scholarly journals Gender Difference in Associations Between Telomere Length and Risk Factors in Patients With Stroke

2021 ◽  
Vol 13 ◽  
Author(s):  
Yuqing Wang ◽  
Fengjuan Jiao ◽  
Huancheng Zheng ◽  
Qingsheng Kong ◽  
Ran Li ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gender Difference ◽  
Telomere Length ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Stroke Patients ◽  
Male And Female ◽  
Association Analyses ◽  
Negatively Associated ◽  
Female Patients

Multiple risk factors of stroke are associated with telomere length shortening. Although leukocyte telomere length (LTL) is shorter in patients with stroke, the heterogeneity is high. Risk factors may be differentially associated with LTL in male and female patients contributing to the heterogeneity. However, the gender difference in associations between LTL and risk factors in stroke patients has not been investigated. In this study, we investigated the gender difference in associations between LTL and risk factors in 312 stroke patients. Real-time quantitative PCR was used to determine relative LTL, and multiple linear regression analysis was applied for association analyses. We found that LTL was negatively associated with triglyceride (TG) in all patients [β(95% CI) = −0.69 (−1.26, −0.11), P < 0.05] after adjusting confounders. Importantly, LTL was negatively associated with lack of exercise [β(95% CI) = −1.80 (−3.12, −0.49), P < 0.05] and LDL levels [β(95% CI) = −3.22 (−6.05, −0.390), P < 0.05] in male patients, while LTL was negatively associated with dyssomnia [β(95%CI) = −2.00 (−3.96, −0.07), P < 0.05] and diabetes [β(95%CI) = −2.13 (−4.10, −0.27), P < 0.01] in female patients. Our study showed that LTL is differently associated with risk factors in male and female patients with stroke, indicating that gender difference should be considered when LTL is potentially applied as an index of risk and prognosis for stroke. Our study also provides an insight into that gender differences should be considered when developing intervention strategies for stroke prevention and treatment.

Study time, glasses utilization and age affect quality of life among senior first-year Chinese myopia students

2021 ◽  
pp. 112067212098252
Author(s):  
Ziqian Zhu ◽  
Yan He ◽  
Jiezheng Yang ◽  
Qiaoli Li ◽  
HuanHuan Cheng ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Risk Factors ◽  
Regression Analysis ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Study Time ◽  
First Year ◽  
Normal Vision ◽  
First Year Students

Purpose: To compare the quality of life of senior first-year students with normal vision and myopia, and to explore the risk factors related to quality of life in students with myopia. Methods: In this study, 1103 senior first-year students were enrolled in ten high schools. These students were divided according to the diopter degree, with 916 myopia students and 187 normal vision students. Visual function indexes, such as naked eye vision, were measured and recorded, and social demographic indexes and the National Eye Institute 25-Item Visual Function Questionnaire (NEI VFQ-25) was used. The differences in quality of life between the two groups were compared. Multiple linear regression analysis was used to explore the possible risk factors for quality of life in myopia students. Results: In the NEI VFQ-25, the total quality of life scores of myopia students (77.06 ± 15.66) were lower than those of normal vision students (85.49 ± 12.37). The difference was statistically significant ( p = 0.007). In the correlation analysis, the total scores of quality of life in myopia students were positively correlated with wearing glasses ( p = 0.049), and were negatively correlated with study time ( p = 0.029). Multiple linear regression analysis showed that study time, wearing glasses and age were risk factors affecting quality of life in myopia students. Conclusion: Our results show that senior first-year myopia students have lower quality of life scores than students with normal vision. Study time, wearing glasses and age are risk factors for quality of life in senior first-year myopia students.

scholarly journals Risk factors for Hyperhomocysteinemia for Specific MTHFR C677T Genotypes and Gender in Chinese Population.

2020 ◽  
Author(s):  
Hang Xiang ◽  
Tianyuan Xiang ◽  
Muyang Yan ◽  
Sheng Yu ◽  
Matthew John Horwedel ◽  
...  
Keyword(s):  
Risk Factors ◽  
Linear Regression Analysis ◽  
Mthfr C677t ◽  
Multiple Linear Regression Analysis ◽  
Plasma Homocysteine ◽  
Independent Variables ◽  
Specific Risk ◽  
Physical Examinations ◽  
The Common ◽  
And Gender

