Clinical and immunological monitoring of gingival fluid cytokines in patients with perimplantitis during photodynamic therapy

2020 ◽  
Vol 1 (12) ◽  
pp. 15-18
Author(s):  
E. V. Ippolitov ◽  
S. T. Ilyasova ◽  
G. J. Akhmedov ◽  
A. V. Arutyunyan ◽  
V. N. Tsarev
Keyword(s):  
Treatment Options ◽  
Main Group ◽  
Cytokine Profile ◽  
Control Group ◽  
Immunological Monitoring ◽  
Tnf Α ◽  
The Republic ◽  
Group 2 ◽  
Medical University ◽  
Gingival Fluid

The effect of FDT on the processes of mucosal immunity, in particular, the cytokine profile, remains practically unstudied.Objective: clinical and immunological assessment of the effectiveness of FDT in the complex treatment of periimplantitis at the initial stage of the relief of the inflammatory process.Materials and research methods. The study included patients who contacted the dental institutions of the Republic of Dagestan and the clinic of the Department of Surgical Dentistry of Moscow State Medical University aged 20 to 49 years with a diagnosis of periimplantitis, a total of 61 people. 33 patients received the ABT (the main group 1), 28 patients received the PDT (the main group 2). The control group consisted of 76 patients with stable implants without signs of inflammation or periodontitis (intact periodontium). The concentration of cytokines TNF, IL-1β, IL-6, and IL-17A in the oral fluid was determined by ELISA twice using the INFINITE F50 analyzer (TECAN, Austria) and test systems (Vector-Best, Novosibirsk, Russia). Results. Differences in the state of the cytokine profile in ABT (amoxicillin / sodium clavulanate at 825/125 mg 2 times a day for 7 days) and PDT (FotoSan 350 apparatus, photosensitizer toluidine blue: 4 sessions every 1 day for 40 sec) were found. The maximum cytokine response was observed in the evaluation of IL-1β (137–139 pg/ml) and IL-17A (161–172 pg/ml). After 1 month, statistically significant differences were revealed between the groups of patients with periimplantitis receiving different treatment options. The level of TNF-α decreased by 2.5 times and corresponded to the norm in the case of PDT, but with ABT it remained significantly higher, although we also observed a downward trend. The level of IL-17A showed a statistically significant decrease in PDT, while in ABT, the decrease was not significant. 3 months after treatment, complete normalization of the levels of TNF-α, IL-6 and IL-17A was observed in both compared groups, with the exception of IL-1β, which remained elevated: 8.6 times with PDT and 25 times with ABT.Conclusion. The cytokine profile of gingival fluid in periimplantitis is an important diagnostic marker for the severity of inflammation, which can confirm the presence of periimplantitis and predict the course. The content of IL-1β and IL-17 A reflects the severity of the process. Restoring normal levels of IL-1β is slower than IL-17 A.

scholarly journals The Potential of Nano Curcumin in Preventing the Formation of Artificial Antisperm Antibody in Wistar Rats through Inflammatory Pathway Regulation

2021 ◽  
Vol 9 (A) ◽  
pp. 114-118
Author(s):  
Didit Pramudhito ◽  
Suwandi Sugandi ◽  
Ida Parwati ◽  
Muchtan Sujatno ◽  
Soetojo Soetojo
Keyword(s):  
Wistar Rats ◽  
Inflammatory Cytokine ◽  
Interleukin 10 ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Research Subjects ◽  
Immunological Mechanisms ◽  
Tnf Α ◽  
Pathway Regulation ◽  
Group 2

