Royal Jelly Acid, 10-Hydroxy-Trans-2-Decenoic Acid,for Psychiatric and Neurological Disorders: How helpful could it be?!

10-hydroxy-trans-2-decenoic acid (10H2DA), also known as royal jelly acid, is the main lipid component of RJ. It possesses anti-tumor, neurogenic, anti-inflammatory, antioxidant, bactericidal, nematocidal, and estrogen-like properties. A limited number of studies demonstrate the potentials of its main fatty acid, 10-H2DA, for alleviating anxiety and depressive-like behaviors as well as for enhancing neuronal functioning. However, the exact mechanism through which 10-H2DA produces its effect is not well-understood. This mini review gives examples of how 10H2DA might positively contribute to the treatment of psychiatric and neurological disorders. In addition, it surveys the available knowledge about the molecular mechanism through which it regulates transcriptional processes and gene expression in the brain.

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Physical positioning markedly enhances brain transduction after intrathecal AAV9 infusion

Science Advances ◽

10.1126/sciadv.aau9859 ◽

2018 ◽

Vol 4 (11) ◽

pp. eaau9859 ◽

Cited By ~ 7

Author(s):

Michael J. Castle ◽

Yuhsiang Cheng ◽

Aravind Asokan ◽

Mark H. Tuszynski

Keyword(s):

Gene Expression ◽

Gene Delivery ◽

Neurological Disorders ◽

Fold Increase ◽

Brain Regions ◽

Intrathecal Administration ◽

Simple Method ◽

Virus Serotype ◽

Cortical Regions ◽

The Brain

Several neurological disorders may benefit from gene therapy. However, even when using the lead vector candidate for intrathecal administration, adeno-associated virus serotype 9 (AAV9), the strength and distribution of gene transfer to the brain are inconsistent. On the basis of preliminary observations that standard intrathecal AAV9 infusions predominantly drive reporter gene expression in brain regions where gravity might cause cerebrospinal fluid to settle, we tested the hypothesis that counteracting vector “settling” through animal positioning would enhance vector delivery to the brain. When rats are either inverted in the Trendelenburg position or continuously rotated after intrathecal AAV9 infusion, we find (i) a significant 15-fold increase in the number of transduced neurons, (ii) a marked increase in gene delivery to cortical regions, and (iii) superior animal-to-animal consistency of gene expression. Entorhinal, prefrontal, frontal, parietal, hippocampal, limbic, and basal forebrain neurons are extensively transduced: 95% of transduced cells are neurons, and greater than 70% are excitatory. These findings provide a novel and simple method for broad gene delivery to the cortex and are of substantial relevance to translational programs for neurological disorders, including Alzheimer’s disease and related dementias, stroke, and traumatic brain injury.

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Pancreatic Cholesterol Esterase, ES-10, and Fatty Acid Ethyl Ester Synthase III Gene Expression are Increased in the Pancreas and Liver but Not in the Brain or Heart with Long-term Ethanol Feeding in Rats

Pancreas ◽

10.1097/00006676-200207000-00021 ◽

2002 ◽

Vol 25 (1) ◽

pp. 101-106 ◽

Cited By ~ 34

Author(s):

Roland H. Pfützer ◽

Stasa D. Tadic ◽

Ha-Sheng Li ◽

Bryan S. Thompson ◽

Ji-Ying Zhang ◽

...

Keyword(s):

Gene Expression ◽

Fatty Acid ◽

Ethyl Ester ◽

Acid Ethyl Ester ◽

Fatty Acid Ethyl Ester ◽

Cholesterol Esterase ◽

Ethanol Feeding ◽

The Brain

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10-Hydroxy-2-decenoic Acid, the Major Lipid Component of Royal Jelly, Extends the Lifespan ofCaenorhabditis elegansthrough Dietary Restriction and Target of Rapamycin Signaling

Journal of Aging Research ◽

10.1155/2015/425261 ◽

2015 ◽

Vol 2015 ◽

pp. 1-7 ◽

Cited By ~ 21

Author(s):

Yoko Honda ◽

Yoko Araki ◽

Taketoshi Hata ◽

Kenji Ichihara ◽

Masafumi Ito ◽

...

