Cerebral Microbleeds Were Related With Poor Cognitive Performances on the Dual Task Condition in Older Adults

Background: The dual task (DT) was commonly used to assess the risk of falls in older adults and patients with neurological disorders. However, the performance on DT conditions has not been well investigated in patients with cerebral microbleed (CMB). This study is aimed to compare the performance in DT tests between older adults with and without CMB, and to explore the association between CMB and cognitive performances of DT.Methods: This is a cross-sectional study. A total of 211 old adults participated, involving 68 CMB patients. The task protocol involved two global cognition tests, two single cognitive tests (serial 7 subtraction and semantic fluency), two single motor tasks [8-m walking and timed up and go test (TUG)], and three DT tests [walking and serial subtraction (WSS), walking and semantic fluency (WSF), and TUG and serial subtraction (TUGSS)]. The time taken to complete each task and the number of correct responses were recorded. For each DT condition, the correct response rate (CRR) and the dual-task effect (DTE) for the correct number were calculated.Results: Compared with subjects without CMB, CMB patients had worse cognitive performances on DT condition in CRR of WSS (p = 0.003), WSF (p = 0.030) and TUGSS (p = 0.006), and DTE of WSS (p = 0.017). Binary logistic regression analysis showed that the presence of CMB was an independent risk factor for the impairment group for CRR of TUGSS (OR, 2.54; 95% CI, 1.11–5.82; p = 0.027) with the adjustment for confounders, rather than CRR of WSS and WSF, or DTE of WSS. Multiple linear regression analysis showed that CRR of TUGSS decreased with the increase of CMB number grades (β, −0.144; 95% CI, −0.027, −0.002; p = 0.028).Conclusion: The present study indicated that CMBs were closely associated with poor cognitive performances on DT in the elderly. Strongest effect size was seen for CRR of TUGSS, where performance deficits increased in proportion to the degree of CMB burden.

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Oxidative stress and gut-derived lipopolysaccharides in children affected by Paediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections.

10.21203/rs.2.19372/v3 ◽

2020 ◽

Author(s):

Lorenzo Loffredo ◽

Alberto Spalice ◽

Francesca Salvatori ◽

De Castro Giovanna ◽

Cristiana Alessia Guido ◽

...

Keyword(s):

Regression Analysis ◽

Linear Regression ◽

Linear Regression Analysis ◽

Prostaglandin F2α ◽

Neuropsychiatric Disorders ◽

Serum Levels ◽

Multiple Linear Regression Analysis ◽

Tic Disorders ◽

Streptococcal Infections ◽

Cross Sectional

Abstract Background: pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections syndrome (PANDAS) identifies patients with acute onset of obsessive-compulsive and tic disorders. The objective of this study was to assess NOX2 levels, as well as serum 8-iso-prostaglandin F2α (iso-PGF2α) and lipopolysaccharide (LPS) derived from Gram-negative bacteria in the gut of patients with PANDAS. Methods: a cross sectional study was performed to compare serum levels of soluble NOX2-dp (sNOX-2-dp), isoprostanes and LPS in 60 consecutive subjects, including 30 children affected by PANDAS and 30 controls (CT) matched for age and gender. Serum zonulin was used to assess gut permeability. Results: compared with CT, PANDAS children had higher values of sNOX-2-dp, 8-iso-PGF2-alpha and LPS. Simple linear regression analysis showed that sNOX2-dp was signiﬁcantly correlated with serum LPS (Rs=0.359; p=0.005), zonulin (Rs=0.444; p<0.001) and iso-PGF2α (Rs=0.704; p<0.001). LPS signiﬁcantly correlated with serum zonulin (Rs=0.610; p<0.001), and iso-PGF2α (Rs=0.591; p=0.001). A multiple linear regression analysis was performed to define the independent predictors of sNOX-2-dp. Isoprostanes and zonulin emerged as the only independent predictive variables associated with sNOX2-dp (R2=68%). Conclusion: this study provides evidences that children affected by PANDAS have high circulating levels of sNOX2-dp, isoprostanes and of LPS that could be potentially implicated in the process of neuroinflammation.

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Analysis of the chemerin and resistin adipokines in children and adolescents

Revista da Associação Médica Brasileira ◽

10.1590/1806-9282.66.3.300 ◽

2020 ◽

Vol 66 (3) ◽

pp. 300-306

Author(s):

Vanessa S. Fontes ◽

Kácia Mateus ◽

Michele P. Netto ◽

Renata M. S. Oliveira ◽

George L. L. Machado-Coelho ◽

...

