scholarly journals Current Pattern in Antimicrobial Susceptibility in Enteric Fever In A Private Medical College

2013 ◽  
Vol 13 (1) ◽  
pp. 67-69
Author(s):  
Md Yasir Arafat ◽  
Md Abdus Sobur ◽  
Md Azizul Haq ◽  
Md Nazrul Islam
Keyword(s):  
Antimicrobial Susceptibility ◽  
Enteric Fever ◽  
Medical Science ◽  
Multidrug Resistant ◽  
P Value ◽  
Current Pattern ◽  
College Hospital ◽  
Medical College ◽  
Sensitivity Pattern ◽  
Z Value

Background and objectives: Enteric fever continues to be an important health problem in Bangladesh. Emerging drug resistance adds magnitude to this problem. Only surveillance studies can help form guidelines for therapy under such a situation. The present study was undertaken to determine the current pattern in antimicrobial susceptibility of enteric fever cases in a private medical college and to find out the incidence of multidrug resistant (MDR) cases. Study design: Hospital based observational study. Study setting and period: Medicine units of Ibn Sina Medical College hospital from october’11 to august’12. Source of materials/participants: Fever cases with clinical diagnosis of enteric fever and positive blood culture, attending the outpatient and admitted at hospital were included in the study. Susceptibility of the isolates to commonly available antibiotics were recorded. Treatment and responses were followed up. Results: 100 adult patients with fever had positive blood cultures were included in the study. Majority of patients were 19 – 30 yr olds (63%). Susceptibility of the isolates were tested against 14 available antibiotics. Ceftriaxone was sensitive in 99% cases followed by ciprofloxacin (96%), Gentamycin ( 96%) and cefixime (91%). Adeclining trend in sensitivity to Azithromycin ( 61%) was observed. Resurgence of chloramphenicol (81%) and cotrimoxazole (75%) sensitivity was noted. In 98 cases sensitivity to all three (amoxicillin, co-trimoxazole and chloramphenicol) were tested. 13 cases were found resistant to all the three drugs (13/98=13.2%). These MDR cases were sensitive to ceftriaxone (100%), cefixime (100%), azithromycin (100%), gentamycin(94%)and ciprofloxacin (88%). Conclusion: Antibiotic sensitivity pattern showed a trend with onset of emerging resistance to azithromycin (ceftriaxone vs azithromycin z value = 7.63; P value =0.001 (Significant) and azithromycin vs ciprofloxacin Z value = 6.66; P value =0.001 (Significant). Multidrug resistant cases present showed reduced susceptibility to gentamycin. Sensitivity of these drugs must be preserved through constant surveillance and use only under a protocol. DOI: http://dx.doi.org/10.3329/bjms.v13i1.17440 Bangladesh Journal of Medical Science Vol. 13 No. 01 January2014: 67-69

scholarly journals Pattern of Antimicrobial Susceptibility for Salmonella Typhi in Dhaka Medical College Hospital from 2013-2014

2017 ◽  
Vol 25 (2) ◽  
pp. 115-118
Author(s):  
Sultana Shazeda Nahar ◽  
Aliya Rashid ◽  
Sagana Shahreen Chowdhury ◽  
Ayesha Begum ◽  
Nadira Akter ◽  
...  
Keyword(s):  
Antimicrobial Susceptibility ◽  
Antibiotic Sensitivity ◽  
Salmonella Typhi ◽  
Multidrug Resistant ◽  
Salmonella Spp ◽  
College Hospital ◽  
Female Ratio ◽  
Medical College ◽  
Antimicrobial Susceptibility Pattern ◽  
Sensitivity Pattern

