scholarly journals Ikaros Proteins in Tumor: Current Perspectives and New Developments

2021 ◽  
Vol 8 ◽  
Author(s):  
Ruolan Xia ◽  
Yuan Cheng ◽  
Xuejiao Han ◽  
Yuquan Wei ◽  
Xiawei Wei
Keyword(s):  
Drug Resistance ◽  
Clinical Trials ◽  
Tumor Suppressors ◽  
Therapeutic Effects ◽  
New Developments ◽  
Field Of Vision ◽  
The Relationship ◽  
Associated Tumors ◽  
Potential Use

Ikaros is a zinc finger transcription factor (TF) of the Krüppel family member, which significantly regulates normal lymphopoiesis and tumorigenesis. Ikaros can directly initiate or suppress tumor suppressors or oncogenes, consequently regulating the survival and proliferation of cancer cells. Over recent decades, a series of studies have been devoted to exploring and clarifying the relationship between Ikaros and associated tumors. Therapeutic strategies targeting Ikaros have shown promising therapeutic effects in both pre-clinical and clinical trials. Nevertheless, the increasingly prominent problem of drug resistance targeted to Ikaros and its analog is gradually appearing in our field of vision. This article reviews the role of Ikaros in tumorigenesis, the mechanism of drug resistance, the progress of targeting Ikaros in both pre-clinical and clinical trials, and the potential use of associated therapy in cancer therapy.

scholarly journals Uric Acid and Hypertension: Prognostic Role and Guide for Treatment

2021 ◽  
Vol 10 (3) ◽  
pp. 448
Author(s):  
Federica Piani ◽  
Arrigo F. G. Cicero ◽  
Claudio Borghi
Keyword(s):  
Clinical Trials ◽  
Uric Acid ◽  
Mendelian Randomization ◽  
Strong Association ◽  
Epidemiological Studies ◽  
Hypertensive Disease ◽  
Genetic Studies ◽  
Lowering Therapy ◽  
The Relationship

The relationship between serum uric acid (SUA) and hypertension has been a subject of increasing interest since the 1870 discovery by Frederick Akbar Mahomed. Several epidemiological studies have shown a strong association between high SUA levels and the presence or the development of hypertension. Genetic analyses have found that xanthine oxidoreductase (XOR) genetic polymorphisms are associated with hypertension. However, genetic studies on urate transporters and Mendelian randomization studies failed to demonstrate a causal relationship between SUA and hypertension. Results from clinical trials on the role of urate-lowering therapy in the management of patients with hypertension are not uniform. Our study sought to analyze the prognostic and therapeutic role of SUA in the hypertensive disease, from uric acid (UA) biology to clinical trials on urate-lowering therapies.

scholarly journals Teacher Education and Development in Africa: A Modern Perspective

2020 ◽  
Vol 3 (1) ◽  
pp. 107
Author(s):  
Peter Wekesa Wamalwa ◽  
Edwin Nyongesa Masibo
Keyword(s):  
Teacher Education ◽  
Education Programme ◽  
New Developments ◽  
Teacher Education Programme ◽  
Emerging Issues ◽  
Education And Development ◽  
Education And Society ◽  
The Relationship

Teacher education programme is a critical component of education and the life of any society. It normally lays the very foundations of the society. It spurs and pushes the various aspects of development in the society through well-established culture and character of such a society. But for this programme of education to perform this development function efficiently it must be well designed, developed and constantly reformed and modernized so as to keep it abreast with the emerging issues both in education and society. This process is only possible through the conduct of regular studies in education and society to establish new developments and also facilitate the generation of relevant innovations to promote the quality of Teacher education programme. However, there is no evidence that such a process has ever been initiated and conducted in Teacher education programme since the inception of this programme in modern Africa. This paper is designed to explore the importance of Teacher education programme in modern Africa, the relationship between Teacher education programme and development in modern Africa, the roe of this programme in modern Africa, strategies of harnessing the programme for development in modern Africa and the challenges of the programme in modern Africa. This narrative is likely to shade light on the need of Teacher education programme in development in modern Africa and the role of innovative research in this process. Hence, set in motion the desired development in modern Africa.

scholarly journals The Role of Autophagy in the Progression and Treatment of Tumors

2021 ◽  
Vol 1 ◽  
pp. 62-71
Author(s):  
Ismail Al-Janabi
Keyword(s):  
Clinical Trials ◽  
Cancer Progression ◽  
Cancer Type ◽  
Homeostatic Mechanism ◽  
Context Dependent ◽  
Initiation Stage ◽  
The Relationship

