scholarly journals Analysis of Ovarian Injury Associated With COVID-19 Disease in Reproductive-Aged Women in Wuhan, China: An Observational Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Ting Ding ◽  
Tian Wang ◽  
Jinjin Zhang ◽  
Pengfei Cui ◽  
Zhe Chen ◽  
...  
Keyword(s):  
Linear Regression ◽  
Ovarian Reserve ◽  
Ovarian Function ◽  
Linear Regression Analysis ◽  
Reproductive Age ◽  
Menstrual Status ◽  
Serum Hormone ◽  
Reproductive Endocrine ◽  
Severe Group ◽  
Reproductive Aged Women

Objective: This study was intended to investigate the relationship between COVID-19 disease and ovarian function in reproductive-aged women.Methods: Female COVID-19 patients of reproductive age were recruited between January 28 and March 8, 2020 from Tongji Hospital in Wuhan. Their baseline and clinical characteristics, as well as menstrual conditions, were recorded. Differentials in ovarian reserve markers and sex hormones (including anti-Müllerian hormone [AMH], follicle-stimulating hormone [FSH], the ratio of FSH to luteinizing hormone [LH], estradiol [E2], progesterone [P], testosterone [T], and prolactin [PRL] were compared to those of healthy women who were randomly selected and individually matched for age, region, and menstrual status. Uni- and multi-variable hierarchical linear regression analyses were performed to identify risk factors associated with ovarian function in COVID-19 women.Results: Seventy eight patients agreed to be tested for serum hormone, of whom 17 (21.79%) were diagnosed as the severe group and 39 (50%) were in the basal level group. Menstrual status (P = 0.55), menstrual volumes (P = 0.066), phase of menstrual cycle (P = 0.58), and dysmenorrhea history (P = 0.12) were similar without significant differences between non-severe and severe COVID-19 women. Significant lower serum AMH level/proportion (0.19/0.28 vs. 1.12 ng/ml, P = 0.003/0.027; AMH ≤ 1.1 ng/ml: 75/70.4 vs. 49.7%, P = 0.009/0.004), higher serum T (0.38/0.39 vs. 0.22 ng/ml, P < 0.001/0.001) and PRL (25.43/24.10 vs. 12.12 ng/ml, P < 0.001/0.001) levels were observed in basal level and the all-COVID-19 group compared with healthy age-matched control. When adjusted for age, menstrual status and parity variations in multivariate hierarchical linear regression analysis, COVID-19 disease was significantly associated with serum AMH (β = −0.191; 95% CI: −1.177–0.327; P = 0.001), T (β = 0.411; 95% CI: 11.154–22.709; P < 0.001), and PRL (β = 0.497; 95% CI: 10.787–20.266; P < 0.001), suggesting an independent risk factor for ovarian function, which accounted for 3.2% of the decline in AMH, 14.3% of the increase in T, and 20.7% of the increase in PRL.Conclusion: Ovarian injury, including declined ovarian reserve and reproductive endocrine disorder, can be observed in women with COVID-19. More attention should be paid to their ovarian function under this pandemic, especially regarding reproductive-aged women.Clinical Trial Number: ChiCTR2000030015.

MULTILEVEL LINEAR REGRESSION ANALYSIS OF FACTORS INFLUENCING BODY MASS INDEX AMONG BANGLADESHI MARRIED NON-PREGNANT WOMEN

2016 ◽  
Vol 49 (4) ◽  
pp. 498-508 ◽  
Author(s):  
Md Kamruzzaman ◽  
A. S. M. A. Mamun ◽  
Sheikh Muhammad Abu Bakar ◽  
Aik Saw ◽  
T. Kamarul ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Regression Analysis ◽  
Linear Regression ◽  
Linear Regression Analysis ◽  
Reproductive Age ◽  
Cluster Effect ◽  
Women Of Reproductive Age ◽  
First Marriage ◽  
Factors Influencing ◽  
Age At First Marriage

