scholarly journals D-chiro-inositol, Vitamin D, and Epigallocatechin Gallate Avoid Surgery in Females with Uterine Fibroids: Two Case Reports

2021 ◽  
pp. 95-101
Author(s):  
Mario Montanino Oliva
Keyword(s):  
Vitamin D ◽  
Case Reports ◽  
Tumour Size ◽  
Waiting Times ◽  
Uterine Fibroids ◽  
Epigallocatechin Gallate ◽  
Hand Surgery ◽  
Reproductive Age ◽  
Older Individuals ◽  
Risk Of Rupture

Uterine fibroids (UF) represent the most common benign tumours in females of reproductive age, and can negatively affect fertility. Patients with UFs need to reduce the tumour size with pharmacological treatments or surgically remove the fibroid before using assisted reproductive technology (ART). On the other hand, surgery implies long waiting times before ART to avoid the risk of rupture of the uterus. Long waiting periods are often unacceptable for older individuals who want to undergo ART procedures. Unfortunately, no specific and safe treatment for UFs is currently available. Here the author reports two cases of patients with UFs and associated heavy menstrual bleeding who seek pregnancy through ART. Both underwent a daily treatment with epigallocatechin gallate, vitamin D, vitamin B6, and D-chiro-inositol for 3 months. The patients showed a volume reduction of 73.8% and 68.4%, respectively. This was associated with decreased blood loss (42.1% and 48.7%, respectively). After 3 months from the end of the treatment, both patients underwent ART procedure without the need for surgical intervention.

scholarly journals Management of Fibroids Prior to in Vitro Fertilization. Case Reports

2021 ◽  
Author(s):  
Teresa Gastañaga-Holguera ◽  
Virginia González González ◽  
Marta Calvo Urrutia ◽  
Isabel Campo Gesto ◽  
Marta Vidaurreta Lázaro ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Case Reports ◽  
Uterine Fibroids ◽  
Reproductive Age ◽  
Surgical Approaches ◽  
Uterine Neoplasms ◽  
Vitro Fertilization ◽  
First Case ◽  
Pharmacologic Treatments

Abstract BACKGROUND. Uterine fibroids are common benign uterine neoplasms in women in reproductive age and pregnancy desire. Several surgical approaches for symptomatic fibroids are available, such as surgical or pharmacologic treatments. We report three cases of fibroids treatment in women with primary sterility. CASE PRESENTATION. The first case of a successful in vitro fertilization (IVF) after ulipristal acetate (UPA) as an alternative treatment to reduce the fibroids size in a patient with two previous abdominal myomectomies, resulting in an evolutive pregnancy. The second patient underwent several myomectomies (both abdominal and hysteroscopic) in a long period of time. And the third one of a successful IVF after UPA in a patient with a submucous fibroid which induced myoma migration leading to its prolapse.CONCLUSIONS. Myomectomy appears to be the gold standard treatment for fibroids in women with reproductive desires. Nevertheless, more series are essential for establishing the safety of UPA as a treatment of symptomatic fibroids prior to pregnancy.

scholarly journals Comparative Plasma Levels of Vitamin D in Women with or without Uterine Fibriods in Lagos State University Teaching Hospital, Ikeja, Lagos, Nigeria

2021 ◽  
pp. 1-5
Author(s):  
Abidoye Gbadegesin ◽  
Keyword(s):  
Vitamin D ◽  
Plasma Levels ◽  
Uterine Fibroids ◽  
Serum Levels ◽  
Reproductive Age ◽  
University Teaching ◽  
State University ◽  
Reproductive Age Women ◽  
25 Hydroxy Vitamin D ◽  
Control Study

Background: Fibroids are commonest benign tumour of the uterus in reproductive age women. Surgical treatment has been the mainstay of treatment for symptomatic fibroids. Recently, hypovitamin D has been associated with fibroid. The aim of the study was to compare the level of vitamin D in women with fibroids and women without fibroids. Aim: To determine and compare plasma levels of Vitamin D in women with uterine fibroids and those without uterine fibroids Method: An institution based case control study comprising of 274 women. It compared the serum levels of 25 hydroxy vitamin D in 137 women with uterine fibroids and 137 women without uterine fibroids as controls. Result: The level of vitamin D in the women with and without uterine fibroids were {13.5ng /ml, (IQR 3.8 – 22.1)} and {52.1 ng/ml, (IQR 30.6 – 75.0)} (P = < 0.001) respectively. Conclusion: The plasma level of 25-Hydoxy vitamin D was significantly lower in women with uterine fibroids and higher in women without fibroids. Subsequently, prompt detection of vitamin D deficiency by screening with effective treatment may reduce the incidence of fibroids and its sequelae in these group of women.

scholarly journals The associations between serum vitamin D, calcium and uterine fibroids in Chinese women: a case-controlled study

