scholarly journals Burn Wound Healing Activity of Prunella Grandiflora L. Exctract

Biomeditsina ◽  
2021 ◽  
Vol 17 (4) ◽  
pp. 50-56
Author(s):  
E. V. Bolotnik ◽  
L. I. Alekseeva ◽  
L. P. Larionov
Keyword(s):  
Wound Healing ◽  
Wistar Rats ◽  
Dosage Forms ◽  
Control Groups ◽  
Burn Wound ◽  
Dry Extract ◽  
Burn Wound Healing ◽  
Male Wistar Rats ◽  
And Control ◽  
Wound Healing Activity

The qualitative composition of phenolic acids and burn wound healing activity of Prunella grandiflora L. extract were studied. The content of rosmarinic (621±5 mg/g), coffeic (11.2±0.2 mg/g), syringic (46.5±1.4 mg/g), n-coumaric (25.8±0.5 mg/g), and ferulic (42.7±2.9 mg/g) acids in dry extracts of P. grandiflora was determined by HPLC. Three new burn-healing agents of different composition containing 5% of the dry extract of Prunella grandiflora L. (big-flowered self-heal) were developed. The developed agents were tested on male Wistar rats with second- and third-degree thermal burns. An assessment of skin restoration was carried out in experimental and control groups of animals. It was revealed that animals treated with the developed soft dosage forms restored the epithelium and coat 6–8 days faster that those treated with compositions containing no extract under study. It was found that the developed soft dosage forms based on P. grandiflora extract exhibit anti-inflammatory and wound-healing action.

scholarly journals FORMULATION OF GEL FROM GYNURA SEGETUM EXTRACT AND ITS ACTIVITY ON BURN WOUND HEALING

2021 ◽  
pp. 269-271
Author(s):  
ARIF BUDIMAN ◽  
MUHARAM ◽  
ANIDA CRISTI MAULIDA ◽  
DIAH LIA AULIFA
Keyword(s):  
Wound Healing ◽  
Wistar Rats ◽  
Healing Process ◽  
Physical Stability ◽  
Wound Healing Process ◽  
Burn Wound ◽  
Hot Plate ◽  
Topical Preparation ◽  
Burn Wound Healing ◽  
Male Wistar Rats

Objective: The aims of this study were to formulate gel from Gynura segetum (GS) extract and evaluate its burn-healing activity. Methods: GS extract was formulated using carbomer and carboxymethylcellulose (CMC) as a stabilizer with various concentrations. Furthermore, the gel of GS extract was evaluated, including organoleptic, pH and viscosity. A burn-healing evaluation was conducted by making a wound with a hot plate on male Wistar rats, and 600 mg of the gel was applied. Subsequently, the presence of erythema and width contraction of the burns were observed for 15 d. Results: The result showed that the formulation containing 1 % of carbomer and 1.2 % of GS extract has the best physical stability. The gel also increased the rate of the healing process with decreased burn wound contraction (5.67 mm after 15 d) and the erythema than the control (8.50 mm after 15 d). The significance value was less than 0.05, indicating that the rate of the healing process was significantly different between the GS extract gel and the control. Conclusion: This finding demonstrated that the gel of GS extract can significantly improve the burns wound healing process and may also be safely used for topical preparation.

scholarly journals Herbal Products for Treatment of Burn Wounds

2020 ◽  
Vol 41 (3) ◽  
pp. 457-465
Author(s):  
Anna Herman ◽  
Andrzej P Herman
Keyword(s):  
Wound Healing ◽  
Adverse Effects ◽  
Current Knowledge ◽  
Herbal Therapy ◽  
Burn Wound ◽  
Herbal Products ◽  
Burn Wound Healing ◽  
Preclinical And Clinical Studies ◽  
Antioxidant Mechanisms ◽  
Wound Healing Activity

Abstract The purpose of this review is to summarize the current knowledge acquired during preclinical and clinical studies regarding topically used herbal products with burn wound-healing activity. Moreover, antimicrobial, anti-inflammatory, and antioxidant mechanisms of their action as well as adverse effects of herbal therapy will be also described.

scholarly journals Burn Wound Healing Activity of Ethanolic Extract of Acalypha indica in Oinment Formulated against Rabbits (Ocyctagus caniculus)

2020 ◽  
Vol 8 (3) ◽  
pp. 18-20
Author(s):  
Khairani Fitri ◽  
Tetty Noverita Khairani ◽  
Fajar Apollo Sinaga ◽  
Amenia Gracia Talunohi
Keyword(s):  
Wound Healing ◽  
Ethanolic Extract ◽  
Negative Control ◽  
Burn Wound ◽  
Leaf Extracts ◽  
Laboratory Design ◽  
Burn Wound Healing ◽  
Healing Phase ◽  
Wound Healing Activity ◽  
Acalypha Indica

Objectives: The purpose of this study was to determine burn wound healing activity of Acalypha indica L. in oinment formulated. Design: This study uses an experimental laboratory design. This study used rabbits as test animals induced by burns with hot iron plates on the back. Extract ointment applied to the wound then observed the development of healing. Interventions: The extract was formulated in ointments with concentrations of 3, 5 and 7%. positive control used was ointment containing sesame oil and negative control used is an ointment base. Main outcome measure: The results showed a concentration of 3% had a slow and low effect, at a concentration of 5% it had a moderate healing phase, and a concentration of 7% had a good healing phase. Conclusion: The ointments containing Acalypha indica leaf extracts have good activity in healing burns in rabbits.    

scholarly journals PERAN BATATA (Ipomea batatas L) TERHADAP PENYEMBUHAN LUKA BAKAR

