Role of BMI in the Relationship Between Dietary Inflammatory Index and Depression: An Intermediary Analysis

Introduction: This study investigated this association and the role of BMI in the inflammatory process in a large population-based observational study.Methods: A total of 1,865 elderly people (≥55 years) were followed from the Community Cohort Study of Nervous System Diseases (CCSNSD) cohort study from 2018 to 2019 (Mean [SD] age, 66.31 [0.32] years; 716 [38.4%] males). The semi-quantitative FFQ and geriatric depression scale (GDS) were used to evaluate the diet and depressive symptoms of the elderly, respectively. The multivariable logistic regression model estimated the OR and 95% CI between Empirical Dietary Inflammatory Index (E-DII) and depression. The interaction of E-DII and BMI on depressive events was tested, and the mediation analysis of BMI was performed.Results: As measured by E-DII, the mean (SE) value of the inflammatory potential of the diet in our study was 1.56 (0.12). E-DII ranged from 5.23 to 5.58. In comparison with the first quartile, the elderly from the second quartile (OR: 1.15 [95% CI: 1.09, 1.28]) to the fourth quartile (OR: 1.31 [95% CI: 1.16, 1.42]) have a higher risk of depression before adjustment for BMI. An interaction was observed between E-DII and BMI in terms of the risk of depression (PInteraction < 0.001). The whole related part is mediated by BMI (31.06%).Conclusion: Our findings indicate that the higher pro-inflammatory potential of diet is associated with a higher risk of depression, and this association may be mediated by BMI. Further research is needed to verify our findings and clarify the latent mechanism.

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Dietary inflammatory index and risk of multiple sclerosis: Findings from a large population-based incident case–control study

Clinical Nutrition ◽

10.1016/j.clnu.2020.02.033 ◽

2020 ◽

Vol 39 (11) ◽

pp. 3402-3407 ◽

Cited By ~ 1

Author(s):

Ibrahim Abdollahpour ◽

Dejan Jakimovski ◽

Nitin Shivappa ◽

James R. Hébert ◽

Farhad Vahid ◽

...

Keyword(s):

Multiple Sclerosis ◽

Case Control Study ◽

Large Population ◽

Population Based ◽

Case Control ◽

Dietary Inflammatory Index ◽

Incident Case ◽

Inflammatory Index ◽

Control Study

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Dietary Inflammatory Index and Recurrence of Depressive Symptoms

Clinical Psychological Science ◽

10.1177/2167702616645777 ◽

2016 ◽

Vol 4 (6) ◽

pp. 1125-1134 ◽

Cited By ~ 45

Author(s):

Tasnime N. Akbaraly ◽

Clarisse Kerleau ◽

Marilyn Wyart ◽

Nathalie Chevallier ◽

Louise Ndiaye ◽

...

Keyword(s):

Depressive Symptoms ◽

Depression Scale ◽

Epidemiologic Studies ◽

Dietary Inflammatory Index ◽

C Reactive Protein ◽

Inflammatory Index ◽

Reactive Protein ◽

Circulating Inflammatory Markers

There is a growing interest in understanding the role of inflammation in the diet–depression relationship. The present study examined whether the Dietary Inflammatory Index (DII; a measure of the inflammatory potential of individuals’ diets) is associated with recurrent depressive symptoms (DepS) (Center for Epidemiologic Studies Depression Scale score > 16 or taking antidepressants both at baseline and follow-up) assessed over 5 years in middle-aged men ( n = 3,178) and women ( n = 1,068) from the Whitehall II Study. For each increment of 1 SD of DII score, odds of recurrent DepS increased by 66% (95% confidence interval [CI] = [1.30, 2.12]) in women, whereas no significant association between DII and recurrent DepS was observed in men (odds ratio [OR] = 1.12; 95% CI = [0.92, 1.36]). This association was little attenuated after adjustment for confounders and after taking into account levels of interleukin-6 and C-reactive protein. In conclusion, there is an association between proinflammatory diet and recurrent DepS in women that seems to not be driven by circulating inflammatory markers.

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Association of C-Reactive Protein with Risk of Developing Type 2 Diabetes Mellitus, and Role of Obesity and Hypertension: A Large Population-Based Korean Cohort Study

Scientific Reports ◽

10.1038/s41598-019-40987-8 ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 8

Author(s):

Suganya Kanmani ◽

Minji Kwon ◽

Moon-Kyung Shin ◽

Mi Kyung Kim

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Cohort Study ◽

Large Population ◽

Population Based ◽

C Reactive Protein ◽

Reactive Protein

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The relationship between the dietary inflammatory index and risk of total cardiovascular disease, ischemic heart disease and cerebrovascular disease: Findings from an Australian population-based prospective cohort study of women

Atherosclerosis ◽

10.1016/j.atherosclerosis.2016.07.929 ◽

2016 ◽

Vol 253 ◽

pp. 164-170 ◽

Cited By ~ 31

Author(s):

Linda E.T. Vissers ◽

Michael A. Waller ◽

Yvonne T. van der Schouw ◽

James R. Hebert ◽

Nitin Shivappa ◽

...

