Surface Treatment and Bioinspired Coating for 3D-Printed Implants

Three-dimensional (3D) printing technology has developed rapidly and demonstrates great potential in biomedical applications. Although 3D printing techniques have good control over the macrostructure of metallic implants, the surface properties have superior control over the tissue response. By focusing on the types of surface treatments, the osseointegration activity of the bone–implant interface is enhanced. Therefore, this review paper aims to discuss the surface functionalities of metallic implants regarding their physical structure, chemical composition, and biological reaction through surface treatment and bioactive coating. The perspective on the current challenges and future directions for development of surface treatment on 3D-printed implants is also presented.

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Three-dimensional printing for heart diseases: clinical application review

Bio-Design and Manufacturing ◽

10.1007/s42242-021-00125-8 ◽

2021 ◽

Author(s):

Yanyan Ma ◽

Peng Ding ◽

Lanlan Li ◽

Yang Liu ◽

Ping Jin ◽

...

Keyword(s):

3D Printing ◽

Clinical Application ◽

Heart Diseases ◽

Three Dimensional ◽

Convincing Evidence ◽

Surgical Interventions ◽

Three Dimensional Printing ◽

Complex Anatomy ◽

Precise Understanding ◽

3D Printed

AbstractHeart diseases remain the top threat to human health, and the treatment of heart diseases changes with each passing day. Convincing evidence shows that three-dimensional (3D) printing allows for a more precise understanding of the complex anatomy associated with various heart diseases. In addition, 3D-printed models of cardiac diseases may serve as effective educational tools and for hands-on simulation of surgical interventions. We introduce examples of the clinical applications of different types of 3D printing based on specific cases and clinical application scenarios of 3D printing in treating heart diseases. We also discuss the limitations and clinically unmet needs of 3D printing in this context.

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Three-Dimensional Printing of Hydroxyapatite Composites for Biomedical Application

Crystals ◽

10.3390/cryst11040353 ◽

2021 ◽

Vol 11 (4) ◽

pp. 353

Author(s):

Yanting Han ◽

Qianqian Wei ◽

Pengbo Chang ◽

Kehui Hu ◽

Oseweuba Valentine Okoro ◽

...

Keyword(s):

Tissue Engineering ◽

3D Printing ◽

Biomedical Application ◽

Three Dimensional ◽

Antibacterial Properties ◽

Natural Polymers ◽

Three Dimensional Printing ◽

3D Printed ◽

Dental Applications ◽

Hard Tissue Engineering

Hydroxyapatite (HA) and HA-based nanocomposites have been recognized as ideal biomaterials in hard tissue engineering because of their compositional similarity to bioapatite. However, the traditional HA-based nanocomposites fabrication techniques still limit the utilization of HA in bone, cartilage, dental, applications, and other fields. In recent years, three-dimensional (3D) printing has been shown to provide a fast, precise, controllable, and scalable fabrication approach for the synthesis of HA-based scaffolds. This review therefore explores available 3D printing technologies for the preparation of porous HA-based nanocomposites. In the present review, different 3D printed HA-based scaffolds composited with natural polymers and/or synthetic polymers are discussed. Furthermore, the desired properties of HA-based composites via 3D printing such as porosity, mechanical properties, biodegradability, and antibacterial properties are extensively explored. Lastly, the applications and the next generation of HA-based nanocomposites for tissue engineering are discussed.

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Three-dimensionally printed polycaprolactone/multicomponent bioactive glass scaffolds for potential application in bone tissue engineering

Biomedical glasses ◽

10.1515/bglass-2020-0006 ◽

2020 ◽

Vol 6 (1) ◽

pp. 57-69

Author(s):

Amirhosein Fathi ◽

Farzad Kermani ◽

Aliasghar Behnamghader ◽

Sara Banijamali ◽

Masoud Mozafari ◽

...