BACKGROUND: Immunological mechanisms of infertility are still poorly understood and controversial, both the cause and treatment. Inflammation, immunology, cell proliferation, cell differentiation, and cell survival are influenced by several proteins, including nuclear factor kappa-B (NFĸB), tumor necrosis factor-α (TNF-α), and interleukin-10 (IL-10). AIM: This study aimed to explore the potential of nano curcumin to prevent anti-sperm antibodies (ASA) formation due to the testes’ inflammatory process in Wistar rats. METHODS: This research is an experimental study with a pre-post-test approach with control group. The research subjects were rats (Rattus norvegicus) of the Wistar strain. The induced animals were grouped into three groups: Group 1 received nano curcumin 1 × 80 mg/kg BW orally, Group 2 received dexamethasone 1 × 0.3 mg/kg BW, and Group 3 received placebo aquadest 1 × 1 mL orally. TNF-α, NF-kB, and IL10 levels in serum were examined with enzyme-linked immunosorbent assay. RESULTS: The nano curcumin treatment showed the ability to reduce the pro-inflammatory cytokine protein TNF-α expression (47.3 ± 2.32) more optimally than dexamethasone treatment (54.4 ± 3.22). Nano curcumin has also shown the ability to reduce the pro-inflammatory cytokine transcription factor, NF-kB (32.5 ± 2.76) more optimally than treatment with dexamethasone (44.6 ± 2.43). CONCLUSION: Nano curcumin can prevent the formation of ASA in testicular trauma through inhibition of the inflammatory response.

scholarly journals Abnormal Macrophage Polarization in Patients with Myelodysplastic Syndrome

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Gaochao Zhang ◽  
Liyan Yang ◽  
Yu Han ◽  
Haiyue Niu ◽  
Li Yan ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Myelodysplastic Syndrome ◽  
Macrophage Polarization ◽  
Control Group ◽  
M2 Macrophages ◽  
M1 Macrophages ◽  
Tnf Α ◽  
Bone Marrow Microenvironments ◽  
Medical University

Background. This study is aimed at assessing the subsets of bone marrow macrophages in patients with myelodysplastic syndrome (MDS) and exploring the role of macrophages in the pathogenesis of MDS. Methods. Thirty-eight newly diagnosed MDS patients were enrolled in the Department of Hematology of General Hospital of Tianjin Medical University from June 2015 to June 2016. Bone marrow monocytes and macrophage subsets (M1/M2) were detected in patients with MDS and normal controls by flow cytometry. M1 macrophages were cultured in vitro, and the expression of IL-1β and TNF-α mRNA was measured using real-time polymerase chain reaction. Results. Compared with the normal control group, the proportion of bone marrow monocytes was higher ( 2.11 ± 0.93 % vs. 3.66 ± 3.38 % ), and the mean fluorescence intensity of surface molecule CD14 was lower in the higher-risk (HR) MDS group ( 639.05 ± 359.78 vs. 458.26 ± 306.72 , p < 0.05 ). The ratio of M2 macrophages to monocytes was higher in patients with HR-MDS ( 1.82 ± 2.47 % vs. 3.93 ± 3.81 % , p < 0.05 ). The ratio of M1 to M2 macrophages was lower in the HR-MDS group ( 3.50 ± 3.22 vs. 1.80 ± 0.88 , p < 0.05 ). The expression of IL-1β and TNF-α mRNA in M1 macrophages was significantly lower in the MDS group ( p < 0.05 ). Conclusions. Patients with MDS had abnormal macrophage polarization, which may be involved in the alteration of bone marrow microenvironments.

scholarly journals Effectiveness of Lomustine Combined With Bevacizumab in Glioblastoma: A Meta-Analysis

2021 ◽  
Vol 11 ◽  
Author(s):  
Xing Ren ◽  
Di Ai ◽  
Tong Li ◽  
Lei Xia ◽  
Lingzhi Sun
Keyword(s):  
Clinical Trials ◽  
Meta Analysis ◽  
Treatment Options ◽  
Progression Free Survival ◽  
Cochrane Library ◽  
Control Group ◽  
Subgroup Analyses ◽  
Group A ◽  
Group 2 ◽  
The Cochrane Library

