ABSTRACT Background: It is widely known that physical activity has benefits on overall quality of life. Several studies have reported that children with higher physical activity levels had greater whitematter integrity and subcortical structures which critical for learning and memory than children in lower physical activity levels. The purpose of this study was to investigate the effect of physical activity on the academic achievement in primary school students. Subjects and Method: This was meta-analysis and systematic review. The study was conducted by collecting published articles from Google Scholar, PubMed, Springer Link, and Research Gate databases, from 2011-2020. Keywords used “Physical activity” OR “Academic achievement” AND “Cross sectional”. The inclusion criteria were full text, using English or Indonesian language, using cross-sectional study design, and reporting adjusted odds ratio. The study population (P) was primary school students. Intervention (I) was physical activity with comparison (C) sedentary behavior. The study outcome (O) was academic achievement. The collected articles were selected by PRISMA flow chart. The quantitative data were analyzed using Revman 5.3. Results: 6 studies from Saudi Arabia, Malaysia, Chili, United Kingdom, Spanish, and Norway, were met the criteria 6. This study showed that high physical activity improved academic achievement in primary school students (aOR= 1.44; 95% CI= 1.16 to 1.80; p<0.001, with I2= 94%). Conclusion: High physical activity improves academic achievement in primary school students. Keywords: physical activity, academic achievement Correspondence: Fatchurrohmah Ines Prabandari. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: [email protected]. Mobile: 087836588843. DOI: https://doi.org/10.26911/the7thicph.03.128