scholarly journals Rehabilitation Challenge of Motor Neuron Disease Following Occupational Exposure to Magnetic Fields and Electric Shocks: Case Series

KYAMC Journal ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 218-221
Author(s):  
Fatema Newaz ◽  
Md Israt Hasan ◽  
Mohammed Emran ◽  
Syed Mozaffar Ahmed ◽  
Jasmine Jashimuddin
Keyword(s):  
Motor Neuron ◽  
Motor Neurons ◽  
Neurodegenerative Disorder ◽  
Life Quality ◽  
Case Series ◽  
Psychological Issue ◽  
Performance Deficits ◽  
Electric Injury ◽  
High Level

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder of motor neurons and their axons characterized by signs of upper and lower motor neuron dysfunction. ALS has been associated with exposures in so called electrical occupation. We have found two young patient who developed features of MND following electrocution within 1 year. Due to this great diversity of possible causing agents for ALS, new researches are necessary to elucidate possible etiologies for a better approach to the patients, promoting preventive programs for the disease, optimizing functions and improving the life quality of the patients. A number of studies have demonstrated cognitive performance deficits following electric injury observed cognitive symptoms and neurobehavioral defecit. As treatment approach rehabilitation is important part of treatment as pharmacological part didn't prove strong recovery. As MND causes high level of disability and dependency on caregiver causes gap in rehabilitation due to psychological issue. Neuropalliative rehabilitation is more important in these patient which is unavailable in our country. KYAMC Journal Vol. 11, No.-4, January 2021, Page 218-221

scholarly journals ALS-Like Disorder in Three HIV-Positive Patients: Case Series

2021 ◽  
pp. 59-64
Author(s):  
Zachary Aaron Satin ◽  
Elham Bayat
Keyword(s):  
Antiretroviral Therapy ◽  
Motor Neuron ◽  
Motor Neuron Disease ◽  
Motor Neurons ◽  
Case Series ◽  
Retrospective Chart Review ◽  
Effective Control ◽  
Hiv Positive ◽  
Disease Course ◽  
Retroviral Infection

There appears to be a relationship between retroviruses such as HIV and the development of an ALS-like syndrome. Few cases have been reported; however, there exists evidence of a higher frequency of motor neuron disease in HIV-infected patients, as well as potential slowing and reversibility of disease course with combination antiretroviral therapy. We conducted a retrospective chart review of patients presenting to the George Washington University ALS Clinic from September 2006 to June 2018 to identify patients with HIV receiving HAART who were subsequently diagnosed with ALS or an ALS-like disorder. Our goals were to describe our patients’ disease course and compare them to general characteristics of ALS. We report three cases of HIV-positive individuals, all male, who were subsequently diagnosed with ALS. Each presented with symptoms of limb onset ALS with involvement of upper and lower motor neurons and whose disease originated at the cervical level. All three had been diagnosed with HIV prior to presentation and were presumably compliant with antiretroviral therapy throughout. Our patients demonstrated effective control of their HIV infection. Each experienced relatively slow progression of motor impairment compared to general ALS characteristics. Our study offers a distinct profile of HIV-positive patients compliant with HAART subsequently diagnosed with an ALS-like disorder. Further study should aim to uncover pathophysiological similarities between motor neuron disease both in the presence and absence of retroviral infection and to develop effective medical therapy for each.

scholarly journals Amyotrophic lateral sclerosis: one or multiple causes?

2011 ◽  
Vol 3 (1) ◽  
pp. 4 ◽  
Author(s):  
Aline Furtado Bastos ◽  
Marco Orsini ◽  
Dionis Machado ◽  
Mariana Pimentel Mello ◽  
Sergio Nader ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Motor Neuron ◽  
Motor Neuron Disease ◽  
Motor Neurons ◽  
Viral Infections ◽  
Vigorous Physical Activity ◽  
Disease Etiology ◽  
New Research ◽  
Lateral Sclerosis

The Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease in the adulthood, and it is characterized by rapid and progressive compromise of the upper and lower motor neurons. The majority of the cases of ALS are classified as sporadic and, until now, a specific cause for these cases still is unknown. To present the different hypotheses on the etiology of ALS. It was carried out a search in the databases: Bireme, Scielo and Pubmed, in the period of 1987 to 2011, using the following keywords: Amyotrophic lateral sclerosis, motor neuron disease, etiology, causes and epidemiology and its similar in Portuguese and Spanish. It did not have consensus as regards the etiology of ALS. Researches demonstrates evidences as regards intoxication by heavy metals, environmental and occupational causes, genetic mutations (superoxide dismutase 1), certain viral infections and the accomplishment of vigorous physical activity for the development of the disease. There is still no consensus regarding the involved factors in the etiology of ALS. In this way, new research about these etiologies are necessary, for a better approach of the patients, promoting preventive programs for the disease and improving the quality of life of the patients.

scholarly journals Omega-3 Hastens and Omega-6 Delays the Progression of Neuropathology in a Murine Model of Familial ALS

2017 ◽  
Vol 11 (1) ◽  
pp. 84-91 ◽  
Author(s):  
Edward F. Boumil ◽  
Rishel Brenna Vohnoutka ◽  
Yuguan Liu ◽  
Sangmook Lee ◽  
Thomas B Shea
Keyword(s):  
Quality Of Life ◽  
Motor Neuron ◽  
Motor Function ◽  
Motor Neurons ◽  
Omega 3 ◽  
Self Medication ◽  
Familial Als ◽  
Neuron Function ◽  
The Impact

Background: Amyotrophic lateral sclerosis (ALS) is a progressive disease of motor neurons that has no cure or effective treatment. Any approach that could sustain minor motor function during terminal stages would improve quality of life. Objective: We examined the impact of omega-3 (Ω-3) and Ω-6, on motor neuron function in mice expressing mutant human superoxide dismutase-1 (SOD-1), which dominantly confers familial ALS and induces a similar sequence of motor neuron decline and eventual death when expressed in mice. Method: Mice received standard diets supplemented with equivalent amounts of Ω-3 and Ω-6 or a 10x increase in Ω-6 with no change in Ω-3 commencing at 4 weeks of age. Motor function and biochemical/histological parameters were assayed by standard methodologies. Results: Supplementation with equivalent Ω-3 and Ω-6 hastened motor neuron pathology and death, while 10x Ω-6 with no change in Ω-3 significantly delayed motor neuron pathology, including preservation of minor motor neuron function during the terminal stage. Conclusion: In the absence of a cure or treatment, affected individuals may resort to popular nutritional supplements such as Ω-3 as a form of “self-medication”. However, our findings and those of other laboratories indicate that such an approach could be harmful. Our findings suggest that a critical balance of Ω-6 and Ω-3 may temporarily preserve motor neuron function during the terminal stages of ALS, which could provide a substantial improvement in quality of life for affected individuals and their caregivers.

scholarly journals Myomirnas Role in Als Suggest a Crosstalk between Muscle and Motor Neuron

2018 ◽  
Author(s):  
Valentina Pegoraro ◽  
Antonio Merico ◽  
Corrado Angelini
Keyword(s):  
Skeletal Muscle ◽  
Motor Neuron ◽  
Aerobic Exercise ◽  
Muscle Atrophy ◽  
Motor Neurons ◽  
Neuromuscular Junctions ◽  
Neurodegenerative Disorder ◽  
Disease Process ◽  
Muscle Fibres ◽  
Wide Range

Amyotrophic lateral sclerosis (ALS) is a rare, progressive, neurodegenerative disorder caused by degeneration of upper and lower motor neurons. The disease process leads from lower motor neuron involvement to progressive muscle atrophy, weakness, fasciculations for the upper motor neuron involvement to spasticity. Muscle atrophy in ALS is caused by a dysregulation in the molecular network controlling fast and slow muscle fibres. Denervation and reinnervation processes in skeletal muscle occur in the course of ALS and are modulated by rehabilitation. MicroRNAs (miRNAs) are small non-coding RNAs that modulate a wide range of biological functions under various pathophysiological conditions. MiRNAs can be secreted by various cell types and they are markedly stable in body fluids. MiR-1, miR-133 a, miR-133b, and miR-206 are called “myomiRs” and are considered markers of myogenesis during muscle regeneration and neuromuscular junction stabilization or sprouting. We observed a positive effect of a standard aerobic exercise rehabilitative protocol conducted for six weeks in 18 ALS patients during hospitalization in our center. We correlated clinical scales with molecular data on myomiRs. After six weeks of moderate aerobic exercise, myomiRNAs were down-regulated, suggesting an active proliferation of satellite cells in muscle and increased neuromuscular junctions. Our data suggest that circulating miRNAs modulate during skeletal muscle recovery in response to physical rehabilitation in ALS.