Keyword(s):

Blood Pressure ◽

Regression Analysis ◽

Linear Regression ◽

Children And Adolescents ◽

Blood Pressure Measurement ◽

Linear Regression Analysis ◽

Multiple Linear Regression Analysis ◽

Excess Weight ◽

Cross Sectional ◽

Significance Level

SUMMARY OBJECTIVES To compare the serum concentrations of adipokines resistin and chemerin in children and adolescents with eutrophic and overweight and to evaluate their relationship with anthropometric, biochemical, and blood pressure variables. METHODS a cross-sectional epidemiological study was conducted with 234 students enrolled in public elementary schools in the city of Juiz de Fora / MG. Anthropometric evaluation, biochemistry, and blood pressure measurement were performed. Statistical analyzes included the Student-t or Mann-Whitney tests, Pearson or Spearman correlation, used according to the distribution of the variables, and linear regression analysis, by means of the evaluation of the effect of the independent variables on the serum levels of chemerin and resistin, adjusted for age and sex. For the data analysis, SPSS® software version 21.0 and STATA® version 10.1 were used, assuming a significance level of 5%. RESULTS the concentrations of chemerin were higher in eutrophic individuals than in those with excess weight (p> 0.05). In contrast, levels of resistin were higher in the young with excess weight than in the eutrophic ones (p <0.05). In the multiple linear regression analysis, the levels of chemerin were associated with the values of resistin, systolic, and diastolic blood pressure. Resistance levels maintained association only with BMI and chemerin values. CONCLUSION the adipokines analyzed presented a distinct profile in the groups of children and adolescents with eutrophic and overweight.

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Oxidative stress and gut-derived lipopolysaccharides in children affected by Paediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections.

10.21203/rs.2.19372/v4 ◽

2020 ◽

Author(s):

Lorenzo Loffredo ◽

Alberto Spalice ◽

Francesca Salvatori ◽

De Castro Giovanna ◽

Cristiana Alessia Guido ◽

...

Keyword(s):

Regression Analysis ◽

Linear Regression ◽

Linear Regression Analysis ◽

Prostaglandin F2α ◽

Neuropsychiatric Disorders ◽

Serum Levels ◽

Multiple Linear Regression Analysis ◽

Tic Disorders ◽

Streptococcal Infections ◽

Cross Sectional

Abstract Background: pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections syndrome (PANDAS) identifies patients with acute onset of obsessive-compulsive and tic disorders. The objective of this study was to evaluate serum NOX2 levels, as well as 8-iso-prostaglandin F2α (iso-PGF2α) and lipopolysaccharide (LPS) of PANDAS patients. Methods: a cross sectional study was performed to compare serum levels of soluble NOX2-dp (sNOX-2-dp), isoprostanes and LPS in 60 consecutive subjects, including 30 children affected by PANDAS and 30 controls (CT) matched for age and gender. Serum zonulin was used as intestinal permeability assay. Results: compared with CT, PANDAS children had increased values of sNOX-2-dp, 8-iso-PGF2-alpha and LPS. Simple linear regression analysis showed that sNOX2-dp was signiﬁcantly correlated with serum LPS (Rs=0.359; p=0.005), zonulin (Rs=0.444; p<0.001) and iso-PGF2α (Rs=0.704; p<0.001). Serum LPS signiﬁcantly correlated with zonulin (Rs=0.610; p<0.001), and iso-PGF2α (Rs=0.591; p=0.001). Finally, a multiple linear regression analysis was performed to define the independent predictors of sNOX-2-dp. Serum isoprostanes and zonulin resulted as the only independent predictive variables associated with sNOX2-dp (R2=68%). Conclusion: this study shows that children affected by PANDAS have high circulating levels of sNOX2-dp, isoprostanes and of LPS that could be potentially implicated in the process of neuroinflammation.

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GAMBARAN SUPERVISI, IKLIM KERJA SERTA KEPUASAN KERJA KARYAWAN PT. TRIBUANA REKAYASA BANDUNG

Journal of Business Management Education (JBME) ◽

10.17509/jbme.v3i1.14256 ◽

2018 ◽

Vol 3 (1) ◽

pp. 81-86

Author(s):

Devi Robissalami ◽

Sumiyati Sumiyati ◽

Eded Tarmedi

Keyword(s):

Regression Analysis ◽

Linear Regression Analysis ◽

Multiple Linear Regression Analysis ◽

Positive Influence ◽

Cross Sectional ◽

Employee Job Satisfaction ◽

Analysis Technique ◽

The Difference ◽

Cross Sectional Design ◽

The Impact

Purpose - The purpose of this study is to determine the effect of supervision and working climate on employee job satisfactionDesign / methodology / approach - This research was conducted in less than 1 year period, the research design is cross-sectional design. The method used is exolanatory survey, and population 67 employees. The analysis technique used is descriptive, the questionnaire is used as a research instrument to collect data from respondents.Findings - based on the results of the study using multiple linear regression analysis, the result that there is a positive influence of supervision and work climate on employee job satisfaction.Originality / value - this study provides a basis for find out the impact of supervision and working climate on employee job satisfaction. The difference of this study with previous research is on the objects, variables, theories and the references.

