scholarly journals The Effect of Vitamin B12, Physical and Cognitive Activity on Idiopathic Forgetfulness

2021 ◽  
Vol 10 (2) ◽  
pp. 41-48
Author(s):  
Selcuk Mistik ◽  
Emine Agadayi ◽  
Emel Koseoglu
Keyword(s):  
Physical Activity ◽  
Cognitive Functions ◽  
Verbal Memory ◽  
Visual Memory ◽  
Cognitive Activity ◽  
Vitamin B ◽  
Vitamin Supplement ◽  
Positive Effects ◽  
Activity Group ◽  
Keywords Dementia

Aim: In this study, we aimed to evaluate the effect of physical activity, vitamin B supplementation and mental activity on cognitive functions in middle-aged individuals with subjective forgetfulness. Methods: We included 82 people between 40-65 years of age who were admitted to Erciyes University Faculty of Medicine, Family Medicine and Neurology Departments polyclinics with the complaint of subjective forgetfulness between May 2017 and May 2018. General physical examination, blood tests including B12, folic acid level and thyroid functions were performed. In addition to the socio-demographic questionnaire, Beck Anxiety and Beck Depression Scale, Montreal Cognitive Assessment Test, Visual and Verbal Memory Tests were performed. Sixty-eight subjects were randomly allocated to 3 groups as cognitive activity, physical activity and vitamin B supplementation. The physical activity group made a minimum of half-hour brisk walk daily. The cognitive activity group was asked to solve a hooked puzzle every day. Vitamin supplement group used daily vitamin B complex. At the end of the third month, cognitive tests and B12 blood level test were repeated. Results: Improvement in cognitive functions was found only in the walking group. Long-term visual memory and verbal memory sub-test scores improved significantly in all groups. There were some differences between the groups in terms of verbal memory subtest scores. Conclusion: In people with forgetfulness, walking, puzzle and vitamin B supplementation seem to have positive effects even after a period of three months in terms of cognitive functions and memory. Keywords: dementia, cognitive activity, exercise, physical, B vitamins

scholarly journals Impact of Physical Activity on Cognitive Functions: A New Field for Research and Management of Cystic Fibrosis

Diagnostics ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 489 ◽  
Author(s):  
Valentina Elce ◽  
Alessandro Del Pizzo ◽  
Ersilia Nigro ◽  
Giulia Frisso ◽  
Lucia Martiniello ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cystic Fibrosis ◽  
Neural Plasticity ◽  
Cognitive Functions ◽  
Structural Changes ◽  
Gray Matter Volume ◽  
Synaptic Activity ◽  
World Health ◽  
Brain Health ◽  
Positive Effects

Cystic Fibrosis (CF) is a genetic disease inherited by an autosomal recessive mechanism and characterized by a progressive and severe multi-organ failure. Mutations in Cystic Fibrosis Conductance Regulator (CFTR) protein cause duct obstructions from dense mucus secretions and chronic inflammation related to organ damage. The progression of the disease is characterized by a decline of lung function associated with metabolic disorders and malnutrition, musculoskeletal disorders and thoracic deformities, leading to a progressive decrement of the individual’s quality of life. The World Health Organization (WHO) qualifies Physical Activity (PA) as a structured activity produced by skeletal muscles’ movements that requires energy consumption. In the last decade, the number of studies on PA increased considerably, including those investigating the effects of exercise on cognitive and brain health and mental performance. PA is recommended in CF management guidelines, since it improves clinic outcomes, such as peripheral neuropathy, oxygen uptake peak, bone health, glycemic control and respiratory functions. Several studies regarding the positive effects of exercise in patients with Cystic Fibrosis were carried out, but the link between the effects of exercise and cognitive and brain health in CF remains unclear. Animal models showed that exercise might improve learning and memory through structural changes of brain architecture, and such a causal relationship can also be described in humans. Indeed, both morphological and environmental factors seem to be involved in exercise-induced neural plasticity. An increase of gray matter volume in specific areas is detectable as a consequence of regular training in humans. Neurobiological processes associated with brain function improvements include biochemical modifications, such as neuromodulator or neurohormone release, brain-derived neurotrophic factor (BDNF) production and synaptic activity changes. From a functional point of view, PA also seems to be an environmental factor enhancing cognitive abilities, such as executive functions, memory and processing speed. This review describes the current state of research regarding the impacts of physical activity and exercise on cognitive functions, introducing a possible novel field of research for optimizing the management of Cystic Fibrosis.