SummaryThe aim of this study was to investigate the socioeconomic and demographic factors influencing the body mass index (BMI) of non-pregnant married Bangladeshi women of reproductive age. Secondary (Hierarchy) data from the 2011 Bangladesh Demographic and Health Survey, collected using two-stage stratified cluster sampling, were used. Two-level linear regression analysis was performed to remove the cluster effect of the variables. The mean BMI of married non-pregnant Bangladeshi women was 21.60±3.86 kg/m2, and the prevalence of underweight, overweight and obesity was 22.8%, 14.9% and 3.2%, respectively. After removing the cluster effect, age and age at first marriage were found to be positively (p<0.01) related with BMI. Number of children was negatively related with women’s BMI. Lower BMI was especially found among women from rural areas and poor families, with an uneducated husband, with no television at home and who were currently breast-feeding. Age, total children ever born, age at first marriage, type of residence, education level, level of husband’s education, wealth index, having a television at home and practising breast-feeding were found to be important predictors for the BMI of married Bangladeshi non-pregnant women of reproductive age. This information could be used to identify sections of the Bangladeshi population that require special attention, and to develop more effective strategies to resolve the problem of malnutrition.

Serum anti-Müllerian hormone levels in reproductive-age women with relapsing–remitting multiple sclerosis

2014 ◽  
Vol 21 (1) ◽  
pp. 41-47 ◽  
Author(s):  
Jan Thöne ◽  
Susanne Kollar ◽  
Darryl Nousome ◽  
Gisa Ellrichmann ◽  
Ingo Kleiter ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Ovarian Reserve ◽  
Ovarian Function ◽  
Reproductive Age ◽  
Unexpected Finding ◽  
Healthy Controls ◽  
Relapsing Remitting ◽  
Disease Modifying Treatment ◽  
Relapsing Remitting Multiple Sclerosis ◽  
Control Study

Background: Fertility might be reduced in women with multiple sclerosis (MS), although only few studies exist and the underlying reasons are not well understood. Similar to other autoimmune diseases, a decreased ovarian reserve may contribute to impaired fertility in women with MS. Anti-Müllerian hormone (AMH) is an established marker of the ovarian reserve and an objective indicator of ovarian function, which is independent of the hypothalamus-pituitary-gonadal axis function. Objective: The purpose of this study was to determine AMH levels in females with relapsing–remitting MS (RRMS) in combination with other reproduction and lifestyle factors. Methods: A total of 76 reproductive-age females with RRMS and 58 healthy controls were included in this case control study. An enzymatically amplified two-site immunoassay was used to measure serum AMH level. Results: Mean AMH level was significantly decreased in females with RRMS ( p<0.04), and a higher proportion of females with RRMS showed very low AMH values (<0.4 ng/ml) compared to healthy controls ( p<0.05). The majority of these women were currently without any disease modifying treatment. Conclusions: Our data contribute to our understanding of impaired fertility in women with MS. The unexpected finding that the majority of MS subjects with very low AMH levels were currently without medication requires further evaluation.

Opportunities for ovarian reserve preservation in the treatment of oncological diseases

GYNECOLOGY ◽  
2020 ◽  
Vol 21 (6) ◽  
pp. 21-25
Author(s):  
Juliia E. Dobrokhotova ◽  
Kseniia V. Morozova
Keyword(s):  
Cancer Patients ◽  
Ovarian Reserve ◽  
Ovarian Function ◽  
Modern Medicine ◽  
Reproductive Age ◽  
Hormonal Function ◽  
Literary Sources ◽  
Oncological Diseases ◽  
Anticancer Treatment ◽  
Function Preservation

This article presents the data of multi-year research on the problem of ovarian reserve preservation in cancer patients. The review includes 64 literary sources. The review provides the main methods for ovarian function preservation during the treatment of malignant diseases in patients of reproductive age. Given the increasing number of cancer patients in the group of patients of reproductive age, modern medicine is faced with the task not only to provide effective anticancer treatment, but also to try to preserve ovarian function in order to maintain hormonal levels and fertility. Unfortunately, most cancer treatment methods inhibit ovarian function. Thanks to modern approaches, there are medicinal methods for protecting against ovarian inhibition, which allows to maintain hormonal function and come back to solve reproductive problems after recovering from cancer.

