scholarly journals Pattern of Antimicrobial Susceptibility for Salmonella Typhi in Dhaka Medical College Hospital from 2013-2014

2017 ◽  
Vol 25 (2) ◽  
pp. 115-118
Author(s):  
Sultana Shazeda Nahar ◽  
Aliya Rashid ◽  
Sagana Shahreen Chowdhury ◽  
Ayesha Begum ◽  
Nadira Akter ◽  
...  
Keyword(s):  
Antimicrobial Susceptibility ◽  
Antibiotic Sensitivity ◽  
Salmonella Typhi ◽  
Multidrug Resistant ◽  
Salmonella Spp ◽  
College Hospital ◽  
Female Ratio ◽  
Medical College ◽  
Antimicrobial Susceptibility Pattern ◽  
Sensitivity Pattern

Multidrug resistant Salmonella spp has been emerged as a cause of concern. This study was done to evaluate recent status in antimicrobial susceptibility pattern of Salmonella typhi isolated from blood in Dhaka Medical college Hospital.Methods- The retrospective study was done over a two year period between January 2013 to December 2014 at Microbiology laboratory, Dhaka Medical College. A total of 203 isolates of Salmonella typhi obtained from blood cultures. Both the indoor and outdoor patients were enrolled in this study.Results- During the two year study period, total 203 cases were enrolled. Among them 66% were male with a male to female ratio 2:1. The bulk (55%) cases were in the age group of 15-30 years, 34% cases were in less than 15 years and 10% cases were between the ages of 31-45 years. Regarding antibiotic sensitivity pattern, 90.14% strains were sensitive to amikacin, 90.47% to gentamycin and amoxyclav. 89.16% to doxycycline, 83.75% to cotrimoxazole, 71.42% to azithromycin and 86.2% to ceftazidime. All the Salmonella were sensitive to ceftriaxone, 95.07% were sensitive to ciprofloxacin and 88% were nalidixic acid resistant Salmonella typhi (NARST).Conclusion- Ceftriaxone may be used to treat typhoid fever cases and quinolone has no longer efficacy to treat such cases. Azithromycin may be used as an alternative drug if it is found susceptible in culture and sensitivity testing.J Dhaka Medical College, Vol. 25, No.2, October, 2016, Page 115-118

scholarly journals Antimicrobial sensitivity pattern of Salmonella typhi isolated from blood culture in a referral hospital

2011 ◽  
Vol 5 (1) ◽  
pp. 16-20 ◽  
Author(s):  
Bulbul Hasan ◽  
Sabera Gul Nahar ◽  
Laila Akter ◽  
Ahmed Abu Saleh
Keyword(s):  
Blood Culture ◽  
Typhoid Fever ◽  
Antimicrobial Susceptibility ◽  
Salmonella Typhi ◽  
Susceptibility Pattern ◽  
Widal Test ◽  
College Hospital ◽  
Medical College ◽  
Antimicrobial Susceptibility Pattern ◽  
Sensitivity Pattern

The present study has been carried out in an attempt to evaluate antimicrobial susceptibility patterns with special reference to susceptibility of Salmonella Typhi to ciprofloxacin isolated from blood culture. The study is also designed to find out the MIC of Ciprofloxacin by E- test. Blood samples were taken for culture sensitivity, Widal test and ICT from 100 clinically suspected cases of typhoid fever in 1st week of illness who attended at out patient department of Rajshahi Medical College Hospital (RMCH).The study was done in Microbiology Department of Rajshahi Medical College and Shishu Hospital, Dhaka. Diagnosis of patients was based on history of fever, blood culture, Widal test and ICT. The antimicrobial susceptibility pattern of isolates from blood culture was recorded. Further more, the minimum inhibitory concentration of Ciprofloxacin was determined by E-test for the isolates resistance to Ciprofloxacin. Out of 100 suspected cases of typhoid fever, blood culture positive for S. Typhi were 16 (16%). Antimicrobial susceptibility pattern of 16 isolates of S. Typhi showed that no isolate was resistant to Ceftriaxone and Ceftazidime, only 03(18.75%) were resistant to Ciprofloxacin and Azithromycin whereas 10(62.5%) were MDR showing resistance to Ampicillin, Co-trimoxazole and Chloramphenicol which are first-line antityphoidal drugs. On the other hand, all (100%) the isolates were resistant to Nalidixic acid. The study revealed that Ceftriaxone and Ceftazidime are the most effective drugs in the treatment of typhoid fever. Moreover, E-test has been found to be helpful to determine appropriate therapeutic dose of Ciprofloxacin especially in case of drug resistance and pediatric population.DOI: http://dx.doi.org/10.3329/bjmm.v5i1.15816 Bangladesh J Med Microbiol 2011; 05 (01): 16-20