scholarly journals Renal Function and Long-Term Decline in Cognitive Function: The Baltimore Longitudinal Study of Aging

2015 ◽  
Vol 41 (4-5) ◽  
pp. 305-312 ◽  
Author(s):  
Stephen L. Seliger ◽  
Carrington R. Wendell ◽  
Shari R. Waldstein ◽  
Luigi Ferrucci ◽  
Alan B. Zonderman
Keyword(s):  
Renal Function ◽  
Longitudinal Study ◽  
Cognitive Function ◽  
Cognitive Functions ◽  
Verbal Memory ◽  
Visual Memory ◽  
Verbal Learning ◽  
Community Based ◽  
Baltimore Longitudinal Study

Background: Renal disease has been associated with greater risk of dementia and greater cognitive impairment. However, the relationship of lower renal function with long-term decline in specific domains of cognitive function remains unclear among community-dwelling, non-demented individuals. Methods: Stroke- and dementia-free participants (n = 2,116) were enrolled in the Baltimore Longitudinal Study of Aging, a community-based, prospective, longitudinal study. Renal function was estimated by the inverse of serum creatinine adjusted for age, sex and race and (in sensitivity analyses) estimated glomerular filtration rate (eGFR) using the MDRD formula. Outcome measures were changes in scores on 6 cognitive tests encompassing a range of cognitive functions, measured at 2-year intervals. Mixed-effects regression models examined the longitudinal relations of renal function with cognitive functions after adjusting for demographics, comorbidity and other potential confounders. Results: Mean age at initial testing was 53.9 years (SD 17.1), and 94 participants (4.4%) had an eGFR <60 ml/min/1.73 m2 and 18.5% had at least one comorbidity. With increasing age, longitudinal increases in creatinine concentrations were associated with more rapid decline in performance on several cognitive measures, including the learning slope of the California Verbal Learning Test, a test of verbal learning (p < 0.01), and the Benton Visual Retention Test, a test of visual memory (p < 0.01). Associations were similar for changes in eGFRMDRD, which was also associated with the rate of decline in verbal memory. Conclusion: In a community-based adult population, declines in renal function independently associated with greater long-term declines in visual memory and verbal memory and learning.

Adjunctive memantine in clozapine-treated refractory schizophrenia: A one-year extension study

2016 ◽  
Vol 33 (S1) ◽  
pp. S108-S109
Author(s):  
S. Veerman ◽  
P. Schulte ◽  
J.B. Deijen ◽  
L. de Haan
Keyword(s):  
Beneficial Effect ◽  
Verbal Memory ◽  
Psychosocial Functioning ◽  
Visual Memory ◽  
Negative Symptoms ◽  
Rating Scale ◽  
Extension Study ◽  
Long Term Effects ◽  
Positive Effects ◽  
One Year

IntroductionIn a recent 26-week placebo-controlled, crossover trial (n = 52) we found significant positive effects on verbal and visual memory, and negative symptoms in clozapine-treated patients with refractory schizophrenia.ObjectivesIn this 1-year extension study, we report the long-term effects and tolerability of memantine add-on therapy to clozapine.AimsTo evaluate the persistence of improvements in cognitive functioning and symptoms of memantine add-on therapy to clozapine in schizophrenia.MethodsCompleters of the first trial who experienced a beneficial effect of memantine after 12 weeks continued memantine for one year. Primary endpoints were change from baseline to 26 weeks treatment and 26 weeks to 52 weeks treatment on memory and executive function using the Cambridge Neuropsychological Test Automated Battery (CANTAB), Positive and Negative Syndrome Scale (PANSS), and Clinical Global Impression Severity Scale (CGI-S). Secondary endpoints were change on the Health of the Nation Outcome Scales (HoNOS) and Liverpool University Neuroleptic Side Effect Rating Scale (LUNSERS).ResultsOf 32 completers who experienced a beneficial effect of memantine 23 patients continued memantine for one year. Memory improvement was sustained, verbal recognition memory improved even further between t = 26 weeks and t = 52 weeks. Continued treatment with memantine add-on to clozapine was associated with significantly improved PANSS positive, negative and overall score, CGI-S and HoNOS scores.ConclusionsIn the extension phase the positive effect of memantine add-on therapy on verbal memory sustained and positive, negative and overall symptoms of schizophrenia, clinical global status and psychosocial functioning significantly improved. Memantine was well tolerated without serious adverse effects.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Disorders of cognitive activity in patients with multiple sclerosis and hepatocerebral degeneration and its prevention