2020 ◽  
Vol 48 (5) ◽  
pp. 030006052092349
Author(s):  
Saisai Li ◽  
Beilei Chen ◽  
Bo Sheng ◽  
Jing Wang ◽  
Xueqiong Zhu
Keyword(s):  
Vitamin D ◽  
Uterine Fibroids ◽  
Serum Vitamin ◽  
Hypovitaminosis D ◽  
Reproductive Age ◽  
Controlled Study ◽  
Female Population ◽  
Serum 25Ohd ◽  
Female Patients ◽  
Serum Vitamin D

Objective To investigate the associations between serum vitamin D, calcium and uterine fibroids in a Chinese female population. Methods In this case-control study, adult female patients with fibroids (cases) were compared with females without fibroids (controls) in terms of serum 25-hydroxyvitamin D (25OHD) and calcium levels. Results Out of 546 total participants (mean age, 41.68 ± 5.99 years; 279 with fibroids and 267 without fibroids), only 232 had serum 25OHD levels above the sufficient threshold (>20 ng/ml). In addition, females with fibroids had lower serum 25OHD levels versus those without fibroids. The prevalence of fibroids in females with deficient (<12 ng/ml) and insufficient (12–20 ng/ml) 25OHD levels were significantly higher than in females with sufficient (>20 ng/ml) 25OHD levels. Serum calcium levels were within normal range in both groups. Conclusion Hypovitaminosis D was highly prevalent among a population of Chinese females of reproductive-age, and serum 25OHD levels were lower in female patients with fibroids.

The role of vitamin D deficiency in the risk for uterine fibroids relapse after laparoscopic conservative myomectomy in women of reproductive age

GYNECOLOGY ◽  
2019 ◽  
Vol 21 (5) ◽  
pp. 20-24
Author(s):  
Yanina A Lebedeva ◽  
Inna I Kovalenko ◽  
Oleg L Molchanov ◽  
Dmitrii V Baibuz ◽  
Natalia V Kulikova
Keyword(s):  
Vitamin D ◽  
Surgical Treatment ◽  
Vitamin D Deficiency ◽  
Negative Impact ◽  
Uterine Fibroids ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Risk Of Recurrence ◽  
Vitamin D Levels

Relevance. Due to the high prevalence of uterine fibroids in women of reproductive age and the negative impact on reproductive health, one of the priority tasks of specialists is to search not only for new therapeutic methods, but also for ways to prevent this disease. Aim. To determine the role of vitamin D deficiency in the risk of uterine fibroids recurrence after surgical treatment in women of reproductive age. Materials and methods. A comparative analysis of the recurrence rate of uterine fibroids in patients of reproductive age after surgical treatment. The study involved 49 women of reproductive age 20-39 years (average age 31.5±4.3 years) with unrealized reproductive plans. All underwent surgical treatment in the scope of laparoscopic conservative myomectomy for uterine fibroids with different symptoms. All patients were given vitamin D levels. Results. In 93.5% of cases, the risk of recurrence of uterine fibroids increases at vitamin D levels below 34.5 ng/ml, when reaching 38.6 ng/ml and above, the risk of reformation of nodes is minimal. Conclusions. When the vitamin D level exceeds 38.6 ng/ml, it is possible to minimize the risk of recurrence of uterine fibroids in women of reproductive age, thereby avoiding repeated surgical interventions and associated complications.

scholarly journals Vitamin D Status in Women with Uterine Fibroids: A Cross-sectional Study

2020 ◽  
Vol 8 (B) ◽  
pp. 109-113
Author(s):  
Farah Farzaneh ◽  
Kiana Sadeghi ◽  
Mohammad Chehrazi
Keyword(s):  
Vitamin D ◽  
Vitamin D3 ◽  
Positive Family History ◽  
Uterine Fibroids ◽  
Serum Vitamin ◽  
Sun Exposure ◽  
Reproductive Age ◽  
Control Group ◽  
Cross Sectional ◽  
Serum Vitamin D

BACKGROUND: Uterine fibroids (UFs) affect women of reproductive age and lead to major morbidity in premenopausal women. Identifying modifiable risk factors could help develop new UF prevention and treatment strategies. OBJECTIVES: The purpose of this research was to investigate the relationship between serum Vitamin D3 levels and UF in women seeking gynecological services. METHODS: This case–control design was conducted in September 2018 at the outpatient gynecology clinic of Shahid Beheshti University of Medical Sciences, Tehran, Iran. Cases had at least one ultrasound confirmed fibroid lesion with an average volume of 2 cm or greater. The outpatient clinic has enrolled a control group of patients without UF, based on transvaginal ultrasonography or any other gynecologic pathology. Radioimmunoassay techniques were applied to measure serum Vitamin D [25(OH) D3] levels. RESULTS: A total of 148 patients met inclusion criteria, 71 women were had at least one UF and the remaining 77 participants showed normal, UF-free uterine structure. The mean serum concentration of 25-hydroxyvitamin D3 was lower in UF patients (21.37 ± 7.49 ng/mL) than without (24.62 ± 9.21 ng/mL) (p = 0.02). A modified odds ratio derived from a backward logistic regression model for 25-hydroxyvitamin D3 that included positive family history, age, body mass index, bleeding volume, physical activity, sun exposure, and history of abortion was 0.92 (95% CI, 0.88–0.98) (P = 0.02). CONCLUSION: For women with UFs, the serum level of 25-hydroxyvitamin D3 was significantly lower than in controls. Vitamin D3 deficiency is a potential risk factor for UFs to occur.