Antibiotic Sensitivity and Resistance Patterns of Salmonella Typhi in Rajshahi Medical College Hospital

2020 ◽  
Vol 33 (2) ◽  
pp. 10-14
Author(s):  
Md Azizul Haque ◽  
Laila Shamima Sharmin ◽  
KM Faisal Alam ◽  
Md Mohimanul Hoque ◽  
M Morsed Zaman Miah ◽  
...  
Keyword(s):  
Blood Culture ◽  
Enteric Fever ◽  
Antibiotic Sensitivity ◽  
Salmonella Typhi ◽  
Medical College Hospital ◽  
Personal Hygiene ◽  
Care Hospital ◽  
College Hospital ◽  
Medical College ◽  
Sensitivity Pattern

Typhoid and paratyphoid fevers, collectively known as enteric fever, is caused by Salmonella enterica subspecies serovars Typhi and Paratyphi A, B and C. Despite this declining global trend, enteric fever is still considered to be a major public health hazard in Bangladesh and other developing countries due to poor sanitation, inadequate food safety measures and poor personal hygiene. In Bangladesh, the incidence of typhoid fever was reported to be 200 episodes per 100,000 person-years during 2003–2004. Multidrug-resistant (resistance to the first-line antimicrobials ampicillin, cotrimoxazole, and chloramphenicol) strains of S. Typhi and S. Paratyphi are on the rise globally and even cases of extensively drug-resistant (XDR) typhoid cases resistant to chloramphenicol, ampicillin, trimethoprim-sulfamethoxazole, third generation cephalosporins and fluoroquinolones are being reported from many corners of the world. This descriptive, observational study was carried out in Rajshahi Medical College Hospital Hospital, Rajshahi, Bangladesh from July 2017 to June 2019. Antibiotic sensitivity pattern of total 76 cases of enteric fever due to Salmonella Typhi were studied. Blood culture was carried out by BACT ALERT-3D, Automated blood culture analyzer from BioMeriuex SA, France Patented FAN Plus method. Based on the minimum inhibitory concentration (MIC), the organism was categorized as sensitive, intermediate, and resistant against the respective antibiotics as per Clinical and Laboratory Standards Institute (CLSI) criteria. We are reporting antibiotic sensitivity and resistant patterns of S. Typhi documented in Rajshahi Medical College Hospital, a large tertiary care hospital in Northern Bangladesh. TAJ 2020; 33(2): 10-14

scholarly journals Antimicrobial susceptibility pattern for Salmonella Typhi isolated from blood in Shaheed Suhrawardy Medical College, Dhaka

2019 ◽  
Vol 10 (2) ◽  
pp. 96-98 ◽  
Author(s):  
Mst Naznin Tarana ◽  
Samshad Jahan Shumu ◽  
Rashida Akter Khanam ◽  
Hosne Jahan ◽  
Soma Sarker ◽  
...  
Keyword(s):  
Public Health ◽  
Typhoid Fever ◽  
Salmonella Typhi ◽  
Health Concern ◽  
Public Health Concern ◽  
Salmonella Spp ◽  
Sensitivity Testing ◽  
Female Ratio ◽  
Medical College ◽  
Sensitivity Pattern