2020 ◽  
Vol 24 (4) ◽  
pp. 589-594
Author(s):  
I. Voloshyn-Gaponov ◽  
I. Lantukh ◽  
P. Gaponov
Keyword(s):  
Multiple Sclerosis ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Functions ◽  
Verbal Memory ◽  
Cognitive Activity ◽  
Cognitive Disorders ◽  
Biological Aging ◽  
Treatment And Prevention ◽  
The Brain

Annotation. Currently, there is an increase in dementias of various origins, which is largely due to the tendency of the aging population of the globe, with adverse environmental factors. Dementia also occurs at a young, working-aged, which makes them not only a medical but also a social problem. The incidence of Alzheimer's disease (AD) is so high that the WHO has declared the 21st century the century of the AD epidemic. The task of the work is to conduct a comprehensive clinical and laboratory examination of patients with multiple sclerosis (MS) and patients with Wilson's disease (WD) to study the problem of neurodegenerative diseases. The Mini-Mental Status Exam (MMSE) scale was used to screen for cognitive function and to study the level of intellectual performance of patients. To determine verbal memory, the method was used: “memorization of 10 words”, and to study the personality and emotional sphere, the method of Derogatis SCl-90-P was used. The sample of patients with MS was 111 people, and psycho diagnostic examination of patients with WD was performed in 33 patients. Various cognitive disorders are characteristic of MS patients. The level of general intellectual productivity is in the range from normative indicators to very pronounced systemic disorders of cognitive functions. With the age of patients and the duration of the disease, the severity of these disorders increases. A comprehensive clinical and laboratory study showed that the pathogenesis and stages of development of the dementia process in patients with WD and MS coincide with those in patients with Alzheimer’s disease and depends on three groups of factors: genetic predisposition, natural (biological) aging, and endogenous and exogenous pathogenic factors. on the brain. The study concluded that in patients with WD and MS in the pathogenetic process are always involved structures that ensure the functioning of cognitive functions of the brain, which leads to the development of their defects. For the treatment and prevention of these patients, a comprehensive, pathogenetically grounded, and personalized therapy should be prescribed.

scholarly journals Cognitive Impairment in Relapsing-Remitting Multiple Sclerosis Patients with Very Mild Clinical Disability

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
S. Migliore ◽  
A. Ghazaryan ◽  
I. Simonelli ◽  
P. Pasqualetti ◽  
F. Squitieri ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Executive Functions ◽  
Cognitive Dysfunction ◽  
Cognitive Functions ◽  
Verbal Memory ◽  
Visual Memory ◽  
Clinical Stage ◽  
Relapsing Remitting ◽  
Multiple Sclerosis Patients

Cognitive dysfunction affects 40–65% of multiple sclerosis (MS) patients and can occur in the early stages of the disease. This study aimed to explore cognitive functions by means of the Italian version of the minimal assessment of cognitive function in MS (MACFIMS) in relapsing-remitting MS (RRMS) patients with very mild clinical disability to identify the primarily involved cognitive functions. Ninety-two consecutive RRMS patients with Expanded Disability Status Scale (EDSS) scores ≤ 2.5 and forty-two healthy controls (HC) were investigated. Our results show that 51.1% of MS patients have cognitive dysfunction compared to HC. An impairment of verbal and visual memory, working memory, and executive functions was found in the RRMS group. After subgrouping RRMS by EDSS, group 1 (EDSS ≤ 1.5) showed involvement of verbal memory and executive functions; moreover, group 2 (2 ≤ EDSS ≤ 2.5) patients were also impaired in information processing speed and visual memory. Our results show that utilizing a comprehensive neuropsychological assessment, approximately half of MS patients with very mild physical disability exhibit cognitive impairment with a primary involvement of prefrontal cognitive functions. Detecting impairment of executive functions at an early clinical stage of disease could be useful to promptly enroll MS patients in targeted rehabilitation.

