scholarly journals Cardiac, Macro-, and Micro-Circulatory Abnormalities in Association With Individual Metabolic Syndrome Component: The Northern Shanghai Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Fang Zhao ◽  
Rong Yang ◽  
Rusitanmujiang Maimaitiaili ◽  
Jiamin Tang ◽  
Song Zhao ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Prognostic Significance ◽  
Ankle Brachial Index ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Doppler Velocity ◽  
Metabolic Syndrome Component ◽  
Left Ventricle Mass ◽  
Cross Sectional ◽  
Elderly Chinese

Objective: This study investigated the association of metabolic syndrome (MS) and its components with cardiac, macro-, and micro-circulatory abnormalities in an elderly Chinese population.Methods: This cross-sectional study was conducted using data for 1,958 participants from the Northern Shanghai Study aged over 65 years without a history of cardiovascular disease. MS was defined according to the National Cholesterol Education Program Adult Treatment Panel III in 2005 (NCEPIII 2005). Asymptomatic cardiovascular impairment parameters, including the left ventricle mass index (LVMI), peak transmitral pulsed Doppler velocity/early diastolic tissue Doppler velocity (E/Ea), carotid-femoral pulse wave velocity (cf-PWV), ankle-brachial index (ABI), carotid intima-media thickness (CIMT), arterial plaque, and urinary albumin–creatinine rate (UACR), were evaluated.Results: LVMI, E/Ea, cf-PWV, and the proportion of UACR > 30 mg/g exhibited increasing trends while ABI exhibited a decreasing trend according to the number of MS components (all p for trend < 0.01). Logistic regression analysis revealed that MS was significantly associated with LV hypertrophy (LVH), LV diastolic dysfunction, arteriosclerosis, and microalbuminuria (all p < 0.001). Central obesity and high blood pressure were associated with all cardiovascular abnormalities (all p < 0.05), whereas elevated plasma glucose was associated with arteriosclerosis and microalbuminuria (both p < 0.001). In addition, high triglyceride levels were associated with microalbuminuria (p < 0.05).Conclusions: MS is significantly associated with cardiac, macro-, and micro-circulatory abnormalities in elderly Chinese. Moreover, the presence of individual MS components may have specific prognostic significance.

scholarly journals The Relationship between Cardiovascular Risk Scores and Several Markers of Subclinical Atherosclerosis in an Asymptomatic Population

2021 ◽  
Vol 10 (5) ◽  
pp. 955
Author(s):  
Ovidiu Mitu ◽  
Adrian Crisan ◽  
Simon Redwood ◽  
Ioan-Elian Cazacu-Davidescu ◽  
Ivona Mitu ◽  
...  
Keyword(s):  
Risk Score ◽  
Subclinical Atherosclerosis ◽  
Ankle Brachial Index ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Risk Scores ◽  
Cvd Risk ◽  
Cross Sectional ◽  
Single Center Study ◽  
Asymptomatic Individuals

Background: The current cardiovascular disease (CVD) primary prevention guidelines prioritize risk stratification by using clinical risk scores. However, subclinical atherosclerosis may rest long term undetected. This study aimed to evaluate multiple subclinical atherosclerosis parameters in relation to several CV risk scores in asymptomatic individuals. Methods: A cross-sectional, single-center study included 120 asymptomatic CVD subjects. Four CVD risk scores were computed: SCORE, Framingham, QRISK, and PROCAM. Subclinical atherosclerosis has been determined by carotid intima-media thickness (cIMT), pulse wave velocity (PWV), aortic and brachial augmentation indexes (AIXAo, respectively AIXbr), aortic systolic blood pressure (SBPao), and ankle-brachial index (ABI). Results: The mean age was 52.01 ± 10.73 years. For cIMT—SCORE was more sensitive; for PWV—Framingham score was more sensitive; for AIXbr—QRISK and PROCAM were more sensitive while for AIXao—QRISK presented better results. As for SBPao—SCORE presented more sensitive results. However, ABI did not correlate with any CVD risk score. Conclusions: All four CV risk scores are associated with markers of subclinical atherosclerosis in asymptomatic population, except for ABI, with specific particularities for each CVD risk score. Moreover, we propose specific cut-off values of CV risk scores that may indicate the need for subclinical atherosclerosis assessment.

