scholarly journals Novel Volumetric and Surface-Based Magnetic Resonance Indices of the Aging Brain – Does Male and Female Brain Age in the Same Way?

2021 ◽  
Vol 12 ◽  
Author(s):  
Przemysław Podgórski ◽  
Joanna Bladowska ◽  
Marek Sasiadek ◽  
Anna Zimny
Keyword(s):  
Fractal Dimension ◽  
Magnetic Resonance ◽  
Cortical Thickness ◽  
Brain Mri ◽  
Aging Brain ◽  
Men And Women ◽  
Male And Female ◽  
Brain Volumetry ◽  
Gyrification Index ◽  
Sulcal Depth

Introduction: Novel post-processing methods allow not only for assessment of brain volumetry or cortical thickness based on magnetic resonance imaging (MRI) but also for more detailed analysis of cortical shape and complexity using parameters such as sulcal depth, gyrification index, or fractal dimension. The aim of this study was to analyze changes in brain volumetry and other cortical indices during aging in men and women.Material and Methods: Material consisted of 697 healthy volunteers (aged 38–80 years; M/F, 264/443) who underwent brain MRI using a 1.5-T scanner. Voxel-based volumetry of total gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) was performed followed by assessment of cortical parameters [cortical thickness (CT), sulcal depth (SD), gyrification index (GI), and fractal dimension (FD)] in 150 atlas locations using surface-based morphometry with a region-based approach. All parameters were compared among seven age groups (grouped every 5 years) separately for men and women. Additionally, percentile curves for men and women were provided for total volumes of GM, WM, and CSF.Results: In men and women, a decrease in GM and WM volumes and an increase in CSF volume seem to progress slowly since the age of 45. In men, significant GM and WM loss as well as CSF increase start above 55 years of age, while in women, significant GM loss starts above 50 and significant WM loss as well as CSF increase above 60. CT was found to significantly decrease with aging in 39% of locations in women and in 36% of locations in men, SD was found to increase in 13.5% of locations in women and in 1.3% of locations in men, GI was decreased in 3.4% of locations in women and in 2.0% of locations in men, and FD was changed in 2.7% of locations in women compared to 2.0% in men.Conclusions: Male and female brains start aging at the similar age of 45. Compared to men, in women, the cortex is affected earlier and in the more complex pattern regarding not only cortical loss but also other alterations within the cortical shape, with relatively longer sparing of WM volume.

scholarly journals The influence of biophysical parameters in a biomechanical model of cortical folding patterns

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xiaoyu Wang ◽  
Julien Lefèvre ◽  
Amine Bohi ◽  
Mariam Al Harrach ◽  
Mickael Dinomais ◽  
...  
Keyword(s):  
Cortical Thickness ◽  
Mean Curvature ◽  
Three Dimensional ◽  
Biomechanical Model ◽  
Mechanical Forces ◽  
Cortical Folding ◽  
Biophysical Parameters ◽  
Gyrification Index ◽  
Initial Geometry ◽  
Sulcal Depth

AbstractAbnormal cortical folding patterns, such as lissencephaly, pachygyria and polymicrogyria malformations, may be related to neurodevelopmental disorders. In this context, computational modeling is a powerful tool to provide a better understanding of the early brain folding process. Recent studies based on biomechanical modeling have shown that mechanical forces play a crucial role in the formation of cortical convolutions. However, the effect of biophysical parameters in these models remain unclear. In this paper, we investigate the effect of the cortical growth, the initial geometry and the initial cortical thickness on folding patterns. In addition, we not only use several descriptors of the folds such as the dimensionless mean curvature, the surface-based three-dimensional gyrification index and the sulcal depth, but also propose a new metric to quantify the folds orientation. The results demonstrate that the cortical growth mode does almost not affect the complexity degree of surface morphology; the variation in the initial geometry changes the folds orientation and depth, and in particular, the slenderer the shape is, the more folds along its longest axis could be seen and the deeper the sulci become. Moreover, the thinner the initial cortical thickness is, the higher the spatial frequency of the folds is, but the shallower the sulci become, which is in agreement with the previously reported effects of cortical thickness.

scholarly journals Inter- and Intra-Scanner Variability of Automated Brain Volumetry on Three Magnetic Resonance Imaging Systems in Alzheimer’s Disease and Controls