Introduction: Despite surgical and chemotherapeutical treatment options, the prognosis for glioblastoma (GBM) remains poor. Some studies have found that using lomustine plus bevacizumab to treat GBM can prolong overall survival (OS) and progression-free survival (PFS). The aim of this study was to explore the efficacy of the two drugs in combination treatment of GBM using a meta-analysis of the existing literature to help settle the ongoing debate.Materials and Methods: PubMed, EMBASE, and the Cochrane Library were searched for the effectiveness of lomustine plus bevacizumab in GBM literature, updated on June 6, 2020. The main outcomes analyzed included PFS and OS; the effects of this drug combination on the 6-month PFS, which represents the percentage of patients who had PFS for 6 months, were also analyzed. All the data were pooled: OS and PFS with the mean difference (MD) and 6-month PFS with the risk ratio (RR). Because there were different control groups and dose groups, two subgroup analyses were run to ensure they were comparable. All statistical analyses were performed using the Review Manager Version 5.3 software.Results: Six clinical trials were identified which included 1,095 patients (treatment group: 516; control group: 579). The group treated with lomustine and bevacizumab showed an improvement in OS (MD =1.37; 95% CI, 0.49–2.25; p = 0.002), PFS (MD = 0.23; 95% CI, 0.13–0.34; p &lt; 0.00001), and 6-month PFS (RR = 2.29; 95% CI, 1.43–3.65; p = 0.0005). Two subgroup analyses of the main outcome, OS, show that the results of Control group A (p = 0.01) and Dose group 2 (p = 0.003) are significantly different from those of the other control or dose groups.Conclusion: This study shows that lomustine and bevacizumab can effectively increase OS, PFS, and 6-month PFS in patients with GBM. The encouraging results of the lomustine and bevacizumab combination therapy for GBM should be studied in more clinical trials in the future.

scholarly journals Effect of modified neoadjuvant chemotherapy on levels of E6 oncoprotein in HPV-infected cervical tumor tissue

2021 ◽  
Vol 67 (4) ◽  
pp. 531-537
Author(s):  
Elena Frantsiyants ◽  
Anna Menshenina ◽  
Tatiana Moiseenko ◽  
Natalia Ushakova ◽  
Ekaterina Verenikina ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Hpv Infection ◽  
Main Group ◽  
Control Group ◽  
Cervical Tumor ◽  
E6 Oncoprotein ◽  
Tumor Tissues ◽  
Group 2 ◽  
Group 1

. Background. Human papillomavirus (HPV) has been established to be the etiological factor of cervical cancer (CC). HPV infection and CC progression involve the direct participation of the E6 oncoprotein. Aim. An analysis of the E6 oncoprotein levels in tissues of the tumor and its perifocal area in HPV-associated cervical squamous cell cancer as an objective indicator of the effect of treatment depending on preoperative chemotherapy. Material and methods. The study included clinical and laboratory data of 237 patients with high-risk HPV infection of the cervix. The patients were divided into 4 groups: two main groups (CC T2а2–2bN0–1M0) and two control groups. Patients in the main group 1 (n=84) received standard neoadjuvant chemotherapy (NACT), in the main group 2 (n=93) — modified NACT with prior plasmapheresis session and a parallel course of nonspecific immunotherapy with Allokin-alpha. Control group 1 (n=40) included patients with CC T1b2–2a1N0–1M0, surgical treatment; control group 2 (n=20) — HPV-positive patients without CC. Levels of E6 were measured in samples of the cervical tumor and perifocal tissues. Results. The lowest levels of the E6 oncoprotein were registered in the group of HPV-positive patients without CC. After modified NACT, E6 levels in tumor tissues remained 4.6 times higher than in intact tissues, and even so, these patients demonstrated minimal E6 levels compared to other CC patients. E6 in tumor tissues was significantly lower than in main group 1 (by 3.3 times) and 8 times lower than in control group 1. E6 levels in the perifocal tissues of patients in main group 2 were 1.9 times lower than in the corresponding tissues of patients in main group 1 and 2.2 times lower than in control group 1. Conclusions. Inclusion of plasmapheresis and inducers of endogenous interferonogenesis into neoadjuvant treatment for cervical cancer can be considered pathogenetically justified, since it affects the key unit of cervical carcinogenesis.

scholarly journals The arch-like plasty of the left atrium in correction of a mitral valve failure

2021 ◽  
Vol 88 (5-6) ◽  
pp. 18-22
Author(s):  
V. V. Popov ◽  
A. A. Bolshak ◽  
V. V. Lazoryshynets
Keyword(s):  
Mitral Valve ◽  
Left Ventricle ◽  
Ejection Fraction ◽  
Sinus Rhythm ◽  
Left Atrium ◽  
Main Group ◽  
Left Ventricle Ejection Fraction ◽  
Control Group ◽  
Group 2 ◽  
Cardio Vascular

