Biventricular Increases in Mitochondrial Fission Mediator (MiD51) and Proglycolytic Pyruvate Kinase (PKM2) Isoform in Experimental Group 2 Pulmonary Hypertension-Novel Mitochondrial Abnormalities

This research investigates 1) students’ achievement in reading comprehension taught by using Direct Reading Thinking Activity (DR-TA) strategy is higher than taught by using Know, What to Learn, and Learned (KWL) strategy, 2) students’ achievement in reading comprehension with impulsive learning style is higher than students’ achievement in reading comprehension with reflective learning style, and (3) there is interaction between teaching strategies and learning styles on the students’ achievement. Two classes containing of 70 students were chosen as sample by apllying cluster random sampling technique. The experimental group 1 was treated by using DR-TA and the experimental group 2 was treated by using KWL. The students’ achievement was measured by using test. The questionnaire was conducted to find out the students’ learning style. The data were analyzed by applying two-ways analysis of variance. The findings show that (1) the students’ achievement in reading comprehension taught by using DR-TA higher than using KWL; (2) students’ achievement in reading comprehension with impulsive learning style is lower than that with reflective learning style; (3) there is interaction between teaching strategies and learning styles on the students’ achievement in reading comprehension. The analysis revealed that the teaching strategies significantly affected the students’ reading achievement. Keywords: DR-TA, KWL, Impulsive Learning Style, Reflective Learning Style, Reading Comprehension

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Exercise Training in Group 2 Pulmonary Hypertension: Which Intensity and What Modality

Progress in Cardiovascular Diseases ◽

10.1016/j.pcad.2015.11.005 ◽

2016 ◽

Vol 59 (1) ◽

pp. 87-94 ◽

Cited By ~ 8

Author(s):

Ross Arena ◽

Carl J. Lavie ◽

Audrey Borghi-Silva ◽

John Daugherty ◽

Samantha Bond ◽

...

Keyword(s):

Pulmonary Hypertension ◽

Exercise Training ◽

Group 2

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Abstract 15193: Pulmonary Hypertension in Pregnancy: WHO Group 1 Outcomes Improved, Time to Focus on WHO Group 2

Circulation ◽

10.1161/circ.142.suppl_3.15193 ◽

2020 ◽

Vol 142 (Suppl_3) ◽

Author(s):

William H Marshall ◽

Stephen Gee ◽

Woobeen Lim ◽

Elisa A Bradley ◽

Lauren Lastinger ◽

...

Keyword(s):