Keyword(s):

Cardiovascular Disease ◽

Cohort Study ◽

Heart Disease ◽

Ischemic Heart Disease ◽

Prospective Cohort ◽

Population Based ◽

Dietary Inflammatory Index ◽

Australian Population ◽

Inflammatory Index ◽

The Relationship

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Diet, physical activity and cognitive impairment among elders: the EPIC–Greece cohort (European Prospective Investigation into Cancer and Nutrition)

Public Health Nutrition ◽

10.1017/s1368980007001607 ◽

2008 ◽

Vol 11 (10) ◽

pp. 1054-1062 ◽

Cited By ~ 99

Author(s):

T Psaltopoulou ◽

A Kyrozis ◽

P Stathopoulos ◽

D Trichopoulos ◽

D Vassilopoulos ◽

...

Keyword(s):

Physical Activity ◽

Cognitive Function ◽

Formal Education ◽

Mmse Score ◽

Affective State ◽

Geriatric Depression Scale ◽

Depression Scale ◽

The Elderly ◽

Population Based ◽

Prospective Investigation

AbstractObjectivesTo identify dietary and lifestyle variables that may affect cognitive function in the elderly.DesignPopulation-based prospective cohort study.SettingGeneral community residing in Athens and the surrounding Attica region of Greece.SubjectsA total of 732 men and women, 60 years or older, participating in the EPIC–Greece cohort (European Prospective Investigation into Cancer and Nutrition) and residing in the Attica region had sociodemographic, anthropometric, medical, dietary and lifestyle variables ascertained at enrolment (1993–1999). Six to 13 years later, cognitive function was evaluated through the Mini-Mental State Examination (MMSE) score and affective state through the Geriatric Depression Scale (GDS).ResultsMMSE score was positively associated with years of formal education, height and physical activity and inversely with age, diabetes mellitus and GDS score (P < 0·05 for all). Among dietary variables, intake of PUFA was inversely associated with cognitive function and this association was largely accounted for by a similar association with seed oils. Adherence to the Mediterranean diet, as well as intake of olive oil, MUFA and SFA exhibited weakly positive but not significant associations.ConclusionPhysical activity and early life factors as reflected in height are significant predictors of cognitive function in the elderly. Seed oil consumption may adversely affect cognition, whereas other nutritional factors do not appear to have a quantitatively large effect.

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Associations between Body Composition and Mortality: A Large Population-Based Cohort Study

SSRN Electronic Journal ◽

10.2139/ssrn.3529465 ◽

2020 ◽

Author(s):

Fu-Rong Li ◽

Pei-Liang Chen ◽

Xin Cheng ◽

Hai-Lian Yang ◽

Wen-Fang Zhong ◽

...

Keyword(s):

Body Composition ◽

Cohort Study ◽

Large Population ◽

Population Based

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Evaluation of Malnutrition and Depression in Elderly People: An Epidemiological Study in Turkey

European Journal of Public Health ◽

10.1093/eurpub/ckz187.033 ◽

2019 ◽

Vol 29 (Supplement_4) ◽

Author(s):

S Aydoğan ◽

A Ünsal ◽

D Arslantaş

Keyword(s):

Health Care Providers ◽

Nutritional Assessment ◽

Short Form ◽

Geriatric Depression Scale ◽

Depression Scale ◽

Mini Nutritional Assessment ◽

The Elderly ◽

Cluster Sampling ◽

Care Providers ◽

Cross Sectional

Abstract Background Malnutrition is an important cause of morbidity and mortality. Malnutrition increases the number of hospitalizations and prolongs the length of hospitalization by disrupting organ functions, increasing the number and severity of infections and delaying wound healing. The aim of this study was to determine the frequency of suspected malnutrition in the elderly, to examine some related variables and to evaluate the depression. Methods The study is a cross-sectional study conducted between March-April 2019 in individuals aged 60 years and older living in Sivrihisar. Sample size was calculated as 579. Cluster sampling method used. Data was collected by door to door in 4 neighborhoods determined by randomly. Mini Nutritional Assessment Test-Short Form (for malnutrition), Katz Daily Living Activities Scale (for dependency) and Geriatric Depression Scale-Short Form (for depression) were used. Chi-square test, Mann Whitney U test and logistic regression analysis were used for the analyzes. Results The study group consisted of 220 (38%) women and 359 (62%) men. The mean age was 68.9±6.4 (ranged 60-93). Frequency of suspected malnutrition was 25% (n = 145). Being 80 years of age or older (OR:3.24, CI:1.53-6.85), having a primary and lower education level (OR:2.54, CI:1.32-4.90), history of chronic illness (OR:2.34, CI:1.33-4.03), using dentures (OR:1.62, CI:1.03-2.55) and suspected depression (OR:4.97, CI:3.17-7.78) are important risk factors for malnutrition. Those with suspicion of malnutrition had lower scores on DLA (z = 8.982;p=0.001). Conclusions Malnutrition was found to be an important health problem for the elderly. The frequency of suspected malnutrition is higher in individuals with depression. Those with suspected malnutrition have higher level of dependency. In order to reduce the frequency of malnutrition, it may be beneficial to increase the awareness of the elderly and caregivers and to give importance to the elderly nutrition of primary health care providers. Key messages Depression is an important risk factor for malnutrition. Malnutrition increases the dependence of the individual on daily activities.

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