scholarly journals Transarterial Chemoembolization (TACE) with Lipiodol� in HCC PatientsTechnical, clinical and imagistic aspects

2019 ◽  
Vol 56 (1) ◽  
pp. 194-187
Author(s):  
Decebal Fodor ◽  
Bogdan Andrei Suciu ◽  
Ioan Jung ◽  
Simona Gurzu ◽  
Tamas-Csaba Sipos ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Alternative Therapy ◽  
Life Quality ◽  
Case Series ◽  
Hepatic Tumors ◽  
Hepatic Transplantation ◽  
Therapeutic Attitude ◽  
Control Tumor ◽  
Prolongation Of Life

Hepatocellurar carcinoma (HCC) is the most frequent primary hepatic tumor, the vast majority of patients have less than a 12 month survival rate. The aim of this study was to evaluate the efficacy of TACE in patients with HCC, based on a case series and literature review. The study included 12 consecutive patients with HCC who underwent surgical treatment (resection, liver transplantation � resection) at the Department of Transplantation and Surgery, Semmelweis University, Budapest, during 2009-2015. All the patients received at least one TACE session. Patients with BCLC B-stage who benefit from TACE and another alternative therapy (eg, RFA) may be associated with or exhibit tumor stagnation, or tumor necrosis in most cases. In C BCLC stages, desperate cases - the two patients to whom TACE was the last therapeutic attitude, despite the predicted prognosis, TACE assured the prolongation of life and increased life quality. In the majority of patients in this study, stage A BCLC, chemoembolization was a therapeutic attitude that allowed subsequent liver transplantation (when it was not feasible initially due to tumor size) or liver resection in apparently inoperable cases. The arterial chemotherapy is the unanimously accepted indication in patients with stage B, BCLC. The data presented encourages us to opt for TACE with the intention of destaging BCLC and giving an operability character to the hepatic tumors (resection � hepatic transplantation). In stage C BCLC, TACE can be a last attempt to improve the quality of life and to control tumor progression.

scholarly journals Amyotrophic Lateral Sclerosis: The Most Common And Lethal Form Of Motor Neuron Disease-a Case Report From Middle East

2019 ◽  
Vol 09 (02) ◽  
pp. 156-158
Author(s):  
Waseem Mehmood Nizamani ◽  
Ameet Jesrani ◽  
Mujtaba Khan ◽  
Kalthoum Tlili ◽  
Nader Al Khuraish ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Motor Neuron ◽  
Motor Neurons ◽  
Clinical Presentation ◽  
Neurodegenerative Disorder ◽  
Signs And Symptoms ◽  
Corticospinal Tracts ◽  
Familial Form ◽  
Lateral Sclerosis ◽  
Made In

A neurodegenerative disorder which is fatal, rapidly progressive and has no effective treatment till date is amyotrophic lateral sclerosis. Almost 90% of all cases occur in the sporadic form, with the rest occurring in the familial form. It is a devastating disease leading to death within 3-5 years in most cases. The diagnosis of AML is difficult to made in spite of acknowledgment for 140 years. It is diagnosed by clinical presentation which is a combination of upper and lower motor neuron signs and electro diagnostic studies which gives information about diffuse motor axonal injury. This neurodegenerative disorder results in degeneration of corticospinal tracts and anterior horn cells and involving motor neurons of the cerebral cortex, brainstem, and spinal cord. There are a variable signs and symptoms of this disease, so the diagnosis is very important for the management and better outcome of the patients. Cause of death in these patients is usually respiratory failure

scholarly journals LUMBAR SPINAL STENOSIS: EVALUATION OF PAIN AND LIFE QUALITY AFTER SURGICAL TREATMENT

2019 ◽  
Vol 18 (1) ◽  
pp. 37-42
Author(s):  
Gustavo Alvarenga ◽  
João Otávio Araújo Rotini ◽  
Leonardo Yukio Jorge Asano ◽  
Vinícius Alves de Andrade ◽  
André Evaristo Marcondes Cesar ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Surgical Treatment ◽  
Life Quality ◽  
Case Series ◽  
Level Of Evidence ◽  
The Mean ◽  
One Year ◽  
Lumbar Spinal

