scholarly journals Increasing Serotonin to Reduce Parkinsonian Tremor

2021 ◽  
Vol 15 ◽  
Author(s):  
Daniele Caligiore ◽  
Francesco Montedori ◽  
Silvia Buscaglione ◽  
Adriano Capirchio
Keyword(s):  
Early Diagnosis ◽  
Pharmacological Treatment ◽  
Neural Mechanisms ◽  
Serotoninergic System ◽  
Serotonin Concentration ◽  
Parkinsonian Tremor ◽  
Resting Tremor ◽  
Concentration Changes ◽  
The One ◽  
Existing Data

While current dopamine-based drugs seem to be effective for most Parkinson's disease (PD) motor dysfunctions, they produce variable responsiveness for resting tremor. This lack of consistency could be explained by considering recent evidence suggesting that PD resting tremor can be divided into different partially overlapping phenotypes based on the dopamine response. These phenotypes may be associated with different pathophysiological mechanisms produced by a cortical-subcortical network involving even non-dopaminergic areas traditionally not directly related to PD. In this study, we propose a bio-constrained computational model to study the neural mechanisms underlying a possible type of PD tremor: the one mainly involving the serotoninergic system. The simulations run with the model demonstrate that a physiological serotonin increase can partially recover dopamine levels at the early stages of the disease before the manifestation of overt tremor. This result suggests that monitoring serotonin concentration changes could be critical for early diagnosis. The simulations also show the effectiveness of a new pharmacological treatment for tremor that acts on serotonin to recover dopamine levels. This latter result has been validated by reproducing existing data collected with human patients.

scholarly journals Web Atlas como Herramienta para la Gestión Integrada Costera: de los Datos al Conocimiento Práctico

2021 ◽  
Vol 6 (Vol Esp. 2) ◽  
pp. 427-454
Author(s):  
Sílvia Maria Sartor ◽  
Marcos Reis Rosa ◽  
Juliana Tristão Pires ◽  
Claudio Augusto Oller Nascimento
Keyword(s):  
Collaborative Work ◽  
Decision Makers ◽  
Scientific Language ◽  
The Public ◽  
Paulo State ◽  
Impact Indicators ◽  
Coastal Area Management ◽  
The One ◽  
Multiple Impact ◽  
Existing Data

Despite the importance of coastal areas to sustainable development, they are poorly known by the public or even by decision-makers. This undermines consistent action towards their protection. Existing data and information, published in very complex language, tend to be restricted to academic use. The Coastal Web Atlas as the one developed here is a tool that makes this information more accessible to managers, by preserving, integrating, comparing, and sharing data as smart maps. The spatial analysis based on multiple impact indicators facilitates the correlation of causes and effects. The Coastal Web Atlas is available to a broad audience and it could be a strong instrument for spatial planning and oversight. The authors propose to improve coastal area management by using colors on maps to decode scientific language to friendly language and to publish it on a geoportal. This technology promotes the use of collected data and enables collaborative work. A pilot experiment is being developed in the Santos Port Region, at the São Paulo state coast, Brazil: http://santoswebatlas.com.br/

Anxiety in cardiology. The use of pregabalin in the treatment of anxiety disorders in patients with cardiovascular diseases

2021 ◽  
Vol 14 (4) ◽  
pp. 428-432
Author(s):  
Anna Antosik-Wójcińska
Keyword(s):  
Cardiovascular Diseases ◽  
Early Diagnosis ◽  
Anxiety Disorders ◽  
Pharmacological Treatment ◽  
Anxiety Symptoms ◽  
Health Consequences ◽  
Cardiovascular Patients ◽  
Starting Point ◽  
Patient Prognosis ◽  
High Level

The paper discusses two issues: the multidirectional relationship between the occurrence of anxiety symptoms and cardiovascular diseases, and the influence of the persistently high level of anxiety on the course of cardiological diseases and patient prognosis. In the discussion on the negative health consequences of anxiety disorders, there is emphasized importance of early diagnosis of these disorders and implementation of its treatment. As a starting point there were presented clinical cases of cardiovascular patients in whom developed anxiety disorders. The following sections discuss various aspects of the pharmacological treatment of anxiety disorders, focusing on the possible use of pregabalin in this.