Visfatin Levels May be an Early Marker of Atherosclerosis in Patients with Acromegaly

2019 ◽  
Vol 51 (10) ◽  
pp. 649-654
Author(s):  
Hamide Piskinpasa ◽  
Yildiz Okuturlar ◽  
Sema Ciftci Dogansen ◽  
Yasemin Sefika Akdeniz ◽  
Ayse Esen ◽  
...  
Keyword(s):  
Ankle Brachial Index ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Control Group ◽  
Healthy Controls ◽  
Cross Sectional ◽  
Normal Ratio ◽  
Visfatin Level ◽  
And Control ◽  
Control Study

AbstractThe purpose of the study was to compare serum visfatin levels between patients with acromegaly and healthy controls and to evaluate the relationships between visfatin levels and epicardial fat thickness (EFT), carotid intima media thickness (cIMT), and ankle brachial index (ABI). We conducted a cross-sectional case-control study of 54 patients with acromegaly (37 females and 17 males) and 34 healthy controls (22 females and 12 males). Serum visfatin was measured by ELISA. Acromegalic and control participants and those with active or controlled acromegaly were compared with respect to their serum visfatin, clinical and metabolic parameters, EFT, cIMT, and ABI. Linear correlation was used to identify associations between these parameters and visfatin in all participants. Serum visfatin and glycated hemoglobin (HbA1c) were higher in the acromegaly group than in the control group (p<0.001 and p=0.007, respectively). There was no difference in visfatin between the active and controlled acromegaly groups, but HbA1c was higher in the active than the controlled acromegaly group (p<0.04). EFT, cIMT, and ABI were similar between the acromegaly and control groups and between the active and controlled acromegaly groups. Serum visfatin positively correlated with HbA1c, growth hormone (GH), and insulin-like growth factor-1 (IGF-1)/upper limit of normal ratio (r=0.245, p=0.024; r=0.259, p=0.017; and r=0.282, p=0.009, respectively). This study has revealed that a high visfatin level is associated with glycemic dysregulation and higher levels of GH and IGF-1 in acromegalic patients.

scholarly journals Relationship Between Metabolic Syndrome and Carotid Intima-Media Thickness: Cross-Sectional Comparison Between Psoriasis and Psoriatic Arthritis

2013 ◽  
Vol 66 (1) ◽  
pp. 97-103 ◽  
Author(s):  
Yih Chang Lin ◽  
Deepan Dalal ◽  
Sarah Churton ◽  
Danielle M. Brennan ◽  
Neil J. Korman ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Psoriatic Arthritis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Cross Sectional ◽  
Media Thickness

scholarly journals Correlation between epicardial fat thickness with intima–media thickness and ankle–brachial index in patients with metabolic syndrome

2021 ◽  
Vol 34 ◽  
pp. 151-153
Author(s):  
KARLA C. ARANA-PAZOS ◽  
JORGE L. NARVAEZRIVERA ◽  
ALBERTO MACEDA-SERRANO ◽  
DANIEL R. BENITEZ-MALDONADO ◽  
ALBERTO FRANCISCO RUBIO-GUERRA
Keyword(s):  
Metabolic Syndrome ◽  
Cardiovascular Risk ◽  
Ankle Brachial Index ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Epicardial Fat ◽  
Epicardial Fat Thickness ◽  
Media Thickness ◽  
Fat Thickness ◽  
Relationship Of

Background An increase in epicardial fat thickness (EFT) has been associated with increased cardiovascular risk and the development of atherosclerosis. Transthoracic echo-cardiography provides a reliable measurement of EFT. We evaluated the relationship of EFT with carotid intima–media thickness (CIMT) and ankle–brachial index (ABI), in patients with metabolic syndrome. Methods We assessed 80 patients with metabolic syndrome who underwent echocardiography; EFT was measured by two cardiologists. The CIMT (B-mode colour imaging of extracranial carotid arteries using high-resolution ultrasound) was also measured by a certified ultrasonographer, and ABI was measured by the main researcher. Results We did not find any correlation between ABI with EFT (r=0.0103, p=0.93) or with CIMT (r=–0.1625, p=0.15). However, we found a significant correlation between EFT and CIMT (r=0.2718, r2=0.074, p=0.015). When we evaluated the risk for a CIMT >0.9 mm in patients with an EFT >3 mm, we found a statistically significant association (p=0.039). Interestingly, only 1 patient with an EFT <3 mm had a CIMT >0.9 mm. Conclusion We found that the EFT correlates with CIMT in patients with metabolic syndrome, which explains, at least in part, the higher risk of atherosclerosis in them. Measurement of EFT should be part of the cardiovascular risk evaluation in patients with metabolic syndrome.