Abstract Background­-- Our previous studies have identified that both gender and genotype of MTHFR C677T were independent variables for plasma homocysteine (Hcy) levels. Based on these results, we want to further explore their systemic information, in order to find specific risk factors for each genetic group, which might be used as predictors or targeting markers for lowering Hcy levels. Patients and Methods­--This cross section study was performed through November 2017 to July 2019. A total of 4534 adults aged 20-75y were selected for this study, and all of them underwent a physical examinations and MTHFR C677T genotyping. Results--The average of Hcy level was higher in TT genotype than CC and CT genotypes (P=0.000). Multiple linear regression analysis found that except the common protective factors (folate and Vit B12) and risk factor (Cr), each group has it specific risk factors for HHcy---female-CT (age, SBP and Hb), female-TT (SBP and AST); male-CC (age, AST and Hb), male-CT (age and AST) and male-TT (SBP, AST and Hb).Conclusion--The plasma Hcy level was influenced by different risk factors for specific gender and genotype. These risk factors might be useful for prediction or prevention of HHcy in the future.

scholarly journals Towards Achievement of Gender Parity in Decision Making? Experience from the Participation of Male and Female MPs in the Parliament of Tanzania

2019 ◽  
Vol 9 (1) ◽  
pp. 126
Author(s):  
Idda Lyatonga Swai ◽  
Orest Sebastian Masue
Keyword(s):  
Decision Making ◽  
Regression Analysis ◽  
Linear Regression ◽  
Linear Regression Analysis ◽  
Active Role ◽  
Multiple Linear Regression Analysis ◽  
Descriptive Statistics ◽  
Women Empowerment ◽  
Male And Female ◽  
Gender Parity

There have been gradual efforts to increase the number of female MPs in Tanzania through women empowerment creation of quotas (special seats) to enable them play an active role in this important decision making body. This article seeks to find out whether the increase in number of women MPs in the Tanzanian Parliament has influenced women’s degree of intervention in terms of: (1) asking basic questions; (2) asking supplementary questions; and (3) making contribution to parliamentary discussions. We obtained data from the official website of the Parliament of Tanzania, and analyzed them through descriptive statistics and multiple linear regression analysis. The results suggest that an increase in number of female MPs will increase their level of intervention; hence, we are inclined to the conclusion that numbers matter in determining female MPs’ influence in the Parliament.

scholarly journals Association of Thyroid-Stimulating Hormone and Thyroid Hormones with Cardiometabolic Risk Factors in Euthyroid Children and Adolescents Aged 10–18 Years: A Population-Based Study

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Cheol Gyu Ma ◽  
Young Suk Shim
Keyword(s):  
Risk Factors ◽  
Children And Adolescents ◽  
Cardiometabolic Risk ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Thyroid Stimulating Hormone ◽  
Cardiometabolic Risk Factors ◽  
Reference Ranges ◽  
Glucose Levels ◽  
Elevated Glucose

Abstract Recent evidence indicates that low-normal thyroid function test results within the reference ranges may be related to increased cardiometabolic risk factors. The current study aimed to evaluate the relationship between thyroid function using thyroid-stimulating hormone (TSH) and free thyroxine (FT4) and cardiometabolic risk factors and the clustering of these risk factors (metabolic syndrome) in euthyroid children and adolescents. A total of 250 euthyroid children and adolescents aged 10–18 years were included using data from the Korea National Health and Nutrition Examination Survey (KNHANES) 2015. In the unadjusted correlation analyses, TSH was positively correlated with glucose (r = 0.172, P = 0.006), hemoglobin A1c (HbA1c) (r = 0.149, P = 0.018), insulin (r = 0.144, P = 0.023), homeostatic model assessment for insulin resistance (HOMA-IR) (r = 0.163, P = 0.010), and triglyceride (TG) (r = 0.155, P = 0.014), whereas FT4 was negatively associated with the waist circumference (WC) standard deviation score (SDS) (r = −0.134, P = 0.035), body mass index (BMI) SDS (r = −0.126, P = 0.046), insulin (r = −0.219, P < 0.001), and HOMA-IR (r = −0.211, P < 0.001). In the multiple linear regression analysis, TSH was positively associated with glucose (β = 1.179, P = 0.021), HbA1c (β = 0.044, P = 0.039), and TG (β = 8.158, P = 0.041) after adjustment for possible confounders. FT4 was negatively associated with serum fasting insulin (β = −5.884, P = 0.017) and HOMA-IR (β = −1.364, P = 0.023) in the multiple linear regression analysis. Boys and girls with elevated glucose levels had a higher adjusted mean TSH level compared to those without elevated glucose levels after controlling for confounding factors in the analysis of covariance (2.16 mIU/L vs 3.88 mIU/L, P = 0.004). Our results suggest that higher TSH and/or lower FT4 levels, even within the reference ranges, may be related to increased cardiometabolic risk factors.

scholarly journals Gender-related differences in critical limb ischemia due to peripheral arterial occlusive disease