Multidrug resistant Salmonella spp has been emerged as a cause of concern. This study was done to evaluate recent status in antimicrobial susceptibility pattern of Salmonella typhi isolated from blood in Dhaka Medical college Hospital.Methods- The retrospective study was done over a two year period between January 2013 to December 2014 at Microbiology laboratory, Dhaka Medical College. A total of 203 isolates of Salmonella typhi obtained from blood cultures. Both the indoor and outdoor patients were enrolled in this study.Results- During the two year study period, total 203 cases were enrolled. Among them 66% were male with a male to female ratio 2:1. The bulk (55%) cases were in the age group of 15-30 years, 34% cases were in less than 15 years and 10% cases were between the ages of 31-45 years. Regarding antibiotic sensitivity pattern, 90.14% strains were sensitive to amikacin, 90.47% to gentamycin and amoxyclav. 89.16% to doxycycline, 83.75% to cotrimoxazole, 71.42% to azithromycin and 86.2% to ceftazidime. All the Salmonella were sensitive to ceftriaxone, 95.07% were sensitive to ciprofloxacin and 88% were nalidixic acid resistant Salmonella typhi (NARST).Conclusion- Ceftriaxone may be used to treat typhoid fever cases and quinolone has no longer efficacy to treat such cases. Azithromycin may be used as an alternative drug if it is found susceptible in culture and sensitivity testing.J Dhaka Medical College, Vol. 25, No.2, October, 2016, Page 115-118

Antibiotic Sensitivity and Resistance Patterns of Salmonella Typhi in Rajshahi Medical College Hospital

2020 ◽  
Vol 33 (2) ◽  
pp. 10-14
Author(s):  
Md Azizul Haque ◽  
Laila Shamima Sharmin ◽  
KM Faisal Alam ◽  
Md Mohimanul Hoque ◽  
M Morsed Zaman Miah ◽  
...  
Keyword(s):  
Blood Culture ◽  
Enteric Fever ◽  
Antibiotic Sensitivity ◽  
Salmonella Typhi ◽  
Medical College Hospital ◽  
Personal Hygiene ◽  
Care Hospital ◽  
College Hospital ◽  
Medical College ◽  
Sensitivity Pattern

Typhoid and paratyphoid fevers, collectively known as enteric fever, is caused by Salmonella enterica subspecies serovars Typhi and Paratyphi A, B and C. Despite this declining global trend, enteric fever is still considered to be a major public health hazard in Bangladesh and other developing countries due to poor sanitation, inadequate food safety measures and poor personal hygiene. In Bangladesh, the incidence of typhoid fever was reported to be 200 episodes per 100,000 person-years during 2003–2004. Multidrug-resistant (resistance to the first-line antimicrobials ampicillin, cotrimoxazole, and chloramphenicol) strains of S. Typhi and S. Paratyphi are on the rise globally and even cases of extensively drug-resistant (XDR) typhoid cases resistant to chloramphenicol, ampicillin, trimethoprim-sulfamethoxazole, third generation cephalosporins and fluoroquinolones are being reported from many corners of the world. This descriptive, observational study was carried out in Rajshahi Medical College Hospital Hospital, Rajshahi, Bangladesh from July 2017 to June 2019. Antibiotic sensitivity pattern of total 76 cases of enteric fever due to Salmonella Typhi were studied. Blood culture was carried out by BACT ALERT-3D, Automated blood culture analyzer from BioMeriuex SA, France Patented FAN Plus method. Based on the minimum inhibitory concentration (MIC), the organism was categorized as sensitive, intermediate, and resistant against the respective antibiotics as per Clinical and Laboratory Standards Institute (CLSI) criteria. We are reporting antibiotic sensitivity and resistant patterns of S. Typhi documented in Rajshahi Medical College Hospital, a large tertiary care hospital in Northern Bangladesh. TAJ 2020; 33(2): 10-14

scholarly journals Blood Culture Isolates and Antibiogram of Salmonella: The Gathering Storm

KYAMC Journal ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 188-190
Author(s):  
Ishrat Binte Reza ◽  
HAM Nazmul Ahasan ◽  
Moshtaque Ahmed ◽  
Homayra Tahseen ◽  
Tasmina Chowdhury
Keyword(s):  
Drug Resistance ◽  
Antibiotic Sensitivity ◽  
Multidrug Resistant ◽  
Bacterial Strains ◽  
College Hospital ◽  
Major Health ◽  
Medical College ◽  
Sensitivity Pattern ◽  
Highly Sensitive ◽  
The World

