0.05). Body weight gain between d 1 to 14 for purple (490.78 g/bird) was more than orange (467 g/bird; p = 0.013) and yellow (461 g/bird; p= 0.004), with control (474 g/bird; p = 0.052) tending to be different. Results indicate that these feed colors had some, albeit limited, influence on broiler performance parameters.

Effect of luteolin on the gene level expression of apoptosis-associated speck-like protein containing a caspase recruitment domain of NLRP3 inflammasome and NF-κB in rats subjected to experimental pancreatitis – influence of HSP70

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Sadanandan Rajapriya ◽  
Arumugam Geetha
Keyword(s):  
Body Weight ◽  
Nlrp3 Inflammasome ◽  
Rank Correlation ◽  
Experimental Period ◽  
Serum Levels ◽  
Normal Diet ◽  
Experimental Pancreatitis ◽  
Caspase 1 ◽  
Spearman’S Rank Correlation ◽  
Pyrin Domain

Abstract Objectives Nod-like receptor pyrin domain containing 3 (NLRP3) is one of the well characterized inflammasome that controls the maturation of pro-inflammatory cytokines and thereby the inflammation in pancreas which could be a promising target for anti-inflammatory drugs. The present study is aimed to explore whether luteolin can target the NLRP3 inflammasome and modulate its activity through the signaling protein, HSP70 in the ethanol-cerulein model of experimental pancreatitis. Methods Male albino Wistar rats were divided into four groups. Groups 1 and 2 rats received normal diet. Groups 3 and 4 rats received isocalorically adjusted diet containing ethanol for 5 weeks and cerulein (20 μg/kg body weight i.p., thrice weekly for the last 3 weeks of the experimental period). Additionally, group 2 and 4 rats received 2 mg/kg body weight of luteolin orally from third week. Results Luteolin co-administration decreased the serum levels of HSP70, oxidative stress markers, myeloperoxidase, GSH/GSSG and GST with concomitant downregulation in the mRNA expression of HSP70, caspase-1, ASC-NLRP3 and NF-κB. Spearman’s rank correlation test showed that serum HSP70 has positive correlation with the expression of ASC-NLRP3, caspase-1, NF-κB and 4-hydroxynonenal and negative correlation with GSH:GSSG ratio. Conclusions The modulating effect of luteolin on the expression of HSP70, NF-κB and thereby on ASC-NLRP3 complex may be claimed for its pancreato-protective activity.

Growth performance, correlation and regression estimates of seven-chicken strains in South-Western Nigeria

2020 ◽  
Vol 45 (2) ◽  
pp. 40-48
Author(s):  
A. J. Atansuyi ◽  
U. C. Ihendu ◽  
C. A. Chineke
Keyword(s):  
Body Weight ◽  
Growth Performance ◽  
Correlation Coefficients ◽  
Tail Length ◽  
Experimental Period ◽  
The Body ◽  
Coefficient Of Determination ◽  
Indigenous Chicken ◽  
Randomized Design ◽  
Study Results

This study was conducted to determine the growth performance, correlation and regression estimates of seven-chicken strains in South-western Nigeria using a total of 300 day-old chicks. The birds were divided into seven groups based on their strain. The seven strains are Normal feather (NF), Fulani ecotype (FE), Frizzle feather (FF), naked neck (NN) and Transylvania indigenous strains while Hubbard and Marshal were meat-type exotic chickens. There were forty- five (45) unsexed day-old chicks in each strain except the Frizzle feather that were 30 in number. Completely randomized design (CRD) was used for the trial that lasted for 8 weeks. The birds were fed experimental diets ad libitum throughout the period of the study. Results showed that there were significant differences (p<0.05) in the initial and final weights of the birds. It was observed that exotic strains weighed heavier (3569.73gHB) than their indigenous counterparts (1391.11gNF). However, the Fulani ecotype weighed heaviest (1840.99g) among Nigeria indigenous strains during the experimental period. This showed that FE strains are generally heavy breed chicken and could be incorporated into a meat producing indigenous chicken if improved upon. The result of the correlation coefficients showed that a very strong, positive and highly significant (P<0.001) relationship existed between body weights and linear body measurements as most of the values are (>0.40). All the body parameter examined had significant (p<0.01) and direct relationship with the body weight. Shoulder-to-tail length (STL) had the highest coefficient of 0.98.The high correlation estimates obtained in this study could be as a result of pleiotropy, heterozygosity or linkage of genes in the birds. The three functions were highly significant (p<0.05) for all the parameters studied. This shows that the functions well described the parameters. On the basis of coefficient of determination (R ), the body weight of poultry birds at any age can be predicted most accurately with BRG using cubic function.