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Association Between Patient Activation and Medication Adherence in Patients With Stroke: A Cross-Sectional Study

Frontiers in Neurology ◽

10.3389/fneur.2021.722711 ◽

2021 ◽

Vol 12 ◽

Author(s):

Weijing Sui ◽

Li-hong Wan

Keyword(s):

Regression Analysis ◽

Medication Adherence ◽

Influencing Factor ◽

Linear Regression Analysis ◽

Univariate Analysis ◽

Patient Activation ◽

Multiple Linear Regression Analysis ◽

Improve Medication Adherence ◽

Cross Sectional ◽

Low Level

Background: Medication adherence is key to secondary prevention in patients with stroke. Poor medication adherence can lead to recurrence, disability, or even death in stroke survivors. Patient activation is associated with increased healthy behaviors and improved clinical outcomes in many chronic diseases. However, the association between patient activation and medication adherence in patients with stroke remains unclear.Objective: The study aimed to explore the influence of patient activation on the medication adherence of patients with stroke and to analyze the reasons for medication nonadherence.Materials and Methods: A cross-sectional design with convenience sampling was used in this study. A total of 119 patients with stroke were recruited from a tertiary hospital in Guangzhou. A social-demographic and clinical data form, a self-developed medication adherence questionnaire, and the 13-item Patient Activation Measure (PAM-13) were used. Univariate analysis and multiple linear regression analysis with dummy variables were conducted to investigate the associations between medication adherence and patient activation. Data were analyzed with IBM® SPSS® version 25.0.Results: The mean PAM-13 score in patients with stroke was 51.56 ± 12.58. A low level of patient activation was reported by up to 66.4% of the patients. The self-reported medication adherence questionnaire score was 5.59 ± 1.52. A low level of medication adherence was reported by up to 59.7% of the patients, while a moderate level was reported by 34.4%, and a high level was reported by only 5.9%. In the multiple stepwise regression analysis, patient activation was found to be an independent influencing factor of medication adherence in patients with stroke (p < 0.05).Conclusion: Medication adherence was poor in patients in Guangzhou, China, following an ischemic stroke. Patient activation as the independent influencing factor identified in this study will support healthcare givers to develop the tailored intervention to improve medication adherence among patients with stroke in China.

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Fear of future workplace violence and its influencing factors among nurses in Shandong, China: a cross-sectional study

BMC Nursing ◽

10.1186/s12912-021-00644-w ◽

2021 ◽

Vol 20 (1) ◽

Author(s):

Chang Fu ◽

Yaru Ren ◽

Guowen Wang ◽

Xiuxin Shi ◽

Fenglin Cao

Keyword(s):

Social Support ◽

Regression Analysis ◽

Influencing Factors ◽

Workplace Violence ◽

Linear Regression Analysis ◽

Multiple Linear Regression Analysis ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

High Level

Abstract Background Fear of workplace violence has become a critical issue worldwide, which can lead to burnout, low levels of job satisfaction, and turnover. However, to date, little attention has been directed toward fear of workplace violence among nurses. Accordingly, this study investigated the level of fear of future workplace violence and its influencing factors among nurses in Shandong, China. Methods A cross-sectional study was conducted from July 30 through September 30, 2020 in Shandong Province, China. A total of 1898 nurses were enrolled from 12 tertiary hospitals. Fear of future workplace violence was measured using the Fear of Future Violence at Work scale. Demographic information, employment characteristics, social support, and experience of workplace violence were assessed. Multiple linear regression analysis was used to explore the influencing factors of fear of future workplace violence. Results The average score of fear of future violence at work was 67.43 ± 17.20 among nurses. Multiple linear regression analysis showed that higher fear of future violence at work scores were reported among nurses who were female (B = 7.10, p < 0.001), married (B = 3.50, p = 0.028), with a monthly income ≥5000 Chinese yuan (CNY) (B = 3.14, p = 0.007), working in the department of internal medicine (B = 2.90, p = 0.032), surgery (B = 5.03, p < 0.001), pediatrics (B = 5.38, p = 0.003), or emergency department (B = 4.50, p = 0.010), working as a contract employee (B = 2.41, p = 0.042), or who had experienced workplace violence (B = 7.02, p < 0.001). Lower fear of future violence at work scores were found among nurses who took vacations (1–14 days: B = − 2.52, p = 0.047; ≥15 days: B = − 3.69, p = 0.007) and had a high-level of social support (B = − 2.03, p = 0.020). Conclusions There was a high level of fear of future workplace violence among nurses in Shandong, China. This should be considered an important issue by hospital administrators and government officials. Effective interventions need to be enacted to address the influencing factors of fear of future workplace violence.