scholarly journals Influence of L-tryptophan use on the dynamics of cognitive functions in the complex therapy of delayed psycho-speech development in children

2018 ◽  
Vol 17 (2) ◽  
pp. 71-79 ◽  
Author(s):  
V. M. Polyakov ◽  
L. V. Rychkova ◽  
T. A. Belogorova ◽  
V. I. Mikhnovich ◽  
O. V. Bugun ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Cognitive Functions ◽  
Standard Therapy ◽  
Visual Memory ◽  
Cognitive Activity ◽  
Group Versus ◽  
Main Group ◽  
Speech Development ◽  
Control Group ◽  
Complex Therapy

The purpose of this studyis to evaluate the ability of L-tryptophan used in complex therapy of delayed psycho-speech development in children to influence the dynamics of cognitive performance.Materials and methods. The study included 80 children aged 3–7 years with delayed psycho-speech development (DPSD). The main group consisted of 37 children (25 male and 12 female), a control group – 43 patients (30 male and 13 female). Both groups of children were comparable in age, sex, degree of speech and cognitive impairment, and IQ level. Patients in the main group have taken standard therapy with L-tryptophan (25–50 mg per day depending on the age) supplement for 14 days. Control patients have taken standard therapy only. Psychodiagnostic tests at the entrance and exit of patients from this study was carried out for evaluation the dynamics of cognitive functions. All differences were considered significant at p < 0.05.Results. The study suggests that oral L-tryptophan intake selectively affects the dynamics of cognitive performance in children with DPSD. So, we studied pre- and post-treatment cognitive performance in both group patients and noted a significant improvement in the visual memory (p < 0.001) and an increase in thinking productivity (p < 0.001) in the tryptophan group versus similar indicators in the control group. Intergroup differences (p < 0.001 and p = 0.026, respectively, for the main and control groups) also found.Conclusion. Two-week L-tryptophan intake in complex therapy of DPSD in children can significantly improve the cognitive activity, and greatly increase both the effectiveness and sustainability of treatment outcomes, which will significantly reduce the time and frequency of hospitalization and financial costs for the rehabilitation of this patients. 

Physical Activity and Inactivity Impacts on Cognitive and Emotional Functioning in Later Life

2018 ◽  
Author(s):  
Patrick D. Gajewski ◽  
Michael Falkenstein
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Older People ◽  
Healthy Aging ◽  
Intervention Studies ◽  
Cognitive Activity ◽  
Well Being ◽  
Positive Effects ◽  
Brain Physiology ◽  
The Impact

Healthy aging is associated with changes in sensory, motor, cognitive, and emotional functions. Such changes depend on various factors. In particular, physical activity not only improves physical and motor but also cognitive and emotional functions. Observational (i.e., associations) and cross-sectional studies generally show a positive effect of regular physical exercise on cognition in older adults. Most longitudinal randomized controlled intervention studies also show positive effects, but the results are inconsistent due to large heterogeneity of methodological setups. Positive changes accompanying physical activity mainly impact executive functions, memory functions, and processing speed. Several factors influence the impact of physical activity on cognition, mainly the type and format of the activity. Strength training and aerobic training yield comparable but also differential benefits, and all should be used in physical activities. Also, a combination of physical activity with cognitive activity appears to enhance its effect on cognition in older age. Hence, such combined training approaches are preferable to homogeneous trainings. Studies of brain physiology changes due to physical activity show general as well as specific effects on certain brain structures and functions, particularly in the frontal cortex and the hippocampus, which are those areas most affected by advanced age. Physical activity also appears to improve cognition in patients with mild cognitive dysfunction and dementia and often ameliorates the disease symptoms. This makes physical training an important intervention for those groups of older people. Apart from cognition, physical activity leads to improvement of emotional functions. Exercise can lead to improvement of psychological well-being in older adults. Most importantly, exercise appears to reduce symptoms of depression in seniors. In future intervention studies it should be clarified who profits most from physical activity. Further, the conditions that influence the cognitive and emotional benefits older people derive from physical activity should be investigated in more detail. Finally, measures of brain activity that can be easily applied should be included as far as possible.