Tremor is attenuated during walking in essential tremor with resting tremor but not parkinsonian tremor

2011 ◽  
Vol 18 (9) ◽  
pp. 1224-1228 ◽  
Author(s):  
Kei Uchida ◽  
Masaaki Hirayama ◽  
Fumitada Yamashita ◽  
Norio Hori ◽  
Tomohiko Nakamura ◽  
...  
Keyword(s):  
Essential Tremor ◽  
Parkinsonian Tremor ◽  
Resting Tremor

scholarly journals Tear Fluid Catecholamines As Biomarkers of the Parkinson’s Disease: A Clinical and Experimental Study

Acta Naturae ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 99-103 ◽  
Author(s):  
A. R. Kim ◽  
M. R. Nodel ◽  
T. A. Pavlenko ◽  
N. B. Chesnokova ◽  
N. N. Yakhno ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Clinical Stage ◽  
Tear Fluid ◽  
Fluid Composition ◽  
Stage Model ◽  
Preclinical Stage ◽  
Norepinephrine Concentration ◽  
Important Approach ◽  
Concentration Changes ◽  
Early Clinical Stage

An important approach to an early diagnosis of Parkinsons disease (PD) is screening for peripheral biomarkers in patients at the early clinical stage. In this study, we evaluated catecholamine concentration changes in the tear fluid of untreated PD patients as biomarkers. Norepinephrine and dopamine concentrations in the tear fluid of patients were found to increase compared to those in age controls, which was especially pronounced on the side where motor symptoms appeared. On the contrary, the epinephrine concentration in the tear fluid of patients was reduced bilaterally. Since there was no reason to consider the markers found in the clinical stage of PD as markers of the preclinical stage, we additionally studied the tear fluid composition in mouse neurotoxic models of PD preclinical and clinical stages. The norepinephrine concentration in the tear fluid of mice from the clinical stage model was found to be higher than that in controls; in the preclinical stage model, the norepinephrine concentration had a tendency to increase. Therefore, both PD patients and mice from PD preclinical and clinical stage models manifest unidirectional changes in their tear fluid compositions, which may be considered as promising biomarkers for the development of early diagnosis.

scholarly journals Challenges and Risks in the Due Diligence Process Answered with an Innovative Approach

2021 ◽  
Vol 2 (1) ◽  
pp. 51-66
Author(s):  
Christoph Müller
Keyword(s):  
Mergers And Acquisitions ◽  
Positive Impact ◽  
Due Diligence ◽  
Expert Interviews ◽  
Manufacturing Companies ◽  
Key Factors ◽  
The One ◽  
Qualitative Part ◽  
Strategic Controlling ◽  
Existing Data

In existing academic studies on the Due Diligence process, the different areas have been considered separately. This is time consuming and causes inefficiencies. The proposed approach to Due Diligence integrates these separate areas into one process. While every company’s success can be defined by a few key factors, these differ by industry. The goal of this analysis is to develop a basis for decision-making regarding Mergers and Acquisitions for small- and medium-sized manufacturing companies by generating a scorecard model that enables the potential acquirer to perform an overall analysis of the existing data as well as to generate an informed outlook for the future using a standardized and efficient approach that also has a positive impact on the success rate of mergers and acquisition transactions. The model is based on different research methods. First of all, a literature research was executed, to define the theoretical framework. There are two main areas, the Strategic Controlling on the one hand and M&A on the other hand. The theoretical findings are specified through expert interviews. The expert interviews are semi-standardized. There is a quantitative and a qualitative part. Based on the analysis, a concept for a leaner DD approach is developed. The article presents a sum up of the research. Doi: 10.28991/HIJ-2021-02-01-06 Full Text: PDF

scholarly journals Notes on the Kinematic Structure of the Three-Flavor Neutrino Oscillation Framework

1997 ◽  
Vol 12 (28) ◽  
pp. 5081-5101 ◽  
Author(s):  
D. V. Ahluwalia
Keyword(s):  
Neutrino Oscillation ◽  
Mass Scale ◽  
Strong Mixing ◽  
Mixing Angles ◽  
Astronomical Observations ◽  
Mass Eigenstates ◽  
Relativistic Regime ◽  
The One ◽  
Design Proposal ◽  
Existing Data

