scholarly journals Uridine – An Indicator of Post-Exercise Uric Acid Concentration and Blood Pressure

2015 ◽  
pp. 467-477 ◽  
Author(s):  
W. DUDZINSKA ◽  
A. LUBKOWSKA ◽  
B. DOLEGOWSKA ◽  
M. SUSKA ◽  
M. JANIAK
Keyword(s):  
Blood Pressure ◽  
Uric Acid ◽  
Physical Exercise ◽  
Acid Concentration ◽  
Healthy Subjects ◽  
High Performance ◽  
Maximal Exercise ◽  
Uric Acid Concentration ◽  
Post Exercise ◽  
Exercise Induced

Studies have shown that uridine concentration in plasma may be an indicator of uric acid production in patients with gout. It has been also postulated that uridine takes part in blood pressure regulation. Since physical exercise is an effective tool in treatment and prevention of cardio-vascular diseases that are often accompanied by hyperuricemia and hypertension, it seemed advisable to attempt to evaluate the relationship between oxypurine concentrations (Hyp, Xan and UA) and that of Urd and BP after physical exercise in healthy subjects. Sixty healthy men (17.2±1.71 years, BMI 23.2±2.31 kg m−2, VO2max 54.7±6.48 ml kg−1 min−1) took part in the study. The subjects performed a single maximal physical exercise on a bicycle ergometer. Blood for analyses was sampled three times: immediately before exercise, immediately after exercise, and in the 30th min of rest. Concentrations of uridine and hypoxanthine, xanthine and uric acid were determined in whole blood using high-performance liquid chromatography. We have shown in this study that the maximal exercise-induced increase of uridine concentration correlates with the post-exercise increase of uric acid concentration and systolic blood pressure. The results of our study show a relationship between uridine concentration in blood and uric acid concentration and blood pressure. We have been the first to demonstrate that a maximal exercise-induced increase in uridine concentration is correlated with the post-exercise and recovery-continued increase of uric acid concentration in healthy subjects. Thus, it appears that uridine may be an indicator of post-exercise hyperuricemia and blood pressure.

scholarly journals Quercetin lowers plasma uric acid in pre-hyperuricaemic males: a randomised, double-blinded, placebo-controlled, cross-over trial

2016 ◽  
Vol 115 (5) ◽  
pp. 800-806 ◽  
Author(s):  
Yuanlu Shi ◽  
Gary Williamson
Keyword(s):  
Blood Pressure ◽  
Uric Acid ◽  
Urinary Excretion ◽  
Acid Concentration ◽  
Fasting Glucose ◽  
Uric Acid Concentration ◽  
Elevated Plasma ◽  
Plasma Uric Acid ◽  
Double Blinded ◽  
Healthy Males

AbstractElevated plasma uric acid concentration is a risk factor for gout, insulin resistance and type 2 diabetes. Quercetin, a flavonoid found in high levels in onions, tea and apples, inhibits xanthine oxidoreductasein vitro, the final step in intracellular uric acid production, indicating that quercetin might be able to lower blood uric acid in humans. We determined the effects of 4 weeks of oral supplementation of quercetin on plasma uric acid, blood pressure and fasting glucose. This randomised, double-blinded, placebo-controlled, cross-over trial recruited twenty-two healthy males (19–60 years) with baseline plasma uric acid concentration in the higher, but still considered healthy, range (339 (sd51) µmol/l). The intervention included one tablet containing 500 mg quercetin daily for 4 weeks, compared with placebo, with a 4-week washout period between treatments. The primary outcome was change in concentrations of plasma uric acid after 2 and 4 weeks; secondary outcome measures were changes in fasting plasma glucose, 24-h urinary excretion of uric acid and resting blood pressure. After quercetin treatment, plasma uric acid concentrations were significantly lowered by −26·5 µmol/l (95 % CI, −7·6, −45·5;P=0·008), without affecting fasting glucose, urinary excretion of uric acid or blood pressure. Daily supplementation of 500 mg quercetin, containing the bioavailable amount of quercetin as present in approximately 100 g red onions, for 4 weeks, significantly reduces elevated plasma uric acid concentrations in healthy males.

scholarly journals Higher baseline uric acid concentration is associated with non-attainment of optimal blood pressure

PLoS ONE ◽  
2020 ◽  
Vol 15 (7) ◽  
pp. e0236602
Author(s):  
Yuji Sato ◽  
Shouichi Fujimoto ◽  
Kunitoshi Iseki ◽  
Tsuneo Konta ◽  
Toshiki Moriyama ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Uric Acid ◽  
Acid Concentration ◽  
Uric Acid Concentration ◽  
Optimal Blood Pressure

scholarly journals Insulin Resistance Induced by Maximal Exercise Correlates With a Post-Exercise Increase in Uridine Concentration in the Blood of Healthy Young Men