ABSTRACT Objective: The objective of this study was to present an analysis of progression of the quality of life and pain in patients undergoing surgical treatment of LSS and the potential correlations between individual factors and the clinical outcome observed. Methods: We studied 111 patients undergoing surgical treatment of LSS from January 2009 to December 2011 using the functional capacity (ODI) and pain (VAS) questionnaires. The preoperative data were compared statistically with the results obtained during the postoperative follow-up at one month, six months, one year, and two years. Results: The population consisted of 60 men and 51 women. The mean age was 61.16 years at the time of surgery, 33.33% were 60 years or older. When the questionnaires were applied, we found improvement in the progressive disability assessment with a mean drop of 23.65 ODI points after 6 months of the surgical treatment and 27.47 at the end of one year of surgery compared to preoperative for this scale. There was a decline of 3.84 points (mean) in the VAS at first postoperative month. Conclusion: Surgical treatment of LSS presented favorable postoperative evolution in a 2-year follow-up regarding pain and quality of life through VAS and ODI. Level of Evidence IV; Case series.

Long-Term Forecasting of World Economy

2014 ◽  
pp. 5-14
Author(s):  
Y. Lukashin ◽  
L. Rakhlina
Keyword(s):  
Quality Of Life ◽  
Life Quality ◽  
Developed Countries ◽  
New Era ◽  
Spare Time ◽  
Processing Gain ◽  
Long Term Forecasting ◽  
High Level

The paper considers contemporary approaches of long-term forecasting of world and national economics. Foreign practice is of especial interest of authors. Researches and results of PricewaterhouseCoopers and Goldman Sachs are exposed in details. Authors make the following conclusions: a production function model is used often to generate forecasts. The parameters of these models are postulated by experts in coincidence with their scenario of World development. Main indicators to forecast are GDP, GDP per capita and changes in country ranks. Authors consider GDP as not ideal indicator for the goal since it may be calculated by three methods. Besides, it has different structure and quality in different countries. Authors point to the need for estimation and comparison of quality of life. They suggest to take into account the revolutionary changing in technologies and to schedule the optimum and the most realistic path to improve the quality of life. Authors suggest that the most developed countries are entering a new era when robots will work more and more instead of people in industry, agriculture, and services. Many operations in control, management and data processing gain higher productivity due to endless progress in computer science. As a result authors foresee further shortening of the working week. On their opinion this is the way which leads to real success in struggle against unemployment. ICT technologies enable many employees to work now at home. Growing of spare time leads to new pattern of life, new possibilities of education, new types of creative work, new possibilities of communication, additional possibilities for health care, high level of life quality. So far, comparison of national economy development on the basis of measuring GDP seems to become obsolete and irrelevant to current social and economic conditions. Now we can expect to see negative rates of GDP growth and augmentation of life quality. Thus, to construct the countries’ ranks in world competition correctly it is of great importance to take into account the social factors and the role of innovation technologies in world economic development.

scholarly journals Pathophysiology and Diagnosis of ALS: Insights from Advances in Neurophysiological Techniques