These notes present a critique of the standard three-flavor neutrino oscillation framework. The design proposal of the MINOS at Fermilab based on a two-mass eigenstate framework may require serious reconsideration if there is strong mixing between all three flavors of neutrinos. For the LSND and KARMEN neutrino oscillation experiments, the amplitude of neutrino oscillation of the "one mass scale dominance" framework vanishes for certain values of mixing angles as a result of opposite signs of two equal and opposite contributions. Recent astronomical observations leave open the possibility that one of the neutrino mass eigenstates may be nonrelativistic in some instances. Neutrino oscillation phenomenology with a superposition of two relativistic, and one nonrelativistic, mass eigenstates is constructed. It is concluded that if the transition from the nonrelativistic to the relativistic regime happens for energies relevant to the reactor and the LSND neutrino oscillation experiments, then one must consider an ab initio analysis of the existing data.

scholarly journals Title: “Labels Matter: Is it stress or is it Trauma?”

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Gal Richter-Levin ◽  
Carmen Sandi
Keyword(s):  
Neural Mechanisms ◽  
The Other ◽  
Traumatic Experiences ◽  
Research Practice ◽  
Research Directions ◽  
Stress Resilience ◽  
The Face ◽  
Stressful Experience ◽  
The One ◽  
Negative Connotation

AbstractIn neuroscience, the term ‘Stress’ has a negative connotation because of its potential to trigger or exacerbate psychopathologies. Yet in the face of exposure to stress, the more common reaction to stress is resilience, indicating that resilience is the rule and stress-related pathology the exception. This is critical because neural mechanisms associated with stress-related psychopathology are expected to differ significantly from those associated with resilience.Research labels and terminology affect research directions, conclusions drawn from the results, and the way we think about a topic, while choice of labels is often influenced by biases and hidden assumptions. It is therefore important to adopt a terminology that differentiates between stress conditions, leading to different outcomes.Here, we propose to conceptually associate the term ‘stress’/‘stressful experience’ with ‘stress resilience’, while restricting the use of the term ‘trauma’ only in reference to exposures that lead to pathology. We acknowledge that there are as yet no ideal ways for addressing the murkiness of the border between stressful and traumatic experiences. Yet ignoring these differences hampers our ability to elucidate the mechanisms of trauma-related pathologies on the one hand, and of stress resilience on the other. Accordingly, we discuss how to translate such conceptual terminology into research practice.

scholarly journals EXPERIMENTAL STUDY ON THE OVERTOPPING BEHAVIOUR OF STEEP SLOPES – TRANSITION BETWEEN MILD SLOPES AND VERTICAL WALLS

2012 ◽  
Vol 1 (33) ◽  
pp. 61
Author(s):  
Lander Victor ◽  
Peter Troch
Keyword(s):  
Slope Angle ◽  
Breaking Waves ◽  
The Other ◽  
Prediction Methods ◽  
Wave Overtopping ◽  
Wave Energy Converters ◽  
Vertical Walls ◽  
The One ◽  
Steep Slopes ◽  
Existing Data

Extensive knowledge is available on the overtopping behaviour of traditional smooth impermeable sea defence structures, such as mildly sloping dikes and vertical walls, both typically featuring a high crest freeboard to reduce wave overtopping. A particular design application emerges in the development of wave energy converters of the overtopping type, where maximisation of wave overtopping is required, i.e. smooth impermeable steep sloping structures with low crest freeboards subjected to non-breaking waves. To date, only relatively limited knowledge is available on the overtopping behaviour of those structures. In this study, the average overtopping rate obtained from new experiments has been analysed and compared with existing prediction methods. This study contributes to a better knowledge on the overtopping behaviour of the steep low-crested structures, which is positioned in between that of mildly sloping dikes and vertical walls on the one hand, and in between that of structures with zero crest freeboards and relatively large crest freeboards on the other hand. The existing prediction methods seem unable to predict the significant effects of the slope angle and small relative crest freeboards on the average overtopping rate accurately. Therefore, a new set of prediction formulae is proposed based on the new experiments combined with existing data from literature. These formulae include wave overtopping at vertical walls subjected to non-impacting waves and at structures with zero crest freeboard.

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