Background: Typhoid fever remains a public health concern in developing countries. Antibiotic therapy constitutes the mainstay of management and multidrug resistant Salmonella spp has been emerged as a major public health concern. Objective: This study was done to evaluate antimicrobial sensitivity pattern of Salmonella typhi isolated from blood in Shaheed Suhrawardy Medical College Hospital. Methods: The retrospective study was done from January 2017 to December 2017 at microbiology laboratory, Shaheed Suhrawardy Medical College. A total of 367 samples, 30 isolates of Salmonella typhi obtained from blood culture. Both the indoor and outdoor patients were enrolled in this study. Results: During one year study period, total 367 cases were enrolled and the prevalence of Salmonella typhi was 30 (8.2 %). Among them (56.1%) were male with a male to female ratio 1.27:1. The bulk (50.1%) cases were in the age group of 15-30 years, 14.4% cases were in less than 15 years and 6.5% cases were in more than 60 years of age. Regarding antibiotic sensitivity pattern, 70% strains were sensitive to amikacin, 73.33% to azithromycin, 63.33% to ceftazidime, 66.66% to ceftriaxone, 86.66% to ciprofloxacin and 70% were nalidixic acid resistant Salmonella typhi. Conclusion: Ciprofloxacin may be used to treat typhoid fever cases and Ceftriaxone, azithromycin may be used as alternative drugs if they are found susceptible in culture and sensitivity testing. J Shaheed Suhrawardy Med Coll, December 2018, Vol.10(2); 96-98

scholarly journals Blood Culture Isolates and Antibiogram of Salmonella: The Gathering Storm

KYAMC Journal ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 188-190
Author(s):  
Ishrat Binte Reza ◽  
HAM Nazmul Ahasan ◽  
Moshtaque Ahmed ◽  
Homayra Tahseen ◽  
Tasmina Chowdhury
Keyword(s):  
Drug Resistance ◽  
Antibiotic Sensitivity ◽  
Multidrug Resistant ◽  
Bacterial Strains ◽  
College Hospital ◽  
Major Health ◽  
Medical College ◽  
Sensitivity Pattern ◽  
Highly Sensitive ◽  
The World

Introduction: Typhoid fever is a common problem all over the world including Bangladesh. It is caused by salmonella typhae and paratyphae and it is an old infectious water born disease. It is encountered in Bangladesh throughout the year. For many years it is treated by Chloramphenicol and subsequently Cotrimoxazole and Amoxicillin. Despite the use of newly developed antibacterial drugs, enteric fevers caused by multidrug-resistant bacterial strains are one of major health problems in Bangladesh. Multidrug resistant Salmonella sp. has been emerged is a cause of concern. Materials and Methods: This is a retrospective study done at the Popular Medical College Hospital over a period of 6 months between January 2018 to june 2018. Results: During the study period, total 115 cases were enrolled. Regarding antibiotic sensitivity pattern, 69% strains were sensitive to Ampicillin, 100% to Cefixime and Ceftriaxone, 75% to Cotrimoxazole, 52% to Nalidixic Acid and 68% to Ciprofloxacin, 69% to Levofloxacin, 80% to Cholarphenicol. Conclusion: Ceftriaxone and Cefixime were found to be highly sensitive. So, we should be very careful for the judicious use of these valuable drug to prevent drug resistance. KYAMC Journal Vol. 10, No.-4, January 2020, Page 188-190

scholarly journals Prevalent Bacteria and Their Sensitivity and Resistance Pattern to Antibiotics: A Study in Dhaka Medical College Hospital

2017 ◽  
Vol 26 (1) ◽  
pp. 52-64
Author(s):  
Mohammad Zaid Hossain ◽  
Akhtarun Naher ◽  
Pratyay Hasan ◽  
Kazi Tuba E Mozazfia ◽  
Homyra Tasnim ◽  
...  
Keyword(s):  
Nalidixic Acid ◽  
Antibiotic Sensitivity ◽  
Sampling Technique ◽  
Salmonella Typhi ◽  
Medical College Hospital ◽  
Resistance Pattern ◽  
College Hospital ◽  
Medical College ◽  
Sensitivity Pattern ◽  
Changes Over Time