scholarly journals Anticipated help-seeking for cancer symptoms before and after the coronavirus pandemic: results from the Onco-barometer population survey in Spain

2021 ◽  
Author(s):  
Dafina Petrova ◽  
Marina Pollán ◽  
Miguel Rodriguez-Barranco ◽  
Dunia Garrido ◽  
Josep M. Borrás ◽  
...  
Keyword(s):  
Poisson Regression ◽  
Help Seeking ◽  
Regression Models ◽  
Population Survey ◽  
Waiting Times ◽  
Perceived Barriers ◽  
Older Individuals ◽  
Cancer Symptoms ◽  
Before And After ◽  
Diagnostic Delays

Abstract Background The patient interval—the time patients wait before consulting their physician after noticing cancer symptoms—contributes to diagnostic delays. We compared anticipated help-seeking times for cancer symptoms and perceived barriers to help-seeking before and after the coronavirus pandemic. Methods Two waves (pre-Coronavirus: February 2020, N = 3269; and post-Coronavirus: August 2020, N = 1500) of the Spanish Onco-barometer population survey were compared. The international ABC instrument was administered. Pre–post comparisons were performed using multiple logistic and Poisson regression models. Results There was a consistent and significant increase in anticipated times to help-seeking for 12 of 13 cancer symptoms, with the largest increases for breast changes (OR = 1.54, 95% CI 1.22–1–96) and unexplained bleeding (OR = 1.50, 1.26–1.79). Respondents were more likely to report barriers to help-seeking in the post wave, most notably worry about what the doctor may find (OR = 1.58, 1.35–1.84) and worry about wasting the doctor’s time (OR = 1.48, 1.25–1.74). Women and older individuals were the most affected. Conclusions Participants reported longer waiting times to help-seeking for cancer symptoms after the pandemic. There is an urgent need for public interventions encouraging people to consult their physicians with symptoms suggestive of cancer and counteracting the main barriers perceived during the pandemic situation.

Chronic kidney disease, pregnancy and haemodialysis: Case reports from a single centre in Kenya and literature review

2021 ◽  
pp. 1753495X2098540
Author(s):  
Samuel K Kabinga ◽  
Jackline Otieno ◽  
John Ngige ◽  
Seth O Mcligeyo
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Case Reports ◽  
Tertiary Hospital ◽  
Reproductive Age ◽  
Review Of Literature ◽  
Single Centre ◽  
End Stage Kidney Disease ◽  
Women Of Reproductive Age ◽  
End Stage

Chronic kidney disease (CKD) and end stage kidney disease are prevalent even in women of reproductive age. These are known to reduce fertility and successful pregnancy. There are chances of conception even in advanced CKD, though laden with complications. We present two cases of women who conceived in advanced CKD and are on haemodialysis in a tertiary hospital in Kenya and review of literature.

scholarly journals Regional Variability in COVID-19 Case Fatality Rate in Canada, February–December 2020

2021 ◽  
Vol 18 (4) ◽  
pp. 1839
Author(s):  
Eunha Shim
Keyword(s):  
British Columbia ◽  
Case Fatality Rate ◽  
Case Reports ◽  
Case Fatality ◽  
Health Interventions ◽  
Fatality Rate ◽  
Older Individuals ◽  
Regional Variability ◽  
Provincial Level ◽  
Mortality Burden

A total of 475,214 COVID-19 cases, including 13,659 deaths, had been recorded in Canada as of 15 December 2020. The daily reports of confirmed cases and deaths in Canada prior to 15 December 2020 were obtained from publicly available sources and used to examine regional variations in case fatality rate (CFR). Based on a factor of underestimation and the duration of time from symptom onset to death, the time-delay adjusted CFR for COVID-19 was estimated in the four most affected provinces (Quebec, Ontario, Alberta, and British Columbia) and nationwide. The model-based adjusted CFR was higher than the crude CFR throughout the pandemic, primarily owing to the incorporation in our estimation of the delay between case reports and deaths. The adjusted CFR in Canada was estimated to be 3.36% nationwide. At the provincial level, the adjusted CFR was the highest in Quebec (5.13%)—where the proportion of deaths among older individuals was also the highest among the four provinces—followed by Ontario (3.17%), British Columbia (1.97%), and Alberta (1.13%). Provincial-level variations in CFR were considerable, suggesting that public health interventions focused on densely populated areas and elderly individuals can ameliorate the mortality burden of the COVID-19 pandemic.

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