Introduction: Typhoid fever is a common problem all over the world including Bangladesh. It is caused by salmonella typhae and paratyphae and it is an old infectious water born disease. It is encountered in Bangladesh throughout the year. For many years it is treated by Chloramphenicol and subsequently Cotrimoxazole and Amoxicillin. Despite the use of newly developed antibacterial drugs, enteric fevers caused by multidrug-resistant bacterial strains are one of major health problems in Bangladesh. Multidrug resistant Salmonella sp. has been emerged is a cause of concern. Materials and Methods: This is a retrospective study done at the Popular Medical College Hospital over a period of 6 months between January 2018 to june 2018. Results: During the study period, total 115 cases were enrolled. Regarding antibiotic sensitivity pattern, 69% strains were sensitive to Ampicillin, 100% to Cefixime and Ceftriaxone, 75% to Cotrimoxazole, 52% to Nalidixic Acid and 68% to Ciprofloxacin, 69% to Levofloxacin, 80% to Cholarphenicol. Conclusion: Ceftriaxone and Cefixime were found to be highly sensitive. So, we should be very careful for the judicious use of these valuable drug to prevent drug resistance. KYAMC Journal Vol. 10, No.-4, January 2020, Page 188-190

scholarly journals Antimicrobial sensitivity pattern of Salmonella typhi isolated from blood culture in a referral hospital

2011 ◽  
Vol 5 (1) ◽  
pp. 16-20 ◽  
Author(s):  
Bulbul Hasan ◽  
Sabera Gul Nahar ◽  
Laila Akter ◽  
Ahmed Abu Saleh
Keyword(s):  
Blood Culture ◽  
Typhoid Fever ◽  
Antimicrobial Susceptibility ◽  
Salmonella Typhi ◽  
Susceptibility Pattern ◽  
Widal Test ◽  
College Hospital ◽  
Medical College ◽  
Antimicrobial Susceptibility Pattern ◽  
Sensitivity Pattern

The present study has been carried out in an attempt to evaluate antimicrobial susceptibility patterns with special reference to susceptibility of Salmonella Typhi to ciprofloxacin isolated from blood culture. The study is also designed to find out the MIC of Ciprofloxacin by E- test. Blood samples were taken for culture sensitivity, Widal test and ICT from 100 clinically suspected cases of typhoid fever in 1st week of illness who attended at out patient department of Rajshahi Medical College Hospital (RMCH).The study was done in Microbiology Department of Rajshahi Medical College and Shishu Hospital, Dhaka. Diagnosis of patients was based on history of fever, blood culture, Widal test and ICT. The antimicrobial susceptibility pattern of isolates from blood culture was recorded. Further more, the minimum inhibitory concentration of Ciprofloxacin was determined by E-test for the isolates resistance to Ciprofloxacin. Out of 100 suspected cases of typhoid fever, blood culture positive for S. Typhi were 16 (16%). Antimicrobial susceptibility pattern of 16 isolates of S. Typhi showed that no isolate was resistant to Ceftriaxone and Ceftazidime, only 03(18.75%) were resistant to Ciprofloxacin and Azithromycin whereas 10(62.5%) were MDR showing resistance to Ampicillin, Co-trimoxazole and Chloramphenicol which are first-line antityphoidal drugs. On the other hand, all (100%) the isolates were resistant to Nalidixic acid. The study revealed that Ceftriaxone and Ceftazidime are the most effective drugs in the treatment of typhoid fever. Moreover, E-test has been found to be helpful to determine appropriate therapeutic dose of Ciprofloxacin especially in case of drug resistance and pediatric population.DOI: http://dx.doi.org/10.3329/bjmm.v5i1.15816 Bangladesh J Med Microbiol 2011; 05 (01): 16-20

scholarly journals Current Clinical Profile of Enteric Fever in a Teaching Hospital