Objective. Studying the possibilities of the method of the left atrium arch-like plasty while correcting of a mitral failure in combination with the left atrium dilatation. Materials and methods. Into the analysis of the surgical treatment results in 190 patients, suffering mitral failure in combination with the left atrium dilatation, who were operated in the National Institute of Cardio-Vascular Surgery named after N. M. Amosov NAMS of Ukraine in a period from 01.01.2012 to 01.01.2021 yr, were included. The main group consisted of 103 patients, to whom correction of a mitral failure in combination with original procedure of the arch-like plasty of left atrium was performed. Into a control group 87 patients were included, to whom the correction of a mitral valve failure was done without concomitant plasty of left atrium. Results. Of 103 operated patients of the main group on the hospital stage 1 have died (0.9% lethality). Dynamics of echocardiographic indices on the treatment stages was following: definitely-systolic index of the left ventricle - (63.1 ± 11.3) ml/m2 (preoperatively), (58.3 ± 8.4) ml/m2 (postoperatively), (49.4 ± 9.2) ml/m2 (remote period); the left ventricle ejection fraction: 0.52 ± 0.04 (preoperatively), 0.55 ± 0.04 (postoperatively), 0.57 ± 0.03 (remote period). Diameter of left atrium: (58.8 ± 6.4) mm (preoperatively), (41.4 ± 5.3) mm (postoperatively), (43.9 ± 2.3) mm (remote period). Sinus rhythm in a remote period was stable in 75 (78.9%) of 95 patients. Of 87 operated patients of a control group 2 died (lethality 2.3%). Dynamics of the echocardiographic indices on the treatment stages was following: definitely-systolic index of left ventricle- (67.3 ± 11.3) ml/m2 (preoperatively), (60.4 ± 9.3) ml/m2 (postoperatively), (52.7 ± 7.2) ml/m2 (remote period); the left ventricle ejection fraction: 0.52 ± 0.05 (preoperatively), 0.54 ± 0.05 (postoperatively), 0.54 ± 0.03 (remote period). Diameter of left atrium: (59.5 ± 2.3) mm (preoperatively), (57.5 ± 3.7) mm (postoperatively), (68.5 ± 3.4) mm (in remote period). Sinus rhythm was stable in 18 (22.5%) of 80 patients, followed in the remote period. Conclusion. The arch-like plasty of left atrium is a low-traumatic and effective procedure, leading to significant improvement of the left atrium morphometry and accompanied by low risk for postoperative lethality.

scholarly journals Influence of a single-nucleotide polymorphism of AKT1 (rs2498796) and HEY2 (rs13328928) genes on the risk of endometrial cancer in women of the Republic of Tatarstan

2019 ◽  
Vol 100 (5) ◽  
pp. 769-773
Author(s):  
R I Gabidullina ◽  
F R Nukhbala ◽  
G A Smirnova ◽  
Yu I Orlova ◽  
A A Shakirov ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Endometrial Cancer ◽  
Statistical Significance ◽  
Control Group ◽  
Endometrioid Carcinoma ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Cancer Group ◽  
The Republic ◽  
Group 2

Aim. To analyze the prevalence of different polymorphisms of AKT1 gene (rs2498796) and HEY2 gene (rs13328928) and to determine the association of revealed polymorphisms with the risk of endometrioid carcinoma in women living in the Republic of Tatarstan. Methods. 161 female citizens of Tatarstan were enrolled. The study group included 60 patients with endometrial cancer (endometrioid carcinoma) and the control group enrolled 101 women without endometrial pathology. The age of the subjects ranged from 41 to 91 years. The single-nucleotide polymorphism of AKT1 gene (rs2498796) and HEY2 gene (rs13328928) was determined by real-time polymerase chain reaction. We ran a 2 test and evaluated the odds ratio. Results. The risk of endometrial cancer was higher in carriers of homozygous T/T genotype of AKT1 gene (rs2498796) without statistical significance (OR=1.61, 95% CI=0.614.21, p=0.62). Homozygous C/C genotype of HEY2 gene (rs13328928) with the mutant allele C was observed in endometrial cancer group with a frequency of 0.383 and 0.287 in the control group (2=1.70, p=0.43). The risk of endometrial cancer was higher in the group of homozygous C/C genotype without statistical significance (OR=1.54, 95% CI=0.793.03, p=0.43). Conclusion. Among 161 females citizens of the Republic of Tatarstan included into the study, the associations of the mutant alleles of AKT1 gene (rs2498796) and HEY2 gene (rs13328928) with the risk of endometrial cancer were not identified; the prevalence of alleles and genotypes was found to be comparable with the European one.