scholarly journals Association between carotid intima media thickness and metabolic syndrome

2018 ◽  
Vol 5 (6) ◽  
pp. 1503
Author(s):  
Abhishek T. G. ◽  
Arathi Darshan ◽  
Jayaprakash S. Appajigol ◽  
Naveen Angadi ◽  
Vijayalakshmi Chikkamath
Keyword(s):  
Metabolic Syndrome ◽  
Total Cholesterol ◽  
Subclinical Atherosclerosis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Cross Sectional Study ◽  
Research Centre ◽  
Cross Sectional ◽  
Media Thickness ◽  
The Mean

Background: Metabolic syndrome and its individual criteria pose a risk for atherosclerosis and cardiovascular disease (CVD). Carotid intima media thickness (CIMT) is a well-known marker of subclinical atherosclerosis. This study was aimed to assess CIMT in patients with metabolic syndrome.Methods: This one year cross-sectional study was conducted in the Department of Medicine, KLES Dr. Prabhakar Kore Hospital and Medical Research Centre, Belagavi from January 2016 to December 2016. A total of 100 patients diagnosed to have metabolic syndrome based on national cholesterol education program adult treatment panel III (NCEP ATP III) criteria were studied. All the patients were subjected to carotid B mode ultrasonography.Results: The most common age group was 51 to 60years (29%). Out of 100 individuals who were diagnosed to have metabolic syndrome, 60% had five criteria, 29% had four criteria and 3% had three criteria. Most of the of the individuals (61.00%) had normal (≤0.10cms) CIMT while high (>0.10cm) levels were noted in 39.00% of the individuals. The mean CIMT was noted as 0.13±0.16cms. The mean SBP (150.15±10.39 vs 142.98±20.09mmHg; p=0.042), DBP (94.51±6.53 vs 90.16±9.91 mmHg; p=0.017), total cholesterol levels (243.53±65.74 vs 195.95±29.8 mg/dL; p<0.001) and triglyceride levels (221.07±48.44 vs 180.85±24.74mg/dL; p <0.001) were noted in individuals with raised CIMT compared to individuals with normal CIMT. Majority of the individuals had abnormal HDL (93.00%) and 41.94% of the individuals with abnormal HDL had raised CIMT (p=0.027).Conclusions: Some individuals with metabolic syndrome are likely to have raised CIMT. The rise in CIMT among the patients with metabolic syndrome is associated with raised SBP, DBP, abnormal HDL (specifically in males), total cholesterol and triglycerides.

scholarly journals Carotid Intima-Media Thickness Correlation with Metabolic Syndrome Parameters in Military Pilots

2020 ◽  
Author(s):  
Masud Pezeshki Rad ◽  
Hamzeh Shahali ◽  
Mahmud Momenzadeh ◽  
Bita Yarmohammadi
Keyword(s):  
Metabolic Syndrome ◽  
Carotid Artery ◽  
Significant Relationship ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Flight Time ◽  
Chi Square ◽  
Cross Sectional ◽  
Symptomatic Carotid ◽  
Military Pilots

Abstract Introduction: Metabolic syndrome is one of the important risk factors in increasing the risk of cardiovascular disease. Recent studies have shown that increasing the thickness of the intima-medial layer of the carotid artery can be a risk factor associated with metabolic syndrome. Methods: This was a cross-sectional analytical study. All individuals underwent ultrasound of the carotid arteries. In the presence of stenosis, the stenosis caused by the plaque by North American symptomatic carotid endarterectomy trial (NASCET) was considered as a decrease in the diameter of the lumen compared to the diameter of the normal lumbar distal lobe and was expressed as a percentage. Statistical analysis of chi-square tests, independent t-test, ANOVA, and regression analysis were performed. Results: This study was performed on 112 male pilots (average age of 41.3 years, average flight time 2435 hours). There was no statistically significant relationship between the mean thickness of intima media carotid and metabolic syndrome (no versus with metabolic syndrome: 0.62 versus 0.64 mm p = 0.355). The average thickness of the intima media carotid was significantly statistically different between the three groups of flight types (transport aircraft: 01.61 against fighter: 0.70 and helicopter: 0.59 mm p = 0.004). There is also a significant correlation between flight time and carotid thickness (p = 0.001, r = 0.380). In addition, there was a significant correlation between the age of the pilots and the thickness of the carotid artery (p = 0.001, r = 0.033) as well as the age of the pilots and the flight time (p = 0.001, r = 0.713). Conclusion: Based on the results, there was no significant relationship between carotid thickness and metabolic syndrome and metabolic syndrome components in the studied pilots.