scholarly journals Milk yield and composition, feed intake and stocking rate of crossbread cows in tropical grasses managed in a rotational grazing system

2010 ◽  
Vol 39 (7) ◽  
pp. 1548-1557 ◽  
Author(s):  
Nelson Massaru Fukumoto ◽  
Julio Cesar Damasceno ◽  
Fermino Deresz ◽  
Carlos Eugênio Martins ◽  
Antônio Carlos Cóser ◽  
...  
Keyword(s):  
Body Weight ◽  
Milk Yield ◽  
Dry Matter ◽  
Experimental Period ◽  
The Body ◽  
Dry Matter Intake ◽  
Panicum Maximum ◽  
Stocking Rate ◽  
Rotational Grazing ◽  
Grazing System

The objective of this study was to evaluate milk yield and composition, dry matter intake, and stocking rate in pastures with tanzania grass (Panicum maximum cv. Tanzânia), star grass (Cynodon nlemfuensis cv. Estrela-Africana), and marandu grass (Brachiaria brizantha cv. Marandu). The grasses were managed in a rotational grazing system with Holstein x Zebu crossbreed cows, with a 30-day resting period and three days of paddock occupation. The pastures were fertilized with 1,000 kg/ha/year using the 20:05:20 (NPK) formula, split in three applications during the rainy season. It was used a complete random block experimental design with three factors being studied and two replications. In the experiment, four cows/paddock were used and, when it was necessary, regulator animals were added in order to obtain a supply of 7% body weight green forage dry matter. The animals were individually fed concentrate at 2 kg/day during the experimental period. Milk yield did not differ among the three grasses, with values of 9.1; 9.1; and 8.7 kg/cow/day for pastures with tanzania grass, star grass and marandu grass, respectively. Similarly, grass did not affect milk chemical composition. Stocking rate was similar among the three grasses, with values of 4.6; 4.5 and 5.0 UA/ha for tanzania grass, star grass and marandu grass, respectively. The highest dry matter intake was observed for tanzania grass with 2.6% of the body weight while stargrass (2.3%) and marandu grass (2.4%) did not differ among each other. The highest dry matter intake on tanzania grass pasture was not reflected on milk yield per animal. Milk yield and composition and stocking rate are similar among the evaluated grasses.

scholarly journals Quantitative characteristics of the carcasses of Moxotó and Canindé goats fed diets with two different energy levels

2010 ◽  
Vol 39 (7) ◽  
pp. 1565-1570 ◽  
Author(s):  
Ana Cristina Chacon Lisboa ◽  
Dermeval Araújo Furtado ◽  
Ariosvaldo Nunes de Medeiros ◽  
Roberto Germano Costa ◽  
Rita de Cássia do Egypto Queiroga ◽  
...  
Keyword(s):  
Body Weight ◽  
Energy Level ◽  
Energy Levels ◽  
Experimental Period ◽  
Carcass Yield ◽  
Final Weight ◽  
Quantitative Characteristics ◽  
Energetic Level ◽  
Average Body ◽  
Average Body Weight