Keyword(s):

Dietary Restriction ◽

Royal Jelly ◽

Target Of Rapamycin ◽

Control Mechanisms ◽

Tor Signaling ◽

Decenoic Acid ◽

C Elegans ◽

Lipid Component ◽

Extended Lifespan ◽

And Oxidative Stress

Royal jelly (RJ) produced by honeybees has been reported to possess diverse health-beneficial properties and has been implicated to have a function in longevity across diverse species as well as honeybees. 10-Hydroxy-2-decenoic acid (10-HDA), the major lipid component of RJ produced by honeybees, was previously shown to increase the lifespan ofCaenorhabditis elegans.The objective of this study is to elucidate signaling pathways that are involved in the lifespan extension by 10-HDA. 10-HDA further extended the lifespan of thedaf-2mutants, which exhibit long lifespan through reducing insulin-like signaling (ILS), indicating that 10-HDA extended lifespan independently of ILS. On the other hand, 10-HDA did not extend the lifespan of theeat-2mutants, which show long lifespan through dietary restriction caused by a food-intake defect. This finding indicates that 10-HDA extends lifespan through dietary restriction signaling. We further found that 10-HDA did not extend the lifespan of the long-lived mutants indaf-15, which encodes Raptor, a target of rapamycin (TOR) components, indicating that 10-HDA shared some longevity control mechanisms with TOR signaling. Additionally, 10-HDA was found to confer tolerance against thermal and oxidative stress. 10-HDA increases longevity not through ILS but through dietary restriction and TOR signaling inC. elegans.

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Global Down-Regulation of Gene Expression in the Brain Using RNA Interference, with Emphasis on Monoamine Transporters and GPCRs: Implications for Target Characterization in Psychiatric and Neurological Disorders

Journal of Receptors and Signal Transduction ◽

10.1080/10799890600929663 ◽

2006 ◽

Vol 26 (5-6) ◽

pp. 527-547 ◽

Cited By ~ 16

Author(s):

DANIEL HOYER ◽

DEEPAK R. THAKKER ◽

FRANÇOIS NATT ◽

RAINER MAIER ◽

DIETER HUESKEN ◽

...

Keyword(s):

Gene Expression ◽

Rna Interference ◽

Neurological Disorders ◽

Regulation Of Gene Expression ◽

Monoamine Transporters ◽

Down Regulation ◽

Target Characterization ◽

The Brain

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The Lyophilization Process Maintains the Chemical and Biological Characteristics of Royal Jelly

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2015/825068 ◽

2015 ◽

Vol 2015 ◽

pp. 1-5 ◽

Cited By ~ 7

Author(s):

Andresa Piacezzi Nascimento ◽

Larissa Ariana Roveroni Moraes ◽

Nathália Ursoli Ferreira ◽

Gabriela de Padua Moreno ◽

Fernanda Grassi Mangolini Uahib ◽

...

Keyword(s):

Antibacterial Activity ◽

Fatty Acid ◽

Royal Jelly ◽

Antibacterial Properties ◽

Chemical Characterization ◽

Resistant Bacteria ◽

Bioactive Substances ◽

Antibiotic Resistant ◽

Chromatographic Profile ◽

Main Fatty Acid

The alternative use of natural products, like royal jelly (RJ), may be an important tool for the treatment of infections caused by antibiotic-resistant bacteria. RJ presents a large number of bioactive substances, including antimicrobial compounds. In this study, we carried out the chemical characterization of fresh and lyophilized RJ and investigated their antibacterial effects with the purpose of evaluating if the lyophilization process maintains the chemical and antibacterial properties of RJ. Furthermore, we evaluated the antibacterial efficacy of the main fatty acid found in RJ, the 10-hydroxy-2-decenoic acid (10H2DA). Chromatographic profile of the RJ samples showed similar fingerprints and the presence of 10H2DA in both samples. Furthermore, fresh and lyophilized RJ were effective against all bacteria evaluated; that is, the lyophilization process maintains the antibacterial activity of RJ and the chemical field of 10H2DA. The fatty acid 10H2DA exhibited a good antibacterial activity againstStreptococcus pneumoniae. Therefore, it may be used as an alternative and complementary treatment for infections caused by antibiotic-resistantS. pneumoniae.