scholarly journals Urinary Bisphenol A Concentrations and Parameters of Ovarian Reserve among Women from A Fertility Clinic

2021 ◽  
Vol 18 (15) ◽  
pp. 8041
Author(s):  
Ewelina Czubacka ◽  
Bartosz Wielgomas ◽  
Anna Klimowska ◽  
Michał Radwan ◽  
Paweł Radwan ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Ovarian Reserve ◽  
Animal Studies ◽  
Ovarian Function ◽  
Ion Trap ◽  
Antral Follicle ◽  
Antral Follicle Count ◽  
Fertilization Rate ◽  
Reproductive Age ◽  
Study Participants

Background: Human exposure to environmentally widespread endocrine disruptors, especially bisphenol A (BPA), has been suggested to affect reproductive health. Animal studies indicate that BPA may play a role in the process of reproduction and impact on maturing oocytes, meiotic cell division or fertilization rate. Nevertheless, data regarding the effects of exposure to BPA on women’s ovarian function are still limited. Therefore, the aim of the current study is to assess the effects of environmental exposure to BPA on ovarian reserve. Methods: The study participants consisted of 511 women in reproductive age (25–39 years) who attended an infertility clinic for diagnosis, due to the couples’ infertility. BPA urinary concentrations were assessed by the validated gas chromatography ion-trap mass spectrometry method. The ovarian reserve was assessed using ovarian reserve parameters: Hormones concentrations: E2 (estradiol), FSH (follicle stimulating hormone), AMH (anti-Müllerian hormone), and AFC (antral follicle count). Results: In the present study, the negative association between BPA urinary concentrations and AMH (p = 0.02) and AFC (p = 0.03) levels was found. Exposure to BPA was not related to other examined parameters of ovarian reserve (FSH, E2). Conclusions: Our results suggest that BPA exposure may affect women ovarian reserve parameters and reduce ovarian reserve. As this is one of the first studies of its kind, the findings need confirmation in a further investigation.

scholarly journals Association between thyroid autoimmunity and ovarian reserve in women with hypothyroidism

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Felipe A. Morales-Martínez ◽  
Luis H. Sordia-Hernández ◽  
Martha Merino Ruiz ◽  
Selene Garcia-Luna ◽  
Otto H. Valdés-Martínez ◽  
...  
Keyword(s):  
Ovarian Reserve ◽  
Ovarian Function ◽  
Thyroid Autoimmunity ◽  
Antral Follicle ◽  
Serum Levels ◽  
Antral Follicle Count ◽  
Reproductive Age ◽  
Autoimmune Hypothyroidism ◽  
Thyroid Hormone Concentration ◽  
The Impact

Abstract Background The ovarian function and therefore the ovarian reserve may be compromised by the pathogenesis of autoimmune diseases of which, Hashimoto’s thyroiditis (HT) is the most common in women of reproductive age. Furthermore, a prolonged reduction in thyroid hormone concentration results in a broad spectrum of reproductive alteration. Previous reports in the literature have been controversial regarding the impact of hypothyroidism and alterations in the ovarian reserve. Thus, this prospective and comparative study aimed to evaluate the association of hypothyroidism with low ovarian reserve. Materials and Methods A subset of 27 patients with primary autoimmune hypothyroidism were compared to healthy women. The ovarian reserve was assessed through the anti-Mullerian hormone (AMH) and the antral follicle count (AFC). Results Overall, the two groups did not display significant differences in length of their menstrual cycles neither in the AMH serum levels nor the AFC. Conclusions No significant alteration was found in the ovarian reserve of women with HT.

scholarly journals Mindfulness and Its Predictors in Women With Polycystic Ovary Syndrome

2020 ◽  
Vol 24 (3) ◽  
pp. 246-257
Author(s):  
Roghayeh Arbabi Moghaddam ◽  
◽  
Seyedeh Batool Hasanpoor-Azghady ◽  
Leila Amiri Farahani ◽  
Shima Haghani ◽  
...  
Keyword(s):  
Linear Regression ◽  
Polycystic Ovary Syndrome ◽  
Multiple Linear Regression ◽  
Polycystic Ovary ◽  
Pearson Correlation ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Model ◽  
Multiple Linear Regression Analysis ◽  
Reproductive Age ◽  
Ovary Syndrome