Autophagy is a conserved homeostatic mechanism enabling cells to cope with various stresses. The pathways leading up to the activation of autophagy are interconnected with those of tumorigenesis. However, the relationship between the two events is not a straightforward one and very often context-dependent. Generally, autophagy appears to act against the tumor during the initiation stage and most often drives cancer progression subsequently. Published clinical trials for the treatment of various tumors, where autophagy was pharmacologically inhibited, were obtained and tabulated. Targeting autophagy for the treatment of tumors can be rewarding in the appropriate context, such as cancer type, grade, and microenvironment.

scholarly journals MicroRNAs-Based Nano-Strategies as New Therapeutic Approach in Multiple Myeloma to Overcome Disease Progression and Drug Resistance

2020 ◽  
Vol 21 (9) ◽  
pp. 3084 ◽  
Author(s):  
Vanessa Desantis ◽  
Ilaria Saltarella ◽  
Aurelia Lamanuzzi ◽  
Assunta Melaccio ◽  
Antonio Giovanni Solimando ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Drug Resistance ◽  
Cancer Progression ◽  
Tumor Suppressors ◽  
Therapeutic Approach ◽  
Physical Stability ◽  
Cellular Processes ◽  
Non Coding Rnas ◽  
Potential Use ◽  
Nuclease Degradation

MicroRNAs (miRNAs, or miRs) are single-strand short non-coding RNAs with a pivotal role in the regulation of physiological- or disease-associated cellular processes. They bind to target miRs modulating gene expression at post-transcriptional levels. Here, we present an overview of miRs deregulation in the pathogenesis of multiple myeloma (MM), and discuss the potential use of miRs/nanocarriers association in clinic. Since miRs can act as oncogenes or tumor suppressors, strategies based on their inhibition and/or replacement represent the new opportunities in cancer therapy. The miRs delivery systems include liposomes, polymers, and exosomes that increase their physical stability and prevent nuclease degradation. Phase I/II clinical trials support the importance of miRs as an innovative therapeutic approach in nanomedicine to prevent cancer progression and drug resistance. Results in clinical practice are promising.

scholarly journals The Role of Autophagy in Gastric Cancer Chemoresistance: Friend or Foe?

2020 ◽  
Vol 8 ◽  
Author(s):  
Jing-Li Xu ◽  
Li Yuan ◽  
Yan-Cheng Tang ◽  
Zhi-Yuan Xu ◽  
Han-Dong Xu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Drug Resistance ◽  
Molecular Mechanisms ◽  
Chemotherapy Resistance ◽  
Dual Roles ◽  
Non Coding Rnas ◽  
Regulatory Effects ◽  
Cancer Chemoresistance ◽  
The Relationship

Gastric cancer is the third most common cause of cancer-related death worldwide. Drug resistance is the main inevitable and vital factor leading to a low 5-year survival rate for patients with gastric cancer. Autophagy, as a highly conserved homeostatic pathway, is mainly regulated by different proteins and non-coding RNAs (ncRNAs) and plays dual roles in drug resistance of gastric cancer. Thus, targeting key regulatory nodes in the process of autophagy by small molecule inhibitors or activators has become one of the most promising strategies for the treatment of gastric cancer in recent years. In this review, we provide a systematic summary focusing on the relationship between autophagy and chemotherapy resistance in gastric cancer. We comprehensively discuss the roles and molecular mechanisms of multiple proteins and the emerging ncRNAs including miRNAs and lncRNAs in the regulation of autophagy pathways and gastric cancer chemoresistance. We also summarize the regulatory effects of autophagy inhibitor and activators on gastric cancer chemoresistance. Understanding the vital roles of autophagy in gastric cancer chemoresistance will provide novel opportunities to develop promising therapeutic strategies for gastric cancer.

Role of the bone marrow microenvironment in drug resistance of hematological malignances

2021 ◽  
Vol 28 ◽  
Author(s):  
Alireza Hosseini ◽  
Michael R Hamblin ◽  
Hamed Mirzaei ◽  
Hamid Reza Mirzaei
Keyword(s):  
Bone Marrow ◽  
Drug Resistance ◽  
Signaling Pathways ◽  
Mapk Pathway ◽  
Hippo Pathway ◽  
Biological Properties ◽  
Final Phase ◽  
Wnt Pathways ◽  
The Relationship

: The unique features of the tumor microenvironment (TME) govern the biological properties of many cancers, including hematological malignancies. TME factors can trigger invasion, and protect against drug cytotoxicity by inhibiting apoptosis and activating specific signaling pathways (e.g. NF-ΚB). TME remodeling is facilitated due to the high self-renewal ability of the bone marrow. Progressing tumor cells can alter some extracellular matrix (ECM) components which act as a barrier to drug penetration in the TME. The initial progression of the cell cycle is controlled by the MAPK pathway (Raf/MEK/ERK) and Hippo pathway, while the final phase is regulated by the PI3K/Akt /mTOR and WNT pathways. In this review we summarize the main signaling pathways involved in drug resistance (DR) and some mechanisms by which DR can occur in the bone marrow. The relationship between autophagy, endoplasmic reticulum stress, and cellular signaling pathways in DR and apoptosis are covered in relation to the TME.