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10-hydroxy-2-decenoic acid of royal jelly exhibits bactericide and anti-inflammatory activity in human colon cancer cells

BMC Complementary and Alternative Medicine ◽

10.1186/s12906-018-2267-9 ◽

2018 ◽

Vol 18 (1) ◽

Cited By ~ 13

Author(s):

Yuan-Chang Yang ◽

Wing-Ming Chou ◽

Debora Arny Widowati ◽

I-Ping Lin ◽

Chi-Chung Peng

Keyword(s):

Colon Cancer ◽

Cancer Cells ◽

Royal Jelly ◽

Human Colon ◽

Inflammatory Activity ◽

Colon Cancer Cells ◽

Decenoic Acid ◽

Human Colon Cancer ◽

Anti Inflammatory ◽

Human Colon Cancer Cells

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Beyond antioxidants: the cellular and molecular interactions of flavonoids and how these underpin their actions on the brain

Proceedings of The Nutrition Society ◽

10.1017/s0029665110000054 ◽

2010 ◽

Vol 69 (2) ◽

pp. 244-260 ◽

Cited By ~ 100

Author(s):

Jeremy P. E. Spencer

Keyword(s):

Gene Expression ◽

Neurological Disorders ◽

Mitogen Activated Protein Kinase ◽

Phosphatidylinositol 3 Kinase ◽

Brain Ageing ◽

Signalling Cascades ◽

Mitogen Activated Protein ◽

Neurological Effects ◽

The Brain ◽

Abnormal Brain

The consumption of flavonoid-rich foods and beverages has been suggested to limit the neurodegeneration associated with a variety of neurological disorders and to prevent or reverse normal or abnormal deteriorations in cognitive performance. Flavonoids mediate these effects via a number of routes, including a potential to protect neurons against injury induced by neurotoxins, an ability to suppress neuroinflammation and a potential to promote memory, learning and cognitive function. Originally, it was thought that such actions were mediated by the antioxidant capacity of flavonoids. However, their limited absorption and their low bioavailability in the brain suggest that this explanation is unlikely. Instead, this multiplicity of effects appears to be underpinned by three separate processes: first, through their interactions with important neuronal and glial signalling cascades in the brain, most notably the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways that regulate pro-survival transcription factors and gene expression; second, through an ability to improve peripheral and cerebral blood flow and to trigger angiogenesis and neurogenesis in the hippocampus; third, by their capacity to directly react with and scavenge neurotoxic species and pro-inflammatory agents produced in the brain as a result of both normal and abnormal brain ageing. The present review explores the potential inhibitory or stimulatory actions of flavonoids within these three systems and describes how such interactions are likely to underlie neurological effects.

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Exercise conditioned plasma dampens inflammation via clusterin and boosts memory

10.1101/775288 ◽

2019 ◽

Cited By ~ 2

Author(s):

Zurine De Miguel ◽

Michael J. Betley ◽

Drew Willoughby ◽

Benoit Lehallier ◽

Niclas Olsson ◽

...

Keyword(s):

Gene Expression ◽

Cognitive Aging ◽

Animal Health ◽

Brain Inflammation ◽

Cognitively Impaired ◽

Complement Cascade ◽

Striking Increase ◽

Cognitive Benefits ◽

Anti Inflammatory ◽

The Brain

Physical exercise seems universally beneficial to human and animal health, slowing cognitive aging and neurodegeneration. Cognitive benefits are tied to increased plasticity and reduced inflammation within the hippocampus, yet little is known about the factors and mechanisms mediating these effects. We discovered “runner” plasma, collected from voluntarily running mice, infused into sedentary mice recapitulates the cellular and functional benefits of exercise on the brain. Importantly, runner plasma reduces baseline neuroinflammatory gene expression and prominently suppresses experimentally induced brain inflammation. Plasma proteomic analysis shows a striking increase in complement cascade inhibitors including clusterin, which is necessary for the anti-inflammatory effects of runner plasma. Cognitively impaired patients participating in structured exercise for 6 months showed higher plasma clusterin levels, which correlated positively with improvements in endurance and aerobic capacity. These findings demonstrate the existence of anti-inflammatory “exercise factors” that are transferrable, benefit the brain, and are present in humans engaging in exercise.

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