scholarly journals Early Management of Hyperuricemia Might Delay the Development of Essential Hypertension

KYAMC Journal ◽  
2021 ◽  
Vol 12 (3) ◽  
pp. 117-121
Author(s):  
Sabera Sultana ◽  
Arifur Rahman ◽  
Farhana Kabir ◽  
Ayesha Yasmin ◽  
Rabeya Sultana
Keyword(s):  
Uric Acid ◽  
Essential Hypertension ◽  
Serum Uric Acid Level ◽  
Developed Countries ◽  
P Value ◽  
Statistical Parameters ◽  
Early Management ◽  
Medical College ◽  
Group I ◽  
Function Impairment

Background: In the 21st century, the prevalence pattern of hypertension in different developing countries differs from developed countries. Persistent hypertension is one of the risk factors and is the leading cause of heart disease, chronic kidney disease (CKD) & cerebrovascular disease. Even mild to moderate essential hypertension usually causes significant renal function impairment only after several years. Objectives: To assess the serum uric acid level in hypertensive patients and compare the findings with those found in normotensive people. Materials & Methods: This case-control study was done at the Department of Biochemistry, Mymensingh Medical College, Mymensingh during the period of January 2010 to December 2010. A total of 143 subjects of both sexes were selected for the purpose. Out of them, 73 were the case and 70 were the control. The subjects were classified into the following groups; Group I includes 73 were essential hypertensive subjects. Group II includes 70 were healthy adults. All statistical parameters analysis were done by SPSS 12.0 version; P-value<0.05 was considered as significant. Results: There was a significant (P<0.05) increase in blood urea in subjects with hypertension compared to that of the control. Conclusion: Evaluation of uric acid before and during treatment of hypertension is required to identify as a risk factor. KYAMC Journal. 2021;12(3): 117-121

scholarly journals Study of Serum Uric Acid in Different Stages of Chronic Kidney Disease

2021 ◽  
pp. 70-79
Author(s):  
Shahida Akhter ◽  
A. S. M. Rizwan
Keyword(s):  
Chronic Kidney Disease ◽  
Uric Acid ◽  
Kidney Disease ◽  
Serum Creatinine ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Medical College ◽  
Bonferroni Test

Background: Hyperuricaemia is a metabolic marker of decreased renal function in chronic kidney disease (CKD). It increases cardiovascular, cerebrovascular and mortality risk in patients with CKD. Objectives: To estimate serum uric acid level in different stages of CKD. Methods: The present study was a cross sectional analytical study and was conducted in the Department of Physiology, Dhaka Medical College, Dhaka from July 2012 to June 2013 on 300 participants. They were divided into group A (150 control healthy participants) and group B (150 diagnosed cases of CKD). Serum creatinine and serum uric acid levels were measured by auto analyzer in Department of Pathology, Dhaka Medical College. Estimated glomerular filtration rate (eGFR) was calculated from serum creatinine level by Modification of Diet in Renal Disease (MDRD) equation. For statistical analysis unpaired Student “t” test, one way ANOVA test, Bonferroni test, Pearson’s correlation coefficient (r) test and Linear regression were performed using SPSS for windows version 20. Result: In this study, serum uric acid level was significantly (p<0.05) higher and eGFR were significantly lower in study groups than that of control group. There was gradual rise of serum uric acid level in CKD subjects from stage I to V. A significant inverse correlation was observed between serum uric acid level and eGFR. Serum uric acid level increased 0.048 mg/dl for each ml/min/1.73m2 decrease of eGFR. Conclusion: This study concludes that serum uric acid level increases gradually in accordance with the higher stages of CKD. There is a negative correlation of serum uric acid with eGFR in all stages of CKD which was statistically significant (p<0.05). Screening of serum uric acid level in different stages of CKD may be beneficial for assessing renal damage as well as prediction of co-morbidities associated with it.

scholarly journals Metabolic Risk Factors and Outcomes in Acute Coronary Syndrome

2020 ◽  
pp. 46-50
Author(s):  
Ritu Attri ◽  
Harsimran Kaur ◽  
Raminderpal Singh Sibia ◽  
Mandip Singh Bhatia
Keyword(s):  
Risk Factors ◽  
Acute Coronary Syndrome ◽  
Positive Family History ◽  
Developed Countries ◽  
P Value ◽  
Health Crisis ◽  
Female Ratio ◽  
Medical College ◽  
Coronary Syndrome ◽  
History Of