Background and rationale: Antibiotic resistance is a global problem. Many factors are complexly related to the issue in multiple dimensions. Bangladesh is right in the middle of this great calamity, and is seeing the rise in resistant strains of several bacteria. Very sadly, the prevalent malpractice of abusing antibiotics in Bangladesh contributes to add complexity to the danger which may prove to be possibly the greatest threat humans have ever faced. There is much scarcity of medical literature in Bangladesh, on the antibiotic sensitivity pattern and prevalent microorganisms. Moreover, antibiotic sensitivity pattern changes over time and place. Again, most of the studies done in Bangladesh, concentrate on a single disease, pathogen, or specimen. This study attempts to see the prevalent microorganisms and the antibiotic sensitivity pattern in multiple types of specimens collected from Dhaka Medical College Hospital. This study also attempts to establish a way of presentation of the relevant findings which can be used in future to ensure easy comparability and contrasting of findings.Methods: The specimens were collected from the adult patients (age >12 years) admitted in the Internal Medicine ward of Dhaka Medical College Hospital, Dhaka, over a period of 6 months. The sampling technique was consecutive sampling method. Specimens which were culture positive, were only included in the study for analysis. Multiple specimens were taken.Results: S. aureus was 100% sensitive to amikacin, moxifloxacin, imipenem, meropenem, piperacillin+tazobactum combination, vancomycin, doxycycline, tetracycline, tigecycline, nitrofurantoin, azactum, linezolid and 100% resistant to cefixime. Enterobacter was 100% sensitive to penicillin, amikacin, gentamicin, netilmicin, doxycycline, tetracycline, tigecycline and 100% resistant to cefixime, ceftazidime, ceftriaxone, cefepime, cotrimoxazole, levofloxacin, vancomycin. E. coli was 100% sensitive to imipenem, meropenem, vancomycin, tigecycline and 100% resistant to mecillinam, aztreonam. Klebsiella was 100% sensitive to flucloxacillin, colistin, vancomycin, tigecycline, linezolid and 100% resistant to nalidixic acid. Proteus was 100% sensitive to cephradine, cefoxitin, cefixime, ceftazidime, ceftriaxone, cefepime, cotrimoxazole, amikacin, ciprofloxacin, imipenem, meropenem, netilmicin, piperacillin+tazobactum combination, tetracycline, tigecycline, azithromycin, azactum and 100% resistant to doxycycline, tetracycline, chloramphenicol and cefuroxime. Pseudomonas was 100% sensitive only to amikacin, netilmicin, and 100% resistant to cefixime, ceftazidime, ceftriaxone, cefepime, cotrimoxazole, gentamicin, ciprofloxacin, levofloxacin, imipenem, meropenem, doxycline, tetracycline, chloramphenicol. Salmonella typhi was 100% sensitive to amoxicillin, cefoxitin, cefixime, ceftriaxone, cefepime, cotrimoxazole, amikacin, netilmicin, azithromycin, chloramphenicol, azactum and 100% resistant to cephradine, doxycycline, tetracycline, nalidixic acid. MRSA was 100% sensitive to imipenem, vancomycin, teicoplanin, nitrofurantoin, linezolid and 100% resistant to cefpirome, cefoxitin, ceftazidime, cotrimoxazole, clindamycin, gentamicin, ciprofloxacin, netilmicin, tetracycline, clarithromycin. Acinetobacter was 100% sensitive to penicillin, cefuroxime, colistin, piperacillin+tazobactum combination, tigecycline, chloramphenicol and 100% resistant to cefixime, nalidixic acid. Citrobacter freundii was 100% sensitive to ceftazidime, ceftriaxone, cotrimoxazole, amikacin, gentamicin, ciprofloxacin, levofloxacin, imipenem, meropenem, netilmicin, nalidixic acid and 100% resistant to ampicillin, cefixime, nitrofurantoin.Conclusion: More and more antibiotics are becoming ineffective due to emergence of resistance. Serious actions should be taken. Awareness should be raised from the policy maker level to the physicians and patients.J Dhaka Medical College, Vol. 26, No.1, April, 2017, Page 52-64

scholarly journals Phage Types of multidrug resistant Salmonella species in a rural area of Maharashtra, India

1970 ◽  
Vol 11 (1) ◽  
pp. 37-39
Author(s):  
ST Sabiha ◽  
SL Nilekar
Keyword(s):  
Antimicrobial Susceptibility ◽  
Phage Type ◽  
Antibiotic Sensitivity ◽  
Salmonella Typhi ◽  
Multidrug Resistant ◽  
Phage Typing ◽  
Diffusion Method ◽  
Inappropriate Use ◽  
Phage Types ◽  
Sensitivity Pattern

