scholarly journals Association of Serum Homocysteine and Serum Lipid with Eclampsia

1970 ◽  
Vol 5 (1) ◽  
pp. 7-10
Author(s):  
Monzarin Mahal ◽  
Farida Yeasmin ◽  
Syed AKM Nurul Amin ◽  
Afia Shahnaj ◽  
Maliha Rashid ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Lipid Profile ◽  
Homocysteine Level ◽  
Elevated Serum ◽  
Hdl Cholesterol ◽  
Significant Negative Correlation ◽  
Cholesterol Concentration ◽  
Mortality And Morbidity ◽  
Serum Homocysteine ◽  
Control Study

Eclampsia is one of the most common pregnancy complications causing high mortality and morbidity for both mother and foetus especially in developing countries. Many studies suggest that elevated homocysteine level is an important risk factor for eclampsia. The aim of this study was to explore the association between serum homocysteine with eclampsia and to establish serum homocysteine measurement as a reliable test for early detection of eclampsia. In a case control study serum homocysteine and lipid profile were measured in 52 controls (healthy uncomplicated pregnant women) and 50 eclamptic pregnant women. Serum homocysteine in eclampsia cases (10.44±4.08 μmol/L) found to be significantly increased (p < 0.001) compared to controls (7.97±3.46 μmol/L). Serum HDL-cholesterol concentration found to be significantly decreased (p < 0.001) in the cases (35.98±6.35 mg/dl) compared to controls (42.69±6.09 mg/dl). A significant negative correlation (r-.801, p < 0.01) was found between serum homocysteine and HDL-cholesterol concentration among cases. It can be concluded that elevated serum homocysteine and HDL-cholesterol deficiency were associated with eclampsia. But elevated homocysteine itself might be a factor associated with eclampsia irrespective of lipid profile status. Key Words: Homocysteine, Eclampsia.   doi: 10.3329/jafmc.v5i1.2842 JAFMC Bangladesh. Vol 5, No 1 (June) 2009 pp.7-10

scholarly journals Study Of Serum Lipid Profile In Pre-Eclampsia And Eclampsia

1970 ◽  
Vol 5 (2) ◽  
pp. 56-59 ◽  
Author(s):  
NAF Islam ◽  
MAR Chowdhury ◽  
GM Kibria ◽  
S Akhter
Keyword(s):  
Pregnant Women ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Significant Rise ◽  
Serum Lipid Profile ◽  
Cholesterol Concentration ◽  
High Density Lipoproteins

The present study was designed to evaluate the association of lipid profile in pre- eclampsia and eclampsia. This case-control study was carried out in the department of biochemistry, M.A.G. Osmani Medical College, Sylhet, during July 2005 to June 2006. Total 100 study subjects were evaluated, 40 normotensive pregnant women (mean age 24.90 ± 4.04) as normal and 60 already diagnosed preeclamptic & eclamptic women (mean age 24.17 ± 4.90) as study group. Age range was 15-45 years, gestational age 24 weeks to term were included. Patients with pre-existing hypertension were excluded. Serum lipid profile (total lipids, cholesterol, triglycerides, HDL-cholesterol and LDLcholesterol) of hundred women with Pre-eclampsia and Eclampsia (n=60), normotensive women (n=40) were monitored. The preeclampsia was associated with a significant rise in triglyceride (225.6 ± 28.93 vs 165.6 ± 17.22) and fall in HDL cholesterol concentration (42.4 ± 9.29 vs 55.7 ± 7.11), while eclamptic women showed significant fall in HDL cholesterol (41.8 ± 8.79 vs 55.7 ± 7.11) and rise in LDL cholesterol (133.4 ± 11.75 vs 115.2 ± 10.72) as compared to normal pregnant women. Lipid metabolism plays a key role in the pathophysiology of Pre-eclampsia and Eclampsia. Increased triglycerides levels along with decreased HDL-cholesterol levels and delayed triglycerides clearance and high blood pressure are associated with development of preeclampsia and eclampsia. This association may be significant in understanding the pathologic processes of preeclampsia and may help in developing strategies for prevention or early diagnosis of the disorder. Key Words: Preeclampsia; High Density Lipoproteins; Triglycerides; Low Density Lipoprotein. DOI: 10.3329/fmcj.v5i2.6823Faridpur Med. Coll. J. 2010;5(2):56-59

scholarly journals A study of serum lipid profile in normal pregnancy and pregnancy induced hypertensive disorders: a case-control study

