scholarly journals Association Between Serum Follicle-Stimulating Hormone and Sarcopenia and Physical Disability Among Older Chinese Men: Evidence From a Cross-Sectional Study

2022 ◽  
Vol 8 ◽  
Author(s):  
Yingying Ke ◽  
Jun Xu ◽  
Xiaoyan Zhang ◽  
Qihao Guo ◽  
Yunxia Zhu
Keyword(s):  
Muscle Mass ◽  
Follicle Stimulating Hormone ◽  
Older Men ◽  
Geriatric Syndrome ◽  
Calf Circumference ◽  
Cross Sectional ◽  
Adverse Health ◽  
European Working ◽  
Iadl Disability ◽  
Stimulating Hormone

Background: Sarcopenia is a geriatric syndrome characterized by progressive loss of muscle mass, function and quality and associated with a range of adverse health outcomes including disability. Despite a negative correlation between muscle mass and follicle-stimulating hormone (FSH) levels in postmenopausal women, it is unclear if FSH is associated with sarcopenia and its poor outcomes, especially in older men.Methods: We used cross-sectional data from 360 men aged over 80 who participated in health check-ups to investigate correlations between serum FSH and sarcopenia, individual sarcopenia components, low physical performance (gait speed ≤ 0.8 m/s) and instrumental activities of daily living (IADL) disability. Sarcopenia and severe sarcopenia were diagnosed according to the revised definition of the European Working Group on Sarcopenia in Old People (EWGSOP2).Results: The prevalence of sarcopenia was 17.8% in this population. In binary logistic regression analysis, compared with higher FSH group, lower FSH group showed a significant reduction in the risk of low calf circumference (a surrogate for muscle mass; OR 0.308, 95% CI 0.109–0.868, P = 0.026) after adjusting potential confounders including age, waist circumference, education, exercise, associated biochemical parameters, other sex hormones and high-sensitivity C-reactive protein. The correlation between FSH and low handgrip strength was marginally significant (OR 0.390, 95% CI 0.151–1.005, P = 0.051). No associations were observed between FSH and sarcopenia, severe sarcopenia, and disability in adjusted models.Conclusion: In older men, circulating FSH was not associated with sarcopenia, sarcopenia severity, the majority of its components and adverse health outcome (IADL disability), with the exception of low calf circumference. Further work is needed to better elucidate the association of FSH and low muscle quantity by adopting more accurate measurement method of appendicular skeletal muscle mass such as DXA, CT or MRI.

scholarly journals High Circulating Follicle-Stimulating Hormone Level Is a Potential Risk Factor for Renal Dysfunction in Post-Menopausal Women

2021 ◽  
Vol 12 ◽  
Author(s):  
Qihang Li ◽  
Dongmei Zheng ◽  
Haiyan Lin ◽  
Fang Zhong ◽  
Jing Liu ◽  
...  
Keyword(s):  
Renal Function ◽  
Risk Factor ◽  
Renal Dysfunction ◽  
Clinical Chemistry ◽  
Follicle Stimulating Hormone ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Menopausal Women ◽  
Post Menopausal ◽  
Stimulating Hormone

