scholarly journals Review on Phytochemicals and Pharmacological Profile of Helicteres isora Linn.

2019 ◽  
Vol 9 (3) ◽  
pp. 2955-2969
Author(s):  
Mangal S. Gaikwad . ◽  
Vipul V. Dhasade .
Keyword(s):  
Pharmacological Profile ◽  
Helicteres Isora

In silico ADME, Bioactivity and Toxicity Parameters Calculation of Some Selected Anti-Tubercular Drugs

2016 ◽  
Vol 6 (6) ◽  
pp. 77 ◽  
Author(s):  
Shashank Shekhar Mishra ◽  
Chandra Shekhar Sharma ◽  
Hemendra Pratap Singh ◽  
Harshda Pandiya ◽  
Neeraj Kumar
Keyword(s):  
Antibiotic Resistance ◽  
In Silico ◽  
Bacillus Calmette Guerin ◽  
Computational Investigation ◽  
Pharmacological Profile ◽  
In Silico Toxicity ◽  
Is Development ◽  
Potent Drug ◽  
Minimal Resistance ◽  
Parameters Calculation

Tuberculosis, one of the most frequent infectious diseases, is caused by a mycobacterium tuberculosis bacteria and it infects several hundred million people each year, results in several million deaths annually. Because there is development of antibiotic resistance, the disease becomes incurable. So, in the absence of effective and potent drug with minimal resistance problems, the mortality rate increases annually. In this computational investigation, we performed In-silico ADME, bioactivity and toxicity parameters calculation of some selected anti-tuberculosis agents. To design a new molecule having good pharmacological profile, this study will provide the lead information.Key Words: Tuberculosis (TB), Bacillus Calmette-Guerin vaccine, TPSA, In Silico toxicity

An Overview on Phytochemical and Pharmacological Profile of Morus alba Linn.

2020 ◽  
Vol 16 ◽  
Author(s):  
Arpita Paul ◽  
Monami Rajiung ◽  
Kamaruz Zaman ◽  
Sushil Kumar Chaudhary ◽  
Hans Raj Bhat ◽  
...  
Keyword(s):  
Traditional Medicine ◽  
Morus Alba ◽  
Biologically Active ◽  
Pharmacological Profile ◽  
Pharmacological Activities ◽  
Significant Information ◽  
The Past ◽  
Comprehensive Information ◽  
The Family ◽  
White Mulberry

Background: Morus alba Linn. commonly known as white mulberry, belongs to the family Moraceae, is a promising traditional medicine. In Asia, besides its use in the preparation of delicacies, every part of this plant is utilized in traditional medicine. Over the past decade, studies related to identification and isolation of biologically active compounds, with flavonoids as the major class of phytoconstituents, from this plant has been reported. These phytoconstituents are not only found to be beneficial for the maintenance of general health but also are associated with a range of potential pharmacological activities such as antioxidant, anti-inflammatory, anti-diabetic, anticancer, hepatoprotective, cardioprotective, neuroprotective to name a few. Objective: This review aims to provide upgraded and comprehensive information regarding the phytochemical, ethnomedicinal use and pharmacological profile of the plant Morus alba Linn. Method: The significant information has been collected through various database viz. PubMed, Scopus, Web of Science, Science Direct based on the recent findings, using different terms of Morus alba. Results: The outcome of the study suggests that Morus alba is a multifunctional plant numerous phytochemicals, and possess a range of pharmacological activities. Conclusion: The data assembled on Morus alba will be beneficial to trigger research in various fields of pharmaceutical and allied science to explore the medicinal importance of this unique plant.

