scholarly journals Raised Serum Homocysteine Level is Associated with Hypertension

2019 ◽  
Vol 11 (1) ◽  
pp. 22-25
Author(s):  
S Biswas ◽  
R Haque ◽  
N Uddin ◽  
AR Saha ◽  
K Sultan ◽  
...  
Keyword(s):  
Homocysteine Level ◽  
Elevated Serum ◽  
Cross Sectional ◽  
Homocysteine Concentration ◽  
National Health Care ◽  
Medical College ◽  
Serum Homocysteine ◽  
Increased Risk ◽  
Clinical Measurements ◽  
Group Serum

An elevated serum homocysteine concentration is associated with an increased risk of coronary, cerebral, and peripheral vascular disease. The objective of the study was to evaluate the association of serum homocysteine level with hypertension (HTN). This cross sectional analytical study was conducted at Sir Salimullah Medical College & Mitford Hospital and National Health Care Network Dhaka, Bangladesh over a duration of 21 months from July 2012 to May 2014. Fifty HTN patients were included as study subjects and age and sex matched fifty non-HTN healtlhy controls were included. All the clinical measurements were taken and serum Hcy was measured for all study subjects. In this study, females were predominant in both groups, mean age of the HTN patients was 41.0±5.6 years and non-HTN healthy subjects was 38.2±5.2 years. BMI and FBG were found higher in HTN group than that of non-HTN group but the differences were not statistically significant. Systolic and diastolic BP were found significantly higher in HTN group than that of non-HTN group. Serum Hcy level was significantly higher in HTN group (19.93±4.12 μmol/L) than that of non-HTN group (13.20±1.88 μmol/L). This study depicted that serum Hcy had significant correlation with SBP and DBP in HTN. In conclusion, it was seen that elevated serum Hcy level is associated with hytpertension. Bangladesh J Med Biochem 2018; 11(1): 22-25

Abstract WP159: The Association Between Cerebral Artery Calcification and Homocysteine Among Stroke Patients

Stroke ◽  
2016 ◽  
Vol 47 (suppl_1) ◽  
Author(s):  
Kwang-Yeol Park ◽  
Jeong-Min Kim ◽  
Dong-Woo Shin ◽  
Moo-Seok Park
Keyword(s):  
Ct Angiography ◽  
Cerebral Artery ◽  
Homocysteine Level ◽  
Elevated Serum ◽  
Multivariate Logistic Regression Analysis ◽  
High Sensitivity ◽  
Bivariate Analysis ◽  
Brain Ct ◽  
Serum Homocysteine ◽  
Increased Risk

Introduction: Elevated serum homocysteine level is known to be associated with increased risk of atherosclerosis and cardiovascular event possibly through endothelial senescence. Also, homocysteine was reported to be a potential regulator of vascular calcification in animal study. Hypothesis: We hypothesized that elevated homocysteine level is associated with cerebral artery calcification. Methods: We identified 708 consecutive patients (mean age 66.3+/-12.9, 297 female patients) who were admitted with acute ischemic stroke or transient ischemic attack. Cerebral artery calcification was assessed from brain CT angiography, and advanced calcification was determined when calcification involved long (more than 1 cm) or thick (50% or more of vessel diameter) segment of distal cavernous internal carotid artery. Hyperhomocyseinemia was defined as serum homocysteine level exceeding 15 umol/L on admission. Results: Cerebral artery calcification from brain CT angiography was present in 546 patients (77.2%). Advanced cerebral artery calcification was detected in 156 patients (22.1%), and hyperhomocysteienemia was detected in 171 patients (24.2%). On bivariate analysis, advanced cerebral artery calcification was associated with hypertension, diabetes mellitus, smoking, atrial fibrillation, previous stroke history, high-sensitivity C-reactive protein (hs-CRP) and elevated homocysteine level. Multivariate logistic regression analysis including hyperhomocysteinemia, vascular risk factors, age>70 years and hsCRP>2.0mg/dL showed that hyperhomocysteinemia is independently associated with advanced cerebral artery calcification (odds ratio 1.8, confidence interval 1.1-2.8, p=0.011). Conclusion: Hyperhomocysteinemia was associated with advanced cerebral artery calcification. Our study suggests that homocysteine may be used as a biomarker for cerebral artery calcification.