scholarly journals An Experimental Study: Benefits of Digoxin on Hepatotoxicity Induced by Methotrexate Treatment

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Banu Taskin ◽  
Mümin Alper Erdoğan ◽  
Gürkan Yiğittürk ◽  
Sibel Alper ◽  
Oytun Erbaş
Keyword(s):  
Rat Model ◽  
Liver Tissue ◽  
Liver Toxicity ◽  
Male Rats ◽  
Control Group ◽  
Therapeutic Effects ◽  
Tissue Samples ◽  
Liver Model ◽  
Tnf Α ◽  
Group 2

Purpose. The aim of the study is to examine the possible therapeutic effects of a known cardiac glycoside, digoxin, on a rat model of MTX-induced hepatotoxicity. Methods. The study was conducted on twenty-four male rats. While eighteen rats received a single dose of 20 mg/kg MTX to obtain an injured liver model, six rats constituted the control group. Also, the eighteen liver toxicity model created rats were equally divided into two groups, one of which received digoxin 0.1 mg/kg/day digoxin (Group 1) and the other group (Group 2) was given saline (% 0.9NaCl) with a dose of 1 ml/kg/day for ten days. Following the trial, the rats were sacrificed to harvest blood and liver tissue samples to determine blood and tissue MDA, serum ALT, plasma TNF-α, TGF-β, IL-6, IL-1-Beta, and PTX3 levels. Results. MTX’s structural and functional hepatotoxicity was observable and evidenced by relatively worse histopathological scores and increased biochemical marker levels. Digoxin treatment significantly reduced the liver enzyme ALT, plasma TNF-α, TGF-β, PTX3, and MDA levels and decreased histological changes in the liver tissue with MTX-induced hepatotoxicity in the rat model. Conclusion. We suggest that digoxin has an anti-inflammatory and antihepatotoxic effect on the MTX-induced liver injury model.

Usage of whey protein may cause liver damage via inflammatory and apoptotic responses

2014 ◽  
Vol 34 (7) ◽  
pp. 769-779 ◽  
Author(s):  
SG Gürgen ◽  
AT Yücel ◽  
AÇ Karakuş ◽  
D Çeçen ◽  
G Özen ◽  
...  
Keyword(s):  
Whey Protein ◽  
Protein Diet ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Short Term ◽  
Tnf Α ◽  
Serum Aspartate Aminotransferase ◽  
Group 2 ◽  
Factor Α

The purpose of this study was to investigate the long- and short-term inflammatory and apoptotic effects of whey protein on the livers of non-exercising rats. Thirty rats were divided into three groups namely (1) control group, (2) short-term whey (WS) protein diet (252 g/kg for 5 days), and (3) long-term whey (WL) protein diet (252 g/kg for 4 weeks). Interleukin 1β (IL-1β), IL-6, tumor necrosis factor α (TNF-α), and cytokeratin 18 (CK-18-M30) were assessed using enzyme-linked immunosorbent assay and immunohistochemical methods. Apoptosis was evaluated using the terminal transferase-mediated deoxyuridine triphosphate nick-end labeling (TUNEL) method. Hepatotoxicity was evaluated by quanitation of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Based on the biochemical levels and immunohistochemical results, the highest level of IL-1β was identified in the WL group ( p < 0.01). The IL-6 and TNF-α results were slightly lower in the WS group than in the control group and were highest in the WL group ( p < 0.01). The CK-18-M30 and TUNEL results were highest in the WS group and exhibited medium intensity in the WL group ( p < 0.01). AST results were statistically significant for all groups, while our ALT groups were particularly significant between the WL and control groups ( p < 0.01). The results showed that when whey protein is used in an uninformed manner and without exercising, adverse effects on the liver may occur by increasing the apoptotic signal in the short term and increasing inflammatory markers and hepatotoxicity in the long term.

scholarly journals Posible differential diagnosis of various chronic nonbacterial prostatites

