scholarly journals Cardiovascular Metrics Associated With Prevention of Aging-Related Parkinsonian Signs Following Exercise Intervention in Sedentary Older Rats

2021 ◽  
Vol 13 ◽  
Author(s):  
Ella A. Kasanga ◽  
Joel Little ◽  
Tamara R. McInnis ◽  
Nicoleta Bugnariu ◽  
J. Thomas Cunningham ◽  
...  
Keyword(s):  
Exercise Intervention ◽  
Treadmill Exercise ◽  
Motor Impairment ◽  
Rest Period ◽  
Male Rats ◽  
Moderate Intensity ◽  
Physically Active ◽  
Exercise Regimen ◽  
Active Lifestyles ◽  
Intensity Of Exercise

Preservation of motor capabilities is vital to maintaining independent daily living throughout a person's lifespan and may mitigate aging-related parkinsonism, a progressive and prevalent motor impairment. Physically active lifestyles can mitigate aging-related motor impairment. However, the metrics of physical activity necessary for mitigating parkinsonian signs are not established. Consistent moderate intensity (~10 m/min) treadmill exercise can reverse aging-related parkinsonian signs by 20 weeks in a 2-week on, 2-week off, regimen in previously sedentary advanced middle-aged rats. In this study, we initiated treadmill exercise in sedentary 18-month-old male rats to address two questions: (1) if a rest period not longer than 1-week off exercise, with 15 exercise sessions per month, could attenuate parkinsonian signs within 2 months after exercise initiation, and the associated impact on heart rate (HR) and mean arterial pressure (MAP) and (2) if continuation of this regimen, up to 20 weeks, will be associated with continual prevention of parkinsonian signs. The intensity and frequency of treadmill exercise attenuated aging-related parkinsonian signs by 8 weeks and were maintained till 23 months old. The exercise regimen increased HR by 25% above baseline and gradually reduced pre-intervention MAP. Together, these studies indicate that a practicable frequency and intensity of exercise reduces parkinsonian sign severity commensurate with a modest increase in HR after exercise. These cardiovascular changes provide a baseline of metrics, easily measured in humans, for predictive validity that practicable exercise intensity and schedule can be initiated in previously sedentary older adults to delay the onset of aging-related parkinsonian signs.

scholarly journals Early Moderate Intensity Aerobic Exercise Intervention Prevents Doxorubicin-caused Cardiac Dysfunction through Inhibition of Cardiac Fibrosis and Inflammation

Cancers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1102
Author(s):  
Hsin-Lun Yang ◽  
Pei-Ling Hsieh ◽  
Ching-Hsia Hung ◽  
Hui-Ching Cheng ◽  
Wan-Ching Chou ◽  
...  
Keyword(s):  
Cardiac Dysfunction ◽  
Cardiac Fibrosis ◽  
Exercise Intervention ◽  
Treadmill Exercise ◽  
Cardiac Injury ◽  
Treated Group ◽  
Exercise Group ◽  
Moderate Intensity ◽  
Cardiac Damage ◽  
Creatine Kinase Mb

Doxorubicin (DOX) is known as an effective drug in the fight against various cancers. However, one of the greatest impediments is DOX-induced cardiomyopathy, which may potentially lead to heart failure. Accumulating evidence has shed light on the pathological mechanism of DOX-induced cardiotoxicity, but treatments to mitigate the cardiac damage are still required. In an attempt to address this issue, we evaluated whether exercise provides cardioprotective effects on the DOX-induced cardiotoxicity. We showed that treadmill exercise (3 times/week; 1-week of exercise acclimatization and 4-weeks of endurance exercise) during the DOX treatment successfully prevented the cardiac dysfunction. The DOX-stimulated expression of IκBα, NF-κB, COX-2, and IL-8 were all downregulated by exercise as well as the fibrosis factors (TGF-β1, phosphorylated ERK, Sp1, and CTGF). Moreover, we showed that treadmill exercise diminished the expression of several cardiac remodeling-associated factors, such as FGF2, uPA, MMP2, and MMP9. These results were in line with the finding that exercise intervention reduced cardiac fibrosis and restored cardiac function, with higher values of ejection fraction and fractional shortening compared to the DOX-treated group. Two commonly used indicators of cardiac injury, lactate dehydrogenase, and creatine kinase-MB, were also decreased in the exercise group. Collectively, our results suggested that it may be beneficial to prescribe treadmill exercise as an adjunct therapy to limit cardiac damage caused by DOX.