Pulmonary Hypertension ◽

Post Partum ◽

Systolic Pressure ◽

Adverse Outcomes ◽

Cardiac Events ◽

Ventricular Systolic Pressure ◽

Group 5 ◽

Group 2 ◽

In Pregnancy ◽

Group 1

Introduction: Pregnancy is contraindicated in women with pulmonary hypertension (PH), yet many still decide to pursue pregnancy. Hypothesis: We hypothesized improved maternal mortality with PH at our center’s cardio-obstetrics program and sought to identify factors to estimate the risk of major adverse cardiac events (MACE). Methods: Pregnant women with right ventricular systolic pressure (RVSP) ≥35 mmHg or tricuspid regurgitant velocity > 2.8 m/s on transthoracic echocardiogram (TTE) were identified. Women with intermediate to high probability PH by ESC criteria (TTE or catheterization, n = 70) were classified using the 6 th World Society of PH definitions. Results: In 70 women with PH (30 ± 6 years-old, RVSP 52 ± 16 mmHg) there were 12 (17%) with WHO Group 1 PH, 45 (64%) with Group 2 PH, 4 (6%) with Group 3 PH and 9 (13%) with Group 5 PH (Figure A). Baseline characteristics were similar except: Group 1 PH had 83% on prostacyclin (PC) therapy, higher RVSP (78 ± 20 mmHg vs. Groups 2 (46 ± 9), 3 (44 ± 2 mmHg) and 5 PH (48 ± 10mmHg), p<0.01), and compared to Group 2 PH, more Group 1 PH women were diagnosed pre-pregnancy (9 (75%) vs. 12 (27%), p = 0.01) and had cardio-obstetrics care (10 (83%) vs. 16 (36%), p < 0.01) (Figure B - E). There were no peripartum deaths, however 3 (4.3%) women with Group 2 PH had late mortality (7 ± 4 months post-partum). MACE occurred in 24 (34%) women and was more likely in those with: NYHA FC ≥ 2 (95% CI 4.7-57, p < 0.01), pre-eclampsia (95% CI 1.2-13, p = 0.03), RVSP >50 mmHg (95% CI 1.3-10, p = 0.02) and LVEF <50% (95% CI 1.1-8.8, p = 0.04) (Figure F). Preterm birth occurred in 32 (49%) pregnancies, with no neonatal mortality. Conclusion: To conclude, in a large single center cohort we report 100% 1-year survival in Groups 1, 3, and 5 PH, with most Group 1 PH patients on PC therapy and under cardio-obstetrics care. We identify Group 2 PH as an under-recognized group for adverse outcomes in pregnancy, with NYHA FC, pre-eclampsia, RVSP >50 mmHg and LVEF <50% associated with increased MACE.

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World Health Organization pulmonary hypertension group 2: pulmonary hypertension due to left heart disease

Pulmonary Circulation ◽

10.1201/9781315382753-49 ◽

2016 ◽

pp. 440-455

Keyword(s):

Pulmonary Hypertension ◽

Heart Disease ◽

World Health Organization ◽

World Health ◽

Left Heart ◽

Left Heart Disease ◽

Group 2 ◽

Health Organization

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How is juvenile rheumatic heart disease different: baseline results from a prospective north Indian registry

European Heart Journal ◽

10.1093/ehjci/ehaa946.1898 ◽

2020 ◽

Vol 41 (Supplement_2) ◽

Author(s):

K Mahajan ◽

D.R Prakash Chand Negi

Keyword(s):

Heart Failure ◽

Atrial Fibrillation ◽

Pulmonary Hypertension ◽

Heart Disease ◽

Funding Source ◽

Thromboembolic Events ◽

Group 3 ◽

Group 2 ◽

Rheumatic Heart ◽

Group 1

Abstract Introduction Juvenile rheumatic heart disease (RHD) refers to RHD in patients <20 years of age. There are no contemporary data highlighting the differences between juvenile and older RHD patients. Purpose We aim to report the age related differences in the pattern, and consequencies of valvular dysfunction in patients of RHD. Methods The 2475 consecutive patients of RHD diagnosed using clinical and echocardiographic criteria were registered prospectively from 2011 till December 2019. Patients were divided into 3 groups according to their age: Group 1 (Juvenile RHD), Group 2 (21–50 years), and Group 2 (>51 years).The data concerning the socio-demographic and clinical profile were recorded systematically, and the nature and severity of valvular dysfunction was assessed by echocardiography. The data were analyzed using the Epi-InfoTM Software. Results Out of 2475 RHD patients, Juvenile RHD comprised of 211 (8.5%) patients. Group 2 and 3 comprised of 1691 (68.3%) and 573 (23.2%) patients respectively. Overall, 1767 (71.4%) patients were females, however this female predilection was less pronounced in juvenile RHD (55.5% females vs 44.5% males) as compared to older groups. Past history of acute rheumatic fever was more commonly recorded in Juvenile RHD group (37.9% vs 18.8% in group 2 and 10% in group 3, p=0.0001). At the time of registration, the presence of advanced heart failure symptoms (dyspnea class III and IV) (11.4% group 1 vs 13.9% group 2 vs 20.6% group 3, p<0.0001), right heart failure symptoms (0.9% group 1 vs 2.5% group 2 vs 7.3% group 3, p<0.01), thromboembolic events (0% group 1 vs 4.1% group 2 vs 3.3% group 3, p<0.01), atrial fibrillation (2.8% group 1 vs 24.5% group 2 vs 45.9% group 3, p<0.0001), and pulmonary hypertension (27.1% group 1 vs 40.3% group 2 vs 51.9% group 3, p<0.01), were all more commonly recorded in non-juvenile older RHD groups. Multivalvular involvement was also less common in juvenile RHD (34.6% vs 42.4% and 44.5%, p=0.04). Mitral regurgitation was the most common lesion in Juvenile RHD followed by aortic regurgitation (68.7% and 40.2% respectively). Stenotic lesions (both mitral and aortic) were present more commonly in older age groups. Conclusion RHD is predominantly a disease of females, however the predilection is less common in juvenile patients. Juvenile RHD predominantly affects the mitral valve and mainly leads to regurgitant lesions. As the age advances, the complications of RHD, mainly heart failure symptoms, thromboembolic events, pulmonary hypertension, and atrial fibrillation, become more common. Funding Acknowledgement Type of funding source: Public hospital(s). Main funding source(s): Self sponsored registry