2021 ◽  
Vol 64 (2) ◽  
pp. 33-36
Author(s):  
Artur Colta ◽  
Keyword(s):  
Chronic Pelvic Pain Syndrome ◽  
Main Group ◽  
Pelvic Pain Syndrome ◽  
Control Group ◽  
No Production ◽  
Main Diagnosis ◽  
Nitric Oxides ◽  
Inos Activity ◽  
Chronic Nonbacterial Prostatitis ◽  
Group 2

Background: The purpose of the study was to diagnose possible chronic nonbacterial prostatitis (CNP) and chronic pelvic pain syndrome (CPPS) among patients, as well as differentiate between the inflammatory (category IIIA) or non-inflammatory (category IIIB) types in selecting and optimizing differential drug treatment of this category of patients. Material and methods: The study was conducted on 43 patients diagnosed with CNP/CPPS. The control group included 10 healthy men. Both the production of nitric oxides (NO) by phagocytes, as well as prostate secretion and ejaculate were determined according to the procedure described by Metelyskaya B.A., which was modified by Gudumac V, et al. Results: There was a 39.0% (p <0. 05) decrease in NO production by induced NO-synthase (iNOS), determined in the blood of 11 patients (from the main group – 2) with CNP/CPPS and a 115% (p <0.05) increase was determined in 32 patients (from the main group 1) if compared to the same indices in the control group. The prostatic secretion and ejaculate showed a higher macrophage iNOS activity by 80% (p <0.05) and 75% (p <0.05) if compared to the same parameters from the control group. The iNOS activity in prostatic fluid and split-ejaculate fractions from the main group – 2 did not differ from that of the control group. Conclusions: The assessment of NO production, prostate secretion and ejaculate allows to somewhat establish the main diagnosis of CNP and category III types (A – inflammatory and B – non-inflammatory prostatitis), which will significantly contribute to the optimization and selection of an appropriate differential treatment based on the drug action mechanisms

scholarly journals The Influence of Sanatorium-Resort Rehabilitation on the Cytokine Profile and Quality of Life Parameters in Juvenile Rheumatoid Arthritis

2021 ◽  
Vol 20 (4) ◽  
pp. 22-27
Keyword(s):  
Quality Of Life ◽  
Rheumatoid Arthritis ◽  
Juvenile Rheumatoid Arthritis ◽  
Cytokine Profile ◽  
Control Group ◽  
Functional Disorders ◽  
Quality Of Life Indicators ◽  
Tnf Α ◽  
Anti Inflammatory

Aim. To study was to assess the dynamics of cytokine profile indicators and quality of life in patients with juvenile rheumatoid arthritis under the influence of the standard sanatorium-resort rehabilitation complex. Material and methods. At the stage of sanatorium rehabilitation, 112 patients aged from 8 to 17 years (mean age 13.2±3.7) with juvenile rheumatoid arthritis were examined. The dynamics of the main quality of life indicators were assessed using the CHAQ questionnaire (pediatric version). Changes in proinflammatory (TNF-α, IL-1, IL-6) and anti-inflammatory cytokines (IL-4, IL-10) were evaluated in correlation with quality of life indices. The control group consisted of 25 healthy equals in age. Results. In juvenile rheumatoid arthritis, the cytokine profile changes, expressed in significantly higher indices of both pro- and antiinflammatory cytokines associated with functional disorders and, as a consequence, lower quality of life indicators as compared with healthy equals in age. Under the influence of sanatorium-resort treatment, functional disorders decreased, quality of life increased, levels of TNF-α, IL-1 as well as anti-inflammatory cytokine IL-4 significantly (p<0,05) decreased. As for other both pro- and antiinflammatory cytokines, only non-significant tendency to decrease was registered. Conclusion. It has been established that before the beginning of sanatorium-resort treatment, the quality of life parameters were lower in patients with juvenile rheumatoid arthritis (JRA), while the values of both proinflammatory (TNF-α, IL-1, IL-6) and anti-inflammatory (IL-4, IL-10) cytokines were significantly (p<0,01) higher than in the control group. At the same time, changes in the studied parameters correlated with the activity of the inflammatory process and the severity of the functional insufficiency of the joints. There were noted the positive influence of the standard complex of sanatorium-resort treatment on the examined quality of life parameters and the tendency to normalization of cytokine profile indexes in patients with JRA.

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