scholarly journals Study of Elevation of Serum Homocysteine Level in Eclampsia in a Specilized Hospital Setting in Bangladesh

1970 ◽  
Vol 19 (2) ◽  
pp. 131-134
Author(s):  
M Mahal ◽  
MS Hossain ◽  
N Sultana ◽  
NS Chowdhury ◽  
SAKMN Amin
Keyword(s):  
Case Control Study ◽  
Homocysteine Level ◽  
Elevated Serum ◽  
Hospital Setting ◽  
Maternal Deaths ◽  
Medical College ◽  
Uncomplicated Pregnancy ◽  
Serum Homocysteine ◽  
The Relationship ◽  
Control Study

Context: Eclampsia is one of the most leading causes of maternal deaths in developing countries. Many studies have demonstrated the relationship between hyperhomocysteinemia and eclampsia. The aim of this study was to examine the association between serum homocysteine with eclampsia. Methods: A case control study carried out in the Department of Biochemistry, Dhaka Medical College, Dhaka. 50 diagnosed cases of eclampsia were taken as cases and 52 healthy women with uncomplicated pregnancy were taken as controls. Serum homocysteine was measured in all study subjects by fluorescence polarization immunoassay (FPIA) method. Result: Serum homocysteine found to be significantly increased (p<0.001) in patients with eclampsia (10.44±4.08 μmol/L) compared to controls (7.97±3.46 μmol/L). Conclusion: It can be concluded that elevated serum homocysteine is associated with eclampsia. Key words: Serum homocysteine; eclampsia. DOI: 10.3329/jdmc.v19i2.7085J Dhaka Med Coll. 2010; 19(2) : 131-134

Association of Serum Homocysteine Level and Interstitial Lung Disease in Systemic Sclerosis: A Case-control Study

2018 ◽  
Vol 15 (1) ◽  
pp. 74-78
Author(s):  
Mohammadali Nazarinia ◽  
Asghar Zare ◽  
Mohammad javad Fallahi ◽  
Mesbah Shams
Keyword(s):  
Systemic Sclerosis ◽  
Healthy Subjects ◽  
Case Control Study ◽  
Homocysteine Level ◽  
Case Control ◽  
Control Group ◽  
Lung Involvement ◽  
Serum Homocysteine ◽  
The Mean ◽  
Control Study

Background:Systemic sclerosis is a disorder of connective tissue with unknown cause, affecting the skin and internal organs, characterized by fibrotic changes.Objective:To determine the correlation between serum homocysteine level and interstitial lung involvement in systemic sclerosis. </P><P> Materials and Methods: In this case – control study, 59 patients who fulfilled the ACR/EULAR classification criteria for systemic sclerosis and were referred to Hafez Hospital of Shiraz, Iran, were included as the case group. Fifty nine healthy subjects were involved as the control group. Patients were divided into two groups based on interstitial lung involvement and two subtypes, diffuse and limited type. Serum homocysteine, vitamin B12, and folate levels compared between the controls, and cases groups.Results:Of 59 case and control group, 53 (%89.8) were female and the mean age did not differ in both groups (P=0.929). Thirty five (%59.3) patients had interstitial lung involvement and 38(%64.4) had diffuse cutaneous systemic sclerosis. The mean serum homocysteine level was 13.9±6.3 µmol/L in the case and 13.7±9.2 µmol/L in the control group (P=0.86). The mean serum homocysteine level did not differ between the patients with and without interstitial lung involvement (P=0.52). The patients with lung involvement was older than those without lung involvement (P=0.004). Lung disease was more common in diffuse type (P=0.014).Conclusion:In our study, serum homocysteine level did not differ between the patients and healthy subjects. Also, there was no correlation between serum homocysteine level and lung involvement, but lung involvement was more common in older patients and also diffuse subtype.

scholarly journals Effect of body weight on serum homocysteine level in patients with polycystic ovarian syndrome: A case control study

2016 ◽  
Vol 14 (2) ◽  
pp. 81-88 ◽  
Author(s):  
Ali Al- Gareeb ◽  
Wafaa Salah Abd Al- Amieer ◽  
Hayder M. Alkuraishy ◽  
Thabat J. Al- Mayahi ◽  
◽  
...  
Keyword(s):  
Body Weight ◽  
Polycystic Ovarian Syndrome ◽  
Case Control Study ◽  
Homocysteine Level ◽  
Case Control ◽  
Serum Homocysteine ◽  
Ovarian Syndrome ◽  
Control Study

scholarly journals Association of Serum Homocysteine and Serum Lipid with Eclampsia

1970 ◽  
Vol 5 (1) ◽  
pp. 7-10
Author(s):  
Monzarin Mahal ◽  
Farida Yeasmin ◽  
Syed AKM Nurul Amin ◽  
Afia Shahnaj ◽  
Maliha Rashid ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Lipid Profile ◽  
Homocysteine Level ◽  
Elevated Serum ◽  
Hdl Cholesterol ◽  
Significant Negative Correlation ◽  
Cholesterol Concentration ◽  
Mortality And Morbidity ◽  
Serum Homocysteine ◽  
Control Study