Phytochemical and Pharmacological Profile of Diospyros melanoxylon

2017 ◽  
Vol 7 (4) ◽  
Author(s):  
Vaishali M. Patil ◽  
Akash Mandal ◽  
Sonia Tomar ◽  
Lalit Kumar ◽  
Neeraj Masand
Keyword(s):  
Pharmacological Profile

scholarly journals Point-Substitution of Phenylalanine Residues of 26RFa Neuropeptide: A Structure-Activity Relationship Study

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4312
Author(s):  
Benjamin Lefranc ◽  
Karima Alim ◽  
Cindy Neveu ◽  
Olivier Le Marec ◽  
Christophe Dubessy ◽  
...  
Keyword(s):  
Receptor Activation ◽  
Pharmacological Profile ◽  
Acid Moiety ◽  
Structural Determinants ◽  
Physiological Processes ◽  
Structure Activity ◽  
Peptide Derivatives ◽  
Targeting Peptide ◽  
G Protein Coupled

26RFa is a neuropeptide that activates the rhodopsin-like G protein-coupled receptor QRFPR/GPR103. This peptidergic system is involved in the regulation of a wide array of physiological processes including feeding behavior and glucose homeostasis. Herein, the pharmacological profile of a homogenous library of QRFPR-targeting peptide derivatives was investigated in vitro on human QRFPR-transfected cells with the aim to provide possible insights into the structural determinants of the Phe residues to govern receptor activation. Our work advocates to include in next generations of 26RFa(20–26)-based QRFPR agonists effective substitutions for each Phe unit, i.e., replacement of the Phe22 residue by a constrained 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid moiety, and substitution of both Phe24 and Phe26 by their para-chloro counterpart. Taken as a whole, this study emphasizes that optimized modifications in the C-terminal part of 26RFa are mandatory to design selective and potent peptide agonists for human QRFPR.

scholarly journals Seasonal food habits of the four-horned antelope (Tetracerus quadricornis de Blainville, 1816) in tropical deciduous forests of Aravalli mountain range, Rajasthan, Western India

2020 ◽  
Vol 81 (1) ◽  
Author(s):  
Ramchandra Meghwal ◽  
Chhaya Bhatnagar ◽  
Vijay Kumar Koli
Keyword(s):  
Plant Species ◽  
Forest Fires ◽  
Habitat Management ◽  
Fleshy Fruit ◽  
Feeding Strategies ◽  
Western India ◽  
Mountain Range ◽  
Local Pressure ◽  
Dendrocalamus Strictus ◽  
Helicteres Isora

Abstract Background Feeding strategies assessment of endangered species during food limited seasons is important in order to understand their niche and advise effective habitat management steps. We assessed the four-horned antelope (Tetracerus quadricornis) seasonal diet from April 2014 to March 2015, in three wildlife sanctuaries in western India, namely, Sitamata, Kumbhalgarh, and Phulwari-ki-nal Wildlife Sanctuaries. Opportunistic focal animal sampling method was used in five 1 km paths in each sanctuary to take feeding observations. Each transect was walked three times a day (morning 06:00-10:00 h; mid-day 10:00-14:00 h; evening 15:00-18:00 h), 1 day a month, during 12 months, with a total of 540 surveys divided between 15 paths. The diet data was categorized into different plant categories. Results A total of 532 feeding records from 85 animal sightings were noted with a mean (± SD) of 14.78 ± 10.04 feeding records/month. Feeding was observed on 63 plant species belonging to 23 families. The highest feeding records noted were on trees (60.91%) in the diet followed by shrubs (20.49%), grasses (16.92%), forbs (1.50%), and climbers (0.18%) respectively. Most of the plant species consumed were from Fabaceae (n = 17) and Poaceae (n = 12) families. The overall browse-grass ratio was 83.08-16.92% (88.02-11.98% for Sitamata WLS; 82.11-17.89% for Kumbhalgarh WLS; 79.10-20.90% for Phulwari-ki-nal WLS). Leaves were the most consumed part of the plants (64.10%), followed by dry fruit (16.55%), fleshy fruit (13.34%), flowers (2.82%), buds (2.06%), and twigs (1.13%) respectively. Use of fleshy fruits, dry fruits, and trees showed significant seasonal dietary difference (P < 0.05) in all three sanctuaries. Conclusions Tetracerus quadricornis was found to consume more browse species than grasses. We recommend conservation and promotion of natural plant regeneration, in particular for the plant species that were the most consumed by four-horned antelope, namely, Aristida adscensionis, Dendrocalamus strictus, Dichrostachys cinerea, Acacia leucophloea, Butea monosperma, Helicteres isora, Ziziphus nummularia, and Ziziphus xylopyrus. Conservation of grassland patches, minimizing local pressure, and planning, construction, and maintenance of fire lines prior to timing of forest fires would help to protected T. quadricornis habitat in all three sanctuaries.