New Developments in and Directions for Goal-Setting Research

2007 ◽  
Vol 12 (4) ◽  
pp. 290-300 ◽  
Author(s):  
Gary P. Latham ◽  
Edwin A. Locke
Keyword(s):  
Empirical Research ◽  
Goal Setting ◽  
High Performance ◽  
Learning Goals ◽  
Paper Briefly ◽  
New Developments ◽  
Personality Variables ◽  
The Impact ◽  
The Relationship

Abstract. Goal setting is an “open” theory built on inductive findings from empirical research. The present paper briefly summarizes this theory. Emphasis is then given to findings that have been obtained in the present millennium with regard to (1) the high performance cycle, (2) the role of goals as mediators of personality effects on performance, (3) personality variables as moderators of goal effects on performance, the effect of (4) distal, (5) proximal, and (6) learning goals on performance on tasks that are complex for people, (7) the ways in which priming affects the impact of a goal, (8) the interrelationship between goal setting and affect, and (9) the results of goal setting by teams. Potential directions for research on goal setting in the workplace are suggested with regard to goal abandonment, perfectionism, an employee's age, subconscious goals, and the relationship between goals and knowledge.

Die 2de en 3de gebruik van die sedewet?

2021 ◽  
Vol 6 (2) ◽  
Author(s):  
Jacobus De Wit de Koning
Keyword(s):  
New Testament ◽  
Persian Period ◽  
Moral Law ◽  
New Developments ◽  
The New Testament ◽  
The Law ◽  
Relationship Of ◽  
The Relationship

In this article, it is indicated that the Protestant teaching of the so-called second and third use of the moral law is not confirmed by Romans 3:31’s statement: “Do we then overthrow the law by this faith? By no means! On the contrary, we uphold the law.” After looking at developments concerning the study of the role of the Torah that indicated a descriptive view rather than a prescriptive view thereof in Israel’s history, until a change to a more prescriptive view during the Persian period and thereafter, the relationship of faith and Torah in the Canonical Pentateuch came under scrutiny. Following this, new developments regarding Paul and the law were considered. Paul’s statement in Romans 3:31 was then examined in the context of Romans 2–4. After establishing the fact that this verse cannot be used to confirm the ongoing relevance of the law for the New Testament Christian concerning the knowledge of sin and rule for Christian living, it was tested against Galatians 3:12, which seems to contradict the findings on Romans 3:31. It was concluded that Paul indeed indicates that the truth of justification through faith is confirmed by the Torah itself and therefore the so-called second and third use of the moral law cannot be confirmed by Romans 3:31. Some implications of this conclusion are finally highlighted.

scholarly journals Potential Role of HMGCS2 in Tumor Angiogenesis in Colorectal Cancer and Its Potential Use as a Diagnostic Marker

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Kejian Zou ◽  
Yan Hu ◽  
Musheng Li ◽  
Hongli Wang ◽  
Yuhua Zhang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tumor Angiogenesis ◽  
Biochemical Analysis ◽  
Tube Formation ◽  
Healthy Control ◽  
The Relationship ◽  
Rate Limiting ◽  
Ht 29 ◽  
Potential Use

Objective. HMGCS2 is the rate-limiting enzyme of ketogenesis, which is vital for tumor initiation or metastasis. The aim of this study is to determine the relationship between HMGCS2 and tumor angiogenesis.Materials and Methods. The study consisted of 100 cases with colorectal cancer and healthy control, the expression of HMGCS2 and the microvessel density (MVD) (marker: CD31) were analyzed by immunohistochemistry and tube formation, and the centration ofβ-hydroxybutyrate in serum was assessed by biochemical analysis.Results. The results showed that HMGCS2 expression is significantly reduced in colorectal cancer compared with healthy control, which is inversely correlated with MVD in colorectal cancer by IHC analysis. What is more, knockdown HMGCS2 expression in HT-29 cells significantly contributed endothelial cell tube formation.Conclusion. These findings implying HMGCS2 may have a negative regulation of tumor angiogenesis and provide an approach to inhibit tumor angiogenesis.

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