2013 ◽  
pp. 163-170 ◽  
Author(s):  
W. DUDZINSKA ◽  
A. LUBKOWSKA ◽  
K. JAKUBOWSKA ◽  
M. SUSKA ◽  
E. SKOTNICKA
Keyword(s):  
Insulin Resistance ◽  
Insulin Sensitivity ◽  
Healthy Subjects ◽  
Maximal Exercise ◽  
Serum Insulin ◽  
Model Assessment ◽  
Post Exercise ◽  
Insulin Levels ◽  
Exercise Induced ◽  
The Impact

Uridine is postulated to participate in the development of insulin resistance. Since exercise is an effective tool in the treatment of insulin resistance it appeared justified to assess the impact of maximal exercise on plasma uridine and insulin sensitivity indices (e.g. insulin and HOMA-IR) in healthy subjects. The study included forty-four healthy males (18.5±2.92 years, VO2max 50.2±6.26 ml kg-1 min-1). Subjects performed a single maximal exercise on a bicycle ergometer. Blood samples were taken three times: immediately before exercise, immediately after exercise and at the 30th min of rest. Uridine concentrations were determined in the whole blood using high-performance liquid chromatography. Serum insulin levels were measured by a specific ELISA method. Insulin sensitivity was assessed by homeostasis model assessment method (HOMA-IR). A maximal exercise-induced increase in the concentration of uridine correlated with post-exercise increases in insulin levels and HOMA-IR. Our results indicate a relationship between the concentration of uridine in the blood and indicators of insulin sensitivity in healthy subjects. We are the first to demonstrate that a maximal exercise-induced increase in the concentration of uridine is correlated with post-exercise increases in insulin levels and HOMA-IR in healthy subjects. It appears that uridine may be an indicator of insulin resistance.

scholarly journals Uric acid concentration as a risk marker for blood pressure progression and incident hypertension: A Chinese cohort study

Metabolism ◽  
2012 ◽  
Vol 61 (12) ◽  
pp. 1747-1755 ◽  
Author(s):  
Tsan Yang ◽  
Chi-Hong Chu ◽  
Chyi-Huey Bai ◽  
San-Lin You ◽  
Yu-Ching Chou ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Uric Acid ◽  
Cohort Study ◽  
Acid Concentration ◽  
Risk Marker ◽  
Uric Acid Concentration ◽  
Incident Hypertension ◽  
Chinese Cohort

Uric acid reduces exercise-induced oxidative stress in healthy adults

2003 ◽  
Vol 105 (4) ◽  
pp. 425-430 ◽  
Author(s):  
W. S. WARING ◽  
A. CONVERY ◽  
V. MISHRA ◽  
A. SHENKIN ◽  
D. J. WEBB ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Uric Acid ◽  
Physical Exercise ◽  
Antioxidant Capacity ◽  
High Intensity ◽  
Healthy Subjects ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Systemic Administration ◽  
Exercise Induced

Uric acid (UA) possesses free-radical-scavenging properties, and systemic administration is known to increase serum antioxidant capacity. However, it is not known whether this protects against oxidative stress. The effects of raising UA concentration were studied during acute aerobic physical exercise in healthy subjects, as a model of oxidative stress characterized by increased circulating 8-iso-prostaglandin F2α (8-iso-PGF2α) concentrations. Twenty healthy subjects were recruited to a randomized double-blind placebo-controlled crossover study, and underwent systemic administration of 0.5 g of UA in 250 ml of 0.1% lithium carbonate/4% dextrose vehicle or vehicle alone as control. subjects performed high-intensity aerobic exercise for 20 min to induce oxidative stress. Plasma 8-iso-PGF2α concentrations were determined at baseline, after exercise and after recovery for 20 min. A single bout of high-intensity exercise caused a significant increase in plasma 8-iso-PGF2α concentrations from 35.0±4.7 pg/ml to 45.6±6.7 pg/ml (P<0.01). UA administration raised serum urate concentration from 293±16 to 487±16 μmol/l (P<0.001), accompanied by increased serum antioxidant capacity from 1786±39 to 1899±45 μmol/l (P<0.01). UA administration abolished the exercise-induced elevation of plasma 8-iso-PGF2α concentrations. High UA concentrations are associated with increased serum antioxidant capacity and reduced oxidative stress during acute physical exercise in healthy subjects. These findings indicate that the antioxidant properties of UA are of biological importance in vivo.

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