The objective of this work was to evaluate the quantitative characteristics of carcasses of Moxotó and Canindé goats finished in feedlots and fed diets of two levels of energy. It was used 40 castrated young goats, 20 from Moxotó breed and 20 from Canindé breed, each one with an average body weight of 15.2 kg. The animals were fed with diets containing 2.20 and 2.71 (Mcal/kg DM). The experimental period lasted 86 days. There was no difference among the barometric measures of Moxotó and Canindé kids. Canindé goats showed higher final weight, higher weight after fasting and higher hot and cold carcass weights when compared to the Moxotó animals. Animals that consumed diets with higher energy level had higher final weight and conformation as well as higher carcass yield. Considering the percentage values of the commercial meat cuts, no difference among treatments was observed. The diet was the factor that most influenced the non-constituent components of the carcass of Moxotó and Canindé goats. In general, animals belonging to the Canindé breed presented higher quantitative characteristics than the Moxotó breed. Supply of diets with higher energetic level (2.71 Mcal/kg DM) for goats from Moxotó and Canindé breeds, in feedlots, favors the production of carcass with higher yields and heavier commercial meat cuts.

scholarly journals Fingernail may not be a reliable biomarker of fluoride body burden from dentifrice

2010 ◽  
Vol 21 (2) ◽  
pp. 91-97 ◽  
Author(s):  
Ynara Bosco Oliveira Lima-Arsati ◽  
Carolina Castro Martins ◽  
Lília Alves Rocha ◽  
Jaime Aparecido Cury
Keyword(s):  
Body Weight ◽  
Young Children ◽  
Body Burden ◽  
Experimental Period ◽  
Reliable Indicator ◽  
Two Phases ◽  
The City

Fingernail has been suggested as a biomarker of fluoride (F) body burden, but there is no consensus if it would be a reliable indicator of F exposure from dentifrice. Therefore, the present study was conducted to investigate if fingernails would have sensitivity to detect F exposure from dentifrice in young children. Twenty-three 1-3-year-old children living in the city of Piracicaba (0.72 ppm F in water), Brazil, were enrolled in two phases of different F exposure: in phase A (1st to 11th week), they were exposed to the combination of F from diet (solids and liquids) and dentifrice (1,500 µg F/g as MFP), and in phase B (12th to 29th week), only to F from diet (the use of F dentifrice was interrupted). Fingernails were weekly clipped during 35 weeks for F determination. F intake from diet and dentifrice in each phase was also determined. Both analyses were made with ion-specific electrode. F intake (Mean ± SD) was significantly higher (p<0.01) when the children were exposed to F from diet+dentifrice than only to F from diet (0.086 ± 0.032 and 0.040 ± 0.009 mg F/day/kg body weight, respectively). However, F concentrations in nails collected during the whole experimental period of 35 weeks presented great variation with no trend of decreasing after F dentifrice intake interruption. The findings suggest that fingernail may not be a reliable F biomarker of body burden from dentifrice.

scholarly journals Health, body condition and blood metabolites in reindeer after submaintenance feed intake and subsequent feeding

Rangifer ◽  
2000 ◽  
Vol 20 (4) ◽  
pp. 187 ◽  
Author(s):  
A. Nilsson ◽  
Ö. Danell ◽  
M. Murphy ◽  
K. Olsson ◽  
B. Åhman
Keyword(s):  
Body Weight ◽  
Plasma Protein ◽  
Rangifer Tarandus ◽  
Plasma Concentrations ◽  
Experimental Period ◽  
Diet Group ◽  
The Body ◽  
Plasma Metabolites ◽  
Control Group ◽  
Feeding Period