1970 ◽  
Vol 15 (2) ◽  
pp. 81-83
Author(s):  
Shahriar Kabir ◽  
MA Azhar ◽  
ARM Saifuddin Ekram ◽  
Quazi Tarikul Islam ◽  
Iftekhar Ahmed
Keyword(s):  
Blood Culture ◽  
Positive Blood Culture ◽  
Enteric Fever ◽  
College Hospital ◽  
Medical College ◽  
Clinical Presentations ◽  
Sensitivity Pattern ◽  
Clinical Profiles ◽  
Bangladeshi Population ◽  
Medical Wards

This study was designed to assess the current of clinical presentations, complications andprognosis of enteric fever cases in Bangladeshi population and also to assess the antimicrobialsensitivity of the causative organisms. A total of 65 patients, with either fever of any durationwith positive blood culture for Salmonella, of fever of more than a week with strong clinicalevidence of enteric fever along with single Widal titre TO >160 of AO >160 or BO> 160, wereselected from indoor medical wards of Rajshahi Medical College Hospital from August 2000 toMay 2001. Blood culture with sensitivity pattern, Widal tests and relevant investigations weredone in all patients. Majority (87.70%) of the patients presented on the second or third week oftheir illness. Other clinical profiles of the patients were comparable to different studies done inour country and in abroad. Common complications were pneumonia, meningitis and typhoidpsychosis. Isolated salmonellae from blood culture were 100% sensitive to Ciprofloxacin andPefloxacin. Two out of sixty five patients (3.07%) expired due to complications.doi: 10.3329/taj.v15i2.3914TAJ December 2002; Vol.15(2): 81-83

scholarly journals Current Microbial Isolates from Wound Swab and Their Susceptibility Pattern in a Private Medical College Hospital in Dhaka city

2015 ◽  
Vol 3 (1) ◽  
pp. 25-30 ◽  
Author(s):  
Shahin Sultana ◽  
Nurunnahar Mawla ◽  
Shamima Kawser ◽  
Nayareen Akhtar ◽  
Md Khoybar Ali
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Wound Infection ◽  
Antimicrobial Susceptibility ◽  
Clinical Laboratory ◽  
Diffusion Method ◽  
College Hospital ◽  
Medical College ◽  
Wound Swab ◽  
Sensitivity Pattern

Background: Wound infection is one of the major health problems that are caused and aggravated by the invasion of pathogenic organisms where empiric treatment is routine. Objective: To isolate and identify the bacteria causing wound infection and to determine the antimicrobial susceptibility pattern.Materials and method: A total of 263 wound swab and pus samples were collected during the period of January to December 2012 from Delta Medical College and Hospital, Dhaka, Bangladesh. Swabs from the wound were inoculated on appropriate media and cultured and the isolates were identified by standard procedures as needed. Antimicrobial susceptibility testing was performed by disk diffusion method according to ‘The Clinical Laboratory Standard Institute’ guidelines. Results: In this study 220 bacterial isolates were recovered from 263 samples showing an isolation rate of 83.65%. The predominant bacteria isolated from infected wounds were Staphylococcus aureus 89 (40.45%) followed by Escherichia coli 62 (28.18%), Pseudomonas aeruginosa 34 (15.45%), Enterococci 18 (8.18%), Acinetobacter 5 (2.27%), Klebsiella 9 (4.09%) and Proteus 3 (3.36%). Staphylococcus aureus was sensitive to linezolid (94.38%), fusidic acid (91.01%), vancomycin (87.64%), amikacin (74.15%) and gentamicin (73.03%). Among the Gram negative isolates Escherichia coli was predominant and showed sensitivity to imipenem (93.54%) amikacin (83.87%) colistin (53.22%) and piperacillin and tazobactum (53.22%) and pseudomonas showed sensitivity to amikacin (73.52%), imipenem (70.58%) and colistin (70.58%). Conclusion: Staphylococcus aureus was the most frequently isolated pathogen from wound swab and the antibiotic sensitivity pattern of various isolates help to assist the clinician in appropriate selection of empirical antibiotics against wound infection. DOI: http://dx.doi.org/10.3329/dmcj.v3i1.22236 Delta Med Col J. Jan 2015; 3(1): 25-30