2013 ◽  
Vol 12 (4) ◽  
pp. 278-283 ◽  
Author(s):  
Vanessa Prado dos Santos ◽  
Carlos Alberto Silveira Alves ◽  
Cicero Fidelis Lopes ◽  
Jose Siqueira de Araujo Filho
Keyword(s):  
Risk Factors ◽  
Critical Limb Ischemia ◽  
Peripheral Arterial Occlusive Disease ◽  
Clinical Characteristics ◽  
Limb Ischemia ◽  
Arterial Occlusive Disease ◽  
Occlusive Disease ◽  
Male And Female ◽  
Female Patients ◽  
Peripheral Arterial

BACKGROUND: Mortality from cardiovascular disease has declined among men and increased among North American women. Recent studies have revealed differences between genders in the epidemiology of atherosclerotic disease. OBJECTIVE: To study possible differences between male and female patients with critical limb ischemia (CLI) according to risk factors of atherosclerosis and clinical characteristics of lower limbs with peripheral arterial occlusive disease (PAOD). METHODS: The study included 171 male and female patients treated for CLI due to infrainguinal PAOD and compared clinical characteristics (Rutherford category and PAOD territory), risk factors for atherosclerosis (diabetes, age, smoking and hypertension) and number of opacified arteries on digital angiograms of the leg. The EPI-INFO software was used for statistical analysis, and the level of significance was set at p<0.05. RESULTS: Mean age was 70 years, and 88 patients were men (52%). For most patients (both genders), Rutherford category was 5 (82 % of men and 70% of women; p=0.16). The group of women had higher mean age (73 vs. 67 years; p=0.0002) and greater prevalence of diabetes (66% vs. 45%; p=0.003) and hypertension (90% vs. 56%; p=0.0000001). Among men, the prevalence of smoking was higher (76% vs. 53%; p=0.0008). The analysis of digital angiograms revealed that opacification of only one artery in the leg was found for 74% of women (vs. 50% of men). CONCLUSION: The prevalence of risk factors for atherosclerosis and the characteristics of PAOD are different between male and female patients with CLI.

scholarly journals Clinical Characteristics and the Risk Factors of Hepatic Injury in 221 Children With Infectious Mononucleosis

2022 ◽  
Vol 9 ◽  
Author(s):  
Chao Zhang ◽  
Shu Cui ◽  
Guoshun Mao ◽  
Guitao Li
Keyword(s):  
Risk Factors ◽  
Infectious Mononucleosis ◽  
Clinical Characteristics ◽  
Hepatic Injury ◽  
Demographic Data ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Cross Sectional Study ◽  
Epstein Barr Virus Infection ◽  
Cross Sectional

Background: Infectious mononucleosis caused by Epstein-Barr Virus infection is a common acute infectious disease in children. About 40–80% of children with infectious mononucleosis have hepatic injury, and hepatic failure is one of the main causes of death in patients with fatal infectious mononucleosis. Identifying the demographics, presenting clinical characteristics and the risk factors of hepatic injury in infectious mononucleosis children are helpful to remind clinicians which patients are prone to have hepatic damage.Methods: A descriptive, cross-sectional study with a 31-month retrospective review was performed on all infectious mononucleosis children hospitalized in the pediatric department of Fuyang People's Hospital. Demographic data, presenting features, radiology imaging, clinical and laboratory parameters, and clinical outcomes of infectious mononucleosis children were collected.Results: Two-hundred twenty-one infectious mononucleosis inpatients were enrolled, and 43.9% (97/221) patients were considered to have a hepatic injury (defined as alanine amino transaminase &gt; 40 U/L). Compared with patients without hepatic injury, hepatic injury patients were marked with a significantly higher percentage of hepatomegaly (31 vs. 49%), splenomegaly (58 vs. 81%) and palpebral edema (47 vs. 63%), higher age (3.05 ± 2.12 vs. 3.84 ± 2.44), hospitalization days (6.85 ± 2.64 vs. 8.08 ± 2.83), leukocyte (14.24 ± 5.32 vs. 18.53 ± 8.63), lymphocytes (9.48 ± 4.49 vs. 13.80 ± 7.47), the proportion of atypical lymphocytes (0.12 ± 0.07 vs. 0.15 ± 0.08) and aspartate aminotransferase (33.71 ± 10.94 vs. 107.82 ± 93.52). The results of correlation analysis and multiple linear regression analysis indicated that age (OR = 1.185; 95% CI = 1.035–1.357, p = 0.014), female (OR = 2.002, 95% CI: 0.261–0.955, p = 0.036) and splenomegaly (OR = 2.171, 95% CI: 1.018–4.628, p = 0.045) were independent risk factors of hepatic injury.Conclusions: In this study, the hepatic injury was associated with gender, age, and splenomegaly, which improved our understanding of risk factors about hepatic injury among infectious mononucleosis children.