Background: Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder in women of reproductive age which can cause many problems such as hyperandrogenic symptoms and fertility problems. Objective: The present study aimed to determine the relationship of mindfulness with hyperandrogenic symptoms and demographic and fertility factors in women with PCOS. Methods: This descriptive correlational study was conducted on 181 women with PCOS referred to Firoozabadi and Firoozgar hospitals in Tehran, Iran who were selected using a continuous sampling method and based on inclusion criteria from June 2018 to August 2019. Data were collected using a demographic/fertility form, the modified Ferriman-Gallwey Scale, Ludwig Hair Loss Scale, and Mindfulness Attention Awareness Scale (MAAS). Data were analyzed using independent t-test, one-way ANOVA, Kruskal-Wallis test, Pearson correlation test, and multiple linear regression analysis. Findings: The mean MAAS score of women was 68.61±9.88 and was significantly correlated with age (P=0.01), wife’s education (P=0.001), wife’s occupation (P=0.005), economic status (P=0.02), husband satisfaction with wife’s body and appearance (P=0.02), body mass index (P=0.01), and duration of marriage (P<0.001). According to the multiple linear regression model, the duration of marriage could predict 22% of the variance in overall MAAS score. Conclusion: Mindfulness is associated with some demographic variables, among which the marriage is its predictor. It is recommended to pay attention to the reported variables in preparation of counseling or educational programs, along with other treatments, for women with PCOS.

EVALUATION OF OVARIAN RESERVE IN FEMALE INFERTILITY

2021 ◽  
pp. 45-45
Author(s):  
Renuka Keshri ◽  
Chandni Singh
Keyword(s):  
Ovarian Reserve ◽  
Function Method ◽  
Ovarian Function ◽  
Age Groups ◽  
Female Infertility ◽  
Reproductive Age ◽  
Age Group ◽  
Level Variation ◽  
Reliable Test ◽  
Reproductive Age Group

INTRODUCTION: Infertility is not uncommon amongst females in reproductive age group. Different hormones like antimullerian hormone (AmH) and FSH levels are expression of ovarian function. The changes in AmH level precedes FSH level variation in detecting decline in ovarian function. METHOD : In our study, we have assessed AmH level in different age groups of females suffering from infertility to evaluate ovarian reserve in them. RESULT : Our study shows that with advancing age ovarian function declines as evidenced by decrease in AmH level causing female infertility. CONCLUSION : AmH level estimation is an important tool to assess ovarian reserve in female infertility. It is a simple, less expensive and reliable test before further investigations to nd out other etiologies of infertility

scholarly journals The Effects of Endometriosis on Ovarian Functions

Endocrines ◽  
2021 ◽  
Vol 2 (2) ◽  
pp. 142-149
Author(s):  
Michio Kitajima ◽  
Kanako Matsumoto ◽  
Itsuki Kajimura ◽  
Ayumi Harada ◽  
Noriko Miyashita ◽  
...  
Keyword(s):  
Ovarian Reserve ◽  
Ovarian Function ◽  
Follicular Development ◽  
Reproductive Age ◽  
Ovarian Hormone ◽  
Hormone Production ◽  
Bilateral Involvement ◽  
Diminish Ovarian Reserve ◽  
Ovarian Endometrioma ◽  
Firm Evidence

Infertility is a main manifestation of endometriosis, though the exact pathogenesis of endometriosis-associated infertility remains unclear. Compromised ovarian functions may be one of the causes of endometriosis related infertility. The ovarian function can be classified into three basic elements, (1) production of ovarian hormones, (2) maintenance of follicular development until ovulation, and (3) reservoir of dormant oocytes (ovarian reserve). The effects of endometriosis on ovarian hormone production and follicular development are inconclusive. Ovarian endometrioma is common phonotype of endometriosis. Development of endometrioma per se may affect ovarian reserve. Surgery for endometriomas further diminish ovarian reserve, especially women with bilateral involvement. Early intervention with surgery and/or medical treatment may be beneficial, though firm evidence is lacking. When surgery is chosen in women at reproductive age, specific techniques that spare ovarian function should be considered.