Introduction: CAD is the most common cause of mortality in India. It is a common multifarious public health crisis today and a leading cause of morbidity and mortality in both developing and developed countries. Hence, understanding the predominant risk factors among the Indian population is important. Materials and Methods: This was a hospital based age and sex matched case control study, carried out at Government Medical College and Rajindra Hospital Patiala. A total of 100 patients of Acute coronary syndrome were studied. Patients and controls were enquired about  the presence of cardiometabolic risk factors and the significance of association of these risk factors with the occurrence of Acute coronary syndrome was given by p value of  <0.05. Results: Majority of the cases were in the age group 61-70 years (32%) with male to female ratio  of 1.25:1. Significant association was found between ACS and risk factors like smoking, positive family history of IHD, hypertension, diabetes, dyslipidemia, waist hip ratio and body mass index. Overall, most common outcome of ACS in the present study was NSTEMI (45%) followed by STEMI (35%) followed by Unstable angina (20%). Conclusion: Significant association was found between smoking and occurrence of STEMI and significant association was found between Hypertension and occurrence of NSTEMI.

scholarly journals Serum uric acid levels in essential hypertension and its correlation with the severity of hypertension

2020 ◽  
Vol 7 (11) ◽  
pp. 1738
Author(s):  
Waseem Ramzan Dar ◽  
Sunil Kumar Gupta ◽  
Afzal Ahmad
Keyword(s):  
Uric Acid ◽  
Essential Hypertension ◽  
Serum Uric Acid ◽  
Serum Uric Acid Level ◽  
Laboratory Data ◽  
Social Software ◽  
National Committee ◽  
Hypertensive Patients ◽  
Co Morbidity ◽  
Significant Difference

Background: Serum uric acid has been closely linked and considered as an independent risk factor for development of hypertension. This study was carried out to assess the serum uric acid levels in essential hypertension and its correlation with the severity and known duration of hypertension.Methods: The present observational case control study was conducted between November 2019 to February 2020 on total 100 out patients (30-65 years) of which 50 known cases of essential hypertension irrespective of treatment status and were graded into different stages of hypertension as per Joint National Committee VII (JNC VII) guidelines. Rest 50 patients who were age- sex matched and without any co-morbidity were included as control. Relevant clinical and laboratory data were recorded using proforma. Statistical analysis was done using Statistical package for social software (SPSS) software.Results: Mean systolic/diastolic blood pressure (BP) was found significantly higher in cases 168/102 mmHg compare to control 114/74 mmHg. Among cases maximum patients were found in stage 2 hypertension which has significant difference in mean systolic/diastolic BP (186/112 mmHg, p<0.001) compare with stage 1 (146/94 mmHg) and isolated hypertensive patients (148/85 mmHg). Serum uric acid levels were significantly higher in stage 2 than other two hypertensive stages among cases and also compare to controls. Patients with >5 years of hypertension also has significant high serum uric acid level than <5 years of hypertension.Conclusions: Serum uric acid can be used probably as an early biochemical marker to determine the severity of hypertension as stage 2 hypertensive had more elevation in serum uric acid levels as compared to other hypertensive patients.

scholarly journals Association of Hyperuricaemia with Perinatal Outcome in Pregnancy Induced Hypertension

2015 ◽  
Vol 32 (3) ◽  
pp. 124-129
Author(s):  
Saida Akter ◽  
Sharmin Sultana ◽  
Seema Rani Dabee
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Perinatal Outcome ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Pregnancy Induced Hypertension ◽  
Group I ◽  
Induced Hypertension ◽  
Group Ii

The high serum uric acid concentration correlates with the degree of severity of the pregnancy induced hypertension (PIH) and perinatal outcome. In this context, maternal serum uric acid level is reported to be one of the prognostic factor for determination of perinatal outcome. Based on the existing data, the present prospective study was undertaken in the Department of Obstetrics and Gynaecology, BIRDEM Academy, from January to December, 2010. Out of 120 women, 60 suffering from PIH (severe preeclampsia and eclampsia) served as group I and 60 normotensive women at third trimester of pregnancy served as group II. This study showed that mean (±SD) serum uric acid was significantly elevated in group I PIH patients (7.21±1.81 mg/dl) compared to group II normotensive pregnancy (4.40±0.84 mg/dl). In group I PIH patients, 39 (86%) had adverse perinatal outcome (preterm, IUGR, stillbirth), and 6 (13.3%) term and healthy deliveries when serum uric acid level was >6 mg/dl. Current study showed that there was positive and statistically significant relationship between diastolic blood pressure and hyperuricaemia in group I PIH patients (r = +0.359, P<0.01). This study also showed that in group I PIH patients, when serum uric acid increased, birth weight significantly decreased (r = 0.279, P<0.05).J Bangladesh Coll Phys Surg 2014; 32: 124-129

scholarly journals A study of angiographic severity in patients with coronary artery disease and hyperuricemia