scholarly journals The optimal WC cut-off points for the prediction of subclinical CVD as measured by carotid intima-media thickness among African adults: a cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
M. C. Ringane ◽  
S. S. R. Choma
Keyword(s):  
Metabolic Syndrome ◽  
Waist Circumference ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Media Thickness ◽  
Bivariate Correlation ◽  
Subclinical Cvd

Abstract Background Increased waist circumference (WC) is one of the cardiovascular disease (CVD) risk factors used to predict cardiovascular events. Waist circumference cut-off values for predicting metabolic syndrome and other cardiovascular risks have been previously studied. Carotid intima-media thickness (CIMT) is one of the cardiovascular risk factor recently described and reported to be suitable as it is a direct measurement of vascular quality. Hence the aim of the present study was to determine the optimal WC cut-off point for the prediction of subclinical CVD. Methods The study was a cross-sectional study using quantitative methods, conducted among 1318 adults aged between 40 and 60 years old, residing in a rural Black population in Limpopo province. Carotid Intima-Media Thickness measurements were performed using a LOGIQ ultrasound system (GE Healthcare, CT, USA). Waist Circumference (WC) (cm) was measured to the nearest 0.1 cm. Bivariate correlation, logistic regression and receiver operating characteristic were analysed using the statistical package for social sciences version 26.0 software. Results Among the total population, 69% were women and 31% men with a mean age of 53 ± 7 years. Among women, WC at a cut-off value of 95 cm gave the highest sensitivity of 57%, the specificity of 55% and an area under the curve (AUC) of 0.588. In men, an optimum WC cut-off point of 82 cm yielded the highest sensitivity and specificity at 72% and 70% respectively, with an AUC of 0.767 p < 0.001. Conclusion The traditional waist circumference cut-off points (94 cm for women and 80 cm for men) that are currently used for the diagnosis of metabolic syndrome might not be suitable in the prediction of an increased CIMT.

scholarly journals Relationships between Serum Uric Acid, Malondialdehyde Levels, and Carotid Intima-Media Thickness in the Patients with Metabolic Syndrome

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Shun-Sheng Wu ◽  
Chew-Teng Kor ◽  
Ting-Yu Chen ◽  
Ko-Hung Liu ◽  
Kai-Lun Shih ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Uric Acid ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Serum Markers ◽  
Oxidative Stress Biomarkers ◽  
Cross Sectional ◽  
Carotid Imt ◽  
Media Thickness

Oxidative stress is the major cause of atherosclerosis and cardiovascular diseases. This cross-sectional study is aimed at determining if parallel serum markers of oxidative stress are related to carotid intima-media thickness (IMT). We enrolled 134 participants with varied metabolic syndrome (Met-S) scores (zero, n=21; one, n=19; two, n=27; three, n=26; four, n=25; five, n=16). Biochemical profiles and potential oxidative stress biomarkers malondialdehyde (MDA) and uric acid were measured in fasting plasma. We found that carotid IMT positively correlated with both MDA and uric acid levels. Multivariate analysis revealed that both MDA (p<0.05) and uric acid (p<0.01) levels were significantly associated with carotid IMT in participants whose Met-S scores were ≥1 or ≥2. However, only uric acid (p<0.01) levels were positively associated with carotid IMT in patients with metabolic syndrome. Linear regression model analysis revealed that the prediction accuracies for carotid IMT from MDA combined with uric acid and from a combination of MDA, uric acid, and Met-S score were 0.176 and 0.237, respectively. These were better than the predication accuracies from MDA (r2=0.075) and uric acid (r2=0.148) individually. These results suggest that measuring uric acid levels along with MDA biomarkers and Met-S scores may be a promising step in the development of an effective model for monitoring the severity of carotid IMT and atherosclerosis in the patients with metabolic syndrome.

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