2019 ◽  
Vol 20 (11) ◽  
pp. 2818 ◽  
Author(s):  
Mehdi A. J. van den Bos ◽  
Nimeshan Geevasinga ◽  
Mana Higashihara ◽  
Parvathi Menon ◽  
Steve Vucic
Keyword(s):  
Motor Neuron ◽  
Motor Neurons ◽  
Neurodegenerative Disorder ◽  
Clinical Phenotype ◽  
Disease Process ◽  
Disease Spread ◽  
Molecular Processes ◽  
Cortical Hyperexcitability ◽  
Upper Motor Neuron Dysfunction ◽  
Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and fatal neurodegenerative disorder of the motor neurons, characterized by focal onset of muscle weakness and incessant disease progression. While the presence of concomitant upper and lower motor neuron signs has been recognized as a pathognomonic feature of ALS, the pathogenic importance of upper motor neuron dysfunction has only been recently described. Specifically, transcranial magnetic stimulation (TMS) techniques have established cortical hyperexcitability as an important pathogenic mechanism in ALS, correlating with neurodegeneration and disease spread. Separately, ALS exhibits a heterogeneous clinical phenotype that may lead to misdiagnosis, particularly in the early stages of the disease process. Cortical hyperexcitability was shown to be a robust diagnostic biomarker if ALS, reliably differentiating ALS from neuromuscular mimicking disorders. The present review will provide an overview of key advances in the understanding of ALS pathophysiology and diagnosis, focusing on the importance of cortical hyperexcitability and its relationship to advances in genetic and molecular processes implicated in ALS pathogenesis.

scholarly journals Doença de Parkinson: Tratamentos Complementares e Qualidade de Vida

2015 ◽  
Vol 8 (1) ◽  
pp. 97
Author(s):  
Sabrina Gabriela Calderaro ◽  
Janete Lane Amadei ◽  
Carolina Cella Conter
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neurodegenerative Disorder ◽  
Life Quality ◽  
Physical Independence ◽  
The Central Nervous System ◽  
Demographical Data ◽  
Disease Questionnaire ◽  
Parkinson’S Disease Questionnaire

A doença de Parkinson (DP) é um transtorno neurodegenerativo progressivo do sistema nervoso central, caracterizado clinicamente por tremor de repouso, rigidez, bradicinesia, instabilidade postural e distúrbios da marcha, apresentando também manifestações não motoras como depressão, distúrbios autonômicos e demência. Essas manifestações causam declínio funcional, dificultando a execução das atividades de vida diária e resultando em diminuição da independência física e da qualidade de vida. O objetivo deste trabalho foi verificar a influência dos tratamentos complementares, como fisioterapia, hidroterapia e fonoaudiologia na qualidade de vida de pessoas vivendo com doença de Parkinson residentes em Maringá e região. Para o estudo foi aplicado questionário contendo dados sócio-demográficos e de hábitos de vida e o instrumento Parkinson’s Disease Questionnaire PDQ-39 para avaliar a qualidade de vida. Das pessoas entrevistadas, a maioria era mulheres (55,0%), maiores de 60 anos (60,0%), com 8 a 12 anos de estudo (40%). A maioria convive com a doença há menos de dez anos (55%), sendo que 70% do total de entrevistados realizam exercícios físicos, com grande parte tendo começado a realizar os exercícios há menos de 10 anos (79%). Foi constatado que os pacientes que fazem tratamento com fisioterapia, hidroterapia e fonoaudiologia, quando comparados aos que não fazem, têm melhor qualidade de vida. Ficou clara a participação positiva da atividade física para o bem-estar das pessoas com DP. Parkinson´s Disease: Complementary Treatments and Life Quality ABSTRACT: Parkinson´s Disease is a progressive neurodegenerative disorder of the central nervous system clinically diagnosed by trembling, rigidity, bradykinesia, posture unstableness and gait troubles featuring difficulties in daily activities and decrease in physical independence and life quality. Current paper verifies the influence of complementary treatments such as physiotherapy, hydrotherapy and phonoaudiology in the life quality of people with Parkinson´s disease in Maringá PR Brazil. A questionnaire with social and demographical data and habits, coupled to Parkinson’s Disease Questionnaire PDQ-39 to evaluate life quality were provided. Interviewed people were mostly females (55.0%), over 60 years old (60.0%), with 8 - 12 years schooling (40%). Most of the diseased people had the disease for the last ten years (55%); 70% of interviewed people practice physical exercises, most of them started exercises less than ten years ago (79%). Results show that patients treated with physiotherapy, hydrotherapy and phonoaudiology have a better life quality when compared to those who do not practice these activities. The positive participation of physical activity in the welfare of PD patients is evident.

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