The transition from experimentally induced poor nutritional conditions to feeding was studied with 69 eight-month-old female reindeer (Rangifer tarandus tarandus). During a pre-experimental period, all reindeer were fed a simulated winter diet with 80% lichens Cladina spp. and 20% Vaccinum myrtillus shrubs and Salix spp. leaves (lichen diet) ad lib. The reindeer were divided into five groups. A control group (group C) was fed the lichen diet ad lib. throughout the experiment. Four groups were fed half of that ration for eight days and were then totally deprived of feed for one day (restriction period). During the following 34 days (feeding period) the groups were re-fed the lichen diet (group L), fed pelleted reindeer feed combined with either lichen (group PL) or grass silage (group PS), or fed silage with a gradually increasing addition of pellets (group SP). Weekly measurements of blood samples and body weighr showed that the control group remained clinically healthy and had stable blood plasma concentrations of protein, urea, glucose and insulin throughout the experiment, but they lost weight. At slaughter, before and after the restriction period, all animals had lost rumen-free body weight, but the reindeer fed a restricted amount of feed lost more than the control group. Also the plasma metabolites were affected by the restricted feeding, with increased concentrations of urea and decreased concentrations of glucose. Group L responded immediately to the ad lib. feeding with blood metabolite levels rapidly approaching those of group C. The body weight developments were similar in groups L and C. Although the feed rations were increased gradually, diarrhoea occurred in some animals belonging to groups PL and PS within the first week of the feeding period. All reindeer recovered, after antibiotic treatment of the worst affected animals. The PL and PS groups, which had high contents of metabolisable energy and crude protein in their diets, showed increased con-centtations of plasma protein, urea and insulin. At the end of the feeding period, these groups had increased their body and carcass weights and gained fat, whereas reindeer fed the lichen diet had lost weight. Severe health problems (malnutrition and so-called wet belly) occurred in group SP during the first weeks of feeding and led to loss of animals, and consequently the SP group was excluded from the remainder of rhe experiment. The general conclusion is that the lichen diet did not cause any digestive problems, but resulted in a continuous decline in body weight and small or deficient fat reserves. After the initial diarrhoea, feeding with diets comprising pellets from the start resulted in improved condition, expressed as increased body weight, fat gain and higher concentrations of plasma protein, urea and insulin in relation to the control group. The diet initially based on grass in the form of silage of the given quality seemed insufficient as feed to reindeer calves in a poor nutritional state.

scholarly journals Dietary calcium levels on productive and reproductive traits of european quails

2020 ◽  
Vol 9 (1) ◽  
pp. e111911723
Author(s):  
Gabriela Queiroz Faria ◽  
Héder José D'Ávila Lima ◽  
Leonardo da Silva Costa ◽  
Jéssica Amaral Miranda ◽  
Graziela Maria Freitas Rocha ◽  
...  
Keyword(s):  
Body Weight ◽  
Reproductive Traits ◽  
Experimental Period ◽  
Dietary Calcium ◽  
Feed Consumption ◽  
Productive Performance ◽  
Coturnix Coturnix ◽  
Randomized Experimental Design ◽  
Negative Effect ◽  
Productive Traits

The objective of this study was to determine the effect of dietary calcium levels on productive and reproductive traits of European male quail (Coturnix coturnix). A total of 60 European male quail, at 35 days of age, weighing 248.9g ± 8.1g were distributed in a completely randomized experimental design with five calcium levels (1.5, 2.0, 2.5, 3.0 and 3.5%), and 12 replicates per treatment (one bird each replicate). The experimental period was 35 to 70 days of age. At 70 days of age, the parameters of male productive traits assessed were: feed consumption, calcium consumption, weight gain and body weight of birds. The reproductive traits analyzed were: hatchability and fertility of eggs. Early, intermediate and late embryonic mortality were also evaluated. The diet containing 3.16% of calcium provides higher percentage of hatched eggs and did not show a negative effect on productive performance of European quails.

BODY WEIGHT AND FOOD CONSUMPTION OF LACTATING RATS NURSING VARIOUS SIZES OF LITTERS

1967 ◽  
Vol 38 (3) ◽  
pp. 263-268 ◽  
Author(s):  
K. ÔTA ◽  
A. YOKOYAMA
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Food Consumption ◽  
Ovarian Function ◽  
Experimental Period ◽  
Close Correlation ◽  
Female Rats ◽  
Linear Relationships ◽  
Rate Of Increase ◽  
Daily Gain

SUMMARY Changes in body weight and food consumption during lactation in rats nursing various sizes of litters were studied. The rate of increase in body weight of the mother rats during the experimental period (day 3–14 of lactation) was very similar in mothers with different numbers (2, 4, 8 and 12) of suckling pups/litter. It is suggested that the weight increase of adult female rats during lactation is related more closely to the alteration of ovarian function caused by the suckling stimulus than to the enhanced food intake during this period. Both the food intake of mother rats and the daily gain in weight of litters increased as the number of suckling pups/litter increased and as lactation advanced. Linear relationships were observed between the logarithm of the litter size and both the food intake of the mother rats and the weight gain of the litters. The presence of a close correlation between the food intake of mother rats and the quantity of milk produced by them is suggested.

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