ObjectiveMenopause contributes to renal dysfunction in women, which is generally attributed to estrogen withdrawal. In addition to decreased estrogen level, serum follicle-stimulating hormone (FSH) level increases after menopause. This study investigated the association between high circulating FSH level and renal function in post-menopausal women.MethodsThis observational cross-sectional study included 624 pre-menopausal, 121 peri-menopausal, and 2540 post-menopausal women. The levels of female sex hormones were examined by chemiluminescence and indices of renal function were measured using a clinical chemistry analyzer. The post-menopausal women were grouped into quartiles according to serum FSH levels.ResultsRenal function progressively declined from pre-menopause to peri-menopause to post-menopause, which was accompanied by increasing serum FSH level. In post-menopausal women, serum creatinine level increased with increasing FSH quartile, which was accompanied by a decrease in estimated glomerular filtration rate (eGFR) (p for trend <0.001); moreover, the prevalence of declined eGFR (<90 ml/min/1.73 m2) and chronic kidney disease (CKD; eGFR <60 ml/min/1.73 m2) increased (p for trend <0.001). Even after adjusting for confounders, the odds ratios (ORs) of declined eGFR and CKD increased with increasing FSH quartiles in post-menopausal women. The ORs of declined eGFR (OR=2.19, 95% confidence interval [CI]: 1.63–2.92) and CKD (OR=10.09, 95% CI: 2.28–44.65) in the highest FSH quartile were approximately 2- and 10-fold higher, respectively, than in the lowest FSH quartile (p<0.05). After stratifying post-menopausal women by median age (61 years), the OR for declined eGFR for each FSH quartile in the older group was higher than that for the corresponding FSH quartile in the younger group.ConclusionsA high circulating FSH level is an independent risk factor for renal dysfunction in women after menopause. Additionally, aging may aggravate the association of high FSH levels with reduced renal function in post-menopausal women.

scholarly journals Dynapenia and Sarcopenia as a Risk Factor for Disability in a Falls and Fractures Clinic in Older Persons

2018 ◽  
Vol 6 (2) ◽  
pp. 344-349 ◽  
Author(s):  
Angela-María Benjumea ◽  
Carmen-Lucía Curcio ◽  
Gustavo Duque ◽  
Fernando Gomez
Keyword(s):  
Older Persons ◽  
Functional Decline ◽  
Cross Sectional Study ◽  
High Risk Population ◽  
Cross Sectional ◽  
Systematic Assessment ◽  
Skeletal Mass ◽  
Health Clinics ◽  
European Working ◽  
Iadl Disability

BACKGROUND: The role of sarcopenia and dynapenia in disability in older persons from falls and bone health clinics remain unknown.AIM: This study aims to compare the association of sarcopenia and dynapenia with physical and instrumental disability in a population of older persons attending a falls and fractures clinic.METHODS: This is a cross-sectional study in Manizales, Andes Mountains, Colombia.  534 subjects (mean age = 74, 75% female) Sarcopenia was measured according to the European Working Group on Sarcopenia in Older People (EWGSOP) including an index of skeletal mass, muscle strength, and gait speed. Dynapenia was defined as a handgrip force ≤ 30 kg for men and ≤ 20 kg for women.RESULTS: Dynapenia and sarcopenia were present in 84.6% and 71.2% respectively. Both were more prevalent in older subjects and women than men.  While sarcopenia was associated with body mass index and hypertension, dynapenia was associated with hypothyroidism and visual impairment.  After controlling for all covariates, sarcopenia was associated with low IADL and mobility disability.CONCLUSIONS: Sarcopenia was associated with mobility, ADL and IADL disability. Dynapenia was not associated with disability in this high - risk population. Systematic assessment of sarcopenia should be implemented in falls and fractures clinics to identify sarcopenia and develop interventions to prevent functional decline among elderly individuals.

scholarly journals THE EFFECT OF DEPOT MEDROXYPROGESTERONE ACETATE ADMINISTRATION ON THE LEVELS OF FOLLICLE-STIMULATING HORMONE, PROGESTERONE, ESTRADIOL, AND CALCIUM

2019 ◽  
Vol 12 (1) ◽  
pp. 293 ◽  
Author(s):  
Nurelilasari Siregar ◽  
Rauza Sukma Rita ◽  
Yusrawati Yusrawati
Keyword(s):  
Health Care ◽  
Medroxyprogesterone Acetate ◽  
Follicle Stimulating Hormone ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Depot Medroxyprogesterone Acetate ◽  
Significant Difference ◽  
Kolmogorov Smirnov ◽  
Estradiol Levels ◽  
Stimulating Hormone