2021 ◽  
Vol 13 ◽  
Author(s):  
Mandy Melissa Jane Wittens ◽  
Gert-Jan Allemeersch ◽  
Diana Maria Sima ◽  
Maarten Naeyaert ◽  
Tim Vanderhasselt ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Imaging System ◽  
Brain Mri ◽  
Intraclass Correlation ◽  
Imaging Systems ◽  
Resonance Imaging ◽  
Brain Volumes ◽  
Brain Volumetry ◽  
Multiple Imaging

Magnetic Resonance Imaging (MRI) has become part of the clinical routine for diagnosing neurodegenerative disorders. Since acquisitions are performed at multiple centers using multiple imaging systems, detailed analysis of brain volumetry differences between MRI systems and scan-rescan acquisitions can provide valuable information to correct for different MRI scanner effects in multi-center longitudinal studies. To this end, five healthy controls and five patients belonging to various stages of the AD continuum underwent brain MRI acquisitions on three different MRI systems (Philips Achieva dStream 1.5T, Philips Ingenia 3T, and GE Discovery MR750w 3T) with harmonized scan parameters. Each participant underwent two subsequent MRI scans per imaging system, repeated on three different MRI systems within 2 h. Brain volumes computed by icobrain dm (v5.0) were analyzed using absolute and percentual volume differences, Dice similarity (DSC) and intraclass correlation coefficients, and coefficients of variation (CV). Harmonized scans obtained with different scanners of the same manufacturer had a measurement error closer to the intra-scanner performance. The gap between intra- and inter-scanner comparisons grew when comparing scans from different manufacturers. This was observed at image level (image contrast, similarity, and geometry) and translated into a higher variability of automated brain volumetry. Mixed effects modeling revealed a significant effect of scanner type on some brain volumes, and of the scanner combination on DSC. The study concluded a good intra- and inter-scanner reproducibility, as illustrated by an average intra-scanner (inter-scanner) CV below 2% (5%) and an excellent overlap of brain structure segmentation (mean DSC > 0.88).

scholarly journals Advanced techniques in magnetic resonance imaging of the brain in children with ADHD

2011 ◽  
Vol 69 (2a) ◽  
pp. 242-252 ◽  
Author(s):  
Giuseppe Pastura ◽  
Paulo Mattos ◽  
Emerson Leandro Gasparetto ◽  
Alexandra Prufer de Queiroz Campos Araújo
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Cortical Thickness ◽  
Diffusion Tensor ◽  
Brain Regions ◽  
Resonance Imaging ◽  
Brain Volumetry ◽  
Aged Child ◽  
Magnetic Resonance Imaging Mri ◽  
The Brain

Attention deficit hyperactivity disorder (ADHD) affects about 5% of school-aged child. Previous published works using different techniques of magnetic resonance imaging (MRI) have demonstrated that there may be some differences between the brain of people with and without this condition. This review aims at providing neurologists, pediatricians and psychiatrists an update on the differences between the brain of children with and without ADHD using advanced techniques of magnetic resonance imaging such as diffusion tensor imaging, brain volumetry and cortical thickness, spectroscopy and functional MRI. Data was obtained by a comprehensive, non-systematic review of medical literature. The regions with a greater number of abnormalities are splenium of the corpus callosum, cingulated girus, caudate nucleus, cerebellum, striatum, frontal and temporal cortices. The brain regions where abnormalities are observed in studies of diffusion tensor, volumetry, spectroscopy and cortical thickness are the same involved in neurobiological theories of ADHD coming from studies with functional magnetic resonance imaging.

scholarly journals Fractal dimension in human cortical surface: Multiple regression analysis with cortical thickness, sulcal depth, and folding area

2006 ◽  
Vol 27 (12) ◽  
pp. 994-1003 ◽  
Author(s):  
Kiho Im ◽  
Jong-Min Lee ◽  
Uicheul Yoon ◽  
Yong-Wook Shin ◽  
Soon Beom Hong ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Fractal Dimension ◽  
Multiple Regression Analysis ◽  
Multiple Regression ◽  
Cortical Thickness ◽  
Cortical Surface ◽  
Sulcal Depth

scholarly journals Altered cortical morphology in major depression disorder patients with suicidality