scholarly journals Sulfated and Sulfur-Containing Steroids and Their Pharmacological Profile

Marine Drugs ◽  
2021 ◽  
Vol 19 (5) ◽  
pp. 240
Author(s):  
Tatyana A. Pounina ◽  
Tatyana A. Gloriozova ◽  
Nick Savidov ◽  
Valery M. Dembitsky
Keyword(s):  
Antitumor Activity ◽  
Confidence Level ◽  
Biological Activities ◽  
Marine Sponges ◽  
Bioactive Lipids ◽  
Pharmacological Profile ◽  
Wide Range ◽  
Sulfated Steroids ◽  
Strong Antitumor Activity ◽  
Sulfur Containing

The review focuses on sulfated steroids that have been isolated from seaweeds, marine sponges, soft corals, ascidians, starfish, and other marine invertebrates. Sulfur-containing steroids and triterpenoids are sourced from sedentary marine coelenterates, plants, marine sediments, crude oil, and other geological deposits. The review presents the pharmacological profile of sulfated steroids, sulfur-containing steroids, and triterpenoids, which is based on data obtained using the PASS program. In addition, several semi-synthetic and synthetic epithio steroids, which represent a rare group of bioactive lipids that have not yet been found in nature, but possess a high level of antitumor activity, were included in this review for the comparative pharmacological characterization of this class of compounds. About 140 steroids and triterpenoids are presented in this review, which demonstrate a wide range of biological activities. Therefore, out of 71 sulfated steroids, thirteen show strong antitumor activity with a confidence level of more than 90%, out of 50 sulfur-containing steroids, only four show strong antitumor activity with a confidence level of more than 93%, and out of eighteen epithio steroids, thirteen steroids show strong antitumor activity with a confidence level of 91% to 97.4%.

scholarly journals In Vitro Pharmaco-Toxicological Characterization of Melissa officinalis Total Extract Using Oral, Pharynx and Colorectal Carcinoma Cell Lines

Processes ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 850
Author(s):  
Kristine Guran ◽  
Roxana Buzatu ◽  
Iulia Pinzaru ◽  
Madalina Boruga ◽  
Iasmina Marcovici ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Melissa Officinalis ◽  
Pharmacological Profile ◽  
In Ovo ◽  
Total Extract ◽  
Antiangiogenic Effect ◽  
Beneficial Effects ◽  
Gram Positive Bacteria ◽  
Potential Benefits

Melissa officinalis is a medicinal herb with an extensive pharmacological profile that has been proven to have beneficial effects in oral and gastrointestinal disorders. However, the effects of this plant in oral, pharyngeal, and colorectal malignancies, types of cancer with an increased incidence in recent years, are less investigated. The present study aims to evaluate the pharmacological profile of a Melissa officinalis total extract for potential benefits in oral, pharynx and colorectal carcinoma. The LC-MS profile of MO total extract (MOte) indicated a rich content in polyphenols, data that support the potent antioxidant capacity exhibited and the antimicrobial activity against both Gram-negative and Gram-positive bacteria. In addition, MOte triggered a dose-dependent and selective decrease in the viability of tumor cells (tongue and pharynx squamous cell carcinomas, and colorectal adenocarcinoma), with the most significant effect being recorded at 100 µg/mL. At the same concentration, MOte exhibited an antiangiogenic effect by inhibiting the process of angiogenesis in ovo. Overall, our findings support the potential benefits of Melissa officinalis leaf total extract as a valuable candidate for the prophylaxis of oral, pharyngeal and colorectal neoplasms.

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