Objective: The purpose of this research is to determine the effect of depot medroxyprogesterone acetate (DMPA) on the levels of follicle-stimulating hormone (FSH), progesterone, estradiol, and calcium.Methods: This was a cross-sectional study, this study was conducted in the region of Lubuk Buaya Health Care and Andalas Health Care on September– November 2017. Examination of FSH, progesterone, and estradiol levels was performed in the Laboratory Biomedicine, Faculty of Medicine, Andalas University by ELISA method, and the examination of calcium level was performed in Laboratory Biochemistry, Faculty of Medicine, Andalas University by calcium Arsenazo method. Then, the data were analyzed by Kolmogorov–Smirnov and independent t-test.Results: This study showed that there was a significant difference of FSH, progesterone, estradiol, and calcium levels on KB DMPA acceptors and non-acceptors with p<0.05.Conclusion: The use of contraception DMPA has the effect on the levels of FSH, progesterone, estradiol, and calcium in the blood.

scholarly journals Prevalence of Sarcopenia in Community-Dwelling Older Adults in Valencia, Spain

2020 ◽  
Vol 17 (23) ◽  
pp. 9130
Author(s):  
Carlos Guillamón-Escudero ◽  
Angela Diago-Galmés ◽  
Jose M. Tenías-Burillo ◽  
Jose M. Soriano ◽  
Julio J. Fernández-Garrido
Keyword(s):  
Older Adults ◽  
Muscle Mass ◽  
Cross Sectional Study ◽  
Community Dwelling ◽  
Cross Sectional ◽  
Men And Women ◽  
Sit To Stand ◽  
European Working ◽  
Appendicular Skeletal Muscle ◽  
Different Populations

This study is an observational and cross-sectional study on the prevalence of sarcopenic disease in 202 autonomous older adults; 18.8 and 81.2% were men and women, respectively, living in their own homes in Valencia, Spain. Sarcopenia was diagnosed using the criteria and cutting points for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), using the tests: SARC-F, grip strength, sit-to-stand, gait speed, appendicular skeletal muscle mass and short physical performance battery. According to the EWGSOP2 criteria, probable sarcopenia was present in 21.1% and 18.3% of men and women, respectively, and the sum of confirmed and severe sarcopenia was 7.9% and 7.3% in men and in women, respectively. A relationship was shown between the prevalence of the disease and the age of the participants, but no significant differences were found between the sum of confirmed and severe sarcopenia between the sexes, nor a relationship between the amount of muscle mass and the strength of grip. The SARC-F questionnaire diagnosed 40% of the sarcopenia cases present in the study. More thorough research is needed to continue using the EWGSOP2 criteria in different populations to establish a correct prevalence of sarcopenic disease in different populations of the world.

Sarcopenia and its components in adult renal transplant recipients: prevalence and association with body adiposity

2019 ◽  
Vol 122 (12) ◽  
pp. 1386-1397 ◽  
Author(s):  
Ana Paula Medeiros Menna Barreto ◽  
Maria Inês Barreto Silva ◽  
Karine Scanci da Silva Pontes ◽  
Mariana Silva da Costa ◽  
Kelli Trindade de Carvalho Rosina ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Muscle Mass ◽  
Physical Performance ◽  
Muscle Function ◽  
Adverse Outcomes ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Cross Sectional ◽  
Body Adiposity ◽  
European Working