2021 ◽  
Vol 1 (1) ◽  
pp. 13-22
Author(s):  
Huiru Li ◽  
Huawei Zhang ◽  
Li Yin ◽  
Feifei Zhang ◽  
Ziqi Chen ◽  
...  
Keyword(s):  
Fractal Dimension ◽  
Cortical Thickness ◽  
Emotional Processing ◽  
Rating Scale ◽  
Brain Regions ◽  
Anterior Cingulate ◽  
Depressed Patients ◽  
Cortical Morphology ◽  
Surface Based Morphometry ◽  
Sulcal Depth

Abstract Background Major depressive disorder (MDD) is associated with high risk of suicide, but the biological underpinnings of suicidality in MDD patients are far from conclusive. Previous neuroimaging studies using voxel-based morphometry (VBM) demonstrated that depressed individuals with suicidal thoughts or behaviors exhibit specific cortical structure alterations. To complement VBM findings, surface-based morphometry (SBM) can provide more details into gray matter structure, including the cortical complexity, cortical thickness and sulcal depth for brain images. Objective This study aims to use SBM to investigate cortical morphology alterations to obtain evidence for neuroanatomical alterations in depressed patients with suicidality. Methods Here, 3D T1-weighted MR images of brain from 39 healthy controls, 40 depressed patients without suicidality (patient controls), and 39 with suicidality (suicidal groups) were analyzed based on SBM to estimate the fractal dimension, gyrification index, sulcal depth, and cortical thickness using the Computational Anatomy Toolbox. Correlation analyses were performed between clinical data and cortical surface measurements from patients. Results Surface-based morphometry showed decreased sulcal depth in the parietal, frontal, limbic, occipital and temporal regions and decreased fractal dimension in the frontal regions in depressed patients with suicidality compared to both healthy and patient controls. Additionally, in patients with depression, the sulcal depth of the left caudal anterior cingulate cortex was negatively correlated with Hamilton Depression Rating Scale scores. Conclusions Depressed patients with suicidality had abnormal cortical morphology in some brain regions within the default mode network, frontolimbic circuitry and temporal regions. These structural deficits may be associated with the dysfunction of emotional processing and impulsivity control. This study provides insights into the underlying neurobiology of the suicidal brain.

Reliability of Hammersmith Examination in Prediction of Neurological Outcomes (REHAPENO) - Research Protocol (Preprint)

2018 ◽  
Author(s):  
Mohamed Fleifel ◽  
Rawya Abdelghani ◽  
Mohamed Ameen
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Image ◽  
Current Practice ◽  
Surgical Intervention ◽  
Brain Mri ◽  
Developmental Outcomes ◽  
Research Protocol ◽  
Neurological Outcomes ◽  
Mri Brain ◽  
Brain Ultrasound

BACKGROUND Background: Studying the neurological developmental outcomes and comparing correlations with MRI (Magnetic resonance image) versus the Hammersmith Infant Neurological Examination (HINE) OBJECTIVE Objective: To investigate the non-inferiority of MRI to HINE in infant developmental outcomes METHODS Settings: Hospital settings including pediatrics and neonatal care units Intervention: No medical or surgical intervention is planned, only correlation and extra analyses would take place to standardize the current practice Measurements: HINE, Brain MRI, Brain Ultrasound and developmental outcomes after 12 months RESULTS Results: The observations collected and correlations measured to figure out the reliability of both HINE and MRI in order to figure to what extent can we rely on HINE alone in expecting the developmental outcomes CONCLUSIONS The more reliability would expressed by HINE assessment the accurate expectation of developmental in preterm infants CLINICALTRIAL https://clinicaltrials.gov/ct2/show/NCT03580252

Magnetic resonance imaging findings and its association to electroencephalogram in children with partial epilepsy (Preprint)

2020 ◽  
Author(s):  
Huynh Quang Huy
Keyword(s):  
Magnetic Resonance Imaging ◽  
Preschool Children ◽  
Magnetic Resonance ◽  
Brain Mri ◽  
Partial Epilepsy ◽  
Small Sample ◽  
Normal Brain ◽  
Resonance Imaging ◽  
Normal Children ◽  
Eeg Abnormalities