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Psychoeducation of Character Personal’s Local Wisdom of Sundanese People’s Behaviour in Internalizing Religious Commitment

TARBIYA Journal of Education in Muslim Society ◽

10.15408/tjems.v3i1.3395 ◽

2016 ◽

Vol 3 (1) ◽

pp. 64-76

Author(s):

Fenti Hikmawati

Keyword(s):

Mixed Methods ◽

Religious Commitment ◽

Control Group ◽

Local Policy ◽

Questionnaire Item ◽

Design Models ◽

Item Number ◽

Group 2 ◽

Experimental Group ◽

Islamic Values

Abstract This research aims to make new breakthroughs, to open the students’ paradigm about psycho-education related to religious commitment as the internalization of the values of the Sundanese Islam. Counseling method in this study used mixed methods with Triangulation A one-phased design models. Based on the analysis, it can be concluded that: (1) The students’ increased commitment of religious is significant (47.37%) which is higher than the control group; (2) The answer of questionnaire item number one, two, and three in the experimental group is relatively balanced, with the emphasis on spoken and acted in number 23, whereas in the control group is relatively less balanced with emphasis on spoken and acted in number 13, and two who answered do not. Results of this study are expected to be an evaluation of the socialization of psychoeducation about the application of Islamic values in the local policy on the vision and mission of the faculty, especially stakeholders. Abstrak Penelitian ini bertujuan untuk membuat terobosan baru dalam memberikan paradigma baru kepada mahasiswa tentang psiko-edukasi terkait dengan komitmen beragama sebagai internalisasi nilai-nilai Islam Sunda. Metode konseling pada penelitian ini menggunakan metode gabungan dengan model desain Triangulasi satu-fase. Berdasarkan analisis data, dapat disimpulkan bahwa: (1) Peningkatan komitmen relijius mahasiswa signifikan (47.37%) yang lebih tinggi daripada kelas kontrol; (2) Jawaban item angket nomor satu, dua, dan tiga pada kelas eksperimen cenderung seimbang dengan penekanan pada lisan dan tindakan di nomor 23, sedangkan di kelas kontrol cenderung tidak seimbang dengan penekanan pada lisan dan tindakan di nomor 13, dan dua orang menjawab tidak tahu. Hasil penelitian mengharapkan adanya evaluasi dari sosialisasi psiko-edukasi tentang penerapan nilai-nilai Islam peraturan lokalpada visi dan misi fakultas, khususnya pemangku kebijakan. How to Cite : Hikmawati, F. (2016). Psychoeducation of Character Personal’s Local Wisdom of Sundanese People’s Behaviour in Internalizing Religious Commitment. TARBIYA: Journal Of Education In Muslim Society, 3(1), 64-76. doi:10.15408/tjems.v3i1.3395. Permalink/DOI: http://dx.doi.org/10.15408/tjems.v3i1. 3395

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MITOL deletion in the brain impairs mitochondrial structure and ER tethering leading to oxidative stress

Life Science Alliance ◽

10.26508/lsa.201900308 ◽

2019 ◽

Vol 2 (4) ◽

pp. e201900308 ◽

Cited By ~ 7

Author(s):

Shun Nagashima ◽

Keisuke Takeda ◽

Nobuhiko Ohno ◽

Satoshi Ishido ◽

Motohide Aoki ◽

...