scholarly journals AB0085 ANTI-MULLERIAN HORMONE IN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE)

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1072.2-1072
Author(s):  
Z. Alekberova ◽  
R. Goloeva ◽  
M. Cherkasova ◽  
A. Lila
Keyword(s):  
Disease Activity ◽  
Reference Values ◽  
Ovarian Reserve ◽  
Ovarian Function ◽  
Reproductive Age ◽  
Control Group ◽  
Surgical Removal ◽  
Potential Contribution ◽  
Dependent Manner ◽  
Gynecological Diseases

Background:Anti-Mullerian hormone (AMH) is one of the key parameters for assessing reproductive function and ovarian reserve. The level of AMH correlates with the residual follicular pool in women of reproductive age.Objectives:To assess AMH levels in SLE female patients of child-bearing potential, and analyze the relationship between AMH levels and disease severity, as well as relationship between serum AMH levels and different therapeutic regimens.Methods:The study group included 12 women with SLE aged 20-40 years, and the control group - 15 age-matching healthy women. SLE diagnosis was established based on the EULAR/ACR classification criteria, 2019. The SLEDAI 2K was used to evaluate disease activity, and the SLICC index – to evaluate damage. AMH levels was measured using ELISA. AMH reference values ranged within 1.0-10.6 ng / ml. Values <1.0 were interpreted as a decreased ovarian reserve.Results:SLE patients’ mean age was 33.5 [29;38] years, and control group subjects’ - 32.0 [26;35] years. Mean disease duration was 11.5 [2.8;18] years. Acute, subacute and chronic SLE was established in 33%, 17%, and 50%, respectively. Disease activity according to SLEDAI 2K was low in 25%, moderate – in 33%, and high – in 42% of pts. The SLICC damage baseline evaluation: no damage – 17%, low – 50%, medium – 16.5%, high-16.5%.Mean AMH level was 3.5 ng/ml in SLE pts, and 3.1 ng/ml - in the control group, showing no statistical difference. A decrease in ovarian reserve (AMH less than 1.0 ng / ml) was significantly more common in SLE pts - 42% vs 13% in the control group. No correlation was found between AMH levels and the SLICC damage index, AMH and SLEDAI 2K, as well as AMH and SLE duration or clinical course.Detailed analysis showed that all pts with reduced ovarian function had CP included into their therapeutic regimens; the only exclusion within this subgroup – i.e., normal AMH level-6 ng/ml and preserved ovarian function - was documented in a patient who received a cumulative CP dose of 5.6 g. In all other patients a cumulative CP dose was higher, i.e.: 7.2 g, 7.8 g, 10.6 g, and 18.4 g – 1 patient per each dose value. Three pts with low AMH levels within 0.1 -0.3 ng/ml were 39 years old, while AMH reference values in 33-39y age group are 0.77-5.24 ng / ml.Analysis of gynecological history indicate that episodes of menstrual disorders were significantly more often reported in SLE pts (50% vs 20% in controls, p=0.001), similarly, gynecological diseases were also documented in 50% of SLE pts (chronic salpyngo-oophoritis, colpitis, endometriosis and uterine endometrioma, subserous uterine myoma, cervical dysplasia, cervical erosion), meanwhile low AMH was found only in 4 SLE pts; there was only 1 subject with gynecological condition – teratoma of the ovaries – in the control group (favorable outcome – surgical removal, preserved fertility and two births after surgery).Conclusion:Ovarian reserve was significantly more often reduced in women with SLE compared to healthy controls. CP therapy negatively affects ovarian function, and most likely in a dose-dependent manner. In this study, 4 out of 5 patients with reduced ovarian function had gynecological diseases additionally compromising the ovarian reserve. Further studies are needed to clarify potential contribution of both - autoimmune inflammation and SLE therapy – into development of gynecological diseases and loss of fertility.Disclosure of Interests:None declared

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