Keyword(s):

Tissue Engineering ◽

3D Printing ◽

Bone Tissue Engineering ◽

Bone Tissue ◽

Three Dimensional ◽

Layer By Layer ◽

Composite Scaffolds ◽

3D Printed ◽

Co Doped

AbstractOver the last years, three-dimensional (3D) printing has been successfully applied to produce suitable substitutes for treating bone defects. In this work, 3D printed composite scaffolds of polycaprolactone (PCL) and strontium (Sr)- and cobalt (Co)-doped multi-component melt-derived bioactive glasses (BGs) were prepared for bone tissue engineering strategies. For this purpose, 30% of as-prepared BG particles (size <38 μm) were incorporated into PCL, and then the obtained composite mix was introduced into a 3D printing machine to fabricate layer-by-layer porous structures with the size of 12 × 12 × 2 mm3.The scaffolds were fully characterized through a series of physico-chemical and biological assays. Adding the BGs to PCL led to an improvement in the compressive strength of the fabricated scaffolds and increased their hydrophilicity. Furthermore, the PCL/BG scaffolds showed apatite-forming ability (i.e., bioactivity behavior) after being immersed in simulated body fluid (SBF). The in vitro cellular examinations revealed the cytocompatibility of the scaffolds and confirmed them as suitable substrates for the adhesion and proliferation of MG-63 osteosarcoma cells. In conclusion, 3D printed composite scaffolds made of PCL and Sr- and Co-doped BGs might be potentially-beneficial bone replacements, and the achieved results motivate further research on these materials.

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On the Post-Processing of 3D-Printed ABS Parts

Polymers ◽

10.3390/polym13101559 ◽

2021 ◽

Vol 13 (10) ◽

pp. 1559

Author(s):

Mohammad Reza Khosravani ◽

Jonas Schüürmann ◽

Filippo Berto ◽

Tamara Reinicke

Keyword(s):

Surface Treatment ◽

Fused Deposition Modeling ◽

Three Dimensional ◽

Acrylonitrile Butadiene Styrene ◽

Experimental Tests ◽

Fracture Load ◽

Post Processing ◽

Fused Deposition ◽

Dog Bone ◽

3D Printed

Application of Additive Manufacturing (AM) has significantly increased in the past few years. AM also known as three-dimensional (3D) printing has been currently used in fabrication of prototypes and end-use products. Considering the new applications of additively manufactured components, it is necessary to study structural details of these parts. In the current study, influence of a post-processing on the mechanical properties of 3D-printed parts has been investigated. To this aim, Acrylonitrile Butadiene Styrene (ABS) material was used to produce test coupons based on the Fused Deposition Modeling (FDM) process. More in deep, a device was designed and fabricated to fix imperfection and provide smooth surfaces on the 3D-printed ABS specimens. Later, original and treated specimens were subjected to a series of tensile loads, three-point bending tests, and water absorption tests. The experimental tests indicated fracture load in untreated dog-bone shaped specimen was 2026.1 N which was decreased to 1951.7 N after surface treatment. Moreover, the performed surface treatment was lead and decrease in tensile strength from 29.37 MPa to 26.25 MPa. Comparison of the results confirmed effects of the surface modification on the fracture toughness of the examined semi-circular bending components. Moreover, a 3D laser microscope was used for visual investigation of the specimens. The documented results are beneficial for next designs and optimization of finishing processes.

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3D printing of a bio-based ink made of cross-linked cellulose nanofibrils with various metal cations

Scientific Reports ◽

10.1038/s41598-021-85865-4 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

J. Benedikt Mietner ◽

Xuehe Jiang ◽

Ulrica Edlund ◽

Bodo Saake ◽

Julien R. G. Navarro

Keyword(s):

3D Printing ◽

Divalent Cations ◽

Cellulose Nanofibrils ◽

Three Dimensional ◽

Metal Cations ◽

Cross Link ◽

Cellulose Pulp ◽

Freeze Dried ◽

3D Printed ◽

Metallic Cations

AbstractIn this work, we present an approach to cross-link cellulose nanofibrils (CNFs) with various metallic cations (Fe3+, Al3+, Ca2+, and Mg2+) to produce inks suitable for three-dimensional (3D) printing application. The printability of each hydrogel ink was evaluated, and several parameters such as the optimal ratio of Mn+:TOCNF:H2O were discussed. CNF suspensions were produced by mechanical disintegration of cellulose pulp with a microfluidizer and then oxidized with 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO). Finally, metal cations were introduced to the deprotonated TEMPO-oxidized CNF (TOCNF) suspension to cross-link the nanofibrils and form the corresponding hydrogels. The performances of each gel-ink were evaluated by rheological measurements and 3D printing. Only the gels incorporated with divalent cations Ca2+ and Mg2+ were suitable for 3D printing. The 3D printed structures were freeze-dried and characterized with Fourier transform infrared spectroscopy (FT-IR) and Scanning Electron Microscopy (SEM). The better interaction of the TOCNFs with the divalent metallic cations in terms of printability, the viscoelastic properties of the inks, and the variation trends owing to various metal cations and ratios are discussed.