2019 ◽  
Vol 8 (5) ◽  
pp. 2071
Author(s):  
Blessy Prabhu Priyanka S. ◽  
A. Padma Vijayasree ◽  
Devraj J. P. ◽  
Santosh Kumar B. ◽  
Mahesh Kumar Mummadi ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Lipid Profile ◽  
Case Control Study ◽  
Case Control ◽  
Significant Rise ◽  
Chronic Hypertension ◽  
Singleton Pregnancy ◽  
Mortality And Morbidity ◽  
Hypertensive Disorders ◽  
Control Study

Background: Pregnancy induced hypertensive disorders are one of the commonest complication of pregnancy which accounts for 12% of the maternal and perinatal mortality and morbidity. Dyslipidemias are associated with endothelial dysfunction that may result in proteinuria and hypertension which is a clinical hallmark of PIH. It affects both maternal health as well as fetal growth. Hence, this study was done to assess the role of altered lipid profile in the development of PIH.Methods: A Case Control study was conducted at the Department of Biochemistry, Kurnool Medical College and Govt General Hospital, Kurnool in collaboration with its Obstetrics Dept during the period of November 2015-2017. A total of 300 pregnant women, primigravida /multigravida with singleton pregnancy, in the age group of 18‐ 35 years with >20 weeks of gestation were included in the study. Subjects were divided into gestational hypertensives, n=39 (BP ≥140/80) and preeclamptic women, n=111 (≥140/80 and proteinuria) as cases. Age matched normotensive pregnant women, n=150 (BP 120/80) were recruited as Controls. Subjects with history of multiple pregnancies, pregnancy with congenital anomalies, chronic hypertension, diabetes mellitus, cardiac/thyroid/hepatic/renal disease, dyslipidemia were excluded. Total cholesterol, TG, HDL, LDL, VLDL were performed.Results: A comparison of these values between hypertensive and normotensive women showed a significant rise in TC, TG, LDL and VLDL. HDL-C showed a significant decrease in hypertensive women compared to normal pregnant women. LDL: HDL and TG:HDL ratios were higher in PIH group.Conclusions: The results of this study suggests an abnormal lipid metabolism, predominantly high TG concentrations and low HDL-C, which may add to the promotion of vascular dysfunction and oxidative stress seen in PIH. This association is significant in understanding the development of hypertension during pregnancy and is useful in early diagnosis and prevention of PIH.

scholarly journals Study of Elevation of Serum Homocysteine Level in Eclampsia in a Specilized Hospital Setting in Bangladesh

1970 ◽  
Vol 19 (2) ◽  
pp. 131-134
Author(s):  
M Mahal ◽  
MS Hossain ◽  
N Sultana ◽  
NS Chowdhury ◽  
SAKMN Amin
Keyword(s):  
Case Control Study ◽  
Homocysteine Level ◽  
Elevated Serum ◽  
Hospital Setting ◽  
Maternal Deaths ◽  
Medical College ◽  
Uncomplicated Pregnancy ◽  
Serum Homocysteine ◽  
The Relationship ◽  
Control Study

Context: Eclampsia is one of the most leading causes of maternal deaths in developing countries. Many studies have demonstrated the relationship between hyperhomocysteinemia and eclampsia. The aim of this study was to examine the association between serum homocysteine with eclampsia. Methods: A case control study carried out in the Department of Biochemistry, Dhaka Medical College, Dhaka. 50 diagnosed cases of eclampsia were taken as cases and 52 healthy women with uncomplicated pregnancy were taken as controls. Serum homocysteine was measured in all study subjects by fluorescence polarization immunoassay (FPIA) method. Result: Serum homocysteine found to be significantly increased (p<0.001) in patients with eclampsia (10.44±4.08 μmol/L) compared to controls (7.97±3.46 μmol/L). Conclusion: It can be concluded that elevated serum homocysteine is associated with eclampsia. Key words: Serum homocysteine; eclampsia. DOI: 10.3329/jdmc.v19i2.7085J Dhaka Med Coll. 2010; 19(2) : 131-134

Association of Serum Homocysteine Level and Interstitial Lung Disease in Systemic Sclerosis: A Case-control Study

2018 ◽  
Vol 15 (1) ◽  
pp. 74-78
Author(s):  
Mohammadali Nazarinia ◽  
Asghar Zare ◽  
Mohammad javad Fallahi ◽  
Mesbah Shams
Keyword(s):  
Systemic Sclerosis ◽  
Healthy Subjects ◽  
Case Control Study ◽  
Homocysteine Level ◽  
Case Control ◽  
Control Group ◽  
Lung Involvement ◽  
Serum Homocysteine ◽  
The Mean ◽  
Control Study

Background:Systemic sclerosis is a disorder of connective tissue with unknown cause, affecting the skin and internal organs, characterized by fibrotic changes.Objective:To determine the correlation between serum homocysteine level and interstitial lung involvement in systemic sclerosis. </P><P> Materials and Methods: In this case – control study, 59 patients who fulfilled the ACR/EULAR classification criteria for systemic sclerosis and were referred to Hafez Hospital of Shiraz, Iran, were included as the case group. Fifty nine healthy subjects were involved as the control group. Patients were divided into two groups based on interstitial lung involvement and two subtypes, diffuse and limited type. Serum homocysteine, vitamin B12, and folate levels compared between the controls, and cases groups.Results:Of 59 case and control group, 53 (%89.8) were female and the mean age did not differ in both groups (P=0.929). Thirty five (%59.3) patients had interstitial lung involvement and 38(%64.4) had diffuse cutaneous systemic sclerosis. The mean serum homocysteine level was 13.9±6.3 µmol/L in the case and 13.7±9.2 µmol/L in the control group (P=0.86). The mean serum homocysteine level did not differ between the patients with and without interstitial lung involvement (P=0.52). The patients with lung involvement was older than those without lung involvement (P=0.004). Lung disease was more common in diffuse type (P=0.014).Conclusion:In our study, serum homocysteine level did not differ between the patients and healthy subjects. Also, there was no correlation between serum homocysteine level and lung involvement, but lung involvement was more common in older patients and also diffuse subtype.

scholarly journals A More Atherogenic Serum Lipoprotein Profile Is Present in Women with Polycystic Ovary Syndrome: A Case-Control Study

2008 ◽  
Vol 93 (2) ◽  
pp. 470-476 ◽  
Author(s):  
Olivier Valkenburg ◽  
Regine P. M. Steegers-Theunissen ◽  
Huberdina P. M. Smedts ◽  
Geesje M. Dallinga-Thie ◽  
Bart C. J. M. Fauser ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Ldl Cholesterol ◽  
Case Control Study ◽  
Polycystic Ovary ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Ovary Syndrome ◽  
Atherogenic Lipid Profile ◽  
Control Study ◽  
Atherogenic Lipid

Abstract Context: Polycystic ovary syndrome (PCOS) is associated with a higher frequency of cardiovascular risk factors. Apolipoprotein (apo) A-I and apoB are potent markers for cardiovascular risk. Data on apo levels in women with PCOS are scarce and contradictory. Objective: Our objective was to identify changes in lipid metabolism in women with PCOS, and the relative impact of obesity, insulin resistance, and hyperandrogenism on lipid parameters. Design: This was a case-control study. Setting: The study was performed at a single referral center. Subjects: PCOS was diagnosed according to the 2003 Rotterdam criteria. Healthy mothers with regular menstrual cycles served as controls. Main Outcome Parameters: Fasting insulin, triglycerides (TGs), cholesterol, high-density lipoprotein (HDL)-cholesterol, apoA-I, and apoB were determined. Low-density lipoprotein (LDL)-cholesterol was calculated using the Friedewald formula. Results: We included 557 women with PCOS and 295 controls. After correction for age and body mass index, PCOS women had higher median levels of insulin (10.1 vs. 6.9 mU/liter), TGs (95 vs. 81 mg/dl), cholesterol (196 vs. 178 mg/dl), and LDL-cholesterol (125 vs. 106 mg/dl) in combination with lower levels of HDL-cholesterol (46 vs. 55 mg/dl) and apoA-I (118 vs. 146 mg/dl) compared with controls (all P values ≤ 0.01). apoB levels were similar in cases and controls. Free androgen index, body mass index, SHBG, and estradiol were independent predictors of apoA-I levels in women with PCOS. Conclusions: PCOS is associated with a more pronounced atherogenic lipid profile. Furthermore, obesity and hyperandrogenism contribute to an adverse lipid profile. Finally, PCOS seems to constitute an additional risk factor for an atherogenic lipid profile.

scholarly journals Effect of body weight on serum homocysteine level in patients with polycystic ovarian syndrome: A case control study

2016 ◽  
Vol 14 (2) ◽  
pp. 81-88 ◽  
Author(s):  
Ali Al- Gareeb ◽  
Wafaa Salah Abd Al- Amieer ◽  
Hayder M. Alkuraishy ◽  
Thabat J. Al- Mayahi ◽  
◽  
...  
Keyword(s):  
Body Weight ◽  
Polycystic Ovarian Syndrome ◽  
Case Control Study ◽  
Homocysteine Level ◽  
Case Control ◽  
Serum Homocysteine ◽  
Ovarian Syndrome ◽  
Control Study

scholarly journals Glycated Hemoglobin and Lipid Profile Association Among Pregnant Women in Saudi Arabian Population

2018 ◽  
Vol 7 (2) ◽  
pp. 216-222
Author(s):  
Farah Anjum ◽  
Rana Zaini ◽  
Ashjan Shami ◽  
Amani Rehaili ◽  
Rahma Kufia
Keyword(s):  
Pregnant Women ◽  
Lipid Profile ◽  
Ldl Cholesterol ◽  
Glycated Hemoglobin ◽  
Previous History ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Oral Glucose ◽  
Diabetic Patients ◽  
Significant Difference

Objectives: Glycated hemoglobin (HbA1c) is the most commonly used glycemic index among diabetic patients. The present study sought to investigate the relationship between HbA1c and lipid parameters among healthy pregnancies and gestational diabetic cases. Materials and Methods: Seventy-five Saudi pregnant women within the age group of 19 to 43 years were selected for this crosssectional study. The participants were categorized into with and without gestational diabetes (GDM), all of whom were non-smokers; in addition, they neither had a previous history of chronic illnesses nor were they on any medications which could alter lipid profile and HbA1c concentrations. Totally, 75 g of oral glucose tolerance test (OGTT) was utilized to identify 25 women with GDM. All biochemical tests including HbA1c, fasting blood sugar (FBG), total cholesterol (TC), low-density lipoprotein (LDL-cholesterol), triglycerides (TG), and high-density lipoprotein (HDL-cholesterol) were performed by a biochemical auto-analyzer. The collected data were statistically analyzed using a paired student’s t test. The P values of <0.05 were considered statistically significant on all the analyses related to healthy pregnancies and those associated with GDM. Results: The HbA1c and FBG values demonstrated significant correlation with GDM (P<0.001 each). However, TC, LDL-cholesterol, and TG failed to indicate any significant difference between the 2 groups. Conversely, HDL-cholesterol and the ratio of TG and HDLcholesterol revealed remarkable differences between GDM and healthy participants (P<0.05 each). Conclusions: In general, the blood levels of glucose, HbA1c, TG, and HDL-cholesterol are of paramount significance in GDM. Predictably, HbA1c can be employed as one of the markers in evaluating the risk factors in developing dyslipidemia among pregnant women.

scholarly journals Raised Serum Homocysteine Level is Associated with Hypertension

2019 ◽  
Vol 11 (1) ◽  
pp. 22-25
Author(s):  
S Biswas ◽  
R Haque ◽  
N Uddin ◽  
AR Saha ◽  
K Sultan ◽  
...  
Keyword(s):  
Homocysteine Level ◽  
Elevated Serum ◽  
Cross Sectional ◽  
Homocysteine Concentration ◽  
National Health Care ◽  
Medical College ◽  
Serum Homocysteine ◽  
Increased Risk ◽  
Clinical Measurements ◽  
Group Serum

An elevated serum homocysteine concentration is associated with an increased risk of coronary, cerebral, and peripheral vascular disease. The objective of the study was to evaluate the association of serum homocysteine level with hypertension (HTN). This cross sectional analytical study was conducted at Sir Salimullah Medical College & Mitford Hospital and National Health Care Network Dhaka, Bangladesh over a duration of 21 months from July 2012 to May 2014. Fifty HTN patients were included as study subjects and age and sex matched fifty non-HTN healtlhy controls were included. All the clinical measurements were taken and serum Hcy was measured for all study subjects. In this study, females were predominant in both groups, mean age of the HTN patients was 41.0±5.6 years and non-HTN healthy subjects was 38.2±5.2 years. BMI and FBG were found higher in HTN group than that of non-HTN group but the differences were not statistically significant. Systolic and diastolic BP were found significantly higher in HTN group than that of non-HTN group. Serum Hcy level was significantly higher in HTN group (19.93±4.12 μmol/L) than that of non-HTN group (13.20±1.88 μmol/L). This study depicted that serum Hcy had significant correlation with SBP and DBP in HTN. In conclusion, it was seen that elevated serum Hcy level is associated with hytpertension. Bangladesh J Med Biochem 2018; 11(1): 22-25

Abstract WP159: The Association Between Cerebral Artery Calcification and Homocysteine Among Stroke Patients

Stroke ◽  
2016 ◽  
Vol 47 (suppl_1) ◽  
Author(s):  
Kwang-Yeol Park ◽  
Jeong-Min Kim ◽  
Dong-Woo Shin ◽  
Moo-Seok Park
Keyword(s):  
Ct Angiography ◽  
Cerebral Artery ◽  
Homocysteine Level ◽  
Elevated Serum ◽  
Multivariate Logistic Regression Analysis ◽  
High Sensitivity ◽  
Bivariate Analysis ◽  
Brain Ct ◽  
Serum Homocysteine ◽  
Increased Risk

Introduction: Elevated serum homocysteine level is known to be associated with increased risk of atherosclerosis and cardiovascular event possibly through endothelial senescence. Also, homocysteine was reported to be a potential regulator of vascular calcification in animal study. Hypothesis: We hypothesized that elevated homocysteine level is associated with cerebral artery calcification. Methods: We identified 708 consecutive patients (mean age 66.3+/-12.9, 297 female patients) who were admitted with acute ischemic stroke or transient ischemic attack. Cerebral artery calcification was assessed from brain CT angiography, and advanced calcification was determined when calcification involved long (more than 1 cm) or thick (50% or more of vessel diameter) segment of distal cavernous internal carotid artery. Hyperhomocyseinemia was defined as serum homocysteine level exceeding 15 umol/L on admission. Results: Cerebral artery calcification from brain CT angiography was present in 546 patients (77.2%). Advanced cerebral artery calcification was detected in 156 patients (22.1%), and hyperhomocysteienemia was detected in 171 patients (24.2%). On bivariate analysis, advanced cerebral artery calcification was associated with hypertension, diabetes mellitus, smoking, atrial fibrillation, previous stroke history, high-sensitivity C-reactive protein (hs-CRP) and elevated homocysteine level. Multivariate logistic regression analysis including hyperhomocysteinemia, vascular risk factors, age>70 years and hsCRP>2.0mg/dL showed that hyperhomocysteinemia is independently associated with advanced cerebral artery calcification (odds ratio 1.8, confidence interval 1.1-2.8, p=0.011). Conclusion: Hyperhomocysteinemia was associated with advanced cerebral artery calcification. Our study suggests that homocysteine may be used as a biomarker for cerebral artery calcification.

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