Eclampsia is one of the most common pregnancy complications causing high mortality and morbidity for both mother and foetus especially in developing countries. Many studies suggest that elevated homocysteine level is an important risk factor for eclampsia. The aim of this study was to explore the association between serum homocysteine with eclampsia and to establish serum homocysteine measurement as a reliable test for early detection of eclampsia. In a case control study serum homocysteine and lipid profile were measured in 52 controls (healthy uncomplicated pregnant women) and 50 eclamptic pregnant women. Serum homocysteine in eclampsia cases (10.44±4.08 μmol/L) found to be significantly increased (p < 0.001) compared to controls (7.97±3.46 μmol/L). Serum HDL-cholesterol concentration found to be significantly decreased (p < 0.001) in the cases (35.98±6.35 mg/dl) compared to controls (42.69±6.09 mg/dl). A significant negative correlation (r-.801, p < 0.01) was found between serum homocysteine and HDL-cholesterol concentration among cases. It can be concluded that elevated serum homocysteine and HDL-cholesterol deficiency were associated with eclampsia. But elevated homocysteine itself might be a factor associated with eclampsia irrespective of lipid profile status. Key Words: Homocysteine, Eclampsia.   doi: 10.3329/jafmc.v5i1.2842 JAFMC Bangladesh. Vol 5, No 1 (June) 2009 pp.7-10

scholarly journals Raised Serum Homocysteine Level is Associated with Hypertension

2019 ◽  
Vol 11 (1) ◽  
pp. 22-25
Author(s):  
S Biswas ◽  
R Haque ◽  
N Uddin ◽  
AR Saha ◽  
K Sultan ◽  
...  
Keyword(s):  
Homocysteine Level ◽  
Elevated Serum ◽  
Cross Sectional ◽  
Homocysteine Concentration ◽  
National Health Care ◽  
Medical College ◽  
Serum Homocysteine ◽  
Increased Risk ◽  
Clinical Measurements ◽  
Group Serum

An elevated serum homocysteine concentration is associated with an increased risk of coronary, cerebral, and peripheral vascular disease. The objective of the study was to evaluate the association of serum homocysteine level with hypertension (HTN). This cross sectional analytical study was conducted at Sir Salimullah Medical College & Mitford Hospital and National Health Care Network Dhaka, Bangladesh over a duration of 21 months from July 2012 to May 2014. Fifty HTN patients were included as study subjects and age and sex matched fifty non-HTN healtlhy controls were included. All the clinical measurements were taken and serum Hcy was measured for all study subjects. In this study, females were predominant in both groups, mean age of the HTN patients was 41.0±5.6 years and non-HTN healthy subjects was 38.2±5.2 years. BMI and FBG were found higher in HTN group than that of non-HTN group but the differences were not statistically significant. Systolic and diastolic BP were found significantly higher in HTN group than that of non-HTN group. Serum Hcy level was significantly higher in HTN group (19.93±4.12 μmol/L) than that of non-HTN group (13.20±1.88 μmol/L). This study depicted that serum Hcy had significant correlation with SBP and DBP in HTN. In conclusion, it was seen that elevated serum Hcy level is associated with hytpertension. Bangladesh J Med Biochem 2018; 11(1): 22-25

scholarly journals Platelet Count In Preeclampsia

2013 ◽  
Vol 18 (2) ◽  
pp. 24-26 ◽  
Author(s):  
Razia Sultana ◽  
SM Fazlul Karim ◽  
Farhana Atia ◽  
Shahnila Ferdousi ◽  
Selina Ahmed
Keyword(s):  
Platelet Count ◽  
Pregnant Women ◽  
Case Control Study ◽  
Case Control ◽  
Third Trimester ◽  
Medical College ◽  
Significant Difference ◽  
The Mean ◽  
The Relationship ◽  
Control Study

Preeclampsia is one of the most leading causes of maternal mortality in developing countries like Bangladesh. Several studies have demonstrated the relationship between platelets count and preeclampsia. The aim of the study was to assess the association of platelets count with preeclampsia. A case control study was conducted in the Department of Biochemistry, Dhaka Medical College, Dhaka from July 2010 to June 2011. A total number of 100 pregnant women in third trimester of pregnancy attending in Obstetrics & Gynaecology Department of Dhaka Medical Hospital were selected as study subjects. Among them 50 diagnosed cases of preeclampsia were selected as cases and 50 normal healthy pregnant women as controls. Platelet count was measured in all study subjects. The mean platelet count in cases and controls were 1,44,260±96,472 and 1,98,100±51,219 respectively. The present study showed significant difference of mean platelet count between cases and controls. The study revealed that low platelets count is associated with preeclampsias. DOI: http://dx.doi.org/10.3329/jdnmch.v18i2.16018 J. Dhaka National Med. Coll. Hos. 2012; 18 (02): 24-26

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