scholarly journals Evaluation of serum homocysteine in young patients presenting with myocardial infarction: a study from rural Maharashtra

2020 ◽  
Vol 7 (11) ◽  
pp. 1635
Author(s):  
Sudam V. Khedkar ◽  
Sudeep Kumar ◽  
Praveen Patil ◽  
Anant A. Takalkar
Keyword(s):  
Myocardial Infarction ◽  
Heart Disease ◽  
Elevated Serum ◽  
Young Patients ◽  
Study Cohort ◽  
Case Control Studies ◽  
Cross Sectional ◽  
Male Predominance ◽  
Serum Homocysteine ◽  
Increased Risk

Background: It has been shown that elevated serum homocysteine levels are associated with an increased risk of ischemic heart disease (IHD) and stroke. Also, higher homocysteine concentrations in IHD or stroke patients than in controls have been reported. Some prospective and case-control studies with inconsistent results, some with highly significant results and others with no association have been observed. Objective of the study was to evaluate the serum homocysteine level in young myocardial infarction patients of rural hospital.Methods: The present hospital based cross sectional observational study was carried out in Department of Medicine, MIMER Medical College and Hospital, Talegaon Dabhade, Pune. The study population included 45 young patients having acute myocardial Infarction coming to our hospital. The data thus collected was entered in MS excel sheet and analysed by using SPSS 24.0 IBM USA.Results: Mean age of the study cohort was 36.7 years with 48.9% cases in between the age of 31-40 years and 33.3% were in the age range of 41-45 years. Male predominance was seen in the study cases with 68.9% males and 31.1% females. Prevalence of hyperhmocysteinemia was observed as 64.4% in present study. Mortality rate in our study was 6.67%. Serum homocysteine and all lipid parameters were in positive correlation except High-density lipoprotein which has negative correlation. Homocysteine levels were correlating significantly with level of atherosclerosis as measured by Gensini score.Conclusions: Coronary heart disease is related to high serum homocysteine concentration. Serum homocysteine levels also correlates well with the severity of MI.

scholarly journals Serum homocysteine level in male smokers of Bangladesh

2016 ◽  
Vol 45 (2) ◽  
pp. 72-74
Author(s):  
Shamima Jahan ◽  
Qazi Shamima Akhter ◽  
Fayeza Karim ◽  
Mir Jakib Hossain ◽  
Tania Yeasmin
Keyword(s):  
Adult Male ◽  
Cardiovascular Events ◽  
Homocysteine Level ◽  
Cross Sectional Study ◽  
Vital Role ◽  
Male Smoker ◽  
Cross Sectional ◽  
Medical College ◽  
Serum Homocysteine ◽  
Group B

Smoking may cause atherosclerosis and acute cardiovascular events and hyperhomocystenemia may found in smokers that play a vital role in development of atherosclerosis and acute cardiovascular events. The present cross sectional study was carried out in the Department of Physiology, Dhaka Medical College, Dhaka between July 2013 to June 2014 to assess the serum homocysteine (Hcy) level in male smokers. A total number of 200 male subjects were selected with age ranging from 20 to 40 years. Among them, 100 male smokers were included in the study group (Group B) and 100 male non-smokers of same age ranging were considered as controls (Group A). Detailed smoking and medical history was taken regarding drug intake and general examinations were done. The mean serum homocysteine level was significantly higher in adult male smoker than that of adult male non smoker (p < 0.001). This study concludes that serum homocysteine level increases in male smokers which may act as risk factor for future cardiovascular diseases and atherosclerosis.Bangladesh Med J. 2016 May; 45 (2): 72-74

scholarly journals Homocysteine – relation to hypertension, age and smoking in patients with newly diagnosed essential hypertension

2015 ◽  
Vol 84 (2) ◽  
pp. 90-96
Author(s):  
Katarzyna Korzeniowska ◽  
Artur Cieślewicz ◽  
Ewa Chmara ◽  
Anna Jabłecka
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Healthy Volunteers ◽  
Homocysteine Level ◽  
Control Group ◽  
Newly Diagnosed ◽  
Peripheral Vascular ◽  
Homocysteine Concentration ◽  
Serum Homocysteine ◽  
Increased Risk