AbstractSarcopenia is a progressive and generalised skeletal muscle disorder associated with adverse outcomes. Ageing causes primary sarcopenia, while secondary causes include chronic kidney disease (CKD), long-term use of glucocorticoids and obesity. The aim of the present study was to evaluate the prevalence of sarcopenia using guidelines recommended by the European Working Group on Sarcopenia in Older People (EWGSOP, 2010; EWGSOP2, 2018) and the Foundation of the National Institutes of Health (FNIH) and analyse the relationship between sarcopenia and body adiposity in adult renal transplant recipients (RTR). This was a cross-sectional study of adult RTR (BMI ≥ 18·5 kg/m2). Body composition was evaluated by dual-energy X-ray absorptiometry (DXA) and anthropometry. Glomerular filtration rate was estimated (eGFR) by CKD-Epidemiology Collaboration equation. The prevalence of sarcopenia in adult RTR (n 185; 57 % men, 50 (se 0·82) years and eGFR 55·80 (se 1·52) ml/min) was 7 % (FNIH), 11 % (EWGSOP2) and 17 % (EWGSOP). Low muscle mass, muscle function and physical performance affected, respectively, up to 28, 46 and 10 % of the participants. According to EWGSOP and EWGSOP2, body adiposity evaluated by anthropometry and DXA (percentage trunk fat) was lower in participants with sarcopenia. Conversely, according to the FNIH criteria, RTR with sarcopenia presented higher waist:height ratio. The present study suggests that adult RTR sarcopenia prevalence varies according to the diagnostic criteria; low muscle mass, low muscle function and low physical performance are common conditions; the association of body adiposity and sarcopenia depends on the criteria used to define this syndrome; and the FNIH criteria detected higher adiposity in individuals with sarcopenia.

Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men

Metabolism ◽  
1997 ◽  
Vol 46 (4) ◽  
pp. 410-413 ◽  
Author(s):  
John E. Morley ◽  
Fran E. Kaiser ◽  
Horace M. Perry ◽  
Ping Patrick ◽  
Patricia M.K. Morley ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Follicle Stimulating Hormone ◽  
Older Men ◽  
Longitudinal Changes ◽  
Stimulating Hormone

scholarly journals Comparison of revised EWGSOP2 criteria of sarcopenia in patients with cancer using different parameters of muscle mass

PLoS ONE ◽  
2021 ◽  
Vol 16 (9) ◽  
pp. e0257446
Author(s):  
Ana Paula Trussardi Fayh ◽  
Iasmin Matias de Sousa
Keyword(s):  
Cancer Patients ◽  
Muscle Mass ◽  
Handgrip Strength ◽  
Lumbar Vertebra ◽  
Cross Sectional Study ◽  
Diagnostic Methods ◽  
Cross Sectional ◽  
Kappa Test ◽  
European Working ◽  
Sensitivity Specificity

Calf circumference (CC) has been established as a marker of muscle mass (MM) with good performance for predicting survival in individuals with cancer. The study aims to determine the prevalence of sarcopenia according to the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) criteria and to evaluate the accuracy of sarcopenia using low CC relative to MM assessment by computed tomography (CT) at third lumbar vertebra level (L3) as a reference. Cross-sectional study with cancer patients aged ≥ 60 years. Data included socio-demographic, clinical and anthropometric variables. MM was assessed by CC and by CT images at the L3. Sarcopenia was diagnosed according to the EWGSOP2 criteria: a) low handgrip strength (HGS) + reduced MM evaluated by CT; and b) low HGS + low CC. Pearson’s correlation, accuracy, sensitivity, specificity, positive predictive and negative predictive value were analyzed. A total of 108 patients were evaluated, age of 70.6 ± 7.4 years (mean ± standard deviation). The prevalence of sarcopenia was of 24.1% (low MM) and 25.9% (low CC). The Kappa test showed a substantial agreement (K = 0.704), 81% sensitivity, and 92% specificity. Although the EWGSOP2 advises that we should use CC measures in the algorithm for sarcopenia when no other MM diagnostic methods are available, the findings allow the use of CC instead of MM by CT in cancer patients.

scholarly journals Sarcopenia em idosas quilombolas : Análise das variáveis antropométricas e de força de preensão manual