2015 ◽  
Vol 7 (2) ◽  
pp. 1-4 ◽  
Author(s):  
Subhraprakash Pramanik ◽  
Koushik Mondal ◽  
Arpan Kumar Dey ◽  
Pijush Kanti Mandal ◽  
Shovan Kumar Das ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Uric Acid ◽  
Coronary Artery ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
P Value ◽  
Gensini Score ◽  
Artery Disease

Backgrounds: Hyperuricemia has not yet been established as cardiovascular risk factor. We aimed to study the angiographic severity in patients with coronary artery disease (CAD) and hyperuricemia.Materials and Methods: In this observational cross-sectional study we measured serum uric acid level in 82 patients of CAD who underwent coronary angiography in catheterisation laboratory of our Institution. Severity of CAD was determined on the basis of Gensini score, number of diseased vessels, critical lesions and total occlusions.Results: The prevalence of hyperuricemia in patients with CAD was 42.68% in our study. Hyperuricemia was associated with higher Gensini score (33.33±10.64 vs. 22.90±6.75, p value <0.001), number of critical lesions (1.03±0.84 vs. 0.63±0.72, p value 0.031), total occlusions (0.67±0.47 vs. 0.37±0.48, p value 0.007) and dyslipidemia (63.6% vs. 30.6%, p value 0.003) more frequently compared to normouricemic patients. And also the higher serum uric acid level was correlated with higher Gensini score (beta 0.418, t 4.430, p value <0.001, 95% CI 0.036 and 0.094) and frequent number of total occlusion (beta 0.338, t 3.589, p value 0.001, 95% CI 0.462 and 1.613).Conclusion: Hyperuricemia was associated with higher Gensini score, frequent total occlusions and critical lesions in patients with Coronary Artery Disease compared to patients with normal uric acid level and also it was significantly correlated with higher Gensini score and frequent total occlusions.Asian Journal of Medical Sciences Vol.7(2) 2015 1-4

scholarly journals Association of Serum Uric Acid Level With Blood Pressure Variability in Newly Diagnosed Essential Hypertension

2015 ◽  
Vol 17 (12) ◽  
pp. 929-935 ◽  
Author(s):  
Kumral Çağlı ◽  
Osman Turak ◽  
Uğur Canpolat ◽  
Fırat Özcan ◽  
Derya Tok ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Uric Acid ◽  
Essential Hypertension ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Blood Pressure Variability ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Newly Diagnosed

scholarly journals Serum uric acid level in Bangladeshi adults with essential hypertension

2020 ◽  
Vol 7 (7) ◽  
pp. 1136
Author(s):  
SK. Kabir Ahammed ◽  
A. B. M. Kamrul Hasan ◽  
Mohammed Ruhul Kabir ◽  
Gunosindhu Paul ◽  
Shishir Kumar Basak ◽  
...  
Keyword(s):  
Uric Acid ◽  
Essential Hypertension ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Control Group ◽  
Cross Sectional ◽  
Hypertensive Group ◽  
Positive Correlations

Background: The association of hyperuricemia with various cardiovascular risk factors has often led to the debate of whether hyperuricemia is an independent risk factor for essential hypertension (HTN).  The current study was conducted to see the relationship between serum uric acid and essential HTN in Bangladeshi adults.Methods: In this cross-sectional study, conducted in a tertiary hospital of Bangladesh, 155 patients with essential hypertension (newly detected or on treatment) aged ≥18 years and 100 age-sex matched normotensive subjects were investigated. Serum uric acid, plasma glucose, serum creatinine, and lipid profile were measured in all in fasting samples.Results: The frequency of hyperuricemia was higher in the hypertensive group in comparison to the normotensive control group (29.7% vs. 6.0%, p<0.001). Serum uric acid level was higher in the hypertensive subjects than the controls (6.10±0.88 vs. 5.38±0.54 mg/dL, mean±SD, p<0.001). In the hypertensive group, subjects with stage II HTN had higher serum uric acid than those with stage I HTN (6.46±0.83 vs. 5.72±0.78 mg/dL, mean±SD, p<0.001). In the hypertensive group, uric acid level showed significant positive correlations with both systolic and diastolic blood pressure though in the control group uric acid showed such correlation with systolic BP only.Conclusion: Patients with essential hypertension had higher serum uric acid compared to normotensive controls; uric acid level showed positive correlations with systolic and diastolic BP in the hypertensive subjects.