Keyword(s):

Oxidative Stress ◽

Microglial Activation ◽

Developmental Disorders ◽

Inflammatory Diseases ◽

Mitochondrial Dynamics ◽

Mitochondrial Fission ◽

Three Dimensional ◽

Abnormal Behavior ◽

Mitochondrial Abnormalities

Mitochondrial abnormalities are associated with developmental disorders, although a causal relationship remains largely unknown. Here, we report that increased oxidative stress in neurons by deletion of mitochondrial ubiquitin ligase MITOL causes a potential neuroinflammation including aberrant astrogliosis and microglial activation, indicating that mitochondrial abnormalities might confer a risk for inflammatory diseases in brain such as psychiatric disorders. A role of MITOL in both mitochondrial dynamics and ER-mitochondria tethering prompted us to characterize three-dimensional structures of mitochondria in vivo. In MITOL-deficient neurons, we observed a significant reduction in the ER-mitochondria contact sites, which might lead to perturbation of phospholipids transfer, consequently reduce cardiolipin biogenesis. We also found that branched large mitochondria disappeared by deletion of MITOL. These morphological abnormalities of mitochondria resulted in enhanced oxidative stress in brain, which led to astrogliosis and microglial activation partly causing abnormal behavior. In conclusion, the reduced ER-mitochondria tethering and excessive mitochondrial fission may trigger neuroinflammation through oxidative stress.

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Penerapan Model Pembelajaran Problem Based Learning untuk Mengukur Kemampuan Berpikir Kritis Mahasiswa Calon Guru pada Mata Kuliah Psikologi Pendidikan

Jurnal Konseling dan Pendidikan ◽

10.29210/114000 ◽

2017 ◽

Vol 5 (1) ◽

pp. 1

Author(s):

Uus Toharudin ◽

Iwan Setia Kurniawan

Keyword(s):

Critical Thinking ◽

Prospective Teachers ◽

Educational Psychology ◽

Thinking Skills ◽

Critical Thinking Skills ◽

Average Score ◽

Test Results ◽

Group 2 ◽

Experimental Group ◽

Group 1

This study aims to determine the critical thinking skills of prospective teachers of biology at Pasundan University in the course of educational psychology. Implementation of Problem Based Learning learning model aims to measure students' critical thinking skills. The method used in this study is a quasi-experimental design with Randomized Control Group Posttest, data obtained based on the analysis, the data is described to obtain information or a description of the results of this research. The population in this study were 104 students, the sample in this study were 39 students for the experimental group-1 and 39 students for the experimental group-2. Data collected test data obtained from the test results of students who are given a score based on the indicators. results of research show that the critical thinking skills of prospective teachers of biology in educational psychology courses including category sufficient for the experimental group-1 and category well for the experimental group-2. The average score of the experimental group-1 amounted to 2.73, and the average score of the experimental group-2 by 3.05. Indicators of critical thinking skills at the highest indicator 3 (I-3) with an average of 3.38 for the experimental group-1 and 3.41 for the experimental group-2. Indicators of critical thinking skills are the lowest in two indicators (I-2) that is equal to 2.23 for the experimental group-1 and 2.74 for the experimental group-2. The average percentage of absorption problems in the experimental group-1 amounted to 51.25%, while the experimental group-2 amounted to 57.21%. The results of significance test p-value (0.008). Based on the significance of the test results can be concluded that the experimental group-2 has the critical thinking skills is better than the experimental group-1.

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