Promoting Physically Active Lifestyles among Youths

1999 ◽  
Vol 70 (6) ◽  
pp. 26-28 ◽  
Author(s):  
Charles B. Corbin ◽  
Darren Dale ◽  
Robert P. Pangrazi
Keyword(s):  
Physically Active ◽  
Active Lifestyles

scholarly journals The effects of an individualized exercise intervention on body composition in breast cancer patients undergoing treatment

2007 ◽  
Vol 125 (1) ◽  
pp. 22-28 ◽  
Author(s):  
Claudio Battaglini ◽  
Martim Bottaro ◽  
Carolyn Dennehy ◽  
Logan Rae ◽  
Edgar Shields ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Body Composition ◽  
Resistance Training ◽  
Cancer Treatment ◽  
Cancer Patients ◽  
Exercise Intervention ◽  
Exercise Group ◽  
Moderate Intensity ◽  
Control Group ◽  
Breast Cancer Patients

CONTEXT AND OBJECTIVE: Changes in metabolism have been reported in the majority of patients undergoing cancer treatment, and these are usually characterized by progressive change in body composition. The effects of aerobic exercise programs to combat the cancer and cancer treatment-related side effects, which include the negative changes in body composition, have been extensively reported in the literature. However, few resistance exercise intervention studies have hypothesized that breast cancer patients might benefit from this type of exercise. The purpose of this study was to determine whether exercise protocols that emphasize resistance training would change body composition and strength in breast cancer patients undergoing treatment. DESIGN AND SETTING: Randomized controlled trial, at the Campus Recreation Center and Rocky Mountain Cancer Rehabilitation Institute of the University of Northern Colorado, and the North Colorado Medical Center. METHODS: Twenty inactive breast cancer patients were randomly assigned to a 21-week exercise group (n = 10) or a control group (n = 10). The exercise group trained at low to moderate intensity for 60 minutes on two days/week. The primary outcome measurements included body composition (skinfold method) and muscle strength (one repetition maximum). RESULTS: Significant differences in lean body mass, body fat and strength (p = 0.004, p = 0.004, p = 0.025, respectively) were observed between the groups at the end of the study. CONCLUSION: The results suggest that exercise emphasizing resistance training promotes positive changes in body composition and strength in breast cancer patients undergoing treatment.

scholarly journals Habitual Physical Activity Behavior of Patients After Primary Total Hip Arthroplasty

2008 ◽  
Vol 88 (9) ◽  
pp. 1039-1048 ◽  
Author(s):  
Robert Wagenmakers ◽  
Martin Stevens ◽  
Wiebren Zijlstra ◽  
Monique L Jacobs ◽  
Inge van den Akker-Scheek ◽  
...  
Keyword(s):  
Physical Activity ◽  
Total Hip Arthroplasty ◽  
Odds Ratio ◽  
Physical Activity Behavior ◽  
Moderate Intensity ◽  
Physically Active ◽  
Normative Population ◽  
Activity Behavior ◽  
Charnley Class ◽  
Health Enhancing Physical Activity

Background and Purpose Despite recognized health benefits of physical activity, little is known about the habitual physical activity behavior of patients after total hip arthroplasty (THA). The purpose of this study was to analyze this behavior and the fulfillment of guidelines for health-enhancing physical activity of these patients compared with a normative population. Subjects and Methods The participants were 273 patients who had undergone a primary THA (minimum of 1 year postoperatively). Comparisons were made between this group and 273 age- and sex-matched individuals from a normative population. Comparisons also were made between participants with THA under 65 years of age and those 65 years of age and older and among participants with THA in different Charnley classes. Level of physical activity was assessed with the Short QUestionnaire to ASsess Health-enhancing physical activity (SQUASH). Results No significant differences in total amount of physical activity or time spent in different categories of physical activity were found between the THA group and the normative group. Participants with THA spent significantly more minutes in activities of moderate intensity compared with the normative group. Participants with THA who were under 65 years of age were significantly more active than older participants with THA. Charnley class had significant effects on time spent at work, time spent in moderate-intensity activities, and total amount of activity, with the least activity performed by participants in Charnley class C. The guidelines were met by 51.2% of the participants with THA and 48.8% of the normative population. Female participants met the guidelines less frequently than male participants in both the combined groups (odds ratio=0.50, 95% confidence interval=0.35–0.72, P<.001) and the THA group (odds ratio=0.48, 95% confidence interval=0.28–0.80, P=.001). Discussion and Conclusion The results suggest that patients after THA are at least as physically active as a normative population. Nevertheless, a large percentage of these patients do not meet the guidelines; therefore, they need to be stimulated to become more physically active.