Objective: The aim of the present study is to know Phage typing and antimicrobial susceptibility pattern of Salmonella species. Methods: A total of 32 Salmonella species isolated from stool and blood specimen were included in the study. They were sent for phage typing to Lady Hardinge Medical College, New Delhi. Antimicrobial susceptibility was done by using Kirby Bauer disc diffusion method. Results: Majority of Salmonella typhi belongs to phage type E1 and biotype I. Decreased susceptibility of the isolate was observed to Ampicillin, Cotrimoxazole, Cephalexin and Gentamicin. Majority of the isolates were sensitive to Ciprofloxacin. Conclusion: Predominant phage type was E1. The antibiotic sensitivity pattern is changing and resistant cases are emerging due to inappropriate use of antibiotics. DOI: http://dx.doi.org/10.3329/bjms.v11i1.9821 BJMS 2012; 11(1): 37-39

scholarly journals Current Pattern in Antimicrobial Susceptibility in Enteric Fever In A Private Medical College

2013 ◽  
Vol 13 (1) ◽  
pp. 67-69
Author(s):  
Md Yasir Arafat ◽  
Md Abdus Sobur ◽  
Md Azizul Haq ◽  
Md Nazrul Islam
Keyword(s):  
Antimicrobial Susceptibility ◽  
Enteric Fever ◽  
Medical Science ◽  
Multidrug Resistant ◽  
P Value ◽  
Current Pattern ◽  
College Hospital ◽  
Medical College ◽  
Sensitivity Pattern ◽  
Z Value

Background and objectives: Enteric fever continues to be an important health problem in Bangladesh. Emerging drug resistance adds magnitude to this problem. Only surveillance studies can help form guidelines for therapy under such a situation. The present study was undertaken to determine the current pattern in antimicrobial susceptibility of enteric fever cases in a private medical college and to find out the incidence of multidrug resistant (MDR) cases. Study design: Hospital based observational study. Study setting and period: Medicine units of Ibn Sina Medical College hospital from october’11 to august’12. Source of materials/participants: Fever cases with clinical diagnosis of enteric fever and positive blood culture, attending the outpatient and admitted at hospital were included in the study. Susceptibility of the isolates to commonly available antibiotics were recorded. Treatment and responses were followed up. Results: 100 adult patients with fever had positive blood cultures were included in the study. Majority of patients were 19 – 30 yr olds (63%). Susceptibility of the isolates were tested against 14 available antibiotics. Ceftriaxone was sensitive in 99% cases followed by ciprofloxacin (96%), Gentamycin ( 96%) and cefixime (91%). Adeclining trend in sensitivity to Azithromycin ( 61%) was observed. Resurgence of chloramphenicol (81%) and cotrimoxazole (75%) sensitivity was noted. In 98 cases sensitivity to all three (amoxicillin, co-trimoxazole and chloramphenicol) were tested. 13 cases were found resistant to all the three drugs (13/98=13.2%). These MDR cases were sensitive to ceftriaxone (100%), cefixime (100%), azithromycin (100%), gentamycin(94%)and ciprofloxacin (88%). Conclusion: Antibiotic sensitivity pattern showed a trend with onset of emerging resistance to azithromycin (ceftriaxone vs azithromycin z value = 7.63; P value =0.001 (Significant) and azithromycin vs ciprofloxacin Z value = 6.66; P value =0.001 (Significant). Multidrug resistant cases present showed reduced susceptibility to gentamycin. Sensitivity of these drugs must be preserved through constant surveillance and use only under a protocol. DOI: http://dx.doi.org/10.3329/bjms.v13i1.17440 Bangladesh Journal of Medical Science Vol. 13 No. 01 January2014: 67-69

scholarly journals Recent Antimicrobial Susceptibility Patterns of Salmonella Isolates in A Tertiay Care Hospital Lahore

Esculapio ◽  
2021 ◽  
Vol 17 (1) ◽  
pp. 45-48
Author(s):  
Hina Bukhari ◽  
Tayyeba Komal ◽  
Raana Akhtar ◽  
Sami Ullah Mumtaz ◽  
Iqra Waheed
Keyword(s):  
Antimicrobial Susceptibility ◽  
Antibiotic Susceptibility ◽  
Clinical Laboratory ◽  
Tertiary Care ◽  
Salmonella Typhi ◽  
Multidrug Resistant ◽  
Care Hospital ◽  
Cross Sectional ◽  
Sensitivity Pattern ◽  
Susceptibility Patterns