scholarly journals Sex-Specific Association between Serum 25-Hydroxyvitamin D and Metabolic Risk Factors in T2DM Patients

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Xiaomin Sun ◽  
Sirui Zhou ◽  
Xin He ◽  
Youfa Wang ◽  
Wei Cui
Keyword(s):  
Risk Factors ◽  
Glycated Albumin ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Metabolic Risk Factors ◽  
Analysis Of Covariance ◽  
Metabolic Risk Factor ◽  
Metabolic Risk ◽  
Dependent Manner ◽  
Lipoprotein A

Objective. To evaluate the relationship between serum 25-hydroxyvitamin (25(OH)D) levels and metabolic risk factor levels in patients with type 2 diabetes mellitus (T2DM) on a sex-specific basis. Methods. Our study comprised 507 patients with T2DM (321 men, 186 women; median age, 59 years). The metabolic risk factors examined included lipoprotein(a), glycated albumin (GA-L), and random blood glucose (RBG); the levels of these parameters were determined enzymatically. Serum 25(OH)D levels were measured by commercial ELISA kits. Participants were divided into low and high 25(OH)D groups according to the median 25(OH)D concentration (13.2 ng/mL). Two-way analysis of covariance and multiple linear regression analysis were performed. Results. The median 25(OH)D concentration was 13.9 ng/mL in men and 12.2 ng/mL in women. 25(OH)D levels inversely correlated with levels of three metabolic risk factors in a sex-dependent manner after adjusting for several confounding factors. These were lipoprotein(a) in men (141.3 ± 137.9 and 195.3 ± 204.8 mg/L in high and low 25(OH)D groups, respectively; P<0.05); GA-L in women (22.2 ± 8.8 vs. 23.3 ± 7.3% in high and low 25(OH)D groups, respectively; P<0.05). In a subgroup analysis, serum 25(OH)D levels inversely correlated with lipoprotein(a) levels in men (β = −0.185, P=0.002) and RBG levels in women (β = −0.176, P=0.028). Conclusion. Higher serum 25(OH)D levels indicate a more favorable lipid profile in men and a more favorable glucose profile in women.

Risk factors for severe clinical events and the incidence of these events in male and female patients with Fabry disease treated with agalsidase beta

2015 ◽  
Vol 114 (2) ◽  
pp. S55
Author(s):  
Robert J. Hopkin ◽  
Gustavo Cabrera ◽  
Joel Charrow ◽  
Roberta Lemay ◽  
Ana Maria Martins ◽  
...  
Keyword(s):  
Risk Factors ◽  
Fabry Disease ◽  
Agalsidase Beta ◽  
Male And Female ◽  
Female Patients ◽  
Clinical Events

scholarly journals Prevalence of Gingival Recession and associated Risk Factors among 18–45-Year-Old Who Attended a Dental Practice in Greece

2016 ◽  
Vol 5 (1) ◽  
pp. 28-33
Author(s):  
Nikolaos Andreas Chrysanthakopoulos
Keyword(s):  
Risk Factors ◽  
Smoking Status ◽  
Linear Regression Analysis ◽  
Gingival Recession ◽  
Multiple Linear Regression Analysis ◽  
Dental Practice ◽  
Level Of Education ◽  
Plaque Control ◽  
Associated Risk Factors ◽  
Oral Hygiene Habits

ABSTRACT Aim To assess the prevalence of gingival recession and to investigate possible associations among gingival recession and periodontal and epidemiological variables in a sample of Greek adults in a general dental practice. Materials and methods A sample of 640 Greek adults was examined clinically and interviewed regarding several periodontal and epidemiological variables. Collected data included demographic background (age, gender, level of education), oral hygiene habits, and smoking status. Clinical examination included the recording of dental plaque and supragingival calculus presence, gingival status, and gingival recession. In addition, the association between gingival recession and the following variables was assessed: gender, smoking status, calculus presence, plaque control methods, plaque index, gingival index, and level of education. Multiple linear regression analysis was carried out to model the association of gingival recession with the mentioned potential risk factors. Results The overall prevalence of gingival recession was 62.7%. The performance of multiple linear regression analysis indicated that smoking (p = 0.001), plaque index (p = 0.021), gingival index (p < 0.0001), plaque control methods (p < 0.001), and level of education (p < 0.001) were the most important associated factors of gingival recession. Conclusion The present study indicates that an association exists between gingival recession and presence of gingival inflammation, inadequate oral hygiene habits, and smoking. How to cite this article Chrysanthakopoulos NA, Saini R. Prevalence of Gingival Recession and associated Risk Factors among 18–45-Year-Old Who Attended a Dental Practice in Greece. Int J Experiment Dent Sci 2016;5(1):28-33.

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