Introduction. An elevated circulating concentration of homocysteine is associated with an increased risk of coronary, cerebral, and peripheral vascular disease. The purpose of this study was to determine the concentrations of homocysteine in the patients with newly diagnosed essential hypertension and healthy subjects and to analyze the correlation between homocysteine level and the other parameters (age, blood pressure, smoking).Material and methods. The study group consisted of 18 patients with essential hypertension, 4 women and 14 men (mean age 43 ± 16 years) and 15 healthy volunteers, 8 women and 7 men (mean age 47 ± 10 years). Serum homocysteine was analyzed by FPIA method (Fluorescence Polarization Immunoassay).Results. The patients with essential hypertension had significantly higher homocysteine concentration compared to control group. No correlation was observed between homocysteine levels and age, diastolic, systolic blood pressure in subjects with essential hypertension. In healthy volunteers, only a correlation between age and homocysteine concentration was found.

scholarly journals Study of Elevation of Serum Homocysteine Level in Eclampsia in a Specilized Hospital Setting in Bangladesh

1970 ◽  
Vol 19 (2) ◽  
pp. 131-134
Author(s):  
M Mahal ◽  
MS Hossain ◽  
N Sultana ◽  
NS Chowdhury ◽  
SAKMN Amin
Keyword(s):  
Case Control Study ◽  
Homocysteine Level ◽  
Elevated Serum ◽  
Hospital Setting ◽  
Maternal Deaths ◽  
Medical College ◽  
Uncomplicated Pregnancy ◽  
Serum Homocysteine ◽  
The Relationship ◽  
Control Study

Context: Eclampsia is one of the most leading causes of maternal deaths in developing countries. Many studies have demonstrated the relationship between hyperhomocysteinemia and eclampsia. The aim of this study was to examine the association between serum homocysteine with eclampsia. Methods: A case control study carried out in the Department of Biochemistry, Dhaka Medical College, Dhaka. 50 diagnosed cases of eclampsia were taken as cases and 52 healthy women with uncomplicated pregnancy were taken as controls. Serum homocysteine was measured in all study subjects by fluorescence polarization immunoassay (FPIA) method. Result: Serum homocysteine found to be significantly increased (p<0.001) in patients with eclampsia (10.44±4.08 μmol/L) compared to controls (7.97±3.46 μmol/L). Conclusion: It can be concluded that elevated serum homocysteine is associated with eclampsia. Key words: Serum homocysteine; eclampsia. DOI: 10.3329/jdmc.v19i2.7085J Dhaka Med Coll. 2010; 19(2) : 131-134

Serum uric acid levels and risk of prehypertension: a meta-analysis

2017 ◽  
Vol 55 (3) ◽  
Author(s):  
Menglin Jiang ◽  
Dandan Gong ◽  
Yu Fan
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Meta Analysis ◽  
Elevated Serum ◽  
China National Knowledge Infrastructure ◽  
Cross Sectional ◽  
Knowledge Infrastructure ◽  
Increased Risk ◽  
Cross Sectional Studies ◽  
The Relationship

AbstractElevated serum uric acid (SUA) levels may increase the risk of prehypertension. However, the findings from these studies remain conflicting. The objective of this study was to determine the relationship between SUA levels and risk of prehypertension by conducting a meta-analysis. We conducted a comprehensive literature search of PubMed, Embase, China National Knowledge Infrastructure, VIP, and the Wangfang database without language restrictions through May 2015. Observational studies assessing the relationship between SUA levels and prevalence of prehypertension were included. Pooled adjust odds ratio (OR) and corresponding 95% confidence intervals (CI) of prehypertension were calculated for the highest vs. lowest SUA levels. Prehypertension was defined as systolic blood pressure (BP) ranging from 120 to 139 mmHg or diastolic BP ranging from 80 to 89 mmHg. Eight cross-sectional studies with a total of 21,832 prehypertensive individuals were included. Meta-analysis showed that elevated SUA levels were associated with increased risk of prehypertension (OR: 1.84; 95% CI: 1.42–2.38) comparing the highest vs. lowest level of SUA levels. Subgroup analyses showed that elevated SUA levels significantly increased the risk of prehypertension among men (OR: 1.60; 95% CI: 1.12–2.21) and women (OR: 1.59; 95% CI: 1.17–2.16). Elevated SUA levels are positively associated with the risk of prehypertension in the general population. However, more well-designed longitudinal studies are needed before a definitive conclusion can be drawn due to the cross-sectional studies included are susceptible to bias.