Treadmill exercise reduces self-administration of morphine in male rats

2009 ◽  
Vol 16 (1) ◽  
pp. 3-7 ◽  
Author(s):  
Mahmoud Hosseini ◽  
Hojjat Allah Alaei ◽  
Asieh Naderi ◽  
Mohammad Reza Sharifi ◽  
Reza Zahed
Keyword(s):  
Treadmill Exercise ◽  
Male Rats ◽  
Self Administration

Early postnatal overnutrition impairs VO2max gains with moderate exercise and increase post-exercise muscle damage in adult male rats

2021 ◽  
pp. 1-5
Author(s):  
Douglas Lopes Almeida ◽  
Gabriel Sergio Fabricio ◽  
Laize Peron Tófolo ◽  
Tatiane Aparecida Ribeiro ◽  
Camila Cristina Ianoni Matiusso ◽  
...  
Keyword(s):  
Early Life ◽  
Male Rats ◽  
Moderate Intensity ◽  
Moderate Exercise ◽  
Moderate Intensity Exercise ◽  
Post Exercise ◽  
Reduced Body ◽  
Male Wistar Rats ◽  
The Impact ◽  
Adaptation To Exercise

Abstract Exercise counteracts obesity effects, but information on how early-life obesity may affect long-term adaptation to exercise is lacking. This study investigates the impact of early-life postnatal overfeeding (PO) on animals’ adaptation to exercise. Only male Wistar rats were used. On postnatal day (PN) 30, rats from control (NL-9 pups) or PO (SL-3 pups) litters were separated into four groups: NL-sedentary (NL-Se), NL-exercised (NL-Ex), SL-sedentary (SL-Se), and SL-exercised (SL-Ex). Exercised groups performed moderate-intensity exercise, running on a treadmill, from PN30 to PN90. Further experiments were carried out between PN90 and PN92. PO promoted obesity in SL versus NL rats (P < 0.05). Exercise reduced body weight (P < 0.001), body fat (P < 0.01), and improved glucose homeostasis in SL-Ex versus SL-Se. SL-Ex presented lower VO2max (P < 0.01) and higher post-exercise LDH (P < 0.05) compared to NL-Ex rats. Although moderate exercise counteracted obesity in SL rats, early-life overnutrition restricts fitness gains in adulthood, indicating that early obesity may impair animals’ adaptation to exercise.

Comparing the Short and Long-Term Effects of Acute Moderate-Intensity Exercise on Mnemonic Similarity and Emotional Memory Tasks

2021 ◽  
Vol 19 (1) ◽  
pp. 33-61
Author(s):  
Cesar Acevedo-Triana ◽  
Diana Cordoba-Patiño ◽  
Juan Francisco Muñoz ◽  
Julian Cifuentes ◽  
Victor Melgarejo Pinto ◽  
...  
Keyword(s):  
Undergraduate Students ◽  
Memory Task ◽  
Discrimination Performance ◽  
Rest Period ◽  
Emotional Memory ◽  
Moderate Intensity ◽  
Exercise Session ◽  
Long Term Effects ◽  
Moderate Intensity Exercise ◽  
Exercise Condition

Mounting research has linked acute moderate-intensity exercise with changes indiscrimination of similar events – i.e., mnemonic memory. Conversely, few studies have compared performance in tasks associated to each type of memory(mnemonic similarity and emotional) and less have evaluatedperformance several days after exercise sessions. Thirty-five undergraduate students were randomly distributed in three groups that differed in the assigned duration of the moderate-intensity exercise session.Weestablished first the moderate-intensityexercise program by calculating the VO2max 50%. Two-to-five days later, participantsengaged in the exercise condition to which they were assigned, followed by a five-minute rest period. Immediately after, all participantswere exposed to the training phase of both memory tasks. The first retrieval phase was tested 45 minutes afterencoding phase was completed. Subsequent retrieval phases were conducted 24, 48, and 168 hours post-training. Exercise of long duration in creased discrimination performance in images of low similarity. Comparison of the effects of exercise on discrimination of the three types of images that the emotional-memory task entailsshowed improved performance only for aversive and neutral images. Exercise improves discrimination of low similarity images, with better overall performance after a longer exercise session. This finding adds to previous reports that have found analogous effects using other memory tasks.It also supports the notion that acute effects due to exercise are specifically related to hippocampal functionality and its ability to separate patterns. Finally, maintenance of emotional information across time suggest a different mechanism,independent of pattern-separation processing.