2015 ◽  
Vol 3 (3) ◽  
Author(s):  
Channesya Sampetoding ◽  
Taufiq F. Pasiak ◽  
George Tanudjaja
Keyword(s):  
Wound Healing ◽  
Treatment Group ◽  
Skin Inflammation ◽  
Control Group ◽  
Burn Wound ◽  
Burn Wound Healing ◽  
Ipomea Batatas ◽  
And Control ◽  
Ipomea Batata

Abstract: Theoretically, batata, Ipomea batata L (Lam) theoritically can be used in wound healing since it acts as antiseptic, antibiotic, and anti-inflammatory agents. Batata ingredients can also stimulate epithelialization in wound bed. This study aimed to obtain the role of batata juice in burn wound healing noticed from the inflammatory response aspect. This was an experimental study conducted in the research laboratory of Faculty of Medicine Univeristy of Sam Ratulangi. Samples were six rabbits divided into 2 groups: treatment group with batata juice, and control group without treatment. The histological examination showed that the quality of inflammatory tissue of the treatment group was denser, settled, and associated with edema expansion compared to the control group with diminished inflammatory components, edema, and vasodilatation, meanwhile, there were angiogenesis, improvement of dermis, and regrowth of epidermis. Conclusion: Batata juice was not superior in healing burns than the natural responses.Keywords: batata (Ipomeas batata L), burns, skin, inflammation, wound healingAbstrak: Batata, Ipomea batata L (Lam) secara teoritik berfaedah untuk penyembuhan luka, yang bekerja sebagai antiseptik, antibiotik, dan anti inflamatorik. Batata berkhasiat dalam penyembuhan luka karena kandungannya yang secara bermakna merangsang pembentukan epitel jaringan luka. Penelitian ini bertujuan untuk mendapatkan peran batata terhadap penyembuhan luka bakar dilihat dari kualitas komponen radang pada jaringan luka. Sampel terdiri dari 6 ekor kelinci yang dibagi atas 2 kelompok: kelompok perlakuan dan kontrol. Kelompok perlakuan diberi jus batata pada luka bakar sedangkan kelompok kontrol tanpa perlakuan. Penelitian ini dilakukan di Laboratorium Riset Fakultas Kedokteran Universitas Sam Ratulangi dengan menggunakan metode eksperimental. Hasil identifikasi mikroskopik menunjukkan bahwa pada kelompok perlakuan kualitas komponen radang jaringan luka bakar lebih padat dan menetap disertai perluasan sembab kolagen dibandingkan kelompok kontrol dimana komponen radang dan sembab berkurang, dilatasi pembuluh darah berkurang, pertumbuhan kapiler baru, jaringan dermis yang membaik, dan epidermis yang mulai tumbuh kembali. Simpulan: Jus batata tidak memperlihatkan penyembuhan luka bakar yang lebih baik dibandingkan dengan penyembuhan luka oleh tubuh sendiri.Kata kunci: batata (Ipomeas batata L), luka bakar, kulit, radang, penyembuhan luka

scholarly journals Determination of Wound Healing Activity of Shark Liver Oil using Burn Wound Model in Wistar Rats

2021 ◽  
Vol 13 (2) ◽  
pp. 113-117
Author(s):  
Samiullah Allahbaksh Auti ◽  
Rakesh Kumar Jat ◽  
Supriya Kumar Das ◽  
Shukla ST Shukla
Keyword(s):  
Wound Healing ◽  
Wistar Rats ◽  
Burn Wound ◽  
Shark Liver Oil ◽  
Wound Model ◽  
Wound Healing Activity

scholarly journals Burn Wound Healing Potential of Honey, Sandal Wood, Calendula and Cooling with Tap Water-A Comparative Study on Wistar Rats

2018 ◽  
Author(s):  
Jayshree Shriram Dawane ◽  
Anand Biradar ◽  
Ketan Vaidya ◽  
Ashutosh Sharma ◽  
Madhura Bhosale ◽  
...  
Keyword(s):  
Wound Healing ◽  
Comparative Study ◽  
Wistar Rats ◽  
Tap Water ◽  
Burn Wound ◽  
Burn Wound Healing

scholarly journals Coconut Shell Liquid Smoke Promotes Burn Wound Healing

2016 ◽  
Vol 22 (3) ◽  
pp. 436-440 ◽  
Author(s):  
Vita Murniati Tarawan ◽  
Kemala Isnainiasih Mantilidewi ◽  
Ika Miqra Dhini ◽  
Putri Teesa Radhiyanti ◽  
Endang Sutedja
Keyword(s):  
Wound Healing ◽  
Animal Model ◽  
Povidone Iodine ◽  
Wound Contraction ◽  
Coconut Shell ◽  
Burn Wound ◽  
Liquid Smoke ◽  
Burn Wound Healing ◽  
Experimental Trials ◽  
Wound Healing Activity

The aim of this study was to evaluate burn wound healing activity of coconut shell liquid smoke (CS-LS) in a burn wound animal model. Burn wound–induced mice were treated with CS-LS (CS-LS group), povidone iodine 10% (povidone group), or NaCl 0.9% (NaCl group). Application of CS-LS promoted wound contraction compared to that of the povidone and NaCl groups ( P < .05). This study showed a positive correlation between the number of fibroblasts and wound contraction. The number of fibroblasts was highest in the CS-LS group, compared to that of the povidone and NaCl groups ( P < .05). In conclusion, CS-LS promotes burn wound healing by one possible mechanism, by increasing the number of fibroblasts. The results indicate that further experimental trials are needed to develop CS-LS as an alternative topical drug for burn wound healing.

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