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Association between Visceral or Subcutaneous Fat Accumulation and B-Type Natriuretic Peptide among Japanese Subjects: A Cross-Sectional Study

Journal of Clinical Medicine ◽

10.3390/jcm10061315 ◽

2021 ◽

Vol 10 (6) ◽

pp. 1315

Author(s):

Yoshinori Hayashi ◽

Hirohide Yokokawa ◽

Hiroshi Fukuda ◽

Mizue Saita ◽

Taiju Miyagami ◽

...

Keyword(s):

Regression Analysis ◽

Linear Regression ◽

Multiple Linear Regression ◽

Natriuretic Peptide ◽

Linear Regression Analysis ◽

Subcutaneous Fat ◽

Multiple Linear Regression Analysis ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional

Background: Some previous studies have shown reduced levels of plasma B-type natriuretic peptide (BNP) in individuals with obesity. We aimed to estimate the relationship between BNP and abdominal fat distribution, adjusted for confounding factors. Methods: This cross-sectional study included 1806 Japanese individuals (981 men and 825 women) who underwent a medical health check-up. Analyzed data included age, sex, visceral fat area (VFA), and subcutaneous fat area (SFA) as obtained from computed tomography, blood pressure, and blood test results including BNP. Multiple linear regression analysis was used to examine the association between BNP, VFA, and SFA after adjusting for age, sex, comorbidities, and body mass index. Results: In the models analyzed separately for VFA and SFA, BNP correlated independently with VFA in multiple linear regression analysis among all subjects and in both men and women, while SFA correlated inversely with BNP in all subjects and women but not in men. In the model that included both VFA and SFA, BNP correlated independently with VFA, but SFA and BNP were not correlated in any models. Conclusion: Higher VFA showed an independent, significant association with lower BNP. In addition, the inverse correlation with BNP was stronger for VFA than for SFA.

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The Association Between the Severity of the Mandibular Inferior Cortex Porosity and the Number of Remaining Teeth in Elderly Indonesian People

10.21203/rs.2.13979/v1 ◽

2019 ◽

Author(s):

Bramma Kiswanjaya ◽

Hanna H Bachtiar-Iskandar

Keyword(s):

Regression Analysis ◽

Linear Regression ◽

Multiple Linear Regression ◽

Linear Regression Analysis ◽

Secondary Data ◽

Multiple Linear Regression Analysis ◽

Nonparametric Tests ◽

Cross Sectional ◽

Panoramic Radiographs ◽

The Relationship

Abstract Background The purpose of this study was to investigate the association between the severity of the mandibular inferior cortex (MIC) porosity and the number of remaining teeth in elderly Indonesian people.Materials and methods This cross-sectional study was conducted by measuring secondary data on panoramic digital examinations of patients aged 50 years and older. A total of 428 panoramic radiographs were measured from January 2017 to December 2018. The number of remaining teeth (including the third molars) was evaluated. Mandibular porosity was measured by using panoramic radiographs, according to the MIC classification: normal; mildly to moderately eroded; and severely eroded cortex.Statistical analysis used Data analysis was done using Mann-Whitney nonparametric tests to verify the relationship between the MIC classification and the number of remaining teeth. Multiple linear regression analysis was performed to investigate the relationship between confounding variables.Results A significant correlation was found between MIC classification and the number of remaining teeth on the Mann-Whitney test (P < 0.001). Multiple linear regression analysis showed that MIC classification was significantly associated with the value of the number of remaining teeth after controlling for gender and age (β = -0.37, R2 = 0.22, P < 0.001). Subjects with MIC class 3 were 7.14 times more likely to lose their teeth than subjects with MIC class 1 or class 2.Conclusions Our study demonstrated that there was an association between the severity of mandibular inferior cortex porosity and the number of remaining teeth in elderly Indonesian people.