A treadmill exercise regimen for identifying cardiovascular phenotypes in transgenic mice

1997 ◽  
Vol 273 (3) ◽  
pp. H1595-H1605 ◽  
Author(s):  
J. G. Fewell ◽  
H. Osinska ◽  
R. Klevitsky ◽  
W. Ng ◽  
G. Sfyris ◽  
...  
Keyword(s):  
Treadmill Exercise ◽  
Genetic Manipulation ◽  
Ultrastructural Examination ◽  
Exercise Protocol ◽  
Hypertrophic Response ◽  
Cardiovascular Stress ◽  
Exercise Regimen ◽  
Ventricular Myosin ◽  
Tubular System ◽  
Transverse Axial

Cardiovascular stress in response to treadmill exercise is frequently used to detect cardiac abnormalities that are not readily apparent at rest. Herein we describe a treadmill exercise protocol for mice that allows for quantitation of the performance of an animal and the ability to gather metabolic information in a nonrestraining manner using telemetry implant devices. Transgenic (TG) mice overexpressing ventricular myosin regulatory light chain (MLC2v) were subjected to a 5-wk exercise regimen. The TG mice had significant decreases in their capacity for exercise at relatively high treadmill speeds compared with their nontransgenic (NTG) littermates. There was no indication of a hypertrophic response occurring in TG or NTG animals in response to the exercise protocol, and exercise had no effect on MLC2v phosphorylation. Ultrastructural examination of TG atria showed overtly normal myofibrillar organization but a proliferation of the transverse-axial tubular system. This exercise protocol should prove useful in detecting subtle phenotypes that occur in mice as a result of genetic manipulation of the cardiac compartment.

Immunomodulations induced in rats by exercise on a treadmill

1990 ◽  
Vol 69 (5) ◽  
pp. 1912-1915 ◽  
Author(s):  
A. Ferry ◽  
B. L. Weill ◽  
M. Rieu
Keyword(s):  
T Cell ◽  
Treadmill Exercise ◽  
Absolute Number ◽  
Not Given ◽  
Spleen Cells ◽  
Immune Parameters ◽  
Exercise Regimen ◽  
Long Duration

Various regimens of treadmill exercise (0% slope) were used with rats: 60 min at 15 m/min (T-15), 180 min at 10 m/min (T-10), and 60 min/day at 15 m/min for 6 consecutive days (T-15-6). Exercise resulted in 1) decreases in the absolute number of mononuclear spleen cells in T-10 rats, 2) significant increases in in vitro splenic T-cell blastogenesis in response to phytohemagglutinin in T-10 rats, and 3) significant decreases in T-cell blastogenesis in T-15-6 rats. T-15-6 rats were given aminoglutethimide per os before exercise sessions to study the role of corticosteroids in the alteration of splenic T-cell blastogenesis. Aminoglutethimide significantly increased the T-cell blastogenesis in these T-15-6 rats compared with those not given aminoglutethimide, whereas it had no effect on immune parameters of sedentary rats. These results show that immunomodulations in the rat depend on the treadmill exercise regimen employed. If the mechanisms of the immunomodulation induced by isolated exercise of long duration are not elucidated, these data suggest that corticosteroids are involved in the alteration in T-cell blastogenesis induced by chronic muscular exercise.

scholarly journals Determination of Step Rate Thresholds Corresponding to Physical Activity Intensity Classifications in Adults

2011 ◽  
Vol 8 (1) ◽  
pp. 45-51 ◽  
Author(s):  
Mark Abel ◽  
James Hannon ◽  
David Mullineaux ◽  
Aaron Beighle
Keyword(s):  
Nonlinear Regression ◽  
Metabolic Cost ◽  
Moderate Intensity ◽  
Physical Activity Intensity ◽  
Physically Active ◽  
Public Health Recommendation ◽  
Step Rate ◽  
Activity Intensity ◽  
Treadmill Speed

Background:Current recommendations call for adults to be physically active at moderate and/or vigorous intensities. Given the popularity of walking and running, the use of step rates may provide a practical and inexpensive means to evaluate ambulatory intensity. Thus, the purpose of this study was to identify step rate thresholds that correspond to various intensity classifications.Methods:Oxygen consumption was measured at rest and during 10 minute treadmill walking and running trials at 6 standardized speeds (54, 80, 107, 134, 161, and 188 m·min-1) in 9 men and 10 women (28.8 ± 6.8 yrs). Two observers counted the participants’ steps at each treadmill speed. Linear and nonlinear regression analyses were used to develop prediction equations to ascertain step rate thresholds at various intensities.Results:Nonlinear regression analysis of the metabolic cost versus step rates across all treadmill speeds yielded the highest R2 values for men (R2 = .91) and women (R2 = .79). For men, the nonlinear analysis yielded 94 and 125 step·min-1 for moderate and vigorous intensities, respectively. For women, 99 and 135 step·min-1 corresponded with moderate and vigorous intensities, respectively.Conclusions:Promoting a step rate of 100 step·min-1 may serve as a practical public health recommendation to exercise at moderate intensity.

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