ANTIMICROBIAL SUSCEPTIBILITY IN CULTURE POSITIVE ENTERIC FEVER

2019 ◽  
Vol 3 (7) ◽  
Author(s):  
Dr. Manish Kulshrestha ◽  
Dr. Anjali Kulshrestha
Keyword(s):  
Bone Marrow ◽  
Blood Culture ◽  
Nalidixic Acid ◽  
Antimicrobial Susceptibility ◽  
Salmonella Enterica ◽  
Enteric Fever ◽  
Multidrug Resistant ◽  
Bone Marrow Culture ◽  
Diffusion Method ◽  
Culture Positive

INTRODUCTION: Enteric fever includes typhoid and paratyphoid fever. Peak incidence is seen in children 5–15 years of age; but in regions where the disease is highly endemic, as in India, children younger than 5 years of age may have the highest infection rates. There are about 22 million new typhoid cases occur each year. Young children in poor, resource limited areas, who make up the majority of the new cases and there is a mortality figures of 215,000 deaths annually. A sharp decline in the rates of complications and mortality due to typhoid fever is observed as a result of introduction of effective antibiotic therapy since 1950s. MDR-ST became endemic in many areas of Asia, including India soon after multidrug-resistant strains of Salmonella enterica serotype typhi (MDR-ST) that were resistant to all the three first-line drugs then in use, namely chloramphenicol, amoxycillin and co-trimoxazole emerged in early 1990s. MATERIAL AND METHODS: Only blood culture or bone marrow culture positive cases were included. The patients with culture isolated enteric fever were included in the study. Antimicrobial susceptibility testing was carried out by disk diffusion method using antibiotic discs. The analysis of the antimicrobial susceptibility was carried out as per CLSI interpretative guidelines. RESULTS: A total of 82 culture positive cases were included in the present study. 80 culture isolates were from blood culture and 2 from the bone marrow culture. Salmonella entericasubspecies enterica serovartyphi (S typhi) was isolated from 67 (81.70%) patients while Salmonella enterica subspecies entericaserovarparatyphi (S paratyphi A) was isolated from 13 (15.85%) cases and 2 (2.44%) were Salmonella enterica subspecies entericaserovarschottmuelleri (S paratyphi B). Of the 82 cases 65(79.3%) isolates were resistant to ciprofloxacin, 17 (20.7%) were resistant to nalidixic acid, one (1.2%) case each was resistant to Cefotaxime and ceftriaxone, 2 (2.4%) were resistant to chloramphenicol, 10 (12.2%) were resistant and to cotrimoxazole 3 (3.7%) were resistant. CONCLUSION: In a culture positive cases 65(79.3%) isolates were resistant to ciprofloxacin and 17 (20.7%) were resistant to nalidixic acid. Multidrug resistant isolates were 65(79.3%).

scholarly journals Choledochal Cyst Coexisting with Gallbladder Carcinoma - An Uncommon Case Report

2017 ◽  
Vol 16 (4) ◽  
pp. 602-605
Author(s):  
Jahangir Hossain Bhuiyan ◽  
Mohibul Aziz ◽  
Omar Faruk ◽  
Mahbub Hasan
Keyword(s):  
Choledochal Cyst ◽  
Gallbladder Carcinoma ◽  
Medical Science ◽  
Rare Condition ◽  
Exploratory Laparotomy ◽  
Abdominal Ultrasound ◽  
Low Grade ◽  
College Hospital ◽  
Medical College ◽  
Operative Recovery