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A review on the role of 3D printing in the fight against COVID-19: safety and challenges

Rapid Prototyping Journal ◽

10.1108/rpj-08-2020-0198 ◽

2021 ◽

Vol ahead-of-print (ahead-of-print) ◽

Author(s):

Sapam Ningthemba Singh ◽

Vavilada Satya Swamy Venkatesh ◽

Ashish Bhalchandra Deoghare

Keyword(s):

Supply Chain ◽

3D Printing ◽

Three Dimensional ◽

Content Type ◽

Medical Supplies ◽

Future Challenges ◽

Safety And Reliability ◽

3D Printed ◽

Comprehensive Study

Purpose During the COVID-19 pandemic, the three-dimensional (3D) printing community is actively participating to address the supply chain gap of essential medical supplies such as face masks, face shields, door adapters, test swabs and ventilator valves. This paper aims to present a comprehensive study on the role of 3D printing during the coronavirus (COVID-19) pandemic, its safety and its challenges. Design/methodology/approach This review paper focuses on the applications of 3D printing in the fight against COVID-19 along with the safety and challenges associated with 3D printing to fight COVID-19. The literature presented in this paper is collected from the journal indexing engines including Scopus, Google Scholar, ResearchGate, PubMed, Web of Science, etc. The main keywords used for searches were 3D printing COVID-19, Safety of 3D printed parts, Sustainability of 3D printing, etc. Further possible iterations of the keywords were used to collect the literature. Findings The applications of 3D printing in the fight against COVID-19 are 3D printed face masks, shields, ventilator valves, test swabs, drug deliveries and hands-free door adapters. As most of these measures are implemented hastily, the safety and reliability of these parts often lacked approval. The safety concerns include the safety of the printed parts, operators and secondary personnel such as the workers in material preparation and transportation. The future challenges include sustainability of the process, long term supply chain, intellectual property and royalty-free models, etc. Originality/value This paper presents a comprehensive study on the applications of 3D printing in the fight against COVID-19 with emphasis on the safety and challenges in it.

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Additive technology applied to the realization of K-band microwave terminations: reproducibility improvement

International Journal of Microwave and Wireless Technologies ◽

10.1017/s1759078717001404 ◽

2018 ◽

Vol 10 (1) ◽

pp. 3-8

Author(s):

Azar Maalouf ◽

Ronan Gingat ◽

Vincent Laur

Keyword(s):

3D Printing ◽

Frequency Band ◽

Rectangular Waveguide ◽

Three Dimensional ◽

Low Density ◽

Support Material ◽

Additive Technology ◽

3D Printed ◽

K Band

This study examines K-band rectangular waveguide terminations with three-dimensional (3D)-printed loads, and proposes an Asymmetrical Tapered Wedge topology. This geometry shows a good tradeoff between microwave performance and 3D-printing issues (printing directions and support material requirements), thus improving noticeably the reproducibility of the devices. The effect of the density of the 3D-printed load on the reflection parameter of the termination was investigated. Even for a low density, reflection level remained below −27.5 dB between 18 and 26.5 GHz. Reproducibility was demonstrated by the characterization of six loads that were 3D printed under the same conditions. Measurements demonstrate that a maximum reflection parameter level of −33.5 dB can be ensured over the whole frequency band without any post-machining of the 3D-printed devices.

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Algorithm to Reduce Leading and Lagging in Conformal Direct-Print

Journal of Manufacturing Science and Engineering ◽

10.1115/1.4040730 ◽

2018 ◽

Vol 140 (10) ◽

Cited By ~ 2

Author(s):

Morteza Vatani ◽

Faez Alkadi ◽

Jae-Won Choi

Keyword(s):

Additive Manufacturing ◽

3D Printing ◽

3D Model ◽

Three Dimensional ◽

Motion Direction ◽

B Spline ◽

And Topology ◽

Printing System ◽

3D Printed ◽

Printed Patterns

A novel additive manufacturing algorithm was developed to increase the consistency of three-dimensional (3D) printed curvilinear or conformal patterns on freeform surfaces. The algorithm dynamically and locally compensates the nozzle location with respect to the pattern geometry, motion direction, and topology of the substrate to minimize lagging or leading during conformal printing. The printing algorithm was implemented in an existing 3D printing system that consists of an extrusion-based dispensing module and an XYZ-stage. A dispensing head is fixed on a Z-axis and moves vertically, while the substrate is installed on an XY-stage and moves in the x–y plane. The printing algorithm approximates the printed pattern using nonuniform rational B-spline (NURBS) curves translated directly from a 3D model. Results showed that the proposed printing algorithm increases the consistency in the width of the printed patterns. It is envisioned that the proposed algorithm can facilitate nonplanar 3D printing using common and commercially available Cartesian-type 3D printing systems.