scholarly journals Factorial Structure of Cognitive Activity Using a Neuropsychological Test Battery

1994 ◽  
Vol 7 (2) ◽  
pp. 49-58 ◽  
Author(s):  
A. Ardila ◽  
M. Rosselli ◽  
J. R. Bateman
Keyword(s):  
Verbal Memory ◽  
Visual Memory ◽  
Neuropsychological Test ◽  
Cognitive Activity ◽  
Test Battery ◽  
Factor Ix ◽  
Factor Vii ◽  
Mental Control ◽  
Neuropsychological Test Battery ◽  
Wechsler Memory Scale

A general neuropsychological test battery was assembled and individually given to a 98-subject sample, aged 11–12 years old. The battery included some basic and common tests routinely used in the evaluation of language, memory, spatial abilities, concept formation, and praxic abilities. Twenty-five different scores were calculated. A factor analysis with varimax rotation disclosed nine different factors, accounting for about 70% of the variance. Factor I was measured by a Sequential Verbal Memory test and Verbal Fluency subtests (“verbal factor”). Factor II was measured by the Wechsler Memory Scale Visual Memory subtests (immediate and delayed reproduction), and the Rey-Osterrieth Complex Figure (copy and immediate reproduction) (“non-verbal memory and constructional factor”). Factor III was measured by the WMS Logical Memory subtests (immediate and delayed; “verbal memory factor”). Factor IV was associated with fine movements (tapping subtests, right and left hand; “fine movements factor”). Factor V was specially measured by the Information subtest of the WMS and the Boston Naming Test (“verbal knowledge”). Factor VI represented a “praxic ability factor” (ideomotor praxis tests). Delayed Associative Learning subtest measured Factor VII; and Digits measured Factor VIII. Factor IX was a “mental control factor” (Mental Control subtest of the Wechsler Memory Scale). The implications of these results to theories relating to the structure of cognitive activity are discussed.

Caffeine and Placebo Expectation

2007 ◽  
Vol 21 (2) ◽  
pp. 91-99 ◽  
Author(s):  
Yunfeng Sun ◽  
Yinling Zhang ◽  
Ning He ◽  
Xufeng Liu ◽  
Danmin Miao
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Sleep Deprivation ◽  
Cognitive Performance ◽  
Cognitive Functions ◽  
Cardiovascular Regulation ◽  
Double Blind ◽  
Positive Effects ◽  
Pressure Tests ◽  
Healthy Males

Abstract. Caffeine placebo expectation seems to improve vigilance and cognitive performance. This study investigated the effect of caffeine and placebo expectation on vigilance and cognitive performance during 28 h sleep deprivation. Ten healthy males volunteered to take part in the double-blind, cross-over study, which required participants to complete five treatment periods of 28 h separated by 1-week wash-out intervals. The treatments were no substance (Control); caffeine 200 mg at 00:00 (C200); placebo 200 mg at 00:00 (P200); twice caffeine 200 mg at 00:00 and 04:00 (C200-C200); caffeine 200 mg at 00:00 and placebo 200 mg at 04:00 (C200-P200). Participants were told that all capsules were caffeine and given information about the effects of caffeine to increase expectation. Vigilance was assessed by a three-letter cancellation test, cognitive functions by the continuous addition test and Stroop test, and cardiovascular regulation by heart rate and blood pressure. Tests were performed bihourly from 00:00 to 10:00 of the second day. Results indicated that C200-P200 and C200-C200 were more alert (p < .05) than Control and P200. Their cognitive functions were higher (p < .05) than Control and P200. Also, C200-P200 scored higher than C200 in the letter cancellation task (p < .05). No test showed any significant differences between C200-P200 and C200-C200. The results demonstrated that the combination of caffeine 200 mg and placebo 200 mg expectation exerted prolonged positive effects on vigilance and cognitive performance.

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