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Cognitive Functioning and Associated Factors in Older Adults: Results from the Indonesian Family Life Survey-5 (IFLS-5) in 2014-2015

Current Gerontology and Geriatrics Research ◽

10.1155/2019/4527647 ◽

2019 ◽

Vol 2019 ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Supa Pengpid ◽

Karl Peltzer ◽

Indri Hapsari Susilowati

Keyword(s):

Older Adults ◽

Regression Analysis ◽

Linear Regression ◽

Cognitive Functioning ◽

Family Life ◽

Associated Factors ◽

Linear Regression Analysis ◽

Cognitive Status ◽

Cross Sectional ◽

Indonesian Family Life Survey

Objective. The study aims to investigate cognitive functioning and associated factors in a national general population-based sample of older Indonesians. Methods. Participants were 1228 older adults, 65 years and older (median age 70.0 years, Interquartile Range=6.0), who took part in the cross-sectional Indonesian Family Life Survey-5 (IFLS-5) in 2014-15. They were requested to provide information about sociodemographic and various health variables, including cognitive functioning measured with items from the Telephone Survey of Cognitive Status (TICS). Multivariable linear regression analysis was performed to assess the association of sociodemographic factors, health variables, and cognitive functioning. Results. The overall mean cognition score was 14.7 (SD=4.3) (range 0-34). In adjusted linear regression analysis, older age, having hypertension, and being underweight were negatively associated with better cognitive functioning and higher education was positively associated with better cognitive functioning. Conclusion. Several sociodemographic and health risk factors for poor cognitive functioning were identified which can guide intervention strategies in Indonesia.

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Oxidative Stress and Gut-Derived Lipopolysaccharides in Neurodegenerative Disease: Role of NOX2

Oxidative Medicine and Cellular Longevity ◽

10.1155/2020/8630275 ◽

2020 ◽

Vol 2020 ◽

pp. 1-7 ◽

Cited By ~ 4

Author(s):

Lorenzo Loffredo ◽

Evaristo Ettorre ◽

Anna Maria Zicari ◽

Maurizio Inghilleri ◽

Cristina Nocella ◽

...

Keyword(s):

Oxidative Stress ◽

Regression Analysis ◽

Linear Regression ◽

Linear Regression Analysis ◽

Developed Countries ◽

Multiple Linear Regression Analysis ◽

Cross Sectional Study ◽

Blood Levels ◽

Cross Sectional ◽

Predictive Variables

Background. Neurodegenerative diseases (ND) as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis represent a growing cause of disability in the developed countries. The underlying physiopathology is still unclear. Several lines of evidence suggest a role for oxidative stress and NADPH oxidase 2 (NOX2) in the neuropathological pathways that lead to ND. Furthermore, recent studies hypothesized a role for gut microbiota in the neuroinflammation; in particular, lipopolysaccharide (LPS) derived from Gram-negative bacteria in the gut is believed to play a role in causing ND by increase of oxidative stress and inflammation. The aim of this study was to assess NOX2 activity as well as serum 8-iso-prostaglandin F2α (8-iso-PGF2α), serum H2O2, and LPS in patients with ND compared to controls. Methods. One hundred and twenty-eight consecutive subjects, including 64 ND patients and 64 controls (CT) matched for age and gender, were recruited. A cross-sectional study was performed to compare serum activity of soluble NOX2-dp (sNOX2-dp), blood levels of isoprostanes, serum H2O2, and LPS in these two groups. Serum zonulin was used to assess gut permeability. Results. Compared with CT, ND patients had higher values of sNOX2-dp, 8-iso-PGF2α, H2O2, and LPS. Simple linear regression analysis showed that sNOX2-dp was significantly correlated with serum LPS (Rs=0.441; p<0.001), zonulin (Rs=0.411; p<0.001), serum H2O2 (Rs=0.329; p<0.001), and 8-iso-PGF2α (Rs=0.244; p=0.006). LPS significantly correlated with serum zonulin (Rs=0.818; p<0.001) and 8-iso-PGF2α (Rs=0.280; p=0.001). A multiple linear regression analysis was performed to define the independent predictors of sNOX2-dp. LPS (SE, 0.165; standardized coefficient β, 0.459; p<0.001) and 8-iso-PGF2α (SE, 0.018; standardized coefficient β, 0.220; p=0.005) emerged as the only independent predictive variables associated with sNOX2-dp (R2=57%). Conclusion. This study provides the first report attesting that patients with ND have high NOX2 activation that could be potentially implicated in the process of neuroinflammation.

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