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A STUDY ON PLANNING AND PLATFORM FOR INTERACTIVE EXHIBITION OF SCIENTIFIC CULTURAL HERITAGE

ISPRS - International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences ◽

10.5194/isprs-archives-xlii-2-w15-605-2019 ◽

2019 ◽

Vol XLII-2/W15 ◽

pp. 605-607

Author(s):

Y. H. Jo ◽

J. Kim ◽

N. C. Cho ◽

C. H. Lee ◽

Y. H. Yun ◽

...

Keyword(s):

3D Printing ◽

Cultural Heritage ◽

Three Dimensional ◽

Conservation Science ◽

Scientific Content ◽

Projection Mapping ◽

Digital Database ◽

3D Effects ◽

3D Printed ◽

Bronze Mirrors

<p><strong>Abstract.</strong> This study has developed an experiential exhibition system of scientific cultural heritage through interactive projection mapping. A bronze mirror with fine linear design was selected as an exhibition subject considering the intuitiveness and responsiveness of research and development results. First, three-dimensional (3D) scanning was performed to construct a digital database of the original forms, and computer graphics-based 3D modeling was also performed to build exhibition materials and 3D printed objects. Furthermore, objective scenarios were created based on a traditional science experience, understanding the present bronze mirror, and processes of restoring the corroded original bronze mirror through modern conservation science. The technique selected to implement the scientific content of bronze mirror as media art in this study is interactive projection mapping. Moreover, a large 3D printing of bronze mirror was installed at the center of the exhibition space to allow users and all viewers to concurrently engage in scientific cultural heritage content. Simultaneous projection mapping on the front and rear of the printed bronze mirror model enhanced 3D effects and the immersion of the content. To construct an interactive space connecting the virtual and reality, ore, mold, bronze mirror replicas, 3D printing outputs, and cultural products used in the process of producing bronze mirrors were exhibited to make the exhibit more intuitive for visitors. This interactive projection mapping-based scientific and cultural exhibition of the bronze mirror is an experiential exhibition system which combines traditional science, modern conservation science, and future exhibition technology.</p>

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3D Printing of Thermo-Sensitive Drugs

Pharmaceutics ◽

10.3390/pharmaceutics13091524 ◽

2021 ◽

Vol 13 (9) ◽

pp. 1524

Author(s):

Sadikalmahdi Abdella ◽

Souha H. Youssef ◽

Franklin Afinjuomo ◽

Yunmei Song ◽

Paris Fouladian ◽

...

Keyword(s):

3D Printing ◽

Three Dimensional ◽

Fused Deposition Modelling ◽

Future Directions ◽

Digital Light Processing ◽

Fused Deposition ◽

Printing Technique ◽

3D Printed ◽

Semi Solid ◽

Selection Of

Three-dimensional (3D) printing is among the rapidly evolving technologies with applications in many sectors. The pharmaceutical industry is no exception, and the approval of the first 3D-printed tablet (Spiratam®) marked a revolution in the field. Several studies reported the fabrication of different dosage forms using a range of 3D printing techniques. Thermosensitive drugs compose a considerable segment of available medications in the market requiring strict temperature control during processing to ensure their efficacy and safety. Heating involved in some of the 3D printing technologies raises concerns regarding the feasibility of the techniques for printing thermolabile drugs. Studies reported that semi-solid extrusion (SSE) is the commonly used printing technique to fabricate thermosensitive drugs. Digital light processing (DLP), binder jetting (BJ), and stereolithography (SLA) can also be used for the fabrication of thermosensitive drugs as they do not involve heating elements. Nonetheless, degradation of some drugs by light source used in the techniques was reported. Interestingly, fused deposition modelling (FDM) coupled with filling techniques offered protection against thermal degradation. Concepts such as selection of low melting point polymers, adjustment of printing parameters, and coupling of more than one printing technique were exploited in printing thermosensitive drugs. This systematic review presents challenges, 3DP procedures, and future directions of 3D printing of thermo-sensitive formulations.

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