2017 ◽  
Vol 4 (3) ◽  
pp. 9 ◽  
Author(s):  
Brigida Silva Cunha ◽  
Carla Rejane Gonçalves de Souza ◽  
Lorena Ohrana Braz Prudente ◽  
Neila Barbosa Osório ◽  
Luiz Sinésio da Silva Neto
Keyword(s):  
Muscle Mass ◽  
Physical Performance ◽  
Working Group ◽  
Elderly Women ◽  
Fat Free Mass ◽  
Geriatric Syndrome ◽  
Group Consensus ◽  
Functional Impairments ◽  
European Working Group ◽  
European Working

A sarcopenia é uma síndrome geriátrica com prejuízos na massa e força muscular e desempenho físico e está associada a agravos na funcionalidade e qualidade de vida. Nesse sentido, a compreensão das características antropométricas e funcionais em idosos é adjuvante, em especial nas populações vulneráveis como as quilombolas. O objetivo desse estudo é analisar a sarcopenia, força de preensão manual (FPM) e variáveis antropométricas em idosas quilombolas. A amostra foi composta por 39 mulheres com idade média de 63,77±7,58 anos, das comunidades quilombolas de Malhadinha e Córrego Fundo-Tocantins. Para o diagnóstico de sarcopenia foi utilizado o critério proposto pelo European Working Group consensus (EWGSOP). As variáveis de composição corporal analisadas foram peso, estatura, IMC, circunferência da cintura (CC), circunferência do quadril (CQ), relação cintura quadril (RCQ), percentual de gordura (%G) e massa livre de gordura apendicular (MLGA). A mensuração da massa muscular foi realizada pelo exame de absormetria de raios-x de dupla energia (DXA). A FPM foi obtida por meio do dinamômetro modelo Saehan. A velocidade de marcha foi utilizada para status de desempenho físico. A prevalência de sarcopenia foi de 7,69%. Foram encontradas diferenças significativas de peso (p=0,004), IMC (p=0,005), CC (p=0,002), CQ (p=0,045), MLGA (p=0,001), %G (p=0,002) e FPM (p=0,038), revelando valores médios inferiores nas idosas sarcopênicas. Portanto, a condição de sarcopênica revelou prejuízos na funcionalidade. A medida do IMC pode ser um marcador clínico para sarcopenia. A adoção de medidas que minimizem os prejuízos da sarcopenia como a baixa massa magra e FPM são necessárias.         Palavras-chave: Sarcopenia. Idosos. Quilombolas. Força de Preensão Manual. População Vulnerável. ABSTRACT Sarcopenia is a geriatric syndrome with losses in muscle mass and strength and physical performance and is associated with impairments in functionality and quality of life. In this sense, the understanding of the anthropometric and functional characteristics in the elderly is adjuvant, especially in vulnerable populations such as quilombolas. The objective of this study is to analyze sarcopenia, manual grip strength (MPF) and anthropometric variables in quilombolate elderly women. The sample consisted of 39 women with a mean age of 63.77 ± 7.58 years, from the quilombola communities of Malhadinha and Córrego Fundo-Tocantins. For the diagnosis of sarcopenia, the criterion proposed by the European Working Group consensus (EWGSOP) was used. The variables of body composition analyzed were weight, height, BMI, waist circumference (WC), hip circumference (HR), waist hip ratio (WHR), fat percentage (% G) and appendicular fat free mass . Muscle mass measurement was performed by double-energy x-ray absorptiometry (DXA). FPM was obtained using the Saehan model dynamometer. Travel speed was used for physical performance status. The prevalence of sarcopenia was 7.69%. There were significant differences in weight (p = 0.004), BMI (p = 0.005), WC (p = 0.002), CQ (p = 0.045), MLGA (p = 0.001),% G P = 0.038), revealing lower mean values in the sarcopenic elderly. Therefore, the sarcopenic condition revealed functional impairments. Measurement of BMI may be a clinical marker for sarcopenia. The adoption of measures that minimize the losses of sarcopenia such as low lean mass and FPM are necessary.                                         Keywords: Sarcopenia. Elderly. Quilombolas. Handgrip strength. Vulnerable population.

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