scholarly journals EVALUATION OF CHONDROPROTECTIVE EFFECTS OF HYALURONIC ACID IN A RAT MODEL OF OSTEOARTHRITIS

2022 ◽  
Vol 71 (6) ◽  
pp. 2189-93
Author(s):  
Noaman Ishaq ◽  
Shabana Ali ◽  
Muhammad Waqar Aslam Khan ◽  
Kulsoom Farhat ◽  
Nausheen Ata ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Treatment Group ◽  
Rat Model ◽  
Cruciate Ligament ◽  
Gait Pattern ◽  
Control Group ◽  
P Value ◽  
Army Medical ◽  
Medical College ◽  
Group I

Objective: To evaluate the chondroprotective effects of hyaluronic acid in a rat model of osteoarthritis. Study Design: Laboratory based experimental study. Place and Duration of Study: Department of Pharmacology, Army Medical College, Rawalpindi, in alliance with National Institute of health, Islamabad and Department of Pathology, Army Medical College Rawalpindi, from Apr to Jun 2019. Methodology: Sixteen (16) rats of Sprague Dawley breed were procured in this study. Osteoarthritis was induced in right knee joint of rats by surgical resection of medial meniscus and anterior cruciate ligament. They were allocated into two (02) groups with eight (08) rats in both groups. Group-I was control group that was treated with 0.2 ml intra articular saline once weekly for four weeks. While group-II was treatment group that was intra particularly administered with 0.2ml hyaluronic acid once weekly for four weeks. One week after the last dosage, gait pattern of the animals was scored. Then animals were sacrificed and a part of proximal tibia was obtained for histopathologic analysis. Results: Mean gait score of control group and treatment group was 3.25 ± 0.707 and 1.00 ± 0.756 respectively with a statistically significant p-value of <0.001, while mean histopathological Modified Mankin score of control and treatment group was 11.5 ± 1.195 and 5.50 ± 1.195 respectively with a significant p-value of <0.001. Conclusion: Intra articular viscosupplementation of hyaluronic acid in rat model of osteoarthritis resulted in improved gait pattern and histopathology.

scholarly journals Prevalence of Hyperuricemia and its Association with Sociodemography among Hypertensive Patients at Birat Medical College Teaching Hospital

2021 ◽  
Vol 6 (1) ◽  
pp. 1388-1391
Author(s):  
Ram Kumar Mehta ◽  
Ram L Mallick ◽  
Surya Parajuli ◽  
Rajneesh Jha
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Teaching Hospital ◽  
Serum Uric Acid Level ◽  
College Teaching ◽  
Cardiovascular Morbidity ◽  
Morbidity And Mortality ◽  
Hypertensive Patients ◽  
Medical College ◽  
Cardiovascular Morbidity And Mortality

Introduction: Hypertension is the most common cardiovascular diseases. In only 5-10 % of hypertensive patients, underlying cause can be identified (secondary hypertension). Serum uric acid is thought to play a pathogenic role in development of hypertension and is also a commonly associated condition in patients with hypertension. Management of hyperuricemia will ultimately help in reducing cardiovascular morbidity and mortality. Objectives: To determine the prevalence of hyperuricemia among hypertensive patients atiending Birat Medical College Teaching Hospital and also to find association between hyperuricemia and socio-demographic variables. Methodology: This was a descriptive hospital based cross-sectional study conducted in 168 hypertensive patients at Birat Medical College Teaching Hospital, Nepal for a period of 6 months from 1 September 2020 to 28th February 2021. Sociodemographic variables were recorded and serum uric acid level was obtained based on the pre-structured questionnaires. Data were analyzed by Statistical Package for the Social Sciences version 20 (SPSS 20). Result: Prevalence of hyperuricemia was 42 (25%) among hypertensive patients with more prevalent in male 33 (30.8%) than female 9 (14.8%). Hyperuricemia was more prevalent in patients having higher BMI and patients aged more than 60 years i.e. 38 (34.5%) and 25 (41.7%) respectively. It was more prevalent among patients with hypertension for more than 15 years 10 (41.7%) and non-vegetarian 33 (25.8%). Hyperuricemia was significantly associated with those aged more than 60 years (p=0.002) and BMI >25 kg/m2 (p=0.002). Conclusion: Hyperuricemia was common associated condition among hypertensive patients. Hyperuricemia is mainly associated with male gender, non-vegetarian and patients with longer duration of hypertension. Similarly, it was strongly associated with older age and patients having higher BMI. Monitoring of serum uric acid and management of hyperuricemia might be helpful in management of hypertension and thus decreasing cardiovascular morbidity and mortality. 

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