BACKGROUND It is important to identify the neuroimaging features that are associated with partial epilepsy in preschool children. Advances in technology recently to localize focal epileptogenic lesions, especially that of high-resolution structural imaging with magnetic resonance imaging (MRI). The recommendation that electroencephalography (EEG) should be gold criteria and that M.R.I should be optional has been questioned. OBJECTIVE The present study aims to to explore the brain lesions on MRI and its association to electroencephalogram in children with partial epilepsy. METHODS The present study was conducted among 112 preschool children with history of partial seizures. All patients underwent EEG and brain MRI. The epileptogenic lesions were identified on the basis of the signal intensities and morphological abnormalities seen on MRI. The correlation between MRI and EEG abnormalities was explored using a chi-square test. RESULTS Abnormal MRI were found in 34.8% (n = 39) of the sample. The EEG and MRI agreed with respect to classify into abnormal or normal in 48.2% (n = 54). Of the 27 patients with a normal EEG, six (22.2%) were seen to have an abnormal MRI. CONCLUSIONS A number of MRI abnormalities was found in our study of otherwise normal children, although the correlation between these results was not clear. Follow-up of these children will help us identify the important abnormalities. Despite of small sample, our results showed that a normal E.E.G findings does not predict a normal brain MRI in children with partial epilepsy.

scholarly journals Restrained Eating Is Associated with Lower Cortical Thickness in the Inferior Frontal Gyrus in Adolescents

2021 ◽  
Vol 11 (8) ◽  
pp. 978
Author(s):  
Isabel García-García ◽  
Maite Garolera ◽  
Jonatan Ottino-González ◽  
Xavier Prats-Soteras ◽  
Anna Prunell-Castañé ◽  
...  
Keyword(s):  
Cortical Thickness ◽  
Eating Behaviors ◽  
Inferior Frontal Gyrus ◽  
Brain Mri ◽  
Neural Mechanism ◽  
Restrained Eating ◽  
Eating Patterns ◽  
Restrictive Eating ◽  
And Performance ◽  
Uncontrolled Eating

Some eating patterns, such as restrained eating and uncontrolled eating, are risk factors for eating disorders. However, it is not yet clear whether they are associated with neurocognitive differences. In the current study, we analyzed whether eating patterns can be used to classify participants into meaningful clusters, and we examined whether there are neurocognitive differences between the clusters. Adolescents (n = 108; 12 to 17 years old) and adults (n = 175, 18 to 40 years old) completed the Three Factor Eating Questionnaire, which was used to classify participants according to their eating profile using k means clustering. Participants also completed personality questionnaires and a neuropsychological examination. A subsample of participants underwent a brain MRI acquisition. In both samples, we obtained a cluster characterized by high uncontrolled eating patterns, a cluster with high scores in restrictive eating, and a cluster with low scores in problematic eating behaviors. The clusters were equivalent with regards to personality and performance in executive functions. In adolescents, the cluster with high restrictive eating showed lower cortical thickness in the inferior frontal gyrus compared to the other two clusters. We hypothesize that this difference in cortical thickness represents an adaptive neural mechanism that facilitates inhibition processes.

Toward Understanding the Contributions of Sex and Situation to Behavior in a College Setting

1987 ◽  
Vol 60 (3) ◽  
pp. 875-883
Author(s):  
Nancy Lipsitt ◽  
Rose R. Olver
Keyword(s):  
Sex Differences ◽  
The Other ◽  
Men And Women ◽  
Male And Female ◽  
Relative Contribution ◽  
College Setting ◽  
Female Subjects

The relative contribution of sex and situation has become a contested issue in the understanding of sex differences in behavior. In the present study, 20 male and 20 female undergraduates were asked to describe their behavior and thoughts in six everyday college situations. Three of the situations were constructed to be typically male and three typically female in content. The results indicate that men and women demonstrate sex-specific characteristics in their responses regardless of the type of situation presented. Men exhibited concern with separateness from others, while women exhibited concern with sustaining connection to others, even when faced with situations described to present demand properties that might be expected specifically to elicit the concern characteristic of the other sex. However, for these students the situation also made a difference: female-defined situations elicited the most masculine responses for both male and female subjects.

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