Objective: To determine the recent antimicrobial susceptibility patterns of salmonella isolates (typhi and paratyphi) in a tertiary care hospital of Lahore. Methods: It is cross sectional retrospective study conducted out in King Edward Medical University(Pathology deptt)/Mayo Hospital Lahore.The study period is six months from May 2019 to October 2019(Peak months of Typhoid fever).During this six months study period, total of 4284 samples for blood culture were received that were inoculated on the macConkey and blood agar plates.The growths obtained were then processed through biochemical profiling and analytical profile index(API).The Kirby Bauer technique was used for antibiotic susceptibility testing and reporting was done on the basis of clinical laboratory standard institute(CLSI). Results: During these six months, total 4284 blood samples were inoculated, out of which 433 growths were obtained. There were 84 strains of salmonella typhi isolated. Sensitivity pattern of different antibiotics showed that Azithromycin was sensitive to 70 (83.3%) isolates, imipenem in 72 (85.7%), ciprofloxacin to 56 (66.7%), gentamycin to 48 (57.1%), ceftriaxone to 45 (53.6%), cefepime to 20 (23.8%), chloramphenicol to 12 (14.3%) while ampicillin was least sensitive i.e. 8 (9.5%) isolates. There were 24 MDR(multidrug resistant) and 12 were XDR(extensive drug resistant) strains. We also found out that resistance to azithromycin drug is also emerging as 70 out of 84 strains were sensitive while remaining 14 were resistant. Conclusion: According to recent antibiotic susceptibility against salmonella typhi, the most sensitive drugs are Carbapenems (imipenem or meropenem) these days. Second sensitive antibiotic is azithromycin. Key Words: Antimicrobial susceptibility, Salmonella isolates, Carbapenems, Azithromycin. How to cite: Bukhari H., Komal T., Akhtar R., Mumtaz U.S., Waheed I., Recent Antimicrobial Susceptibility Patterns of Salmonella Isolates in A Tertiay Care Hospital of Lahore. Esculapio 2021;17(01):45-48

scholarly journals Antibiotic Sensitivity Pattern in Neck Space infection

2020 ◽  
Vol 19 (2) ◽  
pp. 28-31
Author(s):  
Md Mukhlesur Rahman ◽  
Mahmuda Begum ◽  
Md Mujibul Hoque Khan ◽  
Mostafa Mahfuzul Anwar
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Agents ◽  
Antibiotic Sensitivity ◽  
Neck Surgery ◽  
College Hospital ◽  
Klebsiella Species ◽  
Medical College ◽  
Space Infection ◽  
Sensitivity Pattern ◽  
Life Threatening

Background: Infection caused by microorganisms are common and may be serious and life threatening, requires immediate attention and management to get best outcome. The purpose of this study is to assess the anatomical spaces and causative microorganisms responsible for neck infections and evaluate the sensitivity pattern of the isolated microorganisms to antimicrobial agents. Materials and methods: This study was carried out in the Department of Otolaryngology- Head and Neck Surgery, Chittagong Medical College Hospital, from January to December 2018. A total of 70 cases were selected consecutively. All underwent surgical incision & drainage. Pus sample was obtained either by aspiration or by swab stick from the involved spaces and culture and sensitivity tests were performed. Results: The most common neck space infection were submandibular abscess 27 (38.57%) followed by Ludwig's angina 20 (28.57%). Out of 70 cases, 51(72.86%) cases yielded positive growth and 19(27.14%) cases showed no growth. Predominant microorganisms were Staphylococcus aureus, Streptococcuspyogenes, klebsiellaspecies and E coli. Staphylococcus aureus showed sensitivity to vancomycin, clindamycin, gentamycin. Streptococcus pyogenes showed sensitivity to cefuroxime, ceftriaxone and klebsiella species showed sensitivity to amikacin. Conclusion: Bacteriological examination and culture help to identify the causative microorganisms in neck abscess. It helps to isolate even the rarest of the organism and by knowing there sensitivity pattern, we can direct specific therapy against them. It thus helps in a more effective treatment and fast recovery of patients. Chatt Maa Shi Hosp Med Coll J; Vol.19 (2); July 2020; Page 28-31

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