scholarly journals Correlation between Serum Homocysteine and Vitiligo Area Scoring Index

2017 ◽  
Vol 5 (3) ◽  
pp. 332-334 ◽  
Author(s):  
Dina R. U. Hasibuan ◽  
Imam B. Putra ◽  
Nelva K. Jusuf
Keyword(s):  
Family History ◽  
Homocysteine Level ◽  
Cross Sectional ◽  
Characteristic Finding ◽  
Serum Homocysteine ◽  
Gender And Age ◽  
Significant Difference ◽  
Chronic Skin ◽  
Scoring Index

Background: Vitiligo is a chronic skin disorder. White macules caused by melanocyte destruction is a characteristic finding that cosmetically disturbing. Until recently, pathogenesis of vitiligo is still unclear. The role of homocysteine in vitiligo is mentioned in previous studies thus it is probable that it can be a biomarker to determine vitiligo severity. Aim : To determine correlation between serum homocysteine and vitiligo area scoring index (VASI)Subject and method: This was a cross-sectional analytic study which involved 30 vitiligo patients that were diagnosed by clinical and Wood’s lamp examinations then VASI score was determined and same numbers of control. We conducted blood sampling and measurement of serum homocysteine level to the patients.Results: There is no significant correlation between serum homocysteine and VASI score (p= 0,133, r= 0,281), family history (p=0,447), and duration of vitiligo (p= 0,993, r= 0,002). There is no significant difference between serum homocysteine in vitiligo patients and controls (p= 0,191). There is a correlation between serum homocysteine with gender (p= 0,001) and age (p= 0,036;r= 0,385)  in vitiligo patient but not in controls (p= 0,266), (p= 0,872; r= 0,031). There is a correlation between serum homocysteine and types of vitiligo. Conclusion: There is no significant correlation between serum homocysteine and VASI score, family history, and duration of vitiligo. There is no significant difference between serum homocysteine in vitiligo patients and controls. There is a correlation between serum homocysteine with gender and age in vitiligo patients.

scholarly journals Pregnancy with previous caesarean section: an overview of adverse fetomaternal sequelae

2018 ◽  
Vol 7 (5) ◽  
pp. 1817 ◽  
Author(s):  
Joyita Bhowmik ◽  
Amit Kyal ◽  
Indrani Das ◽  
Vidhika Berwal ◽  
Pijush Kanti Das ◽  
...  
Keyword(s):  
Caesarean Section ◽  
Cesarean Section ◽  
Previous History ◽  
Successful Outcome ◽  
Maternal Complications ◽  
Cross Sectional ◽  
Medical College ◽  
Increased Risk ◽  
Fetal Complications ◽  
History Of

Background: The Caesarean section epidemic is a reason for immediate concern and deserves serious international attention. The purpose of this study was to evaluate adverse maternal and fetal complications associated with pregnancies with history of previous caesarean section.Methods: A cross-sectional, observational study carried out over a period of 1 year from 1st June 2016 to 31st July 2017 in Medical College Kolkata. 200 antenatal patients with previous history of 1 or more caesarean sections were included. In all cases thorough history, complete physical and obstetrical examination, routine and case specific investigations were carried out and patients were followed till delivery and for 7 days thereafter. All adverse maternal and fetal complications were noted.Results: Out of 200 women, 30 candidates were tried for VBAC, of them 20 (66.66%) had successful outcome. Most common antenatal complication was APH (5.5%) due to placenta praevia followed by scar dehiscence. There were 12 cases (6.66%) of PPH and 6 cases (3.33%) of scar dehiscence in the study group. 3 cases required urgent hysterectomy due to placenta accreta. 42 out of 196 babies required management in SNCU immediately or later after birth.Conclusions: Women with a prior cesarean are at increased risk for repeat cesarean section. Vigilance with respect to indication at primary cesarean delivery, proper counselling for trial of labor and proper antepartum and intrapartum monitoring of patients are key to reducing the cesarean section rates and maternal complications.