Choledochal Cyst is a relatively rare condition. Even rarer is a choledochal cyst in association with a gallbladder carcinoma. This study reports a rare case of choledochal cyst coexisting with gallbladder carcinoma in a Bangladeshi patient. A 35 year old lady presented at IBN Sina Medical College Hospital, Kallyanpur, Dhaka with the history of recurrent right upper quadrant abdominal pain from childhood, which became severe for last 4 days before admission. The pain was colicky in nature and radiated to the back. Episodes were associated with low-grade fever, anorexia as well as vomiting. The preoperative diagnosis was made by abdominal ultrasound and MRCP. Exploratory laparotomy, enbloc cholecystectomy with excision of the choledochal cyst and roux-en-Y hepaticojejunostomy was also done. Post operative recovery was uneventful. Patient was followed up for six months and no obvious complication was noticed. Early suspicion of this rare pancreato-billiary disease is important because surgical treatment is the only way to avoid the complications of the disease.Bangladesh Journal of Medical Science Vol.16(4) 2017 p.602-605

Association of Adverse Outcomes in Patients with Cirrhosis Presented with COVID-19

2021 ◽  
Vol 15 (5) ◽  
pp. 1134-1135
Author(s):  
M. A. Chhutto ◽  
A. H. Mugheri ◽  
A. H. Phulpoto ◽  
I. A. Ansari ◽  
A. Shaikh ◽  
...  
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Adverse Outcomes ◽  
Chronic Liver ◽  
P Value ◽  
College Hospital ◽  
Medical College ◽  
Group A ◽  
Group B ◽  
Disease Study

Objective: To determine the association of adverse outcomes in term of mortality in patients with cirrhosis presented with coronavirus disease. Study Design: Retrospective/observational study Place and Duration of Study: Department of Medicine, Chandka Medical College Hospital, Larkana from 1st March 2019 to 31st December 2020. Methodology: Two hundred and twenty covid-19 patients of both genders with or without chronic liver disease were enrolled in this study. Patients were categorized in to two groups. Group A (with cirrhosis 60 patients) and group B (without cirrhosis 60 patients). Outcomes in term of mortality between both groups were examined. Results: There were 38 (63.33%) males and 22 (36.67%) were females with mean age 46.14±8.44 years in group A while in group B, 40 (66.67%) and 20 (33.33%) patients were males and females with mean age 45.26±9.34 years. Patients with cirrhosis had high mortality rate as compared to patients without cirrhosis (33.33% Vs 13.33%) with p-value 0.0001. Conclusion: A significant association of adverse outcomes was found in cirrhotic patients with coronavirus disease. Keywords: Chronic Liver Disease, Corvid-19, Mortality

scholarly journals Otosclerosis Revisited

2019 ◽  
Vol 27 (1) ◽  
Author(s):  
C V Srinivas
Keyword(s):  
Hearing Loss ◽  
Current Treatment ◽  
P Value ◽  
College Hospital ◽  
Severe Hearing Loss ◽  
Medical College ◽  
Mixed Hearing Loss ◽  
Operative Outcome ◽  
Conductive Component ◽  
Indian Scenario

Introduction: Otosclerosis usually manifests as a progressive conductive or mixed hearing loss occurring clinically to varying degrees in 0.5% - 1% of the general population. Stapedectomy /stapedotomy is the current treatment of choice for conductive component of Otosclerosis. Materials and Methods: Sixty patients attending the department of ENT of a Medical College Hospital in Bangalore between October 2012 and October 2017 were included in the study.  Results: The incidence of otosclerosis is highest in the 3rd and 4th decade. Bilateral symptoms were present in 25% and 75% had unilateral symptoms, right side being more common in our study. Tinnitus and vertigo with deafness are seen in 60% and 25 % of the patients respectively.  Ninety percent of the patients presented with moderate to moderately severe hearing loss. Twenty four (40%) out of 60 audiograms studied showed Carhart's notch. Postoperativeclosure of a-b gap to within 10dB could be achieved in 65% cases. The p value calculated comparing pre and post op results is <0.0001 and significant. Vertigo was found to be most common post-operative complication (35%) followed by sensorineural hearing loss (6.6%). Other complications observed during the study include -  tympanic membrane tears, foot plate extrusion, lax long process of incus, perilymph leak. Conclusion: From the assessment of the postoperative hearing gain and postoperative complications, it can be concluded that small fenestra stapedotomy gives satisfactory post-operative outcome and may be appropriatein the Indian scenario.

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