scholarly journals Study of Patients with First unprovoked Seizure in the Eastern Part of Nepal

2019 ◽  
Vol 8 (1) ◽  
pp. 22-26
Author(s):  
Dilli Ram Kafle ◽  
Surendra Sah ◽  
Miluna Bhusal
Keyword(s):  
Recurrence Risk ◽  
Cross Sectional Study ◽  
P Value ◽  
Seizure Recurrence ◽  
Unprovoked Seizure ◽  
Cross Sectional ◽  
Medical College ◽  
Increased Risk ◽  
Neuro Imaging

Background: About 5-10% of the population get at least one seizure in their lifetime. Treatment is started in patients with first unprovoked seizure if the risk of seizure recurrence is predicted to be high. If patients with first seizure are not treated 40-50% of patients develop recurrence within 2 years of the initial seizure. Starting treatment may cause reduction in the risk of recurrence by almost one half. The aim of the study was to identify the factors causing recurrence in patients with first unprovoked seizure. Materials and Methods: It is a prospective cross-sectional study conducted at Nobel Medical College from March 2015 to March 2019. Patients who presented to Nobel Medical College with first unprovoked seizure were enrolled in the study with follow up during the hospital visit. Results: Eighty six patients participated in our study. Recurrence of seizure occurred in 21(24.4%) patients within the study period of 4 years. Abnormal Electroencephalography was significantly associated with recurrence of seizure in patients with first seizure. (P value<0.001) Neuro imaging abnormality was also associated with increased risk of seizure recurrence (Pvalue<0.001) .Starting an antiepileptic after first seizure reduced the risk of further seizure. Conclusion: Recurrence of seizure was observed in almost a quarter of patients within the study period of four years. Recurrence risk was higher in those patients with abnormal Electro encephalography and in those patients with identified cause than those patients whose seizure was assumed to be idiopathic.

scholarly journals A Pattern of Age-related Macular Degeneration

2009 ◽  
Vol 48 (175) ◽  
Author(s):  
Suprada Pokhrel ◽  
O K Malla ◽  
C L Pradhananga ◽  
S N Joshi
Keyword(s):  
Macular Degeneration ◽  
College Teaching ◽  
Female Gender ◽  
Cross Sectional Study ◽  
Age Related Macular Degeneration ◽  
Cross Sectional ◽  
Medical College ◽  
Age Related ◽  
Increased Risk ◽  
Number Of Individuals

Introduction: Age related macular degeneration is a disorder of the macula most often clinicallyapparent affecting central vision and is one of the leading causes of blindness in the populationabove 50 years. The aim of this study is to determine clinical profi le of AMD in Nepalese presentingto a Teaching Hospital in Kathmandu.Methods: It was a hospital-based cross-sectional study. The subjects included in the study were thosepresenting to the Ophthalmology department of Kathmandu Medical College Teaching Hospitalfrom July 2007- Dec 2007.The total number of individuals included in the study were 402 and totalnumber of eyes were 804.Results: AMD was observed in 5.2% out of 402 subjects of 40 years and above age group withprevalence increasing with age. The prevalence of AMD was 0.7% within 40-50 years of age-groupindividuals increasing to 2.6% in 51-60 years, 6.5% in 61-70 years and to 19.3% among subjectsabove 71 years. This study revealed that the prevalence of AMD in females was higher with femalepreponderance in ratio of 2.5:1. 52.5 % AMD subjects in our study had visual impairment with 6/24-6/60 vision and 15% had vision <3/60-PL. Our study revealed statistically signifi cant increased riskfor AMD with aging (p=0.00). Increased risk was observed in female gender and diabetics though theOdds ratio (OR) was statistically insignifi cant (p=>0.01).Conclusions: Prevalence of AMD in Nepalese presenting to Kathmandu Medical College TeachingHospital was 5% with female preponderance in ratio of 2.5:1. Aging showed statistically signifi cantincreased risk for AMD development in this study.Key Words: Age-